Thu, 30 May 2016 18:30:00 GMTIn a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.
Wed, 08 Jun 2016 20:15:00 GMTEvidence of DNA "scrunching" may one day lead to a new class of drugs against viruses, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, the Georgia Institute of Technology, and Columbia University.
Mon, 06 Jun 2016 13:45:00 GMTResearchers from the Perelman School of Medicine at the University of Pennsylvania have figured out how to make a much-improved research tool that they hope will open the door to new and better HIV vaccine designs.
Fri, 27 May 2016 16:30:00 GMTA benign virus normally found in the skin can lead to a type of rare, lethal skin cancer. Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. Researchers have now identified a type of skin cell as the target of the virus in humans.
Thu, 21 Apr 2016 15:15:00 GMTBeatrice H. Hahn, MD, a professor of Medicine and Microbiology in the Perelman School of Medicine at the University of Pennsylvania, has been elected as a new member of the American Academy of Arts and Sciences, one of the nation's most prestigious honorary societies and a leading center for independent policy research.
Wed, 22 Mar 2016 10:00:00 GMTn international team led by Beatrice Hahn, MD, a professor of Medicine and Microbiology from the Perelman School of Medicine at the University of Pennsylvania, and MD/PhD student Sesh Sundararaman, used a selective amplification technique to sequence the genomes of two divergent Plasmodium species, Plasmodium reichenowi and Plasmodium gaboni, from miniscule volumes of chimpanzee blood to find clues about the evolution and pathogenicity of Plasmodium falciparum, the deadliest malaria parasite that affects people.
Wed, 20 Jan 2016 14:30:00 GMTA powerful new machine-learning technique can be applied to large datasets in the biological sciences to uncover previously unknown features of organisms and their genes, according to a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Fri, 15 Jan 2016 18:00:00 GMTIn a recently published study in Cancer Biology and Therapy, a group of Penn colleagues used a version of the PathoChip microarray, which contains 60,000 probes for all known viruses, as well as a broad range of bacteria, protozoa, fungi, and helminthes, a parasitic worm, to identify the pathogenic agent in the sample of a patient.
Thu, 15 Oct 2015 13:30:00 GMTA new study from the Perelman School of Medicine at the University of Pennsylvania, led by Erle S. Robertson, PhD and James C. Alwine, PhD, has identified, for the first time, an association between two microbial signatures and triple negative breast cancer (TNBC), the most aggressive form of the disease.
Wed, 14 Oct 2015 16:00:00 GMTDifferent treatments for Crohn's disease in children affects their gut microbes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Wed, 30 Sep 2015 13:30:00 GMTUsing a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
Tue, 18 Aug 2015 15:00:00 GMTThere may be two new ways to fight AIDS -- using a heat shock protein or a small molecule – to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Mon, 03 August 2015 17:30:00 GMTResearchers at the Perelman School of Medicine at the University of Pennsylvania have devised an entirely new approach to vaccines – creating immunity without vaccination.
Wed, 17 Jun 2015 14:00:00 GMTFive early-career researchers from three schools at the University of Pennsylvania have received funding from the Burroughs Wellcome Fund (BWF) for their excellence in biomedical research, in topics including heart disease, sleep, and infectious diseases, as part of a nationwide program totaling $22.5 million.
Wed, 03 June 2015 14:30:00 GMTSometimes even cells get tired. When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop "T cell exhaustion," becoming less effective and losing their ability to attack and destroy the invaders of the body. While the PD-1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD-1 actually directly causes exhaustion.
Thu, 12 Mar 2015 18:00:00 GMTThe National Institutes of Allergy and Infectious Diseases has awarded $16 million over the next five years for a collaborative study led by scientists from the Perelman School of Medicine at the University of Pennsylvania.
Mon, 2 Mar 2015 20:00:00 GMTTwo of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists from the Perelman School of Medicine at the University of Pennsylvania, the University of Montpellier, the University of Edinburgh, and others.
