Thu, 27 Oct 2016 18:00:00 GMTCheckpoint inhibitor drugs that boost the immune system to fight cancer owe part of their existence to infectious diseases. Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways -- cell surface receptors such as CTLA4 and PD-1 -- to slow immune cells and prevent their elimination by the host.
Mon, 26 Sep 2016 16:45:00 GMTA high-fat-diet-induced immune reaction causes inflammation leading to intestinal cancer in a mouse model – even among animals that are not obese -- according to a new study from the Perelman School of Medicine at the University of Pennsylvania.
Wed, 24 Aug 2016 18:15:00 GMTSpecial RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania.
Tue, 02 Aug 2016 18:45:00 GMTA new study suggests that tweaking metabolic steps in combination with checkpoint blockade drugs may improve some cancer therapies, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Thu, 28 Jul 2016 17:15:00 GMTE. John Wherry, PhD, a professor of Microbiology, director of the Institute for Immunology, and co-director of the Parker Institute for Cancer Immunotherapy at the Perelman School of Medicine at the University of Pennsylvania, has been awarded the 2016 Frederick W. Alt Award for New Discoveries in Immunology from the Cancer Research Institute (CRI).
Thu, 30 May 2016 18:30:00 GMTIn a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.
Mon, 06 Jun 2016 13:45:00 GMTResearchers from the Perelman School of Medicine at the University of Pennsylvania have figured out how to make a much-improved research tool that they hope will open the door to new and better HIV vaccine designs.
Tue, 19 Apr 2016 15:30:00 GMTScientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.
Fri, 30 Oct 2015 13:30:00 GMTIn contrast to amphibian tissue regeneration, traumatic injuries in mammals typically heal with a fibrous scar. Researchers discovered that some strains of mice heal without a scar, by disrupting a protein, called Sdf1, that normally recruits white blood cells to sites of injury.
Thu, 15 Oct 2015 13:30:00 GMTA new study from the Perelman School of Medicine at the University of Pennsylvania, led by Erle S. Robertson, PhD and James C. Alwine, PhD, has identified, for the first time, an association between two microbial signatures and triple negative breast cancer (TNBC), the most aggressive form of the disease.
Wed, 14 Oct 2015 16:00:00 GMTDifferent treatments for Crohn's disease in children affects their gut microbes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Thu, 01 Oct 2015 10:30:00 GMTDavid Fajgenbaum, MD, MBA, MSc, a research assistant professor of Medicine, division of Hematology/Oncology, in the Perelman School of Medicine at the University of Pennsylvania, has received the RARE Champion of Hope award for science.
Wed, 30 Sep 2015 13:30:00 GMTUsing a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
Mon, 03 August 2015 17:30:00 GMTResearchers at the Perelman School of Medicine at the University of Pennsylvania have devised an entirely new approach to vaccines – creating immunity without vaccination.
Wed, 03 June 2015 14:30:00 GMTSometimes even cells get tired. When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop "T cell exhaustion," becoming less effective and losing their ability to attack and destroy the invaders of the body. While the PD-1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD-1 actually directly causes exhaustion.
Wed, 20 May 2015 18:15:00 GMTA group of researchers from Penn and other institutions in the region will come together this Friday to celebrate 10 years of environmental health research in the Center of Excellence in Environmental Toxicology (CEET).
Fri, 18 May 2015 19:00:00 GMTAn important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin.
Mon, 20 Apr 2015 19:00:00 GMTThe lab of Kristen Lynch, PhD, published a study in the Proceedings of the National Academy of Sciences that describes a cascade of events that may explain changes in gene expression that occur during the development of the human immune system.
Thu, 11 Dec 2014 19:00:00 GMTNew work by Penn researchers has found an effective way to avoid systemic kidney inlammation from frequent dialysis by temporarily suppressing complement during dialysis. Their work appears online in Immunobiology ahead of print.
Mon, 11 Nov 2013 17:00:00 GMTTwo specific genetic variations in people of African descent are responsible for persistent atopic dermatitis (AD), an itchy, inflammatory form of the skin disorder eczema. A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.
Mon, 26 August 2013 20:00:00 GMTResearchers from the Perelman School of Medicine at the University of Pennsylvania demonstrate for the first time that the immune system influences the skin microbiome. A new study found that the skin microbiome – a collection of microorganisms inhabiting the human body – is governed, at least in part, by an ancient branch of the immune system called complement. In turn, it appears microbes on the skin tweak the complement system, as well as immune surveillance of the skin.
Wed, 26 Dec 2012 16:45:00 GMTResearchers at the Perelman School of Medicine at the University of Pennsylvaniashow in an animal model that the enhanced aggressiveness of recurrent tumors may be due to changes in the body's immune response.
Thur, 29 Nov 2012 16:00:00 GMTA new study by researchers at the Perelman School of Medicine, University of Pennsylvania, suggests a novel therapeutical approach that might be used to shift the balance of power in chronic infections. The study appears in the November 30 issue of Science.
Mon, 13 August 2012 11:00:00 GMTYvonne Paterson, PhD, professor of Microbiology, at the Perelman School of Medicine, and professor and associate dean, at the School of Nursing, has been awarded an almost $5 million renewal by the National Institute for General Medical Sciences for the University of Pennsylvania Postdoctoral Opportunities in Research and Training, or PENN-PORT, the postdoctoral-training program she leads.
Mon, 18 June 2012 19:00:00 GMTHealthy humans harbor an enormous and diverse group of bacteria and other bugs that live within their intestines.
