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Last Build Date: Fri, 23 Feb 2018 00:50:00 GMT

 



Category:Professional regulators

Fri, 23 Feb 2018 00:11:21 GMT

Categorise

New page

[[category:regulation]]



Professional Standards Authority

Fri, 23 Feb 2018 00:10:04 GMT

Categorise ← Older revision Revision as of 00:10, 23 February 2018 Line 1: Line 1: -{{stub}}+{{UK|UK specific}} {{QuotationBox|Quis custodiet ipsos custodes?|[[Wikipedia:Quis custodiet ipsos custodes?|Juvenal]]}} {{QuotationBox|Quis custodiet ipsos custodes?|[[Wikipedia:Quis custodiet ipsos custodes?|Juvenal]]}} The Professional Standards Authority (PSA) is a meta-regulator: it regulates other regulators. The Professional Standards Authority (PSA) is a meta-regulator: it regulates other regulators. Line 29: Line 29: *[https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 PSA annual performance review of the General Medical Council's performance for 2016/17][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional Standards Authority. General Medical Council: Annual review of performance 2016/17: Professional Standards Authority, 2018(08 Feb); 1-32.] (or [https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 link to pdf).][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional Standards Authority. General Medical Council: Annual review of performance 2016/17 (snapshot report): Professional Standards Authority, 2018(08 Feb); 1-2.] (or [https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 link to pdf]). *[https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 PSA annual performance review of the General Medical Council's performance for 2016/17][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional Standards Authority. General Medical Council: Annual review of performance 2016/17: Professional Standards Authority, 2018(08 Feb); 1-32.] (or [https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 link to pdf).][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional Standards Authority. General Medical Council: Annual review of performance 2016/17 (snapshot report): Professional Standards Authority, 2018(08 Feb); 1-2.] (or [https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 link to pdf]). - +Category: Organisations]]  +[[Category: Medicolegal]]  +[[Category: Regulation]]  +[[Category: Professional regulators]] {{Refsec}} {{Refsec}} [...]



General Medical Council

Fri, 23 Feb 2018 00:09:24 GMT

Destubbify

← Older revision Revision as of 00:09, 23 February 2018
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-
{{stub}}
 
[[Category: Organisations]]
[[Category: Organisations]]
[[Category: Medicolegal]]
[[Category: Medicolegal]]



NHS Confederation

Fri, 23 Feb 2018 00:02:47 GMT

Categorise

← Older revision Revision as of 00:02, 23 February 2018
Line 4: Line 4:
==External links==
==External links==
*[http://www.nhsconfed.org/ NHS Conderation website]
*[http://www.nhsconfed.org/ NHS Conderation website]
 +
[[category:NHS]]



The Bawa Garba case

Thu, 22 Feb 2018 23:40:01 GMT

22 February 2018 Dame Clare Marx review of medical manslaughter:

← Older revision Revision as of 23:40, 22 February 2018
(One intermediate revision not shown)
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(More detail is available, for those who cannot access the firewalled HSJ article, at [https://twitter.com/ShaunLintern/status/965485674928463872?s=08 Shaun Lintern's Twitter account].)
(More detail is available, for those who cannot access the firewalled HSJ article, at [https://twitter.com/ShaunLintern/status/965485674928463872?s=08 Shaun Lintern's Twitter account].)
 +
 +
====22 February [[2018]] Dame Clare Marx review of medical [[manslaughter]] ====
 +
 +
On 22 February [[2018]], after an outcry about [[The Bawa Garba case|Dr Hadiza Bawa-Garba's]] being struck off, the [[General Medical Council]] announced that 
 +
[[Dame Clare Marx]], Chair of the [[Faculty of Medical Leadership and Management]], was to lead [https://www.gmc-uk.org/news/31514.asp an independent review] to explore how gross negligence manslaughter cases are initiated and investigated in the UK.
===See also===
===See also===



Manslaughter

Thu, 22 Feb 2018 23:35:27 GMT

← Older revision Revision as of 23:35, 22 February 2018
Line 4: Line 4:
See also ganfyd [[negligence]] page.
See also ganfyd [[negligence]] page.
 +
Manslaughter is the crime of killing a person, where there is hintent to harm or criminal negligence or recklessness.
 +
 +
Doctors have increasingly frequently been prosecuted for the crime of "gross negligence manslaughter".
 +
 +
On 22 February [[2018]], after an outcry about [[The Bawa Garba case|Dr Hadiza Bawa-Garba's]] being struck off, the [[General Medical Council]] announced that 
 +
[[Dame Clare Marx]], Chair of the [[Faculty of Medical Leadership and Management]], was to lead [https://www.gmc-uk.org/news/31514.asp an independent review] to explore how gross negligence manslaughter cases are initiated and investigated in the UK.
 +
==External links==
==External links==



National Health Service

Thu, 22 Feb 2018 15:37:07 GMT

← Older revision Revision as of 15:37, 22 February 2018 Line 14: Line 14: *[[The envy of the world]] *[[The envy of the world]] *[[Secretary of state for health]]. *[[Secretary of state for health]].  +==State of the NHS in February 2018==  +On 21 February [[2018]] [[NHS Improvement]] published a report for quarter 3 of the 2017-18 financial year.[https://improvement.nhs.uk/resources/quarterly-performance-nhs-provider-sector-quarter-3-201718/ NHS Improvement. Performance of the NHS provider sector for the month ended 31 December 2017. London: NHS Improvement, 2018(21 February); 1-57.]  It revealed that one in 11 posts across NHS hospital, ambulance and mental health trusts were unfilled, and the figures also show an overall decline in several key performance areas including waiting times.  +  +The [https://www.bma.org.uk/news/media-centre/press-releases/2018/february/bma-responds-to-nhs-improvement-q3-performance-figures BMA Council Chair commented]:  +  +:"These figures paint an extremely worrying picture, with NHS performance in decline in several key areas. Waiting times targets are not being met, the deficit is much greater than anticipated and there are significant staff shortages.  +  +:"It is clear from these figures that the health service just doesn’t have the resource nor capacity to meet rising demand. Without the necessary investment in staff and services the NHS will continue to struggle to meet demand, and current staff will be stretched even more thinly, compounding recruitment and retention problems.  +  +:"These figures must act as a wake-up call to the government. The NHS urgently needs greater funding to halt the decline and put the health service on a sustainable footing for the future."  +  +The [[NHS Confederation]] also reported on the data:  +  +:"Responding to the figures, Niall Dickson, chief executive of the NHS Confederation, commended NHS staff for doing a “heroic job”. But he said the numbers “reflect the intolerable pressure on a system which currently has a staggering 100,000 vacancies to fill.  +  +:"We have repeatedly pointed to severe underfunding in health and care and a year-to-date deficit in the English NHS of £1,281 million is just the latest evidence of this.  +  +:"Our members are at the end of their tether. It is simply not realistic or reasonable to expect the NHS to go on delivering a comprehensive universal service with inexorably rising demand and demonstrably inadequate funding.  +  +:The organisation is working with the Institute of Fiscal Studies and Health Foundation to conduct a study into the funding needs of the UK’s health and care systems over the next 15 years.  +  +:"The work is designed to identify the challenges faced by health and care services and provide objective evidence of what will be needed going forward."[http://www.nhsconfed.org/news/2018/02/providers-project-931m-year-end-deficit NHS Confederation. Providers project £931m year-end deficit. Latest News: NHS Confederation, 2018; Updated 22 Feb 2018; Accessed: 2018 (22 Feb).]  +  +Experts say the vacancies would be enough to staff ten large hospitals; and this does not probably include the stats for general practice. Many across the UK are struggling to recruit GPs and nurses.  + ==External links== ==External links== *[http://www.slideshare.net/Rathfelder/nhs-diagrams A set of diagrams describing the structure of the NHS from 1944.] *[http://www.slideshare.net/Rathfelder/nhs-diagrams A set of diagrams describing the structure of the NHS from 1944.] [...]