Thu, 15 Jan 2015 14:45:00 GMTBeatrice H. Hahn, MD, a professor of Medicine and Microbiology at the Perelman School of Medicine at the University of Pennsylvania, will receive the American College of Physicians Award for Outstanding Work in Science as Related to Medicine by the American College of Physicians (ACP), the national organization of internists.
Thu, 04 Dec 2014 14:45:00 GMTPeople with mental illness are more likely to have been tested for HIV than those without mental illness, according to a new study from a team of researchers at Penn Medicine and the U.S. Centers for Disease Control and Prevention (CDC) published online this week in AIDS Patient Care and STDs.
Thur, 29 Nov 2012 16:00:00 GMTA new study by researchers at the Perelman School of Medicine, University of Pennsylvania, suggests a novel therapeutical approach that might be used to shift the balance of power in chronic infections. The study appears in the November 30 issue of Science.
Mon, 18 June 2012 19:00:00 GMTHealthy humans harbor an enormous and diverse group of bacteria and other bugs that live within their intestines.
Thu, 5 Jan 2012 04:00:00 GMTFour faculty members at the University of Pennsylvania have been named Fellows of the American Association for the Advancement of Science (AAAS), three from the Perelman School of Medicine. This year 539 members have been awarded this honor by AAAS because of their scientifically or socially distinguished efforts to advance science or its applications.
Thur, 17 June 2011 13:00:00 GMTThere are ten microbial cells for every one human cell in the body, and microbiology dogma holds that there is a tight barrier protecting the inside of the body from outside invaders, in this case bacteria.
Fri, 10 June 2011 15:00:00 GMTFor tens of thousands of years, the genomes of malaria parasites and humans have been at war with one another, each involving an attempt to get the upper hand. Scientists have now performed a genetic analysis of 15 ethnic groups across Africa, in an effort to identify gene variants that could explain differing local susceptibility to malaria.
Tue, 29 Mar 2011 20:00:00 GMTThe Centers for Disease Control and Prevention (CDC) gave the Center for Clinical Epidemiology and Biostatistics (CCEB) at the University of Pennsylvania School of Medicine $2 million over the next five years to fund research to find new ways to reduce infections in health care settings.
Mon, 07 Mar 2011 17:30:00 GMTNew research on how tuberculosis (TB) bacteria develop multi-drug tolerance points to ways TB infections might be cured more quickly. The study was published online last week in Cell. The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect.
Tue, 01 Mar 2011 17:00:00 GMTAlthough untreated HIV infection eventually results in immunodeficiency (AIDS), a small group of people infected with the virus, called elite suppressors (0.5 percent of all HIV-infected individuals), are naturally able to control infection in the absence of antiretroviral therapy, or HAART. Elite suppressors and HIV- infected individuals treated with HAART have similar levels of virus in the blood stream. However, levels of HIV integrated into immune cells are much lower in elite suppressors compared to levels in cells from HIV-infected individuals on HAART, according to a study at the University of Pennsylvania School of Medicine
Thu, 07 Oct 2010 20:00:00 GMTDavid Weiner, PhD, professor of Pathology and Laboratory Medicine, will receive $3.2 million, in collaboration with the Public Health Service of Canada and biotech firm Inovio Corp., to develop a universal flu vaccine, one that is intended to protect against all strains of flu.
Thu, 23 Sep 2010 22:00:00 GMTBeatrice Hahn, MD and George Shaw, MD, will be joining the faculty of the Penn Center for AIDS Research in the School of Medicine in 2011. Both are international leaders in human and simian immunodeficiency virus research and have made groundbreaking contributions to this field for over two decades. Hahn and Shaw have also contributed significantly to the study of the transmission of human infectious pathogens from non-human animals.
Tue, 29 Jun 2010 19:00:00 GMTResearchers have shown how a battle for survival at a microscopic level could leave humans as the unlikely victims. They modeled in mice how the common bacterium Streptococcus pneumonia interacts with other bacteria, showing that competition for space between rival bacteria can cause deadlier forms of bacteria to evolve.
Thu, 18 Feb 2010 23:59:59 GMTResearchers from the University of Pennsylvania School of Medicine presented today the results from an ongoing Phase I/II open-label clinical trial of Lexgenleucel-T at the 16th Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco, CA. Lexgenleucel-T is a cell and gene therapy product being investigated for the treatment of HIV infection.
Thu, 03 Dec 2009 16:30:00 GMTTwo studies published this month in the Journal of Clinical Investigation provide a significant advance in understanding how some species of monkeys such as sooty mangabeys and African green monkeys avoid AIDS when infected with SIV, the simian equivalent of HIV. Researchers comparative genomics of SIV infection, attempting to identify possible genes related to disease progression or resistance. Their findings change the way AIDS researchers think about human versus simian AIDS infection.
Wed, 07 Oct 2009 14:00:00 GMTResearchers today announced the opening for enrollment of the first ever study using patients’ cells carrying an engineered T cell receptor to treat HIV. The trial may have important implications in the development of new treatments for HIV potentially slowing – or even preventing – the onset of AIDS.
Mon, 18 May 2009 16:00:00 GMTA University of Pennsylvania School of Medicine researcher has received a $100,000 Grand Challenges Explorations award from the Bill & Melinda Gates Foundation. The grant will support a global health research project conducted by Doron Greenbaum, PhD, Assistant Professor of Pharmacology, to look for new ways to fight malaria.
Fri, 03 Apr 2009 20:50:00 GMTResearchers at the University of Pennsylvania have discovered that parasites hijack host-cell proteins to ensure their survival and proliferation, suggesting new ways to control the diseases they cause. The study, appearing this week online in Science, was led by Doron Greenbaum, PhD, Assistant Professor of Pharmacology in the Penn School of Medicine.
Fri, 20 Mar 2009 21:00:00 GMTCentral line-associated bloodstream infections (CLABSI) fell by more than 90 percent during the past three years at the Hospital of the University of Pennsylvania due to a multi-pronged approach combining leadership initiatives, electronic infection surveillance, checklists to guide line insertion and maintenance, and implementation of the Toyota Production System to encourage best practices in line care. The findings, which Penn physicians say provide a road map for cutting the deadly, costly toll of hospital-acquired infections nationwide, were presented on Friday, March 20 at the 19th Annual Meeting of the Society for Healthcare Epidemiology of America (SHEA).
Wed, 04 Mar 2009 16:30:00 GMTThe University of Pennsylvania School of Medicine, in collaboration with The Children’s Hospital of Philadelphia, Lincoln University, and the Pennsylvania State University, will receive $5.5 million to study why patients infected with methicillin-resistant Staphylococcus aureus (MRSA) frequently experience recurrent infections despite appropriate treatment. The researchers will also determine how often MRSA spreads among household members and the factors contributing to the spread of MRSA within the household. An intervention to prevent new and recurring MRSA infections will be tested.
Mon, 09 Feb 2009 13:30:00 GMTA microbicide gel intended to prevent HIV infection in women, called PRO 2000 (0.5% dose), was 30% effective, according to results from a clinical trial conducted at the University of Pennsylvania School of Medicine and six trial sites in Africa. The results of the study, known as HPTN 035, were presented today at the international Conference on Retroviruses and Opportunistic Infections in Montreal, Canada. This is the first human clinical study to suggest that a microbicide gel may prevent male-to-female sexual transmission of HIV infection.
Tue, 27 Jan 2009 16:00:00 GMTResearchers at the University of Pennsylvania School of Medicine have likely found one reason why the Ebola virus is such a powerful, deadly, and effective virus. Using a cell culture model for Ebola virus infection, they have discovered that the virus disables a cellular protein called tetherin that normally can block the spread of virus from cell to cell.