Thu, 28 Jul 2016 17:15:00 GMTIn an ongoing preclinical program using gene therapy to help cells restore normal levels of IDUA, researchers from the Perelman School of Medicine at the University of Pennsylvania have shown that exposure to the human IDUA protein early in the life of an MPS I canine model increased immune tolerance to the foreign gene.
Wed, 29 Jun 2016 14:45:00 GMTThe Perelman School of Medicine at the University of Pennsylvania has launched a new program, called AAV 3.0™, to create new viral vectors to find quicker and better treatments for an array of diseases.
Wed, 13 Apr 2016 14:45:00 GMTNew preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children. In that disease, fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, alters skeletal bone formation, and limits motion, breathing, and swallowing, among a host of progressive symptoms.
Tue, 02 Feb 2016 16:45:00 GMTA powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists from the Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia (CHOP).
Wed, 07 Oct 2015 13:30:00 GMTDisabling a cancer-causing pathway and administering an immune-molecule-based mop-up therapy eradicated a specific type of breast tumor in mice, according to researchers in the Perelman School of Medicine at the University of Pennsylvania.
Wed, 30 Sep 2015 13:30:00 GMTUsing a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
Fri, 17 Jul 2015 15:00:00 GMTDaniel J. Rader, MD, chair of the Department of Genetics at the Perelman School of Medicine at the University of Pennsylvania, and Danish Saleheen, MD, PhD, an assistant professor of Biostatistics and Epidemiology, have been awarded a four-year, $2 million 2015 Grand Challenge Award from the American Heart Association (AHA).
Wed, 15 Jul 2015 18:00:00 GMTSince 2007, clinical trials using gene therapy have resulted in often-dramatic sight restoration for dozens of children and adults who were otherwise doomed to blindness. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia (CHOP), have found evidence that this sight restoration leads to strengthening of visual pathways in the brain, published this week in Science Translational Medicine.
Wed, 27 May 2015 13:15:00 GMTHow can academic medical centers best manage the emerging issue of conflict of interest among scientists and physicians working to develop the next generation of treatments and cures? How do academic conflict of interest policies affect the process of scientific discovery? Exploring these questions and related issues will be at the heart of the "Conflict of Interest and Scientific Discovery" symposium organized by the Institute for Translational Medicine and Therapeutics at the University of Pennsylvania's Perelman School of Medicine.
Thu, 12 Mar 2015 18:00:00 GMTThe National Institutes of Allergy and Infectious Diseases has awarded $16 million over the next five years for a collaborative study led by scientists from the Perelman School of Medicine at the University of Pennsylvania.
Thu, 19 Feb 2015 13:15:00 GMTThe topical eczema medicine pimecrolimus appears unlikely to be associated with an increased risk of cancer in children, based on a group of children who were followed for 10 years, according to study published online this week in JAMA Dermatology.
Mon, 10 Nov 2014 16:00:00 GMTOncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations.
Mon, 27 Oct 2014 19:00:00 GMTA new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making – provides important clues about how the role of timing may influence the way drugs work in the body.
Thu, 02 Apr 2009 17:40:00 GMTA new federally funded University of Pennsylvania School of Medicine study aims to learn whether women at high risk of breast cancer can use exercise to meaningfully reduce their risk of getting the disease. Building on evidence that reducing estrogen in the body reduces cancer risk, and that elite female athletes experience a drop in estrogen levels that often cause them to stop ovulating and menstruating, the WISER Sister trial will investigate two different levels of regular treadmill exercise as a possible intervention for breast cancer risk reduction.