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MedWorm: Allergy & Immunology



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Allergy & Immunology



Last Build Date: Mon, 28 Mar 2016 14:08:08 +0100

 



Coinfection of Schistosoma Species with Hepatitis B or Hepatitis C Viruses.

Mon, 28 Mar 2016 10:25:02 +0100

Authors: Abruzzi A, Fried B, Alikhan SB Abstract Although a considerable number of studies have been undertaken to date, it is still controversial as to whether or not coinfection with schistosomiasis increases the susceptibility to or progression from Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection. This review is a closer examination of the key studies conducted on human populations on clinical factors that were published in English between 1975 and January 2015. Our review is mainly based on tables containing the salient information, which are arranged first by study population, country of study and publication date. We provide further explanation, clarification and discussion in the text. As such, it includes both studies that have been conducted on general populat...

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A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.

Mon, 28 Mar 2016 03:05:02 +0100

Authors: Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y Abstract More than 60 members of the Rab family of guanosine triphosphatases (GTPases) exist in the human genome. Rab GTPases are small proteins that are primarily involved in the formation, trafficking, and fusion of vesicles. We showed thatCRACR2A(Ca(2+)release-activated Ca(2+)channel regulator 2A) encodes a lymphocyte-specific large Rab GTPase that contains multiple functional domains, including EF-hand motifs, a proline-rich domain (PRD), and a Rab GTPase domain with an unconventional prenylation site. Through experiments involving gene silencing in cells and knockout mice, we demonstrated a role for CRACR2A in the activation of the Ca(2+)and c-Jun N-terminal kinase signaling p...



Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Sun, 27 Mar 2016 22:00:00 +0100

Conclusion and Clinical RelevanceAsthma is associated with enhanced thrombin generation and impaired fibrinolysis, which might contribute to thromboembolic events in this disease.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)



Effect of controlled human exposure to diesel exhaust and allergen on airway surfactant protein D, myeloperoxidase, and club (Clara) cell secretory protein 16

Sun, 27 Mar 2016 22:00:00 +0100

Conclusions & Clinical RelevanceThese findings suggest that allergen and DE variably influence different aspects of the innate immune response of the lung. SPD and MPO, known markers of allergic inflammation in the lung, are strongly increased by allergen while DE has a minor effect therein. DE induces a loss of CC16, a protective protein, while allergen has a minor effect therein. Results support site‐ and exposure‐specific responses in the human lung upon multiple exposures.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)



Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue

Sun, 27 Mar 2016 22:00:00 +0100

Activation of mast cells through FcεRI plays an important role in acute allergic reactions. However, little is known about the function of mast cells in patients with chronic allergic inflammation or the effect of repeated FcεRI triggering occurring in such responses. (Source: Journal of Allergy and Clinical Immunology)



Occupational asthma in a fruit and vegetables vendor.

Sun, 27 Mar 2016 15:04:02 +0100

CONCLUSIONS: The clinical history and the results of the allergologic investigations, plus an on-the-spot inspection, permitted us to ascertain that this subject had developed occupational asthma due to Pleurotus ostreatus spores. We advised her to stop handling and selling mushrooms, and she has no longer suffered asthmatic symptoms, over seven years of follow-up, and regularly continued to work without needing to take anti-asthma drugs. PMID: 27015024 [PubMed - as supplied by publisher] (Source: Medicina del Lavoro)



Angiotensin-converting enzyme inhibitors as a cause of isolated angioedema in a Slovenian population.

Sun, 27 Mar 2016 12:33:04 +0100

CONCLUSION: ACEI was shown to be the most frequent removable cause of isolated AE. About two-thirds of AE cases taking ACEI were resolved after removal of the drug. PMID: 27014771 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)



Often seen, rarely recognized: mast cell activation disease - a guide to diagnosis and therapeutic options.

Sun, 27 Mar 2016 10:13:01 +0100

Authors: Afrin LB, H Butterfield J, Raithel M, J Molderings G Abstract Mast cell (MC) disease has long been thought to be just the rare disease of mastocytosis (in various forms, principally cutaneous and systemic), with aberrant MC mediator release at symptomatic levels due to neoplastic MC proliferation. Recent discoveries now show a new view is in order, with mastocytosis capping a metaphorical iceberg now called "MC activation disease" (MCAD, i.e. disease principally manifesting inappropriate MC activation), with the bulk of the iceberg being the recently recognized "MC activation syndrome" (MCAS), featuring inappropriate MC activation to symptomatic levels with little to no inappropriate MC proliferation. Given increasing appreciation of a great menagerie of mutations in MC re...

