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Penn Medicine Cardiovascular News



The latest news about Cardiovascular Medicine and Surgery from Penn Medicine - the University of Pennsylvania School of Medicine and Health System.



Copyright: 2011, The Trustees of the University of Pennsylvania
 



Minorities, Women Less Likely to Receive Life-Saving Stroke Treatment, Penn-led Study Suggests

Wed, 14 Sep 2016 20:00:00 GMT

Minorities and women suffering from a stroke may be less likely to receive the clot-busting treatment tPA, known as tissue plasminogen activator, according to a new study from Penn Medicine and other institutions published today in the online issue of Neurology, the medical journal of the American Academy of Neurology. 



Penn Preclinical Study Outlines Cardiovascular Side Effects of Breast Cancer Drug

Wed, 13 Jul 2016 17:30:00 GMT

A receptor protein that is the target of the breast cancer drug trastuzumab (Herceptin) is needed for proper heart blood-vessel development, reported researchers from the Perelman School of Medicine at the University of Pennsylvania.



Mechanics of a Heartbeat are Controlled by Molecular Strut in Heart Muscle Cells, Penn Study Finds

Thu, 21 Apr 2016 18:00:00 GMT

Using new high-resolution microscopy, a team from the Perelman School of Medicine and the School of Engineering and Applied Science at the University of Pennsylvania found that molecular struts called microtubules (MT) interact with the heart's contractile machinery to provide mechanical resistance for the beating of the heart.



Penn Study Describes the Molecular Cause of Common Cerebrovascular Disease

Wed, 30 Mar 2016 17:00:00 GMT

A team from the Perelman School of Medicine at the University of Pennsylvania has discovered the molecular mechanism that underlies cerebral cavernous malformations. They published their results this week online ahead of print in Nature.



Penn Study Shows a Form of Genetically Elevated "Good" Cholesterol May Actually be Bad

Thu, 10 Feb 2016 18:00:00 GMT

The generally accepted medical maxim that elevated HDL cholesterol (HDL-C) is "good" has been overturned by a multi-center, international study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania.



Heart Structural Gene Causes Sudden Cardiac Death in Animal Model

Mon, 14 Dec 2015 17:30:00 GMT

The presence or absence of the CAP2 gene causes sudden cardiac death in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania.



New Approach to Treating Heparin-induced Blood Disorder Revealed in Structure of Protein-Antibody Complex, Penn Study Finds

Tue, 06 Oct 2015 17:15:00 GMT

A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root, according to new research from the Perelman School of Medicine at the University of Pennsylvania. 



Penn Medicine Scientist Receives 2015 Henry M. Stratton Medal Recognizing Contributions to Basic Hematology Research

Wed, 05 Aug 2015 14:15:00 GMT

The American Society of Hematology (ASH) has awarded Nancy Speck, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania, the 2015 Henry M. Stratton Medal for Basic Science for her "seminal contributions in the area of hematology research."



Penn Study Questions Presence in Blood of Heart-Healthy Molecules from Fish Oil Supplements

Thu, 30 Jul 2015 17:15:00 GMT

Now, a new study from the Perelman School of Medicine at the University of Pennsylvania, published online this month ahead of the print issue in the Journal of Lipid Research, questions the relevance of fish oil-derived SPMs and their purported anti-inflammatory effects in humans.



Penn Scientists Find That Flow Means "Go" for Proper Lymph System Development

Mon, 27 Jul 2015 20:15:00 GMT

The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn’t been well understood, but now researchers from the Perelman School of Medicine at the University of Pennsylvania have found from experiments in mice that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.



Penn Medicine Researchers Receive $2 Million Grant from the American Heart Association

Fri, 17 Jul 2015 15:00:00 GMT

Daniel J. Rader, MD, chair of the Department of Genetics at the Perelman School of Medicine at the University of Pennsylvania, and Danish Saleheen, MD, PhD, an assistant professor of Biostatistics and Epidemiology, have been awarded a four-year, $2 million 2015 Grand Challenge Award from the American Heart Association (AHA).



Hydraulic Fracturing Linked to Increases in Hospitalization Rates in the Marcellus Shale Region, According to Penn Study

Wed, 15 Jul 2015 18:00:00 GMT

Hospitalizations for heart conditions, neurological illness, and other conditions were higher among people who live near unconventional gas and oil drilling (hydraulic fracturing), according to new research from the University of Pennsylvania and Columbia University published this week in PLOS ONE.



Penn Researchers Identify Stem-like Progenitor Cell that Exclusively Forms Heart Muscle

Thu, 25 Jun 2015 18:00:00 GMT

Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Scientists from the Perelman School of Medicine at the University of Pennsylvania have just taken an important step towards that future by identifying a stem-like "progenitor" cell that produces only heart muscle cells.



Penn Researchers Receive $2.9 Million in Awards from the Burroughs Wellcome Fund to Launch Biomedical Research Careers

Wed, 17 Jun 2015 14:00:00 GMT

Five early-career researchers from three schools at the University of Pennsylvania have received funding from the Burroughs Wellcome Fund (BWF) for their excellence in biomedical research, in topics including heart disease, sleep, and infectious diseases, as part of a nationwide program totaling $22.5 million.



Penn Study Links Better "Good Cholesterol" Function With Lower Risk of Later Heart Disease

Wed, 27 May 2015 13:15:00 GMT

A team led by scientists from the Perelman School of Medicine at the University of Pennsylvania has shown in a large, forward-looking epidemiological study that a person's HDL function—the efficiency of HDL molecules at removing cholesterol—may be a better measure of coronary heart disease risk and a better target for heart-protecting drugs.



Inflammation Stops the Clock: How the Immune System Controls the Human Biological Clock in Times of Infection

Fri, 18 May 2015 19:00:00 GMT

An important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin.



Penn Medicine's Howard Herrmann, MD Receives Top Designation from Society for Cardiovascular Angiography and Interventions

Fri, 15 May 2015 13:45:00 GMT

Howard Herrmann, MD, a professor of Medicine and Surgery, and director of the Interventional Cardiology Program and Cardiac Catheterization Laboratories at the Perelman School of Medicine at the University of Pennsylvania, has been named to the new class of Master Fellows of the Society for Cardiovascular Angiography and Interventions (MSCAI), the professional medical society for adult and pediatric invasive/interventional cardiologists.



Off-Label Use of Device to Prevent Stroke in A-Fib Patients is Prevalent and Potentially Dangerous, According to Penn Medicine Study

Mon, 04 May 2015 15:00:00 GMT

The Lariat device, which has been cleared by the U.S. Food and Drug Administration (FDA) for soft tissue approximation (placement of a suture) during surgical procedures, is associated with a significant incidence of death and urgent cardiac surgery during its frequent off-label use to prevent stroke in patients with the irregular heartbeat known as atrial fibrillation.



Penn-Sponsored Million Dollar Bike Ride to Raise Awareness about Rare Diseases

Tue, 28 Apr 2015 16:00:00 GMT

The second annual Million Dollar Bike Ride will be held on Saturday, May 9, 2015, to support research and raise awareness about rare diseases.



Two Different Carotid Artery Stenting Procedures Show Little Difference in Effectiveness, According to Penn Medicine Study

Mon, 20 Apr 2015 18:00:00 GMT

Use of either proximal embolic protection devices (P-EPDs) or distal filter embolic protection devices (F-EPDs) during elective carotid artery stenting results in low rates of in-hospital stroke and death, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.



Penn Study Describes First Steps in Basic Biological Process that Could be Harnessed to Make Therapeutic Cells

Thu, 16 Apr 2015 18:00:00 GMT

Understanding the molecular signals that guide early cells in the embryo to develop into different types of organs provides insight into how tissues regenerate and repair themselves. By knowing the principles that underlie the intricate steps in this transformation, researchers will be able to make new cells at will for transplantation and tissue repair in such situations as liver or heart disease.



Limber Lungs: One Type of Airway Cell Can Regenerate Another Lung Cell Type

Mon, 13 Apr 2015 09:00:00 GMT

A new collaborative study describes a way that lung tissue can regenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought.



Penn Researchers Describe New Approach to Promote Regeneration of Heart Tissue

Wed, 18 Mar 2015 18:00:00 GMT

A team led by Ed Morrisey, PhD, a professor of Medicine and Cell and Developmental Biology and the scientific director of the Institute for Regenerative Medicine in the Perelman School of Medicine at the University of Pennsylvania, has now shown that a subset of RNA molecules, called microRNAs, is important for cardiomyocyte cell proliferation during development and is sufficient to induce proliferation in cardiomyocytes in the adult heart.



Common Biomarkers of Sleep Debt Found in Humans, Rats, Penn Study Finds

Wed, 11 Feb 2015 18:30:00 GMT

In a study published this week in the Proceedings of the National Academy of Sciences, Penn Medicine researchers found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.



Penn Medicine Completes 1,000th Non-Surgical Aortic Valve Replacement Procedure

Tue, 10 Feb 2015 15:30:00 GMT

Penn Medicine physicians have completed their 1,000th transcatheter aortic valve replacement (TAVR) procedure, marking an important milestone in the health system's treatment of aortic stenosis, a narrowing of the heart's aortic valve.



Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder

Mon, 26 Jan 2015 16:00:00 GMT

Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.



Penn Medicine Study: Web-based TAVR Marketing Found to Overstate Benefits, Understate Risks

Mon, 12 Jan 2015 15:00:00 GMT

While a boon for many patients who would not have been a candidate for conventional surgery, Penn Medicine researchers have discovered that marketing for TAVR does not accurately portray the risks associated with undergoing the procedure. Their analysis is available in the January 12 issue of JAMA Internal Medicine.



Penn Study Examines Patients' Perspectives on Deactivation of Implantable Defibrillators in End-of-Life Scenarios

Mon, 17 Nov 2014 20:00:00 GMT

A new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, which was presented today at the 2014 Scientific Sessions of the American Heart Association, investigated patient perspectives on deactivation of implantable cardioverter defibrillators at the end of life, especially related to decisions to deactivate devices against patient or family wishes.



No Racial Disparities Observed in Development of Atrial Fibrillation Among Heart Failure Patients, According to Penn Medicine Study

Mon, 17 Nov 2014 19:00:00 GMT

Black patients who have been diagnosed with heart failure are no less likely than white patients to get atrial fibrillation (an irregular heartbeat, or arrhythmia), according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, which was presented today at the 2014 Scientific Sessions of the American Heart Association.



New Penn Medicine Study Finds Lay Bystanders in Higher Income Pennsylvania Counties More Likely to Perform CPR When Witnessing a Cardiac Arrest

Sun, 16 Nov 2014 13:30:00 GMT

Members of the public in counties with higher median household incomes are more likely to step into action to perform cardiopulmonary resuscitation, or CPR, when they witness someone have a cardiac arrest, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, which was presented today at the American Heart Association’s Resuscitation Science Symposium 2014.



Media Toolkit: Penn Medicine at the 2014 Scientific Sessions of the American Heart Association

Fri, 14 Nov 2014 18:30:00 GMT

Experts from the Perelman School of Medicine at the University of Pennsylvania will be moderating panels, serving as discussants and presenting research findings on the latest advances in cardiovascular medicine, science and education at the 2014 Scientific Sessions of the American Heart Association in Chicago November 15-19, 2014.



Penn Medicine Physician Given AAMC National Award for Teaching

Tue, 11 Nov 2014 18:00:00 GMT

Emma Meagher, MD, associate professor of Medicine and Pharmacology at the Perelman School of Medicine at the University of Pennsylvania, received the Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Award at the Association of American Medical Colleges (AAMC) annual meeting in Chicago this week.



First Atlas of Body Clock Gene Expression Informs Timing of Drug Delivery

Mon, 27 Oct 2014 19:00:00 GMT

A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making – provides important clues about how the role of timing may influence the way drugs work in the body.



Drug for Rare Blood Disorder Developed at Penn Receives Orphan Drug Status from the FDA

Wed, 22 Oct 2014 17:45:00 GMT

A Penn Medicine-developed drug has received orphan status from the Food and Drug Administration (FDA) this month for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, life-threatening disease that causes anemia due to destruction of red blood cells and thrombosis.



Penn Medicine Cardiovascular Experts Present New Research on Diagnosis and Treatment of Cardiac Arrhythmias at the 2014 Heart Rhythm Society Meeting

Wed, 07 May 2014 14:00:00 GMT

Experts from the Penn Medicine Cardiovascular Institute and the Cardiac Arrhythmia Program will present new research and participate in expert panel discussions at the 35th Annual Scientific Sessions of the Heart Rhythm Society (HRS) May 7-10, 2014 in San Francisco. 



Penn Medicine Fellow Receives National Award for Excellence in Interventional Cardiology

Fri, 25 April 2014 14:00:00 GMT

The Society for Cardiovascular Angiography and Interventions Foundation (SCAI) has presented Penn Medicine's Mitul Kadakia, MD, with the 2014 Gregory Braden Memorial Fellow of the Year Award in recognition of his outstanding performance as an interventional cardiology fellow-in-training.



Penn Researchers Receive National Clinical Research Award for Cardiovascular Science Breakthroughs

Thu, 10 April 2014 13:00:00 GMT

Two researchers from the Perelman School of Medicine at the University of Pennsylvania and the Penn Cardiovascular Institute (CVI) are among the 2014 recipients of the prestigious Clinical Research Achievement Award for their work in cardiovascular science.



New Penn-Designed Gel Allows for Targeted Therapy After Heart Attack

Wed, 02 April 2014 13:15:00 GMT

A team of researchers from the University of Pennsylvania have developed a material that can be applied directly to damaged heart tissue and minimize the long-term damage that can lead to congestive heart failure.



Researchers Present Findings on New Interventions for Treatment Resistant Hypertension, Atherosclerosis at ACC.14

Mon, 31 Mar 2014 13:15:00 GMT

Penn Medicine experts presented research findings that could come to define new standards of cardiovascular care, including findings on the efficacy of novel interventions for treatment resistant hypertension and atherosclerosis, at the 2014 American College of Cardiology Scientific Session, ACC.14.



Michael S. Parmacek, MD, Named Chair of the Department of Medicine at Perelman School of Medicine

Thu, 20 Mar 2014 13:00:00 GMT

Michael S. Parmacek, MD, Herbert C. Rorer Professor of Medical Sciences, has been named Chair of the Department of Medicine at the Perelman School of Medicine at the University of Pennsylvania.



Penn Medicine Teams Up with the City of Philadelphia to Offer Heart Health Screenings to City Employees

Fri, 28 Feb 2014 13:00:00 GMT

Penn Medicine will join forces with the City of Philadelphia to wrap-up American Heart Month on Friday, February 28th by offering free cardiovascular screenings for city employees.



Penn Physician Urges Greater Recognition of How "Misfearing" Influences Women's Perceptions of Heart Health Risks

Thu, 16 Jan 2014 15:45:00 GMT

While more women die from heart disease each year than all forms of cancer combined, many are more fearful of other diseases, particularly breast cancer. This phenomenon, referred to as “misfearing,” describes the human tendency to fear instinctively and according to societal influences rather than based on facts. This trend may be a contributor to the reasons why many women fail to take enough steps -- such as changing diet and fitness habits or risk-taking behaviors -- to guard against heart disease.



Penn Medicine Study Finds No Significant Differences Between Commonly Used Carotid Stenting Systems in U.S.

Thu, 16 Jan 2014 15:45:00 GMT

A study conducted by researchers from several institutions, including the Perelman School of Medicine at the University of Pennsylvania, has found similarly low rates of complication and death among U.S. patients who are treated with the three most common systems for placing stents in blocked carotid arteries of the neck.



New Study Finds No Benefit to Selecting Dose of Blood Thinner Based on Patients' Genetic Makeup

Tue, 19 Nov 2013 15:45:00 GMT

A new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has determined that a gene-based method for selecting patients' doses of the popular heart medication warfarin is no better than standardized dosing methods.



Penn Medicine Review Finds Statin Use Not Linked to a Decline in Cognitive Function

Mon, 18 Nov 2013 21:00:00 GMT

Based on the largest comprehensive systematic review to date, researchers at the Perelman School of Medicine at the University of Pennsylvania concluded that available evidence does not support an association between statins and memory loss or dementia.



New Study Finds Similar Outcomes for Repair or Replacement of Damaged Heart Valves

Mon, 18 Nov 2013 15:45:00 GMT

New research presented today at the 2013 Scientific Sessions of the American Heart Association by researchers at the Perelman School of Medicine at the University of Pennsylvania found no difference in outcomes at one-year between two recommended surgical options for treating ischemic mitral regurgitation (IMR) – repair of the leaky valve or its replacement with an artificial valve.



Perelman School of Medicine at the University of Pennsylvania Presentations at 2013 American Heart Association's Scientific Sessions, November 16 – 20, 2013

Thu, 15 Nov 2013 19:00:00 GMT

Perelman School of Medicine at the University of Pennsylvania faculty will be involved in presenting research findings on the latest advances in cardiovascular medicine, science, and education at the 2013 American Heart Association's Scientific Sessions, in Dallas, TX, November 16 – 20, 2013.



Penn Medicine Surgeon Named President of the Eastern Vascular Society

Wed, 06 Nov 2013 17:00:00 GMT

Michael A. Golden, MD, associate professor of Surgery at the Perelman School of Medicine at the University of Pennsylvania and chief, Division of Vascular Surgery and Endovascular Therapy at Penn Presbyterian Medical Center (PPMC), has been named president of the Eastern Vascular Society (EVS).



Increased Cardiovascular Risk in Men Using Testosterone Therapy Prompts Warning

Mon, 05 Nov 2013 17:00:00 GMT

Men taking testosterone therapy had a 29 percent greater risk of death, heart attack and stroke according to a study of a "real world" population of men. An accompanying editorial in JAMA by an endocrinologist with the Perelman School of Medicine at the University of Pennsylvania notes that the mounting evidence of a signal of cardiovascular risk warrants cautious testosterone prescribing and additional investigation.



International Research Team Weighs in on the Negative Consequences of Noise on Overall Health

Wed, 30 Oct 2013 13:45:00 GMT

The combined toll of occupational, recreational and environmental noise exposure poses a serious public health threat going far beyond hearing damage, according to an international team of researchers writing this week in The Lancet.



Hospital of the University of Pennsylvania Earns Advanced Heart Failure Certification from Joint Commission

Tue, 24 Sept 2013 15:00:00 GMT

The Joint Commission, in conjunction with The American Heart Association, has awarded the Hospital of the University of Pennsylvania (HUP) Advanced Certification in Heart Failure. Achievement of this certification signifies HUP's dedication to fostering better outcomes for patients in its heart failure program.



Obesity/Mortality Paradox Demonstrates Urgent Need for More Refined Metabolic Measures

Thu, 22 August 2013 18:00:00 GMT

Researchers from the Perelman School of Medicine at the University of Pennsylvania point out that the body mass index (BMI), based on the weight and height, is not an accurate measure of body fat content and does not account for critical factors that contribute to health or mortality, such as fat distribution, proportion of muscle to fat, and the sex and racial differences in body composition.



Psoriasis Patients at Increasing Risk for Range of Serious Medical Conditions, Relative to Severity of Skin Disease

Wed, 07 August 2013 20:00:00 GMT

Patients with mild, moderate and severe psoriasis had increasingly higher odds of having at least one major medical disease in addition to psoriasis, when compared to patients without psoriasis. Reporting findings in JAMA Dermatology, researchers from the Perelman School of Medicine at the University of Pennsylvania, concluded that the severity of disease, as measured by the percentage of body surface area affected by psoriasis, was strongly linked to an increased presence of other diseases affecting the lungs, heart, kidneys, liver and pancreas.



Penn Study Shows Vascular Link in Alzheimer's Disease with Cognition

Wed, 10 July 2013 00:01:00 GMT

Researchers in the Perelman School of Medicine at the University of Pennsylvania found that, across a variety of neurodegenerative diseases, cerebrovascular disease affecting circulation of blood in the brain was significantly associated with dementia.



Mariell Jessup, MD, Penn Medicine Cardiologist, Becomes President of the American Heart Association

Mon, 01 July 2013 15:00:00 GMT

Mariell Jessup, MD, professor of Medicine, associate chief, Clinical Affairs, Division of Cardiovascular Medicine, and medical director of the Penn Medicine Heart and Vascular Center, has become the president of the American Heart Association (AHA). Her term begins July 1, 2013.



Penn Medicine Performs 1000th Heart Transplant

Wed, 05 Dec 2012 14:00:00 GMT

Marking the twenty-fifth anniversary of the program, Penn Medicine physicians have completed their 1000th lifesaving heart transplant at the Hospital of the University of Pennsylvania.



Penn Medicine's Daniel J. Rader, MD, Receives American Heart Association's Clinical Research Prize

Sun, 4 Nov 2012 14:00:00 GMT

Daniel J. Rader, MD, professor of Medicine and chief, Division of Translational Medicine and Human Genetics, at the Perelman School of Medicine at the University of Pennsylvania, has been awarded the American Heart Association's (AHA) Clinical Research Prize.



New Medication Shows Promise as Lipid-Lowering Therapy for Rare Cholesterol Disorder, Penn Study Finds

Fri, 2 Nov 2012 13:00:00 GMT

n international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.



Thickening of the Heart's Right Ventricle Could Foreshadow Heart Failure and Cardiovascular Death in Otherwise Heart-Healthy Patients, Penn Study Shows

Thu, 6 Sep 2012 13:00:00 GMT

Researchers at the Perelman School of Medicine at the University of Pennsylvania report in a new study that thickening of the heart's right ventricle is associated with an increased risk of heart failure and cardiovascular death in patients without clinical cardiovascular disease at baseline.



Nehal Mehta, MD, Penn Medicine Cardiologist, Named First NIH-Lasker Clinical Research Scholar

Mon, 9 July 2012 15:00:00 GMT

The National Institutes of Health (NIH), in partnership with the Albert and Mary Lasker Foundation, has announced that Nehal N. Mehta, MD, director of Inflammatory Risk in Preventive Cardiology at Penn Medicine, will be the inaugural Lasker Clinical Research Scholar.



For Cardiac Stenting Procedures, Wrist Access Offers Cost Saving Benefits Over Groin Access, Penn Study Shows

Fri, 6 July 2012 13:00:00 GMT

In the United States, radial artery (wrist) catheterization is performed in the minority of diagnostic angiograms and cardiac stenting procedures despite the benefits it offers to patients in terms of reduced complications and faster mobility after the procedure.



Mariell Jessup, MD, Penn Medicine Cardiologist, Named President-Elect of the American Heart Association

Tue, 26 June 2012 14:00:00 GMT

Mariell Jessup, MD, associate chief-Clinical Affairs, Division of Cardiovascular Medicine and medical director of the Penn Medicine Heart and Vascular Center, has been named president-elect of the American Heart Association (AHA). Dr. Jessup will begin her term on July 1, 2012.



Penn Medicine Cardiologist Chairs National Report on Optimal Use of Vascular Laboratory Tests for Patients with Known or Suspected Arterial Disease

Mon, 11 June 2012 17:00:00 GMT

A new report issued today by the American College of Cardiology (ACC) and developed in collaboration with 10 other leading professional societies provides detailed criteria to help clinicians maximize the appropriate use of certain noninvasive vascular tests when caring for patients with suspected or known non-coronary arterial disorders.



Penn Receives $3.8 Million to Study Psoriasis Treatment and Cardiovascular Disease

Thu, 19 Apr 2012 16:00:00 GMT

A team of researchers in the Perelman School of Medicine at the University of Pennsylvania has received a $3.8 million dollar grant from the National Institute of Health's National Heart, Lung, and Blood Institute (NHLBI), to conduct a trial to study the impact of psoriasis treatment on vascular inflammation and lipid metabolism.



Penn Study Cautions Use of Drugs to Block "Niacin Flush" in Heart Patients

Fri, 6 Apr 2012 16:00:00 GMT

Niacin, or vitamin B3, is the one approved drug that elevates good cholesterol (high density lipoprotein, HDL) while depressing bad cholesterol (low density lipoprotein , LDL), and has thereby attracted much attention from patients and physicians. Niacin keeps fat from breaking down, and so obstructs the availability of LDL building blocks.



Penn Medicine Named as a National Heart, Lung, and Blood Institute Regional Center for Heart Failure Research

Wed, 29 Feb 2012 03:00:00 GMT

The Perelman School of Medicine at the University of Pennsylvania has been has been selected as a Regional Center for the National Heart, Lung, and Blood Institute's (NHLBI) Heart Failure Clinical Trials Network.



Sleep Problems Increase Risk for Cardiovascular Disease, Diabetes and Obesity, Penn Study Shows

Thu, 19 Jan 2012 04:00:00 GMT

People who suffer from sleep disturbances are at major risk for obesity, diabetes, and coronary artery disease, according to new research from the Perelman School of Medicine at the University of Pennsylvania. For the first time in such a large and diverse sample, analyzing the data of over 130,000 people, the new research also indicates that general sleep disturbance (difficulty falling asleep, staying asleep, and/or sleeping too much) may play a role in the development of cardiovascular and metabolic disorders. The study is published online ahead of print in the Journal of Sleep Research.



Penn Lung Biologists to Receive $2.5 Million to Study Repair and Regeneration

Wed, 18 Jan 2012 04:00:00 GMT

The Perelman School of Medicine at the University of Pennsylvania is one of six institutions to be named part of the National Heart, Lung, and Blood Institute's Lung Repair and Regeneration Consortium (LRRC). Each of the institutions will receive $2.5 million over five years. Edward Morrisey, PhD, professor of Medicine and Cell and Developmental Biology and Scientific Director of the Penn Institute for Regenerative Medicine, will lead the Penn consortium.



Penn Medicine Contest Challenges Philadelphians to Help Save Lives With Their Cell Phones

Wed, 8 Dec 2011 04:00:00 GMT

A group of Penn Medicine researchers is set to save lives with cell phone cameras -- and they are challenging the public to help. The MyHeartMap Challenge, a month-long contest slated to take place beginning in mid January, will send thousands of Philadelphians to the streets and to social media sites to locate as many automated external defibrillators (AEDs) as they can. The contest is just a first step in what the Penn team hopes will grow to become a nationwide, crowd-sourced AED registry project that will put the lifesaving devices in the hands of anyone, anywhere, anytime.



National Study Shows Exercise Superior to Stents for Improving Walking Ability in PAD Patients

Wed, 16 Nov 2011 04:00:00 GMT

Supervised exercise improves walking ability as good as, if not better than, stents in patients with peripheral artery disease (PAD), according to research released at the 2011 American Heart Association Scientific Sessions. The study is a joint collaboration from researchers at the Perelman School of Medicine at the University of Pennsylvania, the University of Minnesota Medical School, Rhode Island Hospital, and 13 other academic institutions and medical centers.



Psoriasis is Associated with Impaired HDL Function, Penn Study Finds

Wed, 16 Nov 2011 04:00:00 GMT

Collaborative research from Perelman School of Medicine at the University of Pennsylvania has shown that psoriasis patients have an increased risk of heart attack, stroke and cardiovascular death, especially if the psoriasis is moderate to severe. Now, Penn researchers have discovered the potential underlying mechanism by which the inflammatory skin disease impacts cardiovascular health. In two new studies presented at the 2011 American Heart Association Scientific Sessions, Penn researchers show that the systemic inflammatory impact of psoriasis may alter both the makeup of cholesterol particles and numbers, as well as impair the function of high density lipoprotein (HDL), the "good" cholesterol.



Pneumonia the Most Common Serious Infection After Heart Surgery

Tue, 15 Nov 2011 04:00:00 GMT

New research from the Perelman School of Medicine at the University of Pennsylvania has shown for the first time that pneumonia is the most common serious infection after heart surgery. The new study, presented at the 2011 American Heart Association Scientific Sessions, also revealed that most infections occur about two weeks after surgery, not one week as physicians previously thought.



Only a Third of U.S. State Police Agencies Equip Cars With AEDs, Penn Research Shows

Tue, 15 Nov 2011 04:00:00 GMT

Just 30 percent the nation's state police agencies reported that they equip their vehicles with automated external defibrillators, and of those, nearly 60 percent of said only a minority of their fleet have the lifesaving devices on board, according to new research from the Perelman School of Medicine at the University of Pennsylvania that will be presented today at the American Heart Association's annual Scientific Sessions (Abstract #10721).



Primary Care-based Weight Intervention Helps Obese Patients Reduce Weight, Penn Study Shows

Mon, 14 Nov 2011 04:00:00 GMT

Can a visit to your primary care doctor help you lose weight? Primary care physicians, working with medical assistants in their practices, helped one group of their obese patients lose an average of 10.1 lb during a two-year lifestyle intervention, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Their 10 lb weight loss was associated, over the two years, with improvements in cardiovascular disease (CVD) risk factors, including waist circumference and HDL cholesterol levels. The results of the POWER-UP (Practice-based Opportunities for Weight Reduction at the University of Pennsylvania) trial were reported in the latest edition of the New England Journal of Medicine and at the American Heart Association annual meeting today.



Non-Invasive Measurement Identified as a Strong Predictor for Heart Failure in the General Population, Penn Study Shows

Mon, 14 Nov 2011 04:00:00 GMT

A new study from researchers at the Perelman School of Medicine at the University of Pennsylvania and collaborators at various institutions, presented at the 2011 American Heart Association Scientific Sessions, shows that a novel, non-invasive measurement of arterial wave reflections may be able to predict who is most at risk for heart failure. The authors presented data from an ancillary study of the Multi-Ethnic Study of Atherosclerosis (MESA).



