Wed, 14 Sep 2016 20:00:00 GMTMinorities and women suffering from a stroke may be less likely to receive the clot-busting treatment tPA, known as tissue plasminogen activator, according to a new study from Penn Medicine and other institutions published today in the online issue of Neurology, the medical journal of the American Academy of Neurology.
Mon, 18 Jul 2016 18:00:00 GMTPenn Medicine has established the Penn Neurodegeneration Genomics Center (PNGC) as a national focal point for Alzheimer's disease (AD) genetics research.
Tue, 17 May 2016 15:30:00 GMTA 24-hour rhythm of cellular detoxification in flies and mammals is coordinated by a neuropeptide that also drives feeding in both organisms, found a team led by Amita Sehgal, PhD, a professor of Neuroscience and director of the Chronobiology Program, in the Perelman School of Medicine at the University of Pennsylvania.
Mon, 26 Apr 2016 15:30:00 GMTFragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin – usually associated with diabetes -- is involved in the daily activity patterns and cognitive deficits in the fruitfly model of FXS, according to a new study from the Perelman School of Medicine.
Thu, 31 Mar 2016 14:30:00 GMTA neuroscientist from the Perelman School of Medicine at the University of Pennsylvania, with a colleague from the Johns Hopkins University School of Medicine, authored an essay calling for scientists to do what they can to reduce their carbon footprint while engaging in professional activities, such as fly less often to distant professional society meetings, urge those societies to meet less often, and make greater use of electronic communication to web conference.
Wed, 30 Mar 2016 17:00:00 GMTA team from the Perelman School of Medicine at the University of Pennsylvania has discovered the molecular mechanism that underlies cerebral cavernous malformations. They published their results this week online ahead of print in Nature.
Mon, 29 Feb 2016 18:30:00 GMTThe brain chemical dopamine regulates how mice learn to avoid a disagreeable encounter, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Tue, 09 Feb 2015 13:45:00 GMTA new way of mapping the “transcriptome” -- the collection of RNA read-outs that are expressed by a cell’s active genes -- has been devised by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Wed, 03 Feb 2015 18:00:00 GMTAbolishing the 24-hour clock by knocking out a key gene during development accelerates aging and shortens lifespan by two thirds in mice, but this effect is absent if the gene deletion is delayed until after birth, according to a new study published this week in Science Translational Medicine by scientists from the Perelman School of Medicine at the University of Pennsylvania.
Mon, 31 Dec 2015 18:00:00 GMTIn a new study published today in Science, a multi-institution team anchored at University of Pennsylvania found that caste-specific behaviors of carpenter ants are not set in stone.
Mon, 21 Dec 2015 15:45:00 GMTThe ability to reliably pinpoint the anatomical source of seizures, different for each patient, remains elusive. Researchers at the University of Pennsylvania's School of Engineering and Applied Science and Perelman School of Medicine are looking for ways to refine this process by looking at networks of electrical activity in the brain just prior to the onset of a seizure.
Thu, 03 Dec 2015 19:45:00 GMTErle S. Robertson, PhD, and colleagues published in mBio this week that Epstein-Barr virus and a related virus, Kaposi's sarcoma-associated herpesvirus, can infect and replicate in both cultured and primary neurons.
Mon, 23 Nov 2015 14:00:00 GMTPhysicians and others now recognize that seemingly mild, concussion-type head injuries lead to long-term cognitive impairments surprisingly often. A brain protein called SNTF, which rises in the blood after some concussions, signals the type of brain damage that is thought to be the source of these cognitive impairments, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania, and the University of Glasgow, Glasgow, UK.
Thu, 05 Nov 2015 16:15:00 GMTUsing a transparent zebrafish model, researchers from the Perelman School of Medicine at the University of Pennsylvania, have identified key components of a mechanism that allows the nervous system to heal itself.
Wed, 28 Oct 2015 18:00:00 GMTAutophagy, literally self-eating or the degradation of unwanted cellular bits and pieces by the cell itself, has been shown for the first time to also work in the cell nucleus. In addition, in this setting it plays a role in guarding against the start of cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Mon, 19 Sep 2015 15:45:00 GMTThree professors from the University of Pennsylvania have been elected members to the National Academy of Medicine (NAM), one of the nation's highest honors in biomedicine.
