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Preview: PENN Medicine Diabetes News

PENN Medicine Diabetes News

The latest news from the University of Pennsylvania School of Medicine and Health System.

Copyright: 2008, The Trustees of the University of Pennsylvania

"Beiging" White Fat Cells to Fight Diabetes

Tue, 16 Feb 2016 17:45:00 GMT

Researchers are getting closer to learning how to turn white fat cells into brown fat cells, in a process called “beiging,” to bring down blood sugar levels and fight diabetes.

Two Gatekeepers for One Gate: Penn Study Solves Mystery of Cell Powerhouse’s Balance of Calcium

Mon, 25 Jan 2016 19:30:00 GMT

A decades-long mystery of how the cell’s powerhouse, and its energy currency of calcium ion flow, is maintained under different physiological conditions has been solved by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Reverberations in Metabolism: Protein Maintains Double Duty as Key Cog in Body Clock and Metabolic Control, Penn Study Finds

Thu, 04 Jun 2015 20:00:00 GMT

In a new study published online ahead of print in Science Express, the Mitchell Lazar, MD, PhD, and his team describes how one protein regulates the clock in most cells in the body and metabolic genes in the liver, the body's key organ for metabolism of fat as well as sugar.

Inflammation Stops the Clock: How the Immune System Controls the Human Biological Clock in Times of Infection

Fri, 18 May 2015 19:00:00 GMT

An important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin.

Common Biomarkers of Sleep Debt Found in Humans, Rats, Penn Study Finds

Wed, 11 Feb 2015 18:30:00 GMT

In a study published this week in the Proceedings of the National Academy of Sciences, Penn Medicine researchers found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.

Overly Conservative FDA Label Likely Prevents Use of Metformin in Many Type 2 Diabetics

Mon, 05 Jan 2015 16:30:00 GMT

Many patients with type 2 diabetes in the United States may be discouraged from taking metformin—a proven, oral diabetes medicine—because the U.S. Food and Drug Administration inappropriately labels the drug unsafe for some patients also suffering from kidney problems, researchers from Penn Medicine and Weill Cornel Medical College report this week in a research letter published in JAMA Internal Medicine.

Pancreatic Islet Cell Transplantation Restores Type 1 Diabetes Patients' Ability to Defend Against Life-Threatening Low Blood Sugar, According to Penn Medicine Study

Thu, 18 Dec 2014 14:00:00 GMT

Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.

Four Penn Faculty Named to 2014 Class of AAAS Fellows

Mon, 01 Dec 2014 15:45:00 GMT

Four faculty members from the University of Pennsylvania have been named fellows of the American Association for the Advancement of Science (AAAS). Three are from the Perelman School of Medicine and one is from the School of Arts and Sciences.

Penn Researchers Unwind the Mysteries of the Cellular Clock

Thu, 20 Nov 2014 16:00:00 GMT

In the current issue of the journal Cell, Mitchell Lazar, MD PhD, the Sylvan Eisman Professor of Medicine and director of the Institute for Diabetes, Obesity, and Metabolism and his team report the results of a genome-wide survey of circadian genes and genetic regulatory elements called enhancers. These are key parts of the "dark matter" of the genome; rather than encoding proteins, they control the expression of genes.

Diabetes Drugs Prescribed to More than 15 Million Americans Raises Risk of Bladder Cancer, Penn Medicine Study Shows

Mon, 13 August 2012 14:00:00 GMT

A popular class of diabetes drugs increases patients' risk of bladder cancer, according to a new study published online this month in the Journal of the National Cancer Institute. Researchers from the Perelman School of Medicine at the University of Pennsylvania found that patients taking thiazolidinedione (TZDs) drugs – which account for up to 20 percent of the drugs prescribed to diabetics in the United States -- are two to three times more likely to develop bladder cancer than those who took a sulfonylurea drug, another common class of medications for diabetes.

Liver Fat Gets a Wake-Up Call That Maintains Blood Sugar Levels, According to Penn Study

Mon, 7 May 2012 16:00:00 GMT

A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.

Revising the "Textbook" on Liver Metabolism Offers New Targets for Diabetes Drugs, According to Penn Study

Wed, 22 Feb 2012 14:00:00 GMT

A team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the erelman School of Medicine, University of Pennsylvania, has overturned a "textbook" view of what the body does after a meal.