Thur, 29 Mar 2012 18:00:00 GMTA Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance.
Thur, 15 Mar 2012 01:00:00 GMTA growing body of evidence underscores the importance of human gut bacteria in modulating human health, metabolism, and disease.
Thur, 19 May 2011 18:00:00 GMTPenn scientists collaborating with researchers at the University of Minnesota describe in Science Translational Medicine how immune cells engineered at the Perelman School of Medicine at the University of Pennsylvania can be replicated by the tens of millions in several weeks.
Tue, 15 Feb 2011 19:00:00 GMTJohn Lambris, PhD, the Dr. Ralph and Sallie Weaver Professor of Research Medicine in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, has been awarded a $2 million grant from the National Eye Institute to test a new class of drugs called complement inhibitors in a primate model of age-related macular degeneration (AMD).
Fri, 04 Feb 2011 17:00:00 GMTPenn researchers have identified an immune cell population that acts as the body's border patrol with the outside world. They discovered that these lymphoid tissue inducer cells maintain immunity in the intestine of mice. The research appeared in the most recent online issue of Immunity.
Wed, 27 Oct 2010 19:00:00 GMTA recently identified immune cell that directs other cells to fight infection plays a critical role in regulating the immune system in both health and disease. Researchers from the University of Pennsylvania School of Medicine have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make these T helper 17 cells multi-taskers of sorts: They protect the body against infection and cancer, but are also culprits in some autoimmune diseases and out-of-control, cancerous cell growth. This new understanding suggests that targeting or inhibiting the involved protein pathways might be a new way to treat cancer, chronic infection, and some autoimmune diseases.
Fri, 15 Oct 2010 15:00:01 GMTHow a T cell decides to make protein X, Y, or Z can have profound effects for fighting foreign invaders or staving off dire autoimmune reactions. Researchers at the University of Pennsylvania School of Medicine have identified the steps that control how different forms of an immune cell protein called CD45, which is critical for activating the immune system when faced with pathogens, are controlled in the arc of a body's immune response.
Thu, 18 Feb 2010 23:59:59 GMTResearchers from the University of Pennsylvania School of Medicine presented today the results from an ongoing Phase I/II open-label clinical trial of Lexgenleucel-T at the 16th Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco, CA. Lexgenleucel-T is a cell and gene therapy product being investigated for the treatment of HIV infection.
Tue, 26 Jan 2010 20:00:00 GMTScientists have long pondered the seeming contradiction that taking broad-spectrum antibiotics over a long period of time can lead to severe secondary bacterial infections. Now researchers from the University of Pennsylvania School of Medicine may have figured out why. The investigators show that "good" bacteria in the gut keep the immune system primed to more effectively fight infection from invading pathogenic bacteria.
Thu, 03 Dec 2009 16:30:00 GMTTwo studies published this month in the Journal of Clinical Investigation provide a significant advance in understanding how some species of monkeys such as sooty mangabeys and African green monkeys avoid AIDS when infected with SIV, the simian equivalent of HIV. Researchers comparative genomics of SIV infection, attempting to identify possible genes related to disease progression or resistance. Their findings change the way AIDS researchers think about human versus simian AIDS infection.
Wed, 07 Oct 2009 14:00:00 GMTResearchers today announced the opening for enrollment of the first ever study using patients’ cells carrying an engineered T cell receptor to treat HIV. The trial may have important implications in the development of new treatments for HIV potentially slowing – or even preventing – the onset of AIDS.
Wed, 17 Jun 2009 18:10:00 GMTResearchers have determined the structure of C3 convertase and of the C3b fragment in complex with factor H. These new structures, both involving a central component of an enzyme important to the complement system of the immune response, reveal how this system fights invading microbes while avoiding problems of the body attacking itself.
Thu, 04 Jun 2009 14:20:00 GMTAfter a vaccination or an infection, the human immune system remembers to keep protecting against invaders it has already encountered, with the aid of specialized B-cells and T-cells. Immunological memory has long been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells remain largely undefined. Now, University of Pennsylvania School of Medicine researchers have found that a common anti-diabetic drug might enhance the effectiveness of vaccines. The findings are described this week in an advanced online publication of Nature.
Tue, 10 Feb 2009 14:00:00 GMTResearchers have generated altered immune cells that are able to shrink, and in some cases eradicate, large tumors in mice. The immune cells target mesothelin, a protein that is highly expressed, or translated in large amounts from the mesothelin gene, on the surface of several types of cancer cells. The approach, developed by researchers at the University of Pennsylvania School of Medicine and the National Cancer Institute (NCI), shows promise in the development of immunotherapies for certain tumors. The study appears online this week in the Proceedings of the National Academy of Sciences.
Tue, 27 Jan 2009 16:00:00 GMTResearchers at the University of Pennsylvania School of Medicine have likely found one reason why the Ebola virus is such a powerful, deadly, and effective virus. Using a cell culture model for Ebola virus infection, they have discovered that the virus disables a cellular protein called tetherin that normally can block the spread of virus from cell to cell.
Mon, 22 Dec 2008 20:00:00 GMTMore drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow their antibodies to recognize different foreign invaders or pathogens. But sometimes antibodies are created that recognize and attack the body’s own cells. These self-reactive antibodies, like early drafts of a manuscript, must be edited into safer versions. This process is called receptor editing and is important for central or early B cell tolerance, which occurs while B cells are still developing in the bone marrow. A research team led by Nina Luning Prak, M.D., Ph.D, Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, has discovered that this editing process may go awry in people with certain types of autoimmune diseases.