NHS Confederation

Thu, 22 Feb 2018 15:29:55 GMT

Created page with "{{stub}} {{QuotationBox|The NHS Confederation is the only membership body that brings together and speaks on behalf of all organisations that plan, commission and provides NHS se..."

New page

{{stub}}
{{QuotationBox|The NHS Confederation is the only membership body that brings together and speaks on behalf of all organisations that plan, commission and provides NHS services.|[http://www.nhsconfed.org/about-us NHS Confederation website]}}

==External links==
*[http://www.nhsconfed.org/ NHS Conderation website]



NHS Improvement

Thu, 22 Feb 2018 15:16:20 GMT

← Older revision Revision as of 15:16, 22 February 2018 Line 1: Line 1:  +[[Category:NHS]]  + NHS Improvement established about 2002 hosted a number of NHS improvement projects and a [http://webarchive.nationalarchives.gov.uk/20130221101407/http://system.improvement.nhs.uk/improvementsystem/login.aspx?returnurl=%2fimprovementsystem%2fdefault.aspx website] until 1st April [[2013]]. Some of its functions were then taken over by [[NHS Improving Quality]] (NHS IQ) which on 1st November [[2015]] became the Sustainable Improvement Team, a part of [[NHS England]]. NHS Improvement established about 2002 hosted a number of NHS improvement projects and a [http://webarchive.nationalarchives.gov.uk/20130221101407/http://system.improvement.nhs.uk/improvementsystem/login.aspx?returnurl=%2fimprovementsystem%2fdefault.aspx website] until 1st April [[2013]]. Some of its functions were then taken over by [[NHS Improving Quality]] (NHS IQ) which on 1st November [[2015]] became the Sustainable Improvement Team, a part of [[NHS England]]. The [[Carter report]] resurrected the name as short hand for [[NHS England]]s Sustainable Improvement Team which is not really a surprise as NHS IQ is the direct ancestor quango. In this shape, the [[Sustainable Improvement Team]] will be intensively monitoring NHS secondary and tertiary care from April [[2016]] with a number of metrics directed to financial and efficiency improvement. The [[Carter report]] resurrected the name as short hand for [[NHS England]]s Sustainable Improvement Team which is not really a surprise as NHS IQ is the direct ancestor quango. In this shape, the [[Sustainable Improvement Team]] will be intensively monitoring NHS secondary and tertiary care from April [[2016]] with a number of metrics directed to financial and efficiency improvement. -[[Category:NHS]]+   +==External links==  +*[https://improvement.nhs.uk/ NHS Improvement website]] [...]



Category:Antidepressants

Thu, 22 Feb 2018 08:49:42 GMT

1

← Older revision Revision as of 08:49, 22 February 2018
Line 27: Line 27:
A guide for choosing between the drugs is given in the article on [[depression]].
A guide for choosing between the drugs is given in the article on [[depression]].
===Efficacy versus acceptability===
===Efficacy versus acceptability===
-
This has been studied and the clinical trial evidence suggests some first choice agents. Amitriptyline might be a resource effective choice as of [[2018]]. This is because of its likely relative cost and that amongst 25 drugs amitriptyline has the most efficacy against placebo. The order was  
+
This has been studied and the clinical trial evidence suggests some first choice agents. Amitriptyline might be a resource effective choice as of [[2018]]. This is because of its likely relative cost and that amongst 21 drugs amitriptyline has the most efficacy against placebo. The order was  
#[[Amitriptyline]]
#[[Amitriptyline]]
#[[Mirtazapine]]
#[[Mirtazapine]]



Ganfyd:Current events

Thu, 22 Feb 2018 08:49:00 GMT

update

← Older revision Revision as of 08:49, 22 February 2018
Line 51: Line 51:
== [[2018]] ==
== [[2018]] ==
 +
===February 2018===
 +
*Many [[:Category:Antidepressants|antidepressants]] do work, but now prescribers have some that have better efficacy and acceptability than others.
===January 2018===
===January 2018===
*[[winter pressures|Winter crises]] appear to be getting worse year by year in [[NHS]] as funding and policy decisions,some made years before, continue to disrupt delivery of integrated care
*[[winter pressures|Winter crises]] appear to be getting worse year by year in [[NHS]] as funding and policy decisions,some made years before, continue to disrupt delivery of integrated care