Penn Researchers Find Combined Primary Care and Counseling Programs Improve Diabetes Test Results and Reduce Remission of Depression

Mon, 9 Jan 2012 04:00:00 GMT

Patients suffering from both Type 2 diabetes and depression have been shown to improve both conditions when given a combination of medical treatment and counseling services compared to patients receiving usual care. A new study by researchers from the Perelman School of Medicine at the University of Pennsylvania showed that more than 60 percent of patients receiving combined treatment and counsel to assist with medication compliance had improved blood sugar test results. In the same group, 58 percent had reduced depression symptoms, compared to only 36 percent and 31 percent, respectively, of patients receiving usual care. The full results of the study are published in the January/February issue of The Annals of Family Medicine.

Penn Researchers Show that Inhibiting Cholesterol-Associated Protein Reduces High-Risk Blockages in Arteries
Using the drug darapladib, researchers at the University of Pennsylvania School of Medicine and colleagues have inhibited a cholesterol-and immune system-associated protein, thereby reducing the development of heart-disease plaques that may cause death, heart attacks, and strokes in a pig model of atherosclerosis and diabetes.

Three University of Pennsylvania Professors Named 2007 AAAS Fellows
Three faculty members of the University of Pennsylvania have been named Fellows of the American Association for the Advancement of Science (AAAS). This year AAAS recognized 471 members for their scientifically or socially distinguished efforts to advance science or its applications.  The new Fellows will be officially inducted February 16 during the 2008 AAAS annual meeting in Boston

Common Diabetes Drug Kills Some Cancer Cells
Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. Results from current studies in mice may result in new therapies for a subset of human cancers that tend to be aggressive and resistant to existing treatments. Additionally, the findings open up a new avenue for targeting cancers whose hallmark is the absence of this regulatory gene. The Penn team reported their findings last month in Cancer Research.

Potential New Target for Type 2 Diabetes
Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes, according to a new study that appeared online this week in Nature. The target is a protein, along with its molecular partner, that regulates fat metabolism.

Penn Study Points to New Direction for Pancreas Cell Regeneration
Replacing faulty or missing cells with new insulin-making cells has been the object of diabetes research for the last decade. Past studies in tissue culture have suggested that one type of pancreas cell could be coaxed to transform into insulin-producing islet cells. Now, researchers at the University of Pennsylvania School of Medicine have demonstrated that these pancreatic acinar cells do not become insulin-producing cells in an animal model. However, they did show that injured pancreatic cells readily regenerate back into healthy acinar cells, which has implications for treating cancer and inflammation of the pancreas.

One in Six Americans Have Pre-Diabetes and Most Don't Know It
Fifty-four million Americans -- that's one in six of us -- have pre-diabetes and most don't even realize it. Mark Schutta, MD, medical director of the Penn Rodebaugh Diabetes Center, is urging at-risk patients to be proactive and ask your doctor to give you a simple blood test for pre-diabetes -- to arm yourself with information before the damage is done.

Three Penn School of Medicine Faculty Named to Institute of Medicine
Three professors at the University of Pennsylvania School of Medicine were elected yesterday as members of the Institute of Medicine (IOM), one of the nation's highest honors in biomedicine. The new members bring Penn's total to 58, out of over 1500 worldwide. Overall, 65 new members were named this year.

Mutation in Tumor Suppressor Gene Causes Pancreatic Islet Cells to Reproduce
Researchers at the University of Pennsylvania School of Medicine have found that the acute loss of a protein called menin can cause the proliferation of pancreatic islet cells, which secrete insulin to regulate blood sugar. The menin gene (Men1) mutation in humans causes an inherited disease called Multiple Endocrine Neoplasia type 1 (MEN1). Not only could this discovery inform basic cancer biology, it also has implications for treating Type 1 diabetes.

Mitchell Lazar, MD, PhD, Receives Award Lecture from The Endocrine Society
Mitchell Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism, at the University of Pennsylvania School of Medicine, is the 2006 recipient of The Endocrine Society's Edwin B. Astwood Award Lecture. Lazar will present his talk, entitled, "Nuclear Receptors and Endocrinology" at the society's 88th annual meeting, this week in Boston, MA.

Aida Turturro to Tour the Penn Rodebaugh Diabetes Center
The media is invited to join The Sopranos TV actress, Aida Turturro, as she tours the Penn Rodebaugh Diabetes Center. After the tour, the media is also welcome to attend a discussion between Turturro and several Penn diabetes patients as they talk about the daily challenges of living with diabetes.