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Filaggrin Polymorphism Pro478Ser Is Associated With the Severity of Atopic Dermatitis and Colonization by Staphylococcal aureus.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Lopes C, Rocha L, Sokhatska O, Soares J, Tavaria F, Correia O, Pintado M, Fernandes S, Delgado L, Moreira A PMID: 27012026 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Anaphylaxis Due to Oat Ingestion.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Prados-Castaño M, Piñero-Saavedra M, Leguisamo-Milla S, Pastor C, Cuesta P, Bartolomé B PMID: 27012025 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Successful Capecitabine Desensitization for a Delayed-Type Hypersensitivity Reaction.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Demir S, Olgac M, Saglam S, Gelincik A, Colakoglu B, Buyukozturk S PMID: 27012024 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

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Different Clinical Phenotypes in 2 Siblings With X-Linked Severe Combined Immunodeficiency.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Wada T, Toma T, Yasui M, Inoue M, Kawa K, Imai K, Morio T, Yachie A PMID: 27012023 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Home-Based Oral Immunotherapy With a Baked Egg Protocol.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Bravin K, Luyt D PMID: 27012022 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Does the Effect of Smoking on Fractional Exhaled Nitric Oxide Vary by Race in Adults in a US National Survey?

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Hines C, Mehari A, Gillum RF PMID: 27012021 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Genetic Analysis as a Practical Tool for Diagnosis of Hereditary Angioedema With Normal C1 Inhibitor: A Case Report.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Moreno AS, Maia LS, Palhas PB, Dias MM, Muglia VF, Castelli EC, Bork K, Arruda LK PMID: 27012020 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Potentially Inappropriate Prescription in Patients With a History of Allergy to β-Lactam Antibiotics: A Health Care Challenge.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Manzaneque A, López-Cabezas C, Mensa M, García-Moral A, Sánchez-López J, Bartra J, Luis Valero A PMID: 27012019 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

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The Addition of Benzylpenicillin Does Not Increase the Skin Test Sensitivity Obtained With Classic β-Lactam Determinants.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Lacombe-Barrios J, Salas M, Gómez F, Doña I, Ariza A, Mayorga C, Blanca M, Montañez MI, Torres MJ PMID: 27012018 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Perception of Bronchodilation Assessed by Visual Analog Scale in Asthmatics: A Real-life Study.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Ricciardolo FL, Rindone E, Schiavetti I, Ciprandi G PMID: 27012017 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Life-threatening Reaction to Iron Dextran: Protocol for Induction of Tolerance.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: Cardona R, Sánchez J, Ramírez R PMID: 27012016 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Safety of Ultrarush Venom Immunotherapy: Comparison Between Children and Adults.

Sun, 27 Mar 2016 09:51:02 +0100

CONCLUSIONS: VIT-UR is safer in children. Age below 18 is not a risk factor for VIT-SARs. PMID: 27012015 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area?

Sun, 27 Mar 2016 09:51:02 +0100

CONCLUSIONS: The diagnostic performance of ISAC was adequate for hazelnut and walnut allergy but not for peanut allergy. sIgE sensitivity against Ara h 9 in ISAC needs to be improved. PMID: 27012014 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

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Is the Quantification of Antigen-Specific Basophil Activation a Useful Tool for Monitoring Oral Tolerance Induction in Children With Egg Allergy?

Sun, 27 Mar 2016 09:51:02 +0100

CONCLUSIONS: Food tolerance induction is a specific process for each food that can be mediated by immunologic changes such as a decrease in specific IgE values and in specific and spontaneous basophil activation. PMID: 27012013 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced Bronchoconstriction.

Sun, 27 Mar 2016 09:51:02 +0100

CONCLUSIONS: Levels of EBC LXA4 increased immediately after exercise in asthmatic children with a positive exercise challenge response. We hypothesize that airway LXA4 levels increase to compensate bronchoconstriction and suppress acute inflammation, and that spontaneous bronchodilatation after EIB may be due to LXA4. PMID: 27012012 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Eosinophilic Esophagitis: An Evidence-Based Approach to Therapy.

Sun, 27 Mar 2016 09:51:02 +0100

Authors: González-Cervera J, Lucendo AJ Abstract In recent years, several randomized controlled trials and meta-analyses have evaluated the efficacy of the various therapeutic options available for treating patients with eosinophilic esophagitis, including dietary modifications, proton pump inhibitors, topical corticosteroids, and endoscopic esophageal dilation. Proton pump inhibitors are currently considered the first-line treatment for eosinophilic esophagitis, achieving histological remission and improvement of symptoms in 50.5% and 60.8% of patients, respectively. The efficacy of topical corticosteroids in eosinophilic esophagitis has been assessed in several trials. Meta-analyses summarizing results indicate that budesonide and fluticasone propionate are significantly superio...