Category:Antidepressants

Thu, 22 Feb 2018 08:45:45 GMT

update ← Older revision Revision as of 08:45, 22 February 2018 Line 25: Line 25: Click here for a [http://www.genome.jp/dbget-bin/www_bget?path:map07027 diagram illustrating the structural relationship between the various antidepressant drugs] Click here for a [http://www.genome.jp/dbget-bin/www_bget?path:map07027 diagram illustrating the structural relationship between the various antidepressant drugs] ===Clinical Differences=== ===Clinical Differences=== -A guide for choosing betwwen the drugs is given in the article on [[depression]].+A guide for choosing between the drugs is given in the article on [[depression]].  +===Efficacy versus acceptability===  +This has been studied and the clinical trial evidence suggests some first choice agents. Amitriptyline might be a resource effective choice as of [[2018]]. This is because of its likely relative cost and that amongst 25 drugs amitriptyline has the most efficacy against placebo. The order was  +#[[Amitriptyline]]  +#[[Mirtazapine]]  +#[[Duloxetine]]  +#[[Venlafaxine]]  +#[[Paroxetine]]  +#[[Milnacipran]]  +#[[Fluvoxamine]]  +#[[Escitalopram]]  +#[[Nefazodone]]  +#[[Sertraline]]  +#[[Vortioxetine]]  +#[[Agomelatine]]  +#[[Vilazodone]]  +#[[Levomilnacipran]]  +#[[Bupropion]]  +#[[Fluoxetine]]  +#[[Citalopram]]  +#[[Trazodone]]  +#[[Clomipramine]]  +#[[Desvenlafaxine]]  +#[[Reboxetine]]  +   +Patient tolerability is in the following order:  +#[[Agomelatine]] (significantly more tolerable than placebo)  +#[[Fluoxetine]] (significantly more tolerable than placebo)  +#[[Escitalopram]]  +#[[Nefazodone]]  +#[[Citalopram]]  +#[[Amitriptyline]]  +#[[Paroxetine]]  +#[[Milnacipran]]  +#[[Sertraline]]  +#[[Bupropion]]  +#[[Mirtazapine]]  +#[[Vortioxetine]]  +#[[Venlafaxine]]  +#[[Desvenlafaxine]]  +#[[Duloxetine]]  +#[[Fluvoxamine]]  +#[[Vilazodone]]  +#[[Trazodone]]  +#[[Reboxetine]]  +#[[Levomilnacipran]]  +#[[Clomipramine]](significantly less tolerable than placebo)  +   +In head to head comparison [[vortioxetine]], [[escitalopram]], [[bupropion]], [[mirtazapine]], [[amitriptyline]] and [[agomelatine]] have the best efficacy and tolerability relative to [[reboxetine]].  +[http://dx.doi.org/10.1016/S0140-6736(17)32802-7 Cipriani A et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis Lancet DOI 10.1016/S0140-6736(17)32802-7]  +{{refsec}} [...]



The Bawa Garba case

Wed, 21 Feb 2018 15:22:36 GMT

19 February 2018: Closing parenthesis...

← Older revision Revision as of 15:22, 21 February 2018
Line 51: Line 51:
*Key elements of the General Medical Council’s bid to strike off a doctor convicted of manslaughter were “without merit”
*Key elements of the General Medical Council’s bid to strike off a doctor convicted of manslaughter were “without merit”
-
(More detail is available, for those who cannot access the firewalled HSJ article, at [https://twitter.com/ShaunLintern/status/965485674928463872?s=08 Shaun Lintern's Twitter account].
+
(More detail is available, for those who cannot access the firewalled HSJ article, at [https://twitter.com/ShaunLintern/status/965485674928463872?s=08 Shaun Lintern's Twitter account].)
===See also===
===See also===



Screening

Wed, 21 Feb 2018 12:47:00 GMT

External Links:

← Older revision Revision as of 12:47, 21 February 2018
Line 174: Line 174:
*[http://www.jr2.ox.ac.uk/bandolier/band5/b5-1.html Testing a Screening Test]
*[http://www.jr2.ox.ac.uk/bandolier/band5/b5-1.html Testing a Screening Test]
*[http://www.bir.org.uk/media/3377/01%20thinking%20of%20having%20a%20private%20screening%20test%2020.07.10%20final.pdf ''Thinking of having a private screening test?'' leaflet] from the [http://www.screening.nhs.uk/ UK National Screening Committee].
*[http://www.bir.org.uk/media/3377/01%20thinking%20of%20having%20a%20private%20screening%20test%2020.07.10%20final.pdf ''Thinking of having a private screening test?'' leaflet] from the [http://www.screening.nhs.uk/ UK National Screening Committee].
 +
*[https://www.nhs.uk/conditions/pregnancy-and-baby/screening-tests-abnormality-pregnant/ NHS Choices page] (including a video/cartoon - also [https://youtu.be/_afr5olIpTM on YouTube]) on the screening tests offered ante-natally, and to neonates.
*[http://www.screening.nhs.uk/ UK National Screening Portal (formerly the UK National Screening Committee, at http://www.nsc.nhs.uk/)].  
*[http://www.screening.nhs.uk/ UK National Screening Portal (formerly the UK National Screening Committee, at http://www.nsc.nhs.uk/)].  
*[https://www.evidence.nhs.uk/search?q=screening NHS Evidence - screening]. The [[National electronic library for health]] used to have a specific screening portal, which replaced its "screening branch library" - but it no longer seems to exist.
*[https://www.evidence.nhs.uk/search?q=screening NHS Evidence - screening]. The [[National electronic library for health]] used to have a specific screening portal, which replaced its "screening branch library" - but it no longer seems to exist.



The Bawa Garba case

Wed, 21 Feb 2018 12:37:57 GMT

19 February 2018: Shaun Lintern's twitter feed - link ← Older revision Revision as of 12:37, 21 February 2018 (6 intermediate revisions not shown)Line 34: Line 34: ====15 February [[2018]]====   ====15 February [[2018]]====   Crowdjustice website reports that [https://www.crowdjustice.com/case/help-dr-bawa-garba/ ''"Today, Dr Bawa Garba's legal team lodged an application for permission to appeal at the Court of Appeal to challenge the High Court decision allowing the GMC to erase her from the medical register.  It included an application to expedite the hearing."''] Crowdjustice website reports that [https://www.crowdjustice.com/case/help-dr-bawa-garba/ ''"Today, Dr Bawa Garba's legal team lodged an application for permission to appeal at the Court of Appeal to challenge the High Court decision allowing the GMC to erase her from the medical register.  It included an application to expedite the hearing."'']  +====19 February [[2018]]====  +The HSJ's Shaun Lintern publishes an [https://www.hsj.co.uk/workforce/exclusive-doubts-over-gmcs-handling-of-manslaughter-case-revealed/7021709.article "exclusive"] based on a [[Wikipedia:Freedom of Information Act 2000|freedom of information request]], which revealed that the [[General Medical Council|GMC's]] regulator, the [[Professional Standards Authority|PSA]], had reviewed the GMC decision to appeal the [[General Medical Council#Medical Practitioners Tribunal Service|MPTS]] decision, and concluded that  the GMC’s decision was “very borderline”.[https://www.hsj.co.uk/workforce/exclusive-doubts-over-gmcs-handling-of-manslaughter-case-revealed/7021709.article Lintern S. Doubts over GMC's handling of manslaughter case revealed (paywalled). Health Service Journal, 2018; Updated 19 Feb 2018; Accessed: 2018 (21 Feb).] (Paywalled). The original HSJ article is paywalled. According to a [[Doctors net uk]] [https://www.doctors.net.uk/News/Article.aspx?newsid=27806 report the following day]:  +[https://www.doctors.net.uk/News/Article.aspx?newsid=27806 Doctors.net.uk. Bawa-Garba appeal erred – supervisor. 2018; Updated 20 Feb 2018; Accessed: 2018 (21 Feb).]  +  +  +:"The reviewer says the GMC had a policy of “deference” to panel decisions when they were based on clinical considerations. The GMC argued that the same “deference” did not apply when the panel made a decision following a conviction in courts of law.  +  +:"The reviewer states: “I am not clear that this argument is sustainable. In any event, the panel was required to consider the underlying facts of the conviction and have not sought to minimise them.  +  +:"“In my view the panel was not seeking to go behind the conviction or minimising it.”"  +  +The original HSJ article apparent claimed that, according to the PSA documents:  +  +*PSA did not agree with the GMC appeal in Bawa-Garba case  +*Their analysis suggested the GMC appeal was trying to create new case law  +*Key elements of the General Medical Council’s bid to strike off a doctor convicted of manslaughter were “without merit”  +  +(More detail is available, for those who cannot access the firewalled HSJ article, at [https://twitter.com/ShaunLintern/status/965485674928463872?s=08 Shaun Lintern's Twitter account]. ===See also=== ===See also=== Line 105: Line 123: *[http://www.bmj.com/content/360/bmj.k448 The Bawa-Garba case, doctors, and the GMC—what next?] by [https://mobile.twitter.com/mancunianmedic?lang[...]