Thu, 10 Sep 2015 16:00:00 GMTA team of researchers from the Perelman School of Medicine at the University of Pennsylvania found a location-dependent pattern in cilia length in the mouse nasal cavity that affects sensitivity to odors. The discovery may also have important implications for the study of sight and touch.
Thu, 03 Sep 2015 16:00:00 GMTA team led by Roger Greenberg, MD, PhD, an associate professor of Cancer Biology at Penn, and Frank Sicheri, PhD, in Toronto, report online in Molecular Cell ahead of print, the atomic structures of several BRCC36-containing complexes.
Tue, 25 Aug 2015 15:30:00 GMTJoshua Gold, PhD, a professor of Neuroscience at the Perelman School of Medicine at the University of Pennsylvania, and Joe Kable, PhD, Baird Term Associate Professor of Psychology in the School of Arts and Sciences, have been awarded a three-year $1 million grant from the National Science Foundation.
Mon, 10 Aug 2015 16:00:00 GMTSergei A. Vinogradov, PhD, an associate professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, has been awarded a four-year High Impact Neuroscience Research Resource Center Grant from the National Institutes of Health.
Tue, 28 Jul 2015 17:30:00 GMTA team of researchers from the Perelman School of Medicine at the University of Pennsylvania used fruitflies to probe deeper into the cellular and molecular mechanisms that govern aggression and sleep.
Wed, 15 Jul 2015 18:00:00 GMTHospitalizations for heart conditions, neurological illness, and other conditions were higher among people who live near unconventional gas and oil drilling (hydraulic fracturing), according to new research from the University of Pennsylvania and Columbia University published this week in PLOS ONE.
Thu, 18 Jun 2015 18:30:00 GMTSeveral well-known neurodegenerative diseases, such as Lou Gehrig's (ALS), Parkinson's, Alzheimer's, and Huntington's disease, all result in part from a defect in autophagy – one way a cell removes and recycles misfolded proteins and pathogens. In a paper published this week in Current Biology, postdoctoral fellow David Kast, PhD, and professor Roberto Dominguez, PhD, and three other colleagues from the Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania, show for the first time that the formation of ephemeral compartments key in this process require actin polymerization by the Arp2/3 complex, a composite of seven proteins.
Wed, 17 Jun 2015 14:00:00 GMTFive early-career researchers from three schools at the University of Pennsylvania have received funding from the Burroughs Wellcome Fund (BWF) for their excellence in biomedical research, in topics including heart disease, sleep, and infectious diseases, as part of a nationwide program totaling $22.5 million.
Fri, 18 May 2015 19:00:00 GMTAn important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin.
Tue, 28 Apr 2015 16:00:00 GMTThe second annual Million Dollar Bike Ride will be held on Saturday, May 9, 2015, to support research and raise awareness about rare diseases.
Mon, 23 Mar 2015 14:00:00 GMTResearchers at the Perelman School of Medicine at the University of Pennsylvania describe the first set of genes important in learning in a zebrafish model in the journal Neuron this week. "Using an in-depth analysis of one of these genes, we have already revealed an important relevant signaling pathway," says senior author Michael Granato, PhD, a professor of Cell and Developmental Biology.
Wed, 11 Feb 2015 18:30:00 GMTIn a study published this week in the Proceedings of the National Academy of Sciences, Penn Medicine researchers found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.
Mon, 26 Jan 2015 16:00:00 GMTTens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
Wed, 17 Dec 2014 14:15:00 GMTJames Shorter, PhD, an associate professor of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania received a grant from the ALS Association and the Muscular Dystrophy Association (MDA) for research aimed at finding a potential therapy for ALS, or Lou Gehrig’s disease.
Wed, 26 Nov 2014 15:30:00 GMTPenn Medicine researchers have developed a cognitive test battery, known as Cognition, for the National Space Biomedical Research Institute (NSBRI) to measure the impact of typical spaceflight stressors (like microgravity, radiation, confinement and isolation, exposure to elevated levels of CO2, and sleep loss) on cognitive performance.