The Treatment of Allergic Respiratory Disease During Pregnancy.

Sun, 27 Mar 2016 09:51:02 +0100

This article reviews the recognition and management of asthma and allergic rhinitis during pregnancy, paying close attention to the general principles of allergy and use of asthma medication during pregnancy. Both allergic rhinitis and asthma can adversely affect both maternal quality of life and, in the case of maternal asthma, perinatal outcomes. Optimal management is thus important for both mother and baby. This article reviews the safety of asthma and allergy medications commonly used during pregnancy. PMID: 27012010 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)



Isolation, structural characterization, and immunological activity of a polysaccharide LRLP4-A from the leaves of Lycium ruthenicum

Sun, 27 Mar 2016 08:22:07 +0100

(Source: Journal of Carbohydrate Chemistry)

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Prevalence of Leishmania infantum and co-infections in stray cats in northern Italy.

Sun, 27 Mar 2016 05:20:02 +0100

Authors: Spada E, Canzi I, Baggiani L, Perego R, Vitale F, Migliazzo A, Proverbio D Abstract Stray cats in the city of Milan, Italy, were tested for Leishmania infantum and other selected infections. Twenty-seven cats (30.0%) were seroreactive by indirect fluorescent antibody test (IFAT), with an antibody titer of 1:40 for 16 (17.7%) cats and 1:80 (cut-off for feline L. infantum infection) for 11 (12.2%) cats. One blood (1.1%) and one popliteal lymph node (1.1%) sample tested positive by real-time polymerase chain reaction; no oculoconjunctival swabs tested positive. Feline immunodeficiency virus, feline leukemia virus, and feline coronavirus (FCoV) seroprevalence determined by enzyme-linked immunosorbent assay was 6.1, 6.1, and 39.0%, respectively. Toxoplasma gondii, Bartonella he...



Pheno- and genotypic characterization of Pasteurella multocida isolated from cats, dogs and rabbits from Brazil.

Sun, 27 Mar 2016 05:20:02 +0100

This study aimed to characterize the genetic diversity of P. multocida isolated from dogs, cats and rabbits, and to evaluate their antimicrobial susceptibility profiles. A total of 620 animals were studied; 51 were positive for P. multocida and 92 strains were isolated. 60.9% of the strains belonged to the capsular type A, while the remaining were classified as non-typeable. The hgbA, ptfA, sodC, tadD and hsf2 genes were more frequent among the rabbit strains. Sulfonamides and cotrimoxazole presented the highest resistance rate, followed by erythromycin. PFGE clustered strains according to host species. Our results indicate that P. multocida from companion animals carry several virulence factors and are resistant to antimicrobials commonly used in human and veterinary medicine. PMID: ...



Cathepsin K inhibition renders equine bone marrow nucleated cells hypo-responsive to LPS and unmethylated CpG stimulation in vitro.

Sun, 27 Mar 2016 05:20:02 +0100

In conclusion, CatK inhibition in horses did affect BMNCs other than mature osteoclasts rendering them hypo-responsive to both TLR4- and TLR9-induced inflammation, predicting a proteolytic activity for CatK within the MyD88 pathway and/or the following proteolytic events required for the cytokines secretion. PMID: 27012920 [PubMed - in process] (Source: Comparative immunology, microbiology and infectious diseases.)

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Antimicrobial resistance in faecal Escherichia coli isolates from farmed red deer and wild small mammals. Detection of a multiresistant E. coli producing extended-spectrum beta-lactamase.

Sun, 27 Mar 2016 05:20:02 +0100

Authors: Alonso CA, González-Barrio D, Tenorio C, Ruiz-Fons F, Torres C Abstract Eighty-nine Escherichia coli isolates recovered from faeces of red deer and small mammals, cohabiting the same area, were analyzed to determine the prevalence and mechanisms of antimicrobial resistance and molecular typing. Antimicrobial resistance was detected in 6.7% of isolates, with resistances to tetracycline and quinolones being the most common. An E. coli strain carrying blaCTX-M-1 as well as other antibiotic resistant genes included in an unusual class 1 integron (Intl1-dfrA16-blaPSE-1-aadA2-cmlA1-aadA1-qacH-IS440-sul3-orf1-mef(B)Δ-IS26) was isolated from a deer. The blaCTX-M-1 gene was transferred by conjugation and transconjugants also acquired an IncN plasmid. This strain was typed as ST22...



Clinical isolates of Acinetobacter baumannii from a Portuguese hospital: PFGE characterization, antibiotic susceptibility and biofilm-forming ability.

