Thu, 17 Nov 2016 18:00:00 GMTNow, a new study published online today in Cell Metabolism by a team led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism in the Perelman School of Medicine at the University of Pennsylvania, revealed a surprising relationship between two molecules – one that works to store fat and another that promotes fat burning for energy.
Tue, 16 Feb 2016 17:45:00 GMTResearchers are getting closer to learning how to turn white fat cells into brown fat cells, in a process called “beiging,” to bring down blood sugar levels and fight diabetes.
Mon, 25 Jan 2016 19:30:00 GMTA decades-long mystery of how the cell’s powerhouse, and its energy currency of calcium ion flow, is maintained under different physiological conditions has been solved by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Thu, 04 Jun 2015 20:00:00 GMTIn a new study published online ahead of print in Science Express, the Mitchell Lazar, MD, PhD, and his team describes how one protein regulates the clock in most cells in the body and metabolic genes in the liver, the body's key organ for metabolism of fat as well as sugar.
Fri, 18 May 2015 19:00:00 GMTAn important link between the human body clock and the immune system has relevance for better understanding inflammatory and infectious diseases, discovered collaborators at the Perelman School of Medicine at the University of Pennsylvania and Trinity College, Dublin.
Wed, 11 Feb 2015 18:30:00 GMTIn a study published this week in the Proceedings of the National Academy of Sciences, Penn Medicine researchers found common molecules signifying perturbed metabolism in response to sleep restriction in a comprehensive metabolic profiling of blood from both rats and humans.
Mon, 05 Jan 2015 16:30:00 GMTMany patients with type 2 diabetes in the United States may be discouraged from taking metformin—a proven, oral diabetes medicine—because the U.S. Food and Drug Administration inappropriately labels the drug unsafe for some patients also suffering from kidney problems, researchers from Penn Medicine and Weill Cornel Medical College report this week in a research letter published in JAMA Internal Medicine.
Thu, 18 Dec 2014 14:00:00 GMTType 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.
Mon, 01 Dec 2014 15:45:00 GMTFour faculty members from the University of Pennsylvania have been named fellows of the American Association for the Advancement of Science (AAAS). Three are from the Perelman School of Medicine and one is from the School of Arts and Sciences.
Thu, 20 Nov 2014 16:00:00 GMTIn the current issue of the journal Cell, Mitchell Lazar, MD PhD, the Sylvan Eisman Professor of Medicine and director of the Institute for Diabetes, Obesity, and Metabolism and his team report the results of a genome-wide survey of circadian genes and genetic regulatory elements called enhancers. These are key parts of the "dark matter" of the genome; rather than encoding proteins, they control the expression of genes.
Mon, 13 August 2012 14:00:00 GMTA popular class of diabetes drugs increases patients' risk of bladder cancer, according to a new study published online this month in the Journal of the National Cancer Institute. Researchers from the Perelman School of Medicine at the University of Pennsylvania found that patients taking thiazolidinedione (TZDs) drugs – which account for up to 20 percent of the drugs prescribed to diabetics in the United States -- are two to three times more likely to develop bladder cancer than those who took a sulfonylurea drug, another common class of medications for diabetes.
Mon, 7 May 2012 16:00:00 GMTA Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.
Wed, 22 Feb 2012 14:00:00 GMTA team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the erelman School of Medicine, University of Pennsylvania, has overturned a "textbook" view of what the body does after a meal.
Mon, 9 Jan 2012 04:00:00 GMTPatients suffering from both Type 2 diabetes and depression have been shown to improve both conditions when given a combination of medical treatment and counseling services compared to patients receiving usual care. A new study by researchers from the Perelman School of Medicine at the University of Pennsylvania showed that more than 60 percent of patients receiving combined treatment and counsel to assist with medication compliance had improved blood sugar test results. In the same group, 58 percent had reduced depression symptoms, compared to only 36 percent and 31 percent, respectively, of patients receiving usual care. The full results of the study are published in the January/February issue of The Annals of Family Medicine.