Tue, 25 Nov 2014 19:00:00 GMTNew Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes.
Thu, 13 Nov 2014 19:00:00 GMTResearchers affiliated with the University of Pennsylvania's newly-created Prevention Research Center (PRC), have received two grants totaling over $860,000 from the Center for Disease Control and Prevention's (CDC) Special Interest Project (SIP) to advance the CDC's Healthy Brain Initiative.
Mon, 20 Oct 2014 18:30:00 GMTBlue light can both set the mood and set in motion important biological responses. Researchers at the University of Pennsylvania's School of Medicine and School of Arts and Sciences have teased apart the separate biological responses of the human eye to blue light, revealing an unexpected contest for control.
Mon, 20 Oct 2014 13:45:00 GMTResearchers from the Perelman School of Medicine and School of Engineering at the University of Pennsylvania and The Children's Hospital of Philadelphia have used graphene -- a two-dimensional form of carbon only one atom thick -- to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain.
Mon, 04 Aug 2014 19:30:00 GMTErika Holzbaur, PhD, a professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania, has received the Javits Neuroscience Investigator Award from the National Institutes of Health. She was selected by the National Institute of Neurological Disorders and Stroke (NINDS) and will receive over $1.5 million over the next four years, with another $1.2 million pending satisfactory progress, to study molecular motors and their role in axonal transport and neurodegeneration.
Tue, 13 May 2014 21:00:00 GMTStimulation of a certain population of neurons within the brain can alter the learning process, according to a team of neuroscientists and neurosurgeons at the University of Pennsylvania.
Tue, 13 May 2014 21:00:00 GMTA Penn Medicine team has found that suppressing the hyperactivity of calcium channels alleviated FAD-like symptoms in mice models of the disease.
Mon, 28 April 2014 13:30:00 GMTStroke researchers from the Perelman School of Medicine at the University of Pennsylvania will unveil a map demonstrating geographic hotspots of increased stroke mortality across the United States, among a series of stroke studies being presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.
Fri, 25 April 2014 18:45:00 GMTA trio of studies from the Perelman School of Medicine at the University of Pennsylvania demonstrate new approaches to understanding, treating and potentially staving off Parkinson's disease (PD).
Fri, 25 April 2014 18:45:00 GMTTwo neurologists from the Perelman School of Medicine at the University of Pennsylvania have received high honors from the American Academy of Neurology (AAN).
Fri, 25 April 2014 18:30:00 GMTMore than 90 Penn Medicine neurologists and researchers will present over 120 studies and abstracts at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.
Tue, 22 April 2014 14:15:00 GMTWhen we get sick it feels natural to try to hasten our recovery by getting some extra shuteye. Researchers from the Perelman School of Medicine at the University of Pennsylvania found that this response has a definite purpose, in fruitflies: enhancing immune system response and recovery to infection. Their findings appear online in two related papers in the journal SLEEP, in advance of print editions in May and June.
Mon, 07 April 2014 16:30:00 GMTHow will we, as individuals, and a society, live with brains at risk for Alzheimer's disease dementia? As part of Health Affairs' April issue, a theme issue focusing on Alzheimer's, a neurodegenerative disease ethicist and clinician with the Perelman School of Medicine at the University of Pennsylvania offers keen observations to help navigate ethically-charged points on the course of the disease progression.
Thur, 20 Mar 2014 20:00:00 GMTUsing a University of Pennsylvania-designed device to noninvasively and continuously monitor cerebral blood flow (CBF) in acute stroke patients, researchers from Penn Medicine and the Department of Physics and Astronomy in Penn Arts and Sciences are now learning how head of bed (HOB) positioning affects blood flow reaching the brain.
Wed, 12 Mar 2014 14:45:00 GMT"Cell movement is the basic recipe of life, and all cells have the capacity to move," says Roberto Dominguez, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania. Motility — albeit on a cellular spatial scale — is necessary for wound healing, clotting, fetal development, nerve connections, and the immune response, among other functions. On the other hand, cell movement can be deleterious when cancer cells break away from tumors and migrate to set up shop in other tissues during cancer metastasis.