Sun, 27 Mar 2016 05:20:02 +0100

Authors: Duarte A, Ferreira S, Almeida S, Domingues FC Abstract Acinetobacter baumannii is an emerging pathogen associated with nosocomial infections that in addition has shown an increasing resistance to antibiotics. In this work the genetic diversity of A. baumannii isolates from a Portuguese hospital, their antibiotic resistance profiles and ability to form biofilms was studied. Seventy-nine clinical A. baumannii isolates were characterized by pulsed-field gel electrophoresis (PFGE) with 9 different PFGE profiles being obtained. Concerning the antimicrobial susceptibility, all A. baumannii isolates were resistant to 12 of the 17 tested antibiotics and classified as multidrug-resistant (MDR). In addition, 74.7% of the isolates showed biofilm formation ability, however no statisti...



Molecular evidence of vector-borne pathogens in dogs and cats and their ectoparasites in Algiers, Algeria.

Sun, 27 Mar 2016 05:20:02 +0100

Authors: Bessas A, Leulmi H, Bitam I, Zaidi S, Ait-Oudhia K, Raoult D, Parola P Abstract In Algeria, only limited information is currently available on the prevalence of emergent canine and feline vector-borne diseases. The aim of the present work was to detect by qPCR vector-associated bacteria in stray dogs and cats and their ectoparasites from Algiers. 18/117 (15.38%) dogs and 2/107 (1.87%) cats were positive for at least one vector-borne agent. Coxiella burnetii and Bartonella henselae were identified in 1/117 (0.85%) dog individually. Ehrlichia canis DNA was detected in 17/117 (14.52%) dogs. 1/107 (0.93%) cat was positive to C. burnetii and another 1/107 (0.93%) to B. henselae. DNA of Rickettsia massiliae, Rickettsia conorii and E. canis was detected in Rhipicephalus sanguineu...



Eyeworm infections in dogs and in a human patient in Serbia: A One Health approach is needed.

Sun, 27 Mar 2016 05:20:02 +0100

We describe the first case of human thelaziosis in Serbia, along with two cases in dogs from the same area. A One Health approach, based on cooperation amongst veterinarians and physicians, is strongly advised for this emerging infection in order to assess the risk for and prevent of the zoonotic infection. PMID: 27012916 [PubMed - in process] (Source: Comparative immunology, microbiology and infectious diseases.)



An evaluation of ELISA using recombinant Brucella abortus bacterioferritin (Bfr) for bovine brucellosis.

Sun, 27 Mar 2016 05:20:02 +0100

In this study, cloning and expression of Brucella abortus bacterioferritin (Bfr) was accomplished by PCR amplification into an expression vector system, and purification of a recombinant B. abortus Bfr (rBfr). The immunogenicity of rBfr was confirmed by Western blot with Brucella-positive bovine serum. To determine whether rBfr has a potential benefit for use in the serodiagnosis of bovine brucellosis, rBfr-based ELISA was performed. Interestingly, rBfr was able to detect anti-Brucella antibodies in positive sera in a dependent manner of TAT values but did not show an immunoreaction with negative samples. Particularly, average OD492 values at the lowest, medium and highest TAT titer levels were 1.4, 2.2 and 2.6-fold increase compared with the cutoff value, respectively. The accuracy, speci...

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Faecal virome of red foxes from peri-urban areas.

Sun, 27 Mar 2016 05:20:02 +0100

In this study, we evaluated the faecal virome of juvenile and adult foxes from peri-urban areas in central Croatia. The dominating mammalian viruses were fox picobirnavirus and parvovirus. The highest number of viral reads (N=1412) was attributed to a new fox circovirus and complete viral genome was de novo assembled from the high-throughput sequencing data. Fox circovirus is highly similar to dog circoviruses identified in diseased dogs in USA and Italy, and to a recently discovered circovirus of foxes with neurologic disease from the United Kingdom. Our fox picobirnavirus was more closely related to the porcine and human picobirnaviruses than to known fox picobirnaviruses. PMID: 27012914 [PubMed - in process] (Source: Comparative immunology, microbiology and infectious diseases.)



Quillaja brasiliensis saponins induce robust humoral and cellular responses in a bovine viral diarrhea virus vaccine in mice.

Sun, 27 Mar 2016 05:20:02 +0100

Authors: Cibulski SP, Silveira F, Mourglia-Ettlin G, Teixeira TF, Dos Santos HF, Yendo AC, de Costa F, Fett-Neto AG, Gosmann G, Roehe PM Abstract A saponin fraction extracted from Quillaja brasiliensis leaves (QB-90) and a semi-purified aqