Thu, 07 Apr 2016 16:00:00 GMTA team of researchers from the Perelman School of Medicine at the University of Pennsylvania have shed new light on how the structure of regulatory sequences in DNA is packaged in a cell.
Fri, 30 Oct 2015 13:30:00 GMTIn contrast to amphibian tissue regeneration, traumatic injuries in mammals typically heal with a fibrous scar. Researchers discovered that some strains of mice heal without a scar, by disrupting a protein, called Sdf1, that normally recruits white blood cells to sites of injury.
Wed, 21 Sep 2015 15:00:00 GMTNancy A. Speck, PhD, a widely recognized international leader in the field of blood-cell development, has been named chair of the department of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania.
Thu, 25 Jun 2015 19:00:00 GMTResearchers at the Perelman School of Medicine at the University of Pennsylvania are making headway in this area by studying stem cells in their natural environment in an organism. Stem cell populations reside in areas called niches deep within different types of organs. Scientists think that these niches control stem cell behavior, that is “telling” the stem cell when to produce more stem cells or when to produce daughter cells that will be the workhorses for that tissue or organ.
Thu, 25 Jun 2015 18:00:00 GMTFuture therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Scientists from the Perelman School of Medicine at the University of Pennsylvania have just taken an important step towards that future by identifying a stem-like "progenitor" cell that produces only heart muscle cells.
Thu, 16 Apr 2015 18:00:00 GMTUnderstanding the molecular signals that guide early cells in the embryo to develop into different types of organs provides insight into how tissues regenerate and repair themselves. By knowing the principles that underlie the intricate steps in this transformation, researchers will be able to make new cells at will for transplantation and tissue repair in such situations as liver or heart disease.
Mon, 13 Apr 2015 09:00:00 GMTA new collaborative study describes a way that lung tissue can regenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought.
Tue, 16 Dec 2014 9:00:00 GMTAs the main component of connective tissue in the body, fibroblasts are the most common type of cell. Taking advantage of that ready availability, scientists from the Perelman School of Medicine at the University of Pennsylvania, the Wistar Institute, Boston University School of Medicine, and New Jersey Institute of Technology have discovered a way to repurpose fibroblasts into functional melanocytes, the body's pigment-producing cells.
Mon, 27 Oct 2014 15:30:00 GMTAn all-female panel of luminaries in fields including epigenetics and stem cell biology will come together at a Penn symposium entitled Celebrating Women in Science. The Department of Cell and Developmental Biology at the Perelman School of Medicine, University of Pennsylvania, has organized the symposium, which will take place this week on Wednesday, October 29th, 2014.
Fri, 09 Jan 2009 14:00:00 GMTA research team led by Nancy Speck, PhD, Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine, has identified the location and developmental timeline in which a majority of bone marrow stem cells form in the mouse embryo. The findings, appearing online this week in the journal Nature, highlight critical steps in the origin of hematopoietic (or blood) stem cells (HSCs), says senior author Speck, who is also an Investigator with the Abramson Family Cancer Research Institute at Penn.
Mon, 15 Dec 2008 14:00:00 GMTResearchers at the University of Pennsylvania School of Medicine have discovered stem cells in the esophagus of mice that were able to grow into tissue-like structures and when placed into immune-deficient mice were able to form parts of an esophagus lining. The investigators report their findings online this month in the Journal of Clinical Investigation.
Wed, 12 Nov 2008 12:00:00 GMTA novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers at the University of Pennsylvania School of Medicine led by Linda Greenbaum, MD, Assistant Professor of Medicine in the Division of Gastroenterology, have demonstrated that cells expressing the marker can differentiate into both liver cells and cells that line the bile duct.