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Preview: CJD / vCJD / Mad Cow Disease News From Medical News Today

CJD / vCJD / Mad Cow Disease News From Medical News Today



Creutzfeldt-Jakob disease (CJD) is a rare and fatal condition that affects the brain. CJD causes brain damage that becomes worse over time. Most people with CJD die from an infection within a year of the initial symptoms - often because the immobility cau



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Mutant prion protein could help reveal neurodegenerative disease mechanisms

Thu, 24 Nov 2016 00:00:00 PST

For the first time, scientists have isolated a mutated prion protein that can multiply in the lab but not in living animals, according to a PLOS Pathogens study.



Fruit fly model of deadly brain diseases could lead to blood test for vCJD

Thu, 13 Oct 2016 05:00:00 PST

A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the University of Cambridge, and could lead to a low cost, fast and efficient blood...



A urine test to diagnose Creutzfeldt-Jakob Disease may be possible

Wed, 05 Oct 2016 02:00:00 PST

Researchers at the Medical Research Council (MRC) Prion Unit at UCL have found that it may be possible to determine whether or not a person has sporadic Creutzfeldt-Jakob Disease (sCJD) by testing...



Cascade of events leading to prion disease described

Wed, 10 Aug 2016 07:00:00 PST

New experiments in mice now enable researchers to evaluate disease progression and potential therapeutic interventions in vivo, according to a new report in The American Journal of Pathology.



Impact of prion proteins on the nerves revealed for the first time

Tue, 09 Aug 2016 05:00:00 PST

When prion proteins mutate, they trigger mad cow and Creutzfeldt-Jakob disease. Although they are found in virtually every organism, the function of these proteins remained unclear.



How prions kill neurons: new culture system shows early toxicity to dendritic spines

Fri, 27 May 2016 04:00:00 PST

Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear.



New assay offers improved detection of deadly prion diseases

Mon, 11 Apr 2016 05:00:00 PST

Timed amyloid seeding assay achieves or surpasses sensitivity of currently available tests for transmissible spongiform encephalopathies, according to a report in The Journal of Molecular Diagnostics.



It's complicated: benefits and toxicity of anti-prion antibodies in the brain

Thu, 28 Jan 2016 11:00:00 PST

Immunotherapy to ameliorate neurodegeneration by targeting brain protein aggregates with antibodies is an area of intense investigation.



Alzheimer-type brain pathology after transplantation of dura mater

Wed, 27 Jan 2016 06:00:00 PST

Up to now Alzheimer's disease has not been recognised as transmissible. Now researchers at the University of Zurich and the Medical University Vienna demonstrated Alzheimer-type pathology in brains...



Parkinson's disease: New insights into a traveling protein

Tue, 05 Jan 2016 10:00:00 PST

A laboratory study indicates that one of the main proteins involved in Parkinson's disease pathology does not behave as a 'prion' In Parkinson's disease, the protein "alpha-synuclein" aggregates...



Alzheimer's may be a collection of diseases that should be treated separately

Thu, 05 Nov 2015 00:00:00 PST

It is essential to carefully characterize and classify the mechanisms that underlie Alzheimer's disease, in order to allow for the development of novel therapies that can be prescribed according to...



From good to bad with a copper switch: Here's the mechanism that creates prions, the 'bad' proteins

Tue, 20 Oct 2015 10:00:00 PST

At the molecular level, the difference between Doctor Jekyll and Mr Hyde lies in a metal, copper.



Prion disease detected soon after infection and in surprising place in mouse brains

Wed, 23 Sep 2015 09:00:00 PST

Prion diseases--incurable, ultimately fatal, transmissible neurodegenerative disorders of mammals--are believed to develop undetected in the brain over several years from infectious prion protein.



Finding a way forward in the fight against prion disease

Fri, 04 Sep 2015 06:00:00 PST

UAlberta study finds bile acids may prolong survival in models of prion diseaseFor much of her adult life Valerie Sim has been fascinated by a disease very few in the world can claim to even...



New type of prion may cause, transmit neurodegeneration

Tue, 01 Sep 2015 10:00:00 PST

Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease, is caused by a newly discovered type of prion, akin to the misfolded proteins involved in...



Sequestered prion protein takes the good mood away, suggests new hypothesis on depression

Fri, 14 Aug 2015 04:00:00 PST

The discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of depression, known as the monoamine hypothesis.



Why it's hard to make a bunny mad: examining prion disease resistance in rabbits

Thu, 06 Aug 2015 11:00:00 PST

Rabbits have long been considered immune to prion disease, but recently scientists have shown that they can - under certain circumstances - get transmissible spongiform encephalopathy (or TSE, the...



Brain infection study reveals how disease spreads from gut

Tue, 04 Aug 2015 08:00:00 PST

Research could enable earlier detection of prion diseasesThis magnified image of the small intestine shows specialized structures called Peyer's patches -- which are part of the body's immune...



Prion trials and tribulations: Finding the right tools and experimental models

Fri, 03 Jul 2015 00:00:00 PST

Prions are fascinating, enigmatic, and might teach us not only about rare prion diseases like Creutzfeld-Jakob disease, mad cow disease, or scrapie, but also about other more common neurodgenerative...



Solving the next step in the mystery of prions

Fri, 26 Jun 2015 04:00:00 PST

UAlberta scientists aim to understand how proteins convert from a normal structure to a diseased stateWorking towards the ultimate goal to develop therapeutics to treat diseases such as...



'Cannibal disease' study pinpoints gene responsible for CJD resistance

Mon, 15 Jun 2015 08:00:00 PST

Researchers investigating kuru, a brain disease associated with cannibalism, have discovered a genetic mutation that provided mice with resistance to both the disease and CJD.



Naturally occurring genetic variation gives complete resistance in prion diseases

Thu, 11 Jun 2015 05:00:00 PST

Researchers at the Medical Research Council's Prion Unit have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as...



UTHealth research: Grass plants can transport infectious prions

Mon, 18 May 2015 00:00:00 PST

Grass plants can bind, uptake and transport infectious prions, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).



Small loop in human prion protein prevents chronic wasting disease

Wed, 25 Feb 2015 00:00:00 PST

Finding provides new therapeutic target for prion diseasesPrion protein aggregates (brown) in the brain of a mouse expressing the human-elk protein.



Scripps Florida scientists' 'mad cow' discovery points to possible neuron killing mechanism behind Alzheimer's and Parkinson's diseases

Mon, 16 Feb 2015 02:00:00 PST

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time discovered a killing mechanism that could underpin a range of the most intractable...