Withdrawal of Care Among Cardiac Arrest in Patients Treated with Therapeutic Hypothermia May Occur Too Soon, Penn Researchers Report

Mon, 14 Nov 2011 04:00:00 GMT

Physicians may be making premature predictions about which patients are not likely to survive following cardiac arrest – and even withdrawing care -- before the window in which comatose patients who have received therapeutic hypothermia are most likely to wake up, according to two new studies from the Perelman School of Medicine at the University of Pennsylvania. The research helps to better define the proper timeframe and manner in which doctors may be able to predict which patients will regain consciousness after the use of therapeutic hypothermia, which preserves brain and other organ function following cardiac arrest.



Can Twitter Save Lives?

Sat, 12 Nov 2011 04:00:00 GMT

Discussion about cardiac arrest on Twitter is common and represents a new opportunity to provide lifesaving information to the public, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The Penn investigators will present two studies (ReSS Abstracts #52 and #53) examining cardiac arrest-information exchange on the social media site today at the American Heart Association's annual Scientific Sessions.



Members of the Public Lack Skills, Confidence Necessary to Save Lives With CPR, Penn Researchers Report

Sat, 12 Nov 2011 04:00:00 GMT

Even members of the lay public who have received CPR training are confused about how to perform the lifesaving skill and say they don't have confidence in their ability to do it properly, according to a study from the Perelman School of Medicine at the University of Pennsylvania which will be presented today at the American Heart Association's annual Scientific Sessions (Abstract #65).



Penn Medicine at the 2011 American Heart Association Scientific Sessions, November 12 – 16, Orlando

Thu, 10 Nov 2011 04:00:00 GMT

Resources for News Media Covering the 2011 American Heart Association Scientific Sessions, November 12 – 16, 2011



Institute of Medicine Elects Three New Members from Penn

Thu, 20 Oct 2011 04:00:00 GMT

Three professors from the Perelman School of Medicine at the University of Pennsylvania have been elected members of the Institute of Medicine (IOM), one of the nation's highest honors in biomedicine.



Cardiovascular Disease Linked to Evolutionary Changes That May Have Protected Early Mammals from Trauma, Penn Study Finds

Mon, 17 Oct 2011 04:00:00 GMT

Can a bird have a heart attack? A recent paper published by researchers at the Perelman School of Medicine at the University of Pennsylvania suggests that cardiovascular disease may be an unfortunate consequence of mammalian evolution. The study, published in a recent issue of the journal Blood, demonstrates that the same features of blood platelets that may have provided an evolutionary advantage to early mammals now predispose humans to cardiovascular disease.



Penn Researchers Receive $9 Million NIH Grant to Study Relationship Between Gene Variants and Cardiovascular Disease

Wed, 05 Oct 2011 04:00:00 GMT

Daniel J. Rader, MD, chief, Division of Translational Medicine and Human Genetics, and Edward Morrisey, PhD, professor of Medicine and Cell and Developmental Biology, Perelman School of Medicine, and Scientific Director at the Penn Institute for Regenerative Medicine, and researchers at the Medical College of Wisconsin received a five-year, $9 million grant for stem cell research from the National Institutes of Health's National Human Genome Research (NHGRI) and the National Heart Lung and Blood (NHLBI) Institutes.



Women with Pulmonary Arterial Hypertension Have Greater Response to Treatment than Men, Penn Study Finds

Tue, 27 Sep 2011 02:00:00 GMT

Pulmonary arterial hypertension (PAH) patients of different sexes and races may respond differently to treatment with commonly used medications for the disease, says a new study from researchers at Perelman School of Medicine at the University of Pennsylvania.



Penn Study Indicates Atrial Fibrillation May Be Root Cause of Some Severe Mitral Regurgitation Cases

Wed, 21 Sep 2011 02:00:00 GMT

Mitral regurgitation is a common heart valve disorder, where blood flows backwards through the mitral valve when the heart contracts and reduces the amount of blood that is pumped out to the body.



The Hospital of the University of Pennsylvania Receives American Heart Association's Gold Quality Achievement Award in Heart Failure

Thu, 15 Sep 2011 02:00:00 GMT

The Hospital of the University of Pennsylvania (HUP) has received the Get With The Guidelines®–Heart Failure Gold Quality Achievement Award from the American Heart Association.



The Hospital of the University of Pennsylvania Receives American Heart Association's Gold Quality Achievement Award in Heart Failure

Thu, 15 Sep 2011 02:00:00 GMT

The Hospital of the University of Pennsylvania (HUP) has received the Get With The Guidelines®–Heart Failure Gold Quality Achievement Award from the American Heart Association.



Penn Researchers Find High-Fat Diet and Lack of Enzyme Can Lead to Heart Disease in Mice

Mon, 12 Sep 2011 13:00:00 GMT

It's no secret that a high-fat diet isn't healthy. Now researchers have discovered a molecular clue as to precisely why that is.



Penn Medicine Researcher Receives Burroughs Wellcome Fund Grant to Study Congenital Heart Arrhythmias

Thu, 18 Aug 2011 19:00:00 GMT

Stacey Rentschler, MD, PhD, cardiovascular instructor, Hospital of the University of Pennsylvania (HUP), has received the Burroughs Wellcome Fund's Career Award for Medical Scientists.



Penn Study Shows Link Between Immune System Suppression and Blood Vessel Formation in Tumors

Wed, 13 July 2011 17:00:00 GMT

Targeted therapies that are designed to suppress the formation of new blood vessels in tumors, such as Avastin (bevacizumab), have slowed cancer growth in some patients. However, they have not produced the dramatic responses researchers initially thought they might.



A Change of Heart: Penn Researchers Reprogram Brain Cells to Become Heart Cells

Fri, 8 July 2011 19:00:00 GMT

For the past decade, researchers have tried to reprogram the identity of all kinds of cell types.



200,000 Patients Treated for Cardiac Arrest Annually in U.S. Hospitals, Penn Study Shows

Tue, 28 June 2011 14:00:00 GMT

More than 200,000 people are treated for cardiac arrest in United States hospitals each year, a rate that may be on the rise. The findings are reported online this week in Critical Care Medicine in a University of Pennsylvania Perelman School of Medicine-led study.



AcademyHealth Honors Penn Medicine's Scott D. Halpern, MD, PhD

Tue, 14 June 2011 18:00:00 GMT

Scott D. Halpern, MD, PhD, assistant professor of Medicine and Epidemiology at the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, has been selected for AcademyHealth’s 2011 Alice S. Hersh New Investigator Award.



Penn Study Shows Size, Strength of the Heart's Right Side Varies Between Age, Genders, and Racial/Ethnic Groups

Tue, 6 June 2011 20:00:00 GMT

Researchers at the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania have shown that the size and pumping ability of the right side of the heart differs by age, gender and racial/ethnic groups.



Penn Medicine Cancer Research and Experts at ASCO

Thu, 2 June 2011 01:00:00 GMT

Resources for Media Covering the American Society of Clinical Oncology Meeting June 3-7, 2011



Combination Therapy Shows Promise for Rare, Deadly Cancer Caused by Asbestos, Penn Study Shows

Thu, 2 June 2011 16:00:00 GMT

Pleural mesothelioma patients who undergo lung-sparing surgery in combination with photodynamic therapy (PDT) show superior overall survival than patient treated using the conventional therapy of extrapleural pneumonectomy (EPP) (or en bloc removal of the lung and surrounding tissue) with PDT, indicates new research from the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania. The research is published in the June 2011 issue of the Annals of Thoracic Surgery.



Penn Study Shows Two Heart Drugs Ineffective in Treating Pulmonary Arterial Hypertension

Wed, 18 May 2011 18:00:00 GMT

Despite their beneficial effects in heart disease, neither aspirin nor simvastatin appear to offer benefit to patients suffering from pulmonary arterial hypertension (PAH), according to research from the Perelman School of Medicine at the University of Pennsylvania.



No Increase in Severe Cardiovascular Events for Children, Adolescents Taking ADHD Medications, Penn Study Finds

Mon, 16 May 2011 13:00:00 GMT

Despite recent concerns that medications for attention deficit hyperactivity disorder (ADHD) could increase the risk of cardiovascular events in children and adolescents, an observational study conducted by researchers at the Perelman School of Medicine at the University of Pennsylvania and HealthCore Inc. finds they are no more likely to die from a severe cardiovascular event than those who do not take the drugs. The findings, published online in the journal Pediatrics, provide the first analysis of such events in a large population of children and adolescents receiving ADHD medications compared to non-users.



Penn Study Shows Drop Off in Coronary Artery Bypass Surgeries for Heart Patients

Tue, 03 May 2011 20:00:00 GMT

New research from the University of Pennsylvania School of Medicine shows a substantial decrease in one type of revascularization procedure, coronary artery bypass graft (CABG) surgery, while rates of utilization of the other form, percutaneous coronary intervention (PCI), have remained unchanged.



Medical Student Will Address Hypertension in African American Men Through Innovative Barbershop Program

Mon, 02 May 2011 19:00:00 GMT

(Nicholas) Kenji Taylor, a first-year year student at the University of Pennsylvania School of Medicine, has been named one of 15 Philadelphia Schweitzer Fellows for 2011-2012. Schweitzer Fellows partner with community-based organizations to develop and implement yearlong, mentored service projects that sustainably address the social determinants of health—all on top of their regular graduate school responsibilities.



Penn Study Sheds Light on End of Life Management of Implanted Defibrillators

Tue, 05 Apr 2011 15:00:00 GMT

Each year, more than 100,000 patients in the U.S. undergo implantation of a new implantable cardioverter defibrillator (ICD) for heart rhythm abnormalities. This number constitutes a 20-fold increase over the last 15 years. Current medical guidelines advocate discussion of end of life care of these medical devices, including deactivation, but many patients may not understand their options. Now, researchers at the University of Pennsylvania School of Medicine say that discussions should also address post-mortem donation of ICDs for product improvement or reuse overseas as pacemakers, to help reduce global health disparities.