Mon, 10 Mar 2014 15:00:00 GMTEven the mildest form of a traumatic brain injury, better known as a concussion, can deal permanent, irreparable damage. Now, an interdisciplinary team of researchers at the University of Pennsylvania is using mathematical modeling to better understand the mechanisms at play in this kind of injury, with an eye toward protecting the brain from its long-term consequences.
Thur, 06 Mar 2014 21:00:00 GMTPennsylvania Hospital, Penn Presbyterian Medical Center and Chester County Hospital have received the American Heart Association/American Stroke Association's Get With The Guidelines-Stroke Silver Plus Quality Achievement Award.
Fri, 03 Jan 2014 14:00:00 GMTAmong Parkinson's disease (PD) patients, female, black, and Asian patients are substantially less likely to receive proven deep brain stimulation (DBS) surgery to improve tremors and motor symptoms, according to a new report by a Perelman School of Medicine at the University of Pennsylvania researcher who identified considerable disparities among Medicare recipients receiving DBS for Parkinson's disease. The study, published in Neurology, found that patients from neighborhoods of lower socioeconomic status were less likely to receive DBS, regardless of race or sex. And patients of minority-serving physician practices were also less likely to receive DBS, irrespective of race. The study demonstrates a need to adjust policy and incentives to provide state of the art care for all Parkinson's patients.
Fri, 13 Dec 2013 15:45:00 GMTThe Perelman School of Medicine at the University of Pennsylvania will join a new national network of 25 regional stroke centers selected to advance stroke research on prevention, treatment and recovery.
Wed, 11 Dec 2013 20:15:00 GMTA new study suggests a potential dietary treatment - a cocktail of key amino acids that improved sleep disturbances caused by brain injuries in mice - for millions of people affected by traumatic brain injury (TBI)—a condition that is currently untreatable.
Tue, 19 Nov 2013 14:30:00 GMTA new blood biomarker correctly predicted which concussion victims went on to have white matter tract structural damage and persistent cognitive dysfunction following a mild traumatic brain injury (mTBI).
Mon, 28 Oct 2013 13:15:00 GMTThe largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate.
Wed, 16 Oct 2013 17:15:00 GMTThe latest look at connections between psoriasis and other serious medical conditions revealed for the first time that people with more serious cases of psoriasis are at twice the risk of developing chronic kidney disease and four times the risk of developing end stage renal disease requiring dialysis.
Fri, 04 Oct 2013 13:30:00 GMTA team of experts in neurocritical care, engineering, and informatics, with the Perelman School of Medicine at the University of Pennsylvania, have devised a new way to detect which stroke patients may be at risk of a serious adverse event following a ruptured brain aneurysm. This new, data-driven machine learning model, involves an algorithm for computers to combine results from various uninvasive tests to predict a secondary event.
Wed, 25 Sept 2013 17:00:00 GMTA new approach to treating cancer that has spread to the brain is able to preserve and, in some cases, improve cognitive function in patients, while achieving local control of tumor progression. A study led by researchers with the Perelman School of Medicine at the University of Pennsylvania found that 98 percent of patients who deferred whole brain radiation therapy and had chemotherapeutic wafers placed around the areas where metastatic tumors in the brain had been surgically removed showed preserved cognitive function in one or more of three domains; 65 percent showed preservation in all areas tested: memory, executive function, and fine motor skills.
Mon, 26 August 2013 20:00:00 GMTPerelman School of Medicine researchers at the University of Pennsylvania report the first biomarker results reported from the Parkinson's Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson's disease.
Wed, 21 August 2013 20:00:00 GMTA leading group of Alzheimer's researchers contends that, as biomarkers to detect signals of the disease improve at providing clinically meaningful information, researchers will need guidance on how to constructively disclose test results and track how disclosure impacts both patients and the data collected in research studies. A survey conducted by a group including experts from the Perelman School of Medicine at the University of Pennsylvania found that a majority of Alzheimer's researchers supported disclosure of results to study participants.
Wed, 07 August 2013 20:00:00 GMTMatthew B. Stern, MD, director of the Parkinson's Disease and Movement Disorders Center at Pennsylvania Hospital and Professor of Neurology in the Perelman School of Medicine at the University of Pennsylvania, is serving a two-year term as president of the International Parkinson and Movement Disorder Society.
Fri, 26 July 2013 21:00:00 GMTThe network of arteries supplying blood flow to the brain is more likely to be incomplete in people who suffer migraine, a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania reports. Variations in arterial anatomy lead to asymmetries in cerebral blood flow that might contribute to the process triggering migraines.
Thur, 25 July 2013 18:30:00 GMTA small percentage of people diagnosed with a mysterious neurological condition may only experience psychiatric changes - such as delusional thinking, hallucinations, and aggressive behavior - according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Tue, 17 July 2013 20:30:00 GMTThe trajectory of amyloid plaque buildup—clumps of abnormal proteins in the brain linked to Alzheimer's disease—may serve as a more powerful biomarker for early detection of cognitive decline rather than using the total amount to gauge risk, researchers from Penn Medicine's Department of Radiology suggest in a new study published online July 15 in Neurobiology of Aging. An abstract (#O4-07-03) on the topic was also presented July 17 at the 2013 Alzheimer's Association International Conference (AAIC) in Boston.
Wed, 10 July 2013 00:01:00 GMTResearchers in the Perelman School of Medicine at the University of Pennsylvania found that, across a variety of neurodegenerative diseases, cerebrovascular disease affecting circulation of blood in the brain was significantly associated with dementia.
Wed, 03 July 2013 16:00:00 GMTNeurodegenerative diseases are not all alike. Two individuals suffering from the same disease may experience very different age of onset, symptoms, severity, and constellation of impairments, as well as different rates of disease progression. Researchers in the Perelman School of Medicine at the University of Pennsylvania have shown one disease protein can morph into different strains and promote misfolding of other disease proteins commonly found in Alzheimer's, Parkinson's and other related neurodegenerative diseases.
Wed, 19 June 2013 15:30:00 GMTThe motor neuron disease Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, progresses in a stepwise, sequential pattern which can be classified into four distinct stages, report pathologists with the Perelman School of Medicine at the University of Pennsylvania in the Annals of Neurology.
Thur, 25 April 2013 20:15:00 GMTWith a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully treated with a drug that modifies the disease process, minimizing seizures and improving receptive language.
Tue, 23 April 2013 22:00:00 GMTDeep brain stimulation (DBS) in a precise region of the brain appears to reduce caloric intake and prompt weight loss in obese animal models, according to a new study led by researchers at the University of Pennsylvania.
Mon, 09 April 2013 16:15:00 GMTA variation in the gene ABCA7 causes a twofold increase in the risk of late onset Alzheimer disease among African Americans, according to a meta-analysis by a team of researchers including experts from the Perelman School of Medicine at the University of Pennsylvania. This is the largest analysis to date to determine genetic risk associated with late-onset Alzheimer disease (LOAD) specifically in African American individuals. The study appears in the April 10 issue of JAMA, a genomics theme issue.
Mon, 01 April 2013 16:15:00 GMTNeurosurgeons can visualize important pathways in the brain using an imaging technique called diffusion tensor imaging (DTI), to better adapt brain tumor surgeries and preserve language, visual and motor function while removing cancerous tissue. In the latest issue of Neurosurgical Focus, researchers from the Perelman School of Medicine at the University of Pennsylvania review research showing that this ability to visualize relevant white matter tracts during glioma resection surgeries can improve accuracy and, in some groups, significantly extend survival (median survival of 21.2 months) compared to cases where DTI was not used (median survival of 14 months).
Tue, 26 March 2012 21:00:00 GMTCertified Primary Stroke Centers are three times more likely to administer clot-busting treatment for strokes than non-certified centers, reports a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Fri, 22 March 2012 15:30:00 GMTThe results of two long-awaited clinical trials, testing a closure device versus medication to prevent stroke recurrence in young stroke survivors who have an opening in the atrial wall, have not provided enough evidence to conclude who, if anyone, is likely to benefit from the interventional procedure, according to an accompanying editorial in the New England Journal of Medicine co-authored by a Perelman School of Medicine researcher at the University of Pennsylvania.
Mon, 18 March 2013 15:15:00 GMTThe brain's prefrontal cortex is thought to be the seat of cognitive control, working as a kind of filter that keeps irrelevant thoughts, perceptions and memories from interfering with a task at hand. Now, researchers at the University of Pennsylvania have shown that inhibiting this filter can boost performance for tasks in which unfiltered, creative thoughts present an advantage.
Fri, 15 March 2013 15:00:00 GMTTelestroke programs substantially improve access to life-saving stroke care, extending coverage to less populated areas in an effort to reduce disparities in stroke care access. A new study by researchers from the Perelman School of Medicine at the University of Pennsylvania, being presented at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013, found that telemedicine programs in Oregon pushed stroke coverage into previously uncovered, less populated areas and expanded coverage by approximately 40 percent.
Fri, 15 March 2013 15:00:00 GMTInjecting synthetic tau fibrils into animal models induces Alzheimer's-like tau tangles and imitates the spread of tau pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania being presented at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013.
Fri, 15 March 2013 14:00:00 GMTA series of studies demonstrate improved detection of the second most common form of dementia, providing diagnostic specificity that clears the way for refined clinical trials testing targeted treatments. The new research is being presented by experts from the Perelman School of Medicine at the University of Pennsylvania at the American Academy of Neurology’s 65th Annual Meeting in San Diego March 16-23, 2013.
Fri, 15 March 2013 14:00:00 GMTPenn experts will be presenting the latest advances in treatment and diagnosis of neurological conditions like Alzheimer’s disease, epilepsy and stroke at the American Academy of Neurology 65th Annual Meeting. Given the high global burden of rain disorders, which cause at least 25 percent of death and disability globally, the Penn team will gather with neurologists from around the world in San Diego, CA from March 16-23 as the field discusses the latest advances in neurological medicine, science and education.
Thur, 4 February 2013 19:15:00 GMTMounting evidence demonstrates that the pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals and thereby "spread" disease from one interconnected brain region to another. A new study found no evidence to support concerns that these abnormal disease proteins are "infectious" or transmitted from animals to humans or from one person to another. The study by researchers from the Perelman School of Medicine at the University of Pennsylvania, in conjunction with experts from the U.S. Centers for Disease Control and the Department of Health and Human Services, appears online in JAMA Neurology.
Mon, 07 Jan 2013 21:00:00 GMTWhile approximately one in five Parkinson's disease patients experience impulse control disorder symptoms, the disease itself does not increase the risk of gambling, shopping, or other impulsivity symptoms, according to research from the Perelman School of Medicine at the University of Pennsylvania. A new study is the first to show in a large sample that people with untreated Parkinson's were no more likely to have an increased impulsivity than people without the disease.
Thur, 03 Jan 2013 16:00:00 GMTThe Hospital of the University of Pennsylvania (HUP) has been recognized by The Joint Commission and the American Heart Association/American Stroke Association (AHA/ASA) as meeting The Joint Commission's standards for Disease-Specific Care Comprehensive Stroke Center Certification, becoming the first center in Philadelphia and among a select few hospitals in the United States to be named as part of an elite group of providers focused on complex stroke care.
Wed, 26 Dec 2012 20:00:00 GMTWhen trying to determine the root cause of a person's dementia, using an MRI can effectively and non-invasively screen patients for Alzheimer's disease or Frontotemporal Lobar Degeneration (FTLD), according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Thur, 20 Dec 2012 16:30:00 GMTRobert Siman, PhD, Research Professor of Neurosurgery in the Perelman School of Medicine at the University of Pennsylvania, has received a Zenith Fellows Award from the Alzheimer's Association for his personal commitment to the advancement of Alzheimer's disease research, and his research contributions to better understanding and curing the disease.
Wed, 19 Dec 2012 16:00:00 GMTPeople with Alzheimer's disease are less likely to participate in a clinical trial if they have non-spouse caregivers, according to a study by a team of researchers including the Perelman School of Medicine at the University of Pennsylvania.
Mon, 17 Dec 2012 15:30:00 GMTNew research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, suggesting that cocaine-induced changes in physiology are passed down from father to son.
Thur, 04 Oct 2012 16:00:00 GMTNearly 100 years after a British neurologist first mapped the blind spots caused by missile wounds to the brains of soldiers, Perelman School of Medicine researchers at the University of Pennsylvania have perfected his map using modern-day technology.
Thur, 13 Sep 2012 19:30:00 GMTA year ago, researchers at the Perelman School of Medicine at the University of Pennsylvania reported that Alzheimer's pathology, as reflected by cerebral spinal fluid biomarkers, might be increased in patients after surgery and anesthesia. However, it is not clear whether the anesthetic drugs or the surgical procedure itself was responsible. To separate these possibilities, the group turned to a mouse model of Alzheimer's disease. The results, published online this month in the Annals of Surgery, show that surgery itself, rather than anesthesia, has the more profound impact on a dementia-vulnerable brain.
Thur, 30 August 2012 15:30:00 GMTResearchers at the Perelman School of Medicine will receive $11.9 million over the next five years from the National Institute of Neurological Disorders and Stroke (NINDS) for the Penn Udall Center for Parkinson's Disease (PD) research.
Tue, 21 August 2012 13:00:00 GMTTwo Penn Medicine hospitals have received Primary Stroke Center certification from The Joint Commission for efforts to achieve long-term success in improving outcomes for stroke patients.
Mon, 20 August 2012 17:00:00 GMTEfforts to develop a blood test for Alzheimer's disease are progressing, as a new study co-authored by experts from the Perelman School of Medicine at the University of Pennsylvania (Penn) found a group of biomarkers that hold up in statistical analyses in three independent groups of patients.
Thur, 19 July 2012 16:00:00 GMTWhile clinical trial results are being released regarding drugs intended to decrease amyloid production - thought to contribute to decline in Alzheimer's disease - clinical trials of drugs targeting other disease proteins, such as tau, are in their initial phases.
Tue, 17 July 2012 16:00:00 GMTDiagnostic tests are increasingly capable of identifying plaques and tangles present in Alzheimer's disease, yet the disease remains untreatable.
Mon, 9 July 2012 16:00:00 GMTThe Ecuadorean National Assembly has bestowed its highest scientific award to Donald Silberberg, MD, professor emeritus and former Chair of Neurology in the Perelman School of Medicine at the University of Pennsylvania, for his efforts spanning two decades to raise awareness, enhance medical education and improve patient care for neurological and psychiatric conditions globally, and in Ecuador.
Tue, 19 June 2012 21:00:00 GMTAmyloid fibers are protein aggregates associated with numerous neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments.
Thur, 14 June 2012 19:00:00 GMTFrances E. Jensen, MD, has been named Chair of the Department of Neurology in the Perelman School of Medicine at the University of Pennsylvania.
Thur, 6 June 2012 14:00:00 GMTOn the evening of Thursday, June 7th, Penn Medicine and Penn Athletics will host a Red Carpet premiere of a new film, Head Games, a revealing documentary about the concussion crisis in sports.
Mon, 14 May 2012 14:00:00 GMTPerelman School of Medicine at the University of Pennsylvania researchers have discovered a mechanism involving the neurotransmitter dopamine that switches fruit fly behavior from being active during the day (diurnal) to nocturnal.
Tue, 24 Apr 2012 16:00:00 GMTA cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder, according to research from the Perelman School of Medicine at the University of Pennsylvania.
Fri, 20 Apr 2012 20:40:00 GMTIn a series of studies being presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans, Penn researchers demonstrated that, while tests created for AD are effectively diagnosing the condition when it's clear cut, additional tests are needed to address the many cases with mixed pathology.
Fri, 20 Apr 2012 20:00:00 GMTTwo new studies analyzing treatment decisions in late-stage amyotrophic lateral sclerosis (ALS) patients shed light onto treatments aimed to extend the duration and quality of life in this progressively debilitating neuromuscular disorder.
Fri, 20 Apr 2012 11:00:00 GMTA mysterious, difficult-to-diagnose, and potentially deadly disease that was only recently discovered can be controlled most effectively if treatment is started within the first month that symptoms occur, according to a new report by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Thur, 5 Apr 2012 13:00:00 GMTResearchers have long recognized that autism runs in families, suggesting a genetic component.