General Medical Council

Wed, 21 Feb 2018 10:46:03 GMT

regulated by the Professional Standards Authority.

← Older revision Revision as of 10:46, 21 February 2018
Line 9: Line 9:
The General Medical Council (GMC) is the independent body which regulates the medical profession in the United Kingdom. It issues guidelines/sets standards by which the professional behaviour of medical doctors (or, strictly, [[Registered medical practitioners|''"registered medical practitioners"'']]) is judged. Legally established by the [[Medical Act 1983]].
The General Medical Council (GMC) is the independent body which regulates the medical profession in the United Kingdom. It issues guidelines/sets standards by which the professional behaviour of medical doctors (or, strictly, [[Registered medical practitioners|''"registered medical practitioners"'']]) is judged. Legally established by the [[Medical Act 1983]].
 +
 +
The GMC is regulated by the [[Professional Standards Authority]].
Medically qualified doctors have to be registered with the GMC in order to practice medicine in the UK. Such doctors are also known as registered medical practitioners.  
Medically qualified doctors have to be registered with the GMC in order to practice medicine in the UK. Such doctors are also known as registered medical practitioners.  



Bawa-Garba

Wed, 21 Feb 2018 10:37:02 GMT

Redirected page to The Bawa Garba case

New page

#Redirect [[The Bawa Garba case]]



General Medical Council

Wed, 21 Feb 2018 10:35:14 GMT

Categories ← Older revision Revision as of 10:35, 21 February 2018 Line 1: Line 1: {{stub}} {{stub}} [[Category: Organisations]] [[Category: Organisations]] -[[Category:Medicolegal]]+[[Category: Medicolegal]] -[[Category:Regulation]]+[[Category: Regulation]]  +[[Category: Professional regulators]]  +  {{UK|General Medical Council}} {{UK|General Medical Council}} {{QuotationBox|The [[Office of Health Professionals Adjudicator]] takes over all fitness to practise hearings as from April [[2011]]. 70 GMC staff will transfer to the body and existing GMC panel members will to begin with make up the new panels. Longer term the plan is for three person panels made up of one legal expert, one medical professional and one lay person. The body promises to strip out huge levels of bureaucracy currently in GMC hearings with strict new limits on the quantify of evidence allowed and hearings costs.|Pulse On Line, 2010 (30 June)[http://www.pulsetoday.co.uk/story.asp?storycode=4126443&cid=Latest_headlines_1_300610 I Quinn. Fears over introduction of 'fast-track' GP fitness to practise hearings. ''Pulse On Line'', 2010 (30 June). Last viewed 2010 (30 June)]}} {{QuotationBox|The [[Office of Health Professionals Adjudicator]] takes over all fitness to practise hearings as from April [[2011]]. 70 GMC staff will transfer to the body and existing GMC panel members will to begin with make up the new panels. Longer term the plan is for three person panels made up of one legal expert, one medical professional and one lay person. The body promises to strip out huge levels of bureaucracy currently in GMC hearings with strict new limits on the quantify of evidence allowed and hearings costs.|Pulse On Line, 2010 (30 June)[http://www.pulsetoday.co.uk/story.asp?storycode=4126443&cid=Latest_headlines_1_300610 I Quinn. Fears over introduction of 'fast-track' GP fitness to practise hearings. ''Pulse On Line'', 2010 (30 June). Last viewed 2010 (30 June)]}} [...]



Health and Care Professions Council

Wed, 21 Feb 2018 10:33:46 GMT

← Older revision Revision as of 10:33, 21 February 2018
Line 2: Line 2:
[[Category: Professions allied to medicine]]
[[Category: Professions allied to medicine]]
[[Category: Professional regulators]]
[[Category: Professional regulators]]
 +
[[Category:Regulation]]
The [http://www.hpc-uk.org/ Health & Care Professions Council (HCPC)] (formerly known as the Health Professions Council, HPC) has a similar role for other regulated [[Professions Allied to Medicine|health professions]] as does the [[General Medical Council|GMC]] for [[registered medical practitioners]]. In particular, (as of [[2010|14/12/10]]) it covers the following (with the first few characters of the HPC description of the profession, as per [http://www.hpc-uk.org/aboutregistration/professions/ this page of their web site]):
The [http://www.hpc-uk.org/ Health & Care Professions Council (HCPC)] (formerly known as the Health Professions Council, HPC) has a similar role for other regulated [[Professions Allied to Medicine|health professions]] as does the [[General Medical Council|GMC]] for [[registered medical practitioners]]. In particular, (as of [[2010|14/12/10]]) it covers the following (with the first few characters of the HPC description of the profession, as per [http://www.hpc-uk.org/aboutregistration/professions/ this page of their web site]):



Professional Standards Authority

Wed, 21 Feb 2018 10:28:20 GMT

Created page with "{{stub}} {{QuotationBox|Quis custodiet ipsos custodes?|Juvenal}} The Professional Standards Authority (PSA) is a meta-regulator: it r..." New page{{stub}} {{QuotationBox|Quis custodiet ipsos custodes?|[[Wikipedia:Quis custodiet ipsos custodes?|Juvenal]]}} The Professional Standards Authority (PSA) is a meta-regulator: it regulates other regulators. Among the regulators regulated by the PSA is the [[General Medical Council|General Medical Council (GMC)]]. The full list of the nine regulators regulated by PS (according to [https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator this page of their website], on 21 Feb [[2018]]) comprises (links are to PSA page on the regulator unless otherwise stated): *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/pharmaceutical-society-of-northern-ireland Pharmaceutical Society of Northern Ireland] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/nursing-midwifery-council Nursing & Midwifery Council] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/health-care-professions-council Health & Care Professions Council (HCPC)] ([[Health and Care Professions Council|ganfyd page - note that the HCPC regulates a range of professions allied to medicine]]) *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-pharmaceutical-council General Pharmaceutical Council] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-osteopathic-council General Osteopathic Council] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-optical-council General Optical Council] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-medical-council General Medical Counci] ([[General Medical Council|General Medical Council ganfyd page)]]. *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-dental-council General Dental Council] ([[General dental council|General Dental Council ganfyd page)]] *[https://www.professionalstandards.org.uk/what-we-do/our-work-with-regulators/find-a-regulator/general-chiropractic-council General Chiropractic Council] ==External links== *[https://www.professionalstandards.org.uk/home Professional Standards Authority home page] *[https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 PSA annual performance review of the General Medical Council's performance for 2016/17][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional Standards Authority. General Medical Council: Annual review of performance 2016/17: Professional Standards Authority, 2018(08 Feb); 1-32.] (or [https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 link to pdf).][https://www.professionalstandards.org.uk/latest-news/latest-news/detail/2018/02/08/the-authority-publishes-its-review-of-the-general-medical-council's-performance-for-2016-17 Professional S[...]



General dental council

Wed, 21 Feb 2018 10:25:13 GMT

New page

[[Category:Regulation]]
{{stub}}
General Dental Council (GDC).

Regulates dentists. Regulated by [[Professional Standards Authority]].

==External links==
*[https://www.gdc-uk.org/ General Dental Council GDC homepage]



General Medical Council

Wed, 21 Feb 2018 09:45:03 GMT

Category:Regulation added

← Older revision Revision as of 09:45, 21 February 2018
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[[Category: Organisations]]
[[Category: Organisations]]
[[Category:Medicolegal]]
[[Category:Medicolegal]]
 +
[[Category:Regulation]]
{{UK|General Medical Council}}
{{UK|General Medical Council}}
{{QuotationBox|The [[Office of Health Professionals Adjudicator]] takes over all fitness to practise hearings as from April [[2011]]. 70 GMC staff will transfer to the body and existing GMC panel members will to begin with make up the new panels. Longer term the plan is for three person panels made up of one legal expert, one medical professional and one lay person. The body promises to strip out huge levels of bureaucracy currently in GMC hearings with strict new limits on the quantify of evidence allowed and hearings costs.|Pulse On Line, 2010 (30 June)[http://www.pulsetoday.co.uk/story.asp?storycode=4126443&cid=Latest_headlines_1_300610 I Quinn. Fears over introduction of 'fast-track' GP fitness to practise hearings. ''Pulse On Line'', 2010 (30 June). Last viewed 2010 (30 June)]}}
{{QuotationBox|The [[Office of Health Professionals Adjudicator]] takes over all fitness to practise hearings as from April [[2011]]. 70 GMC staff will transfer to the body and existing GMC panel members will to begin with make up the new panels. Longer term the plan is for three person panels made up of one legal expert, one medical professional and one lay person. The body promises to strip out huge levels of bureaucracy currently in GMC hearings with strict new limits on the quantify of evidence allowed and hearings costs.|Pulse On Line, 2010 (30 June)[http://www.pulsetoday.co.uk/story.asp?storycode=4126443&cid=Latest_headlines_1_300610 I Quinn. Fears over introduction of 'fast-track' GP fitness to practise hearings. ''Pulse On Line'', 2010 (30 June). Last viewed 2010 (30 June)]}}



Talk:Postnatal depression

Wed, 21 Feb 2018 09:43:11 GMT

Created page with "I'm a little surprised we have so little on this common condition. I've discovered that there are various spellings used on ganfyd: post-natal depression and post natal depressi..."

New page

I'm a little surprised we have so little on this common condition.

I've discovered that there are various spellings used on ganfyd: post-natal depression and post natal depression, as well as this page's title, postnatal depression. So I've created redirect pages for the other two versions.

--[[User:Penglish|Penglish]] 09:43, 21 February 2018 (UTC)



Post natal depression

Wed, 21 Feb 2018 09:41:52 GMT

Redirected page to Postnatal depression

New page

#REDIRECT [[Postnatal depression]]



Post-natal depression

Wed, 21 Feb 2018 09:41:18 GMT

Redirected page to Postnatal depression

New page

#REDIRECT [[Postnatal depression]]



Abbreviations

Wed, 21 Feb 2018 09:39:57 GMT

P: ← Older revision Revision as of 09:39, 21 February 2018 Line 656: Line 656: *PMS - Personal Medical Services. See [[PMS and GMS]] *PMS - Personal Medical Services. See [[PMS and GMS]] *PND - [[Paroxysmal nocturnal dyspnoea]] *PND - [[Paroxysmal nocturnal dyspnoea]] -*PND - [[Post-Natal Depression]]+*PND - [[Postnatal depression|PostNatal Depression]] *PNE - [[Lookback exercise|Patient Notification Exercise]] *PNE - [[Lookback exercise|Patient Notification Exercise]] *POD - ''Surgery:'' post-operative day *POD - ''Surgery:'' post-operative day Line 669: Line 669: *PROM - Patient Reported Outcome Measure[http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_081100 Department of Health. The standard NHS contract for acute hospital services and supporting guidance. 2007 (13 December). Gateway Ref No: 9164.] *PROM - Patient Reported Outcome Measure[http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_081100 Department of Health. The standard NHS contract for acute hospital services and supporting guidance. 2007 (13 December). Gateway Ref No: 9164.] *PRHO - [[:Category:Surviving the PRHO/FY1 year|Pre-registration house officer]] *PRHO - [[:Category:Surviving the PRHO/FY1 year|Pre-registration house officer]]  +*PSA - [[Prostate specific antigen|Prostate Specific Antigen]]  +*PSA - [[Professional Standards Authority]] *PSD - Patient Specific Direction (see [[patient group direction]]) *PSD - Patient Specific Direction (see [[patient group direction]]) *POSSUM -[[POSSUM|Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity]] *POSSUM -[[POSSUM|Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity]] [...]



The Bawa Garba case

Tue, 20 Feb 2018 20:35:49 GMT

See also: ← Older revision Revision as of 20:35, 20 February 2018 Line 105: Line 105: *[http://www.bmj.com/content/360/bmj.k448 The Bawa-Garba case, doctors, and the GMC—what next?] by [https://mobile.twitter.com/mancunianmedic?lang=en David Oliver][http://www.bmj.com/content/360/bmj.k448 Oliver D. ''Should NHS doctors work in unsafe conditions?'' BMJ 2018;360, DOI: 10.1136/bmj.k448  ] *[http://www.bmj.com/content/360/bmj.k448 The Bawa-Garba case, doctors, and the GMC—what next?] by [https://mobile.twitter.com/mancunianmedic?lang=en David Oliver][http://www.bmj.com/content/360/bmj.k448 Oliver D. ''Should NHS doctors work in unsafe conditions?'' BMJ 2018;360, DOI: 10.1136/bmj.k448  ] -*[https://www.theguardian.com/healthcare-network/views-from-the-nhs-frontline/2018/feb/19/hadiza-bawa-garba-struck-off-doctor-believe-so Anonymous Guardian article] saying that we should respect the court decision and the GMC view that Bawa Garba should be struck off because. Well, just because. Even if the prosecution was wrong and the court decision was unsafe.[https://www.theguardian.com/healthcare-network/views-from-the-nhs-frontline/2018/feb/19/hadiza-bawa-garba-struck-off-doctor-believe-so Anon. ''Should Hadiza Bawa-Garba have been struck off as a doctor? I believe so.'' Guardian 2018 (19 Feb)] Ah well, Nick Ross has (again) written [http://www.nickross.com/the-response-the-guardian-declined-to-publish/ a great riposte] (even though the Guardian wouldn't print it).[http://www.nickross.com/the-response-the-guardian-declined-to-publish/ Nick Ross. ''The response The Guardian declined to publish.'' nickross.com (blog) 2018 (19 or 20 Feb). Last viewed 2018 (20 Feb)] It is not clear if the person who wrote the original, anonymous article is a registered medical practitioner, although it is clearly implied that they are. It should be noted that the [[General Medical Council|GMC]] is very clear - doctors who publish (including tweets or other comments on social media) and who say they are doctors MUST identify themselves fully: anonymity is not permitted. We shall see whether the author of this article will be investigated and censured by the GMC for this breach.+*[https://www.theguardian.com/healthcare-network/views-from-the-nhs-frontline/2018/feb/19/hadiza-bawa-garba-struck-off-doctor-believe-so Anonymous Guardian article] saying that we should respect the court decision and the GMC view that Bawa Garba should be struck off because. Well, just because. Even if the prosecution was wrong and the court decision was unsafe.[https://www.theguardian.com/healthcare-network/views-from-the-nhs-frontline/2018/feb/19/hadiza-bawa-garba-struck-off-doctor-believe-so Anon. ''Should Hadiza Bawa-Garba have been struck off as a doctor? I believe so.'' Guardian 2018 (19 Feb)] Ah well, Nick Ross has (again) written [http://www.nickross.com/the-response-the-guardian-declined-to-publish/ a great riposte] (even though the Guardian wouldn't print it).[http://www.nickross.com/the-response-the-guardian-declined-to-publish/ Nick Ross. ''The response The Guardian declined to publish.'' nickross.com (blog) 2018 (19 or 20 Feb). Last viewed 2018 (20 Feb)] It is not clear if the person who wro[...]



General Medical Council

Tue, 20 Feb 2018 20:34:10 GMT

← Older revision Revision as of 20:34, 20 February 2018 Line 32: Line 32: It is noteworthy that the GMC decided to appeal the MPTS decision re [[The Bawa Garba case|Dr Bawa-Garba]]. It is noteworthy that the GMC decided to appeal the MPTS decision re [[The Bawa Garba case|Dr Bawa-Garba]].  +  +==GMC controversies==  +It is, perhaps, unsurprising that the medical profession's regulator should strike fear into doctors, and that some of its decisions will be perceived as ill conceived, illiberal, and wrong. Some controversies are described below.  +  +===Bawa-Garba case===  +On 4 November [[2015]] Dr Bawa-Garba was convicted, at Nottingham Crown Court, of manslaughter, on the grounds of gross negligence. Many doctors considered that the prosecution was ill-advised and contrary to the public interest and that the conviction was unsafe. The [[#Medical Practitioners Tribunal Service|MPTS]] decided that Dr Bawa-Garba should not be struck off. The GMC, however, used its recently acquired power to appeal this decision in the appeal court, which over-ruled MPTS. See [[The Bawa Garba case]] for more details.  +  +===Medical anonymity===  +In [[2013]] the GMC consulted on an update to its guidance for doctors ''Good Medical Practice''. A consultation draft included a proposed section 17 which read:  +  +:''"If you are writing in a professional capacity, you should usually identify yourself. Any material written by authors who represent themselves as doctors are likely to be taken on trust and/or to represent the views of the profession more widely. You should also be aware that content uploaded anonymously can, in many cases, be traced back to its point of origin."''  +  +This was reasonably uncontroversial; but the final version of the guidance read:  +  +:''"If you identify yourself as a doctor in publicly accessible social media, you should also identify yourself by name. Any material written by authors who represent themselves as doctors is likely to be taken on trust and may reasonably be taken to represent the views of the profession more widely."''  +  +This was viewed as amountinting to a ban on doctors participating in social media11 anonymously, unless they never let on that they are a doctor. It was viewed by many as inappropriately and unnecessarily draconian. As [http://peterenglish.blogspot.co.uk/2013/03/the-gmc-and-guidance-for-anonymous.html a ganfyd editor advised doctors at the time] in his personal blog:  +  +:"If, in one tweet or another you mention that you're a doctor, or it's in your biography, then, according to these guidelines you "should" also provide your name, and not post anonymously. So, in effect, you must choose between  +:*"posting anonymously and being obliged to keep the fact that you're a doctor a carefully protected secret and  +:*"identifying yourself - at least by name."  +  +Although this guidance relates specifically to social media, it would logically apply to any publication by a somebody who is (and admits to being) a registered medical practitioner. ==See also== ==See also== [...]



The Bawa Garba case

Tue, 20 Feb 2018 20:10:07 GMT

← Older revision Revision as of 20:10, 20 February 2018 Line 10: Line 10: #Why are [[Reflection, reflective practice|reflections]] and (in this case) ''Training Encounter Forms''[http://www.bmj.com/content/360/bmj.k572/rapid-responses Jonathan M Cusack (Dr Bawa-Garba's educational supervisor). ''How should doctors use e-portfolios in the wake of the Bawa-Garba case? (Rapid response)''. BMJ 2018 (08 February). Doi 10.1136/bmj.k572.] made as part of doctors' personal development not legally privileged?   #Why are [[Reflection, reflective practice|reflections]] and (in this case) ''Training Encounter Forms''[http://www.bmj.com/content/360/bmj.k572/rapid-responses Jonathan M Cusack (Dr Bawa-Garba's educational supervisor). ''How should doctors use e-portfolios in the wake of the Bawa-Garba case? (Rapid response)''. BMJ 2018 (08 February). Doi 10.1136/bmj.k572.] made as part of doctors' personal development not legally privileged?   #Was the GMC correct to appeal this case? There are two parts to this; was it legally obliged to do this; and was it the correct thing to do if its role is to enhance patient safety. Nick Ross is particularly [http://www.bmj.com/content/360/bmj.k481/rr-1 eloquent] on this topic,[http://www.bmj.com/content/360/bmj.k481/rr-1 Nick Ross. ''Second letter to the GMC regarding Dr Hadiza Bawa-Garba'' (rapid response). BMJ 2018 (08 February).] as is Lord Darzi.[http://www.telegraph.co.uk/news/2018/02/12/doctors-admit-errors-made-extreme-pressure-should-supported/ Darzi. ''Doctors who admit errors made under extreme pressure should be supported – not struck off'' Telegraph. 2018 (12 February).] #Was the GMC correct to appeal this case? There are two parts to this; was it legally obliged to do this; and was it the correct thing to do if its role is to enhance patient safety. Nick Ross is particularly [http://www.bmj.com/content/360/bmj.k481/rr-1 eloquent] on this topic,[http://www.bmj.com/content/360/bmj.k481/rr-1 Nick Ross. ''Second letter to the GMC regarding Dr Hadiza Bawa-Garba'' (rapid response). BMJ 2018 (08 February).] as is Lord Darzi.[http://www.telegraph.co.uk/news/2018/02/12/doctors-admit-errors-made-extreme-pressure-should-supported/ Darzi. ''Doctors who admit errors made under extreme pressure should be supported – not struck off'' Telegraph. 2018 (12 February).]  +#How does the GMC justify its claim that the MPTS undermined the court's decision? Quite apart from the fact that many consider the conviction to be unsafe, wrong; the MPTS was making a different decision with (appropriately) different criteria, not simply rubber-stamping the court's decision. An account of the events: [http://54000doctors.org/blogs/an-account-by-concerned-uk-paediatric-consultants-of-the-tragic-events-surrounding-the-gmc-action-against-dr-bawa-garba.html ''"An account by concerned UK paediatric consultants of the tragic events surrounding the GMC action against Dr Bawa-Garba"''.] An account of the events: [http://54000doctors.org/blogs/an-account-by-concerned-uk-paediatric-consultants-of-the-tragic-events-surrounding-the-gmc-action-against-dr-bawa-garba.html ''"An[...]



Category:Tyrosine protein kinases

Sun, 18 Feb 2018 21:41:26 GMT

← Older revision Revision as of 21:41, 18 February 2018
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-
[[Category:Enzymes]][[Category:protein kinases]]
+
[[Category:Enzymes]][[Category:protein kinases]][[Category:Tyrosine kinases]]



Tyrosine-protein kinase Tec

Sun, 18 Feb 2018 21:39:11 GMT

for subclusion

New page


{{BiochemistryBox|||EC:2.7.10.2}}
[[Category:Tyrosine protein kinases]][[Category:Enzymes]][[Category:Regulatory proteins]][[Category:Protein kinases]]

The [[TEC]] gene codes for the 631 amino acid [[tyrosine-protein kinase Tec]]. This is widely involved in signalling pathway regulation. These include:
*Regulation of the [[actin]] cytoskeleton.
*Regulation of the [[adaptive immune response]].
*Regulation of the development, function and differentiation of conventional [[T-cell]]s and nonconventional [[NKT-cell]]s.
*Mediates signals that negatively regulate [[IL2RA]] expression
*Helps regulate BCR-signaling for B-cell development and activation
*Participates in platelet signalling downstream of [[integrin]] activation.
*Mediates cytokine-driven activation of [[FOS transcription]].
*Has a role in [[hepatocyte]] proliferation and liver regeneration.
*Involved in HGF-induced ERK signaling pathway.



TEC

Sun, 18 Feb 2018 21:38:54 GMT

New page

{{GeneticsBox|||PSCTK4}}
[[Category:Genes]]
{{:Tyrosine-protein kinase Tec}}



Category:Tyrosine protein kinases

Sun, 18 Feb 2018 21:37:09 GMT

categorise

New page

[[Category:Enzymes]][[Category:protein kinases]]



Tyrosine-protein kinase BTK

Sun, 18 Feb 2018 21:36:38 GMT

categorise

← Older revision Revision as of 21:36, 18 February 2018
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{{BiochemistryBox|||Bruton tyrosine kinase, agammaglobulinemia tyrosine kinase, B-cell progenitor kinase, BTK, ATK, BPK, {{EC|2.7.10.2}}}}
{{BiochemistryBox|||Bruton tyrosine kinase, agammaglobulinemia tyrosine kinase, B-cell progenitor kinase, BTK, ATK, BPK, {{EC|2.7.10.2}}}}
-
[[Category:Enzymes]]
+
[[Category:Enzymes]][[Category:Tyrosine protein kinases]][[Category:protein kinases]]
The [[BTK]] gene at Xq21.3-q22 codes for the 659 amino acid regulatory enzyme [[tyrosine-protein kinase BTK]] which is critical for [[B lymphocyte]] development, differentiation and signalling.
The [[BTK]] gene at Xq21.3-q22 codes for the 659 amino acid regulatory enzyme [[tyrosine-protein kinase BTK]] which is critical for [[B lymphocyte]] development, differentiation and signalling.



Ibrutinib

Sun, 18 Feb 2018 21:20:41 GMT

a me too may be better ← Older revision Revision as of 21:20, 18 February 2018 Line 1: Line 1: -{{PharmacologyBox||PCI-32765|[[image:{{PAGENAME}}Molecule.png|thumb|{{PAGENAME}} Molecule]]|[[image:{{PAGENAME}}.png|center]]|||}}  +{{PharmacologyBox||Imbruvica®PCI-32765|[[image:{{PAGENAME}}Molecule.png|thumb|{{PAGENAME}} Molecule]]|[[image:{{PAGENAME}}.png|center]]|||}}   -[[Ibrutinib]] is an inhibitor of [[Bruton tyrosine kinase]] (Btk) in development. It has proved effective in [[mantle-cell lymphoma]] with over 50% improvement in survival at 18 months compared to best treatment current as of [[2013]][http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=23782158  Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, Grant B, Sharman JP, Coleman M, Wierda WG, Jones JA, Zhao W, Heerema NA, Johnson AJ, Sukbuntherng J, Chang BY, Clow F, Hedrick E, Buggy JJ, James DF, O'Brien S. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. The New England journal of medicine. 2013 Jul 4; 369(1):32-42.]([http://dx.doi.org/10.1056/NEJMoa1215637 Link to article] – subscription may be required.)[http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=23782157  Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford J, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Li L, Zhang L, Newberry K, Ou Z, Cheng N, Fang B, McGreivy J, Clow F, Buggy JJ, Chang BY, Beaupre DM, Kunkel LA, Blum KA. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. The New England journal of medicine. 2013 Aug 8; 369(6):507-16.]([http://dx.doi.org/10.1056/NEJMoa1306220 Link to article] – subscription may be required.). It is also in development for [[chronic lymphocytic leukaemia]] and [[small lymphocytic lymphoma]][http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=23782158  Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, Grant B, Sharman JP, Coleman M, Wierda WG, Jones JA, Zhao W, Heerema NA, Johnson AJ, Sukbuntherng J, Chang BY, Clow F, Hedrick E, Buggy JJ, James DF, O'Brien S. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. The New England journal of medicine. 2013 Jul 4; 369(1):32-42.]([http://dx.doi.org/10.1056/NEJMoa1215637 Link to article] – subscription may be required.)+[[Ibrutinib]] is an inhibitor of [[Bruton tyrosine kinase]] (Btk). It has proved effective in [[mantle-cell lymphoma]] with over 50% improvement in survival at 18 months compared to best treatment current as of [[2013]][http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus&db=pubmed&cmd=Retrieve&am[...]



Acalabrutinib

Sun, 18 Feb 2018 21:11:28 GMT

a BTK inhibitor

New page

{{PharmacologyBox||ACP-196}}
Acalabrutinib is being developed in the indications [[chronic lymphocytic leukaemia]][https://www.ncbi.nlm.nih.gov/pubmed/26641137 Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S, Chaves J, Wierda WG, Awan FT, Brown JR, Hillmen P, Stephens DM, Ghia P, Barrientos JC, Pagel JM, Woyach J, Johnson D, Huang J, Wang X, Kaptein A, Lannutti BJ, Covey T, Fardis M, McGreivy J, Hamdy A, Rothbaum W, Izumi R, Diacovo TG, Johnson AJ, Furman RR. Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia. N Engl J Med. 2016 Jan 28;374(4):323-32. Epub 2015 Dec 7.][https://doi.org/10.1056/NEJMoa1509981 doi: 10.1056/NEJMoa1509981.] and [[mantle cell lymphoma]][https://www.ncbi.nlm.nih.gov/pubmed/29241979 Wang M, Rule S, Zinzani PL, Goy A, Casasnovas O, Smith SD, Damaj G, Doorduijn J, Lamy T, Morschhauser F, Panizo C, Shah B, Davies A, Eek R, Dupuis J, Jacobsen E, Kater AP, Le Gouill S, Oberic L, Robak T, Covey T, Dua R, Hamdy A, Huang X, Izumi R, Patel P, Rothbaum W, Slatter JG, Jurczak W. Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial. Lancet. 2017 Dec 11. pii: S0140-6736(17)33108-2.][https://doi.org/10.1016/S0140-6736(17)33108-2 doi: 10.1016/S0140-6736(17)33108-2. ].
[[Category:BTK inhibitors]]
[[Category:tyrosine kinase inhibitors]]
{{refsec}}



Category:BTK inhibitors

Sun, 18 Feb 2018 20:55:31 GMT

definition

New page

[[Category:Tyrosine kinase inhibitors]]
[[Category:Drug classes]]
Inhibitors of [[Bruton tyrosine kinase]].



Rifampicin

Sun, 18 Feb 2018 20:49:03 GMT

update

← Older revision Revision as of 20:49, 18 February 2018
Line 5: Line 5:
*[[Staphylococcus aureus]]
*[[Staphylococcus aureus]]
 +
**Contrary to many historic guidelines it appears to do more harm than good if used as an add on in Stap aureus bactraemia/sepsis. The jury is still out with regard to its common use with stap aureus infection of artificial heart valves as it transpires studies with sufficient power to look at harm had not been done by [[2018]]
*[[Tuberculosis]]
*[[Tuberculosis]]
*[[Brucellosis]]
*[[Brucellosis]]



Reflection, reflective practice

Sat, 17 Feb 2018 18:17:08 GMT

wikify ← Older revision Revision as of 18:17, 17 February 2018 (One intermediate revision not shown)Line 1: Line 1: {{SubjectBox}} {{SubjectBox}} -{{WarningBox|Following a number of cases (such as that of [[The Bawa Garba case|Hadiza Bawa-Garba]] and the one described by Matthews-King (see [[#References|references]])) in which doctors' reflections have been used to incriminate them in court, doctors should now be advised not to reflect in an unguarded manner that could potentially be used to incriminate them until and unless all such reflections can be made privileged and unavailable to future courts or tribunals.}}+{{WarningBox|Following a number of cases (such as that of [[The Bawa Garba case|Hadiza Bawa-Garba]] and the one described by Matthews-King (see [[#References|references]]) in which doctors' reflections have been used to incriminate them in court, UK doctors should now be advised not to reflect in an unguarded manner that could potentially be used to incriminate them until and unless all such reflections can be made privileged and unavailable to future courts or tribunals.}} -{{KeyPointsBox|The documentation prepared to support revalidation in an [[Training portfolio|education portfolio]] or [[revalidation]] portfolio appears to be legally discoverable in some jurisdictions. So reflective statements on a clinical incident could be medico legally discoverable. Consider taking advice on what you put in a reflective statement in circumstances where the incident could result in a malpractice claim and obtain advice from your defence organisation before releasing any reflective statement to any third party because once released it is definitely discoverable. This issue might be jurisdiction specific as it is likely to require the exemption to be written into law, further complicating the issue for medical practitioners who might practice across jurisdictions}}+{{KeyPointsBox|The documentation prepared to support revalidation in an [[Training portfolio|education portfolio]] or [[revalidation]] portfolio appears to be legally discoverable in some jurisdictions. So reflective statements on a clinical incident could be medico legally discoverable. Consider taking advice on what you put in a reflective statement in circumstances where the incident could result in a malpractice claim and obtain advice from your defence organisation before releasing any reflective statement to any third party because once released it is definitely discoverable. This issue might be jurisdiction specific as it is likely to require the exemption to be written into law, further complicating the issue for medical practitioners who might practice across jurisdictions or be trained in one and later practice in another. See the article on [[legal privilege]]}} ''Reflective practice'' has probably always been part of good medical practice, but it probably came to prominence with Schön's writings.Donald Schön. ''The Reflective Practitioner: How professionals think in action.'' London: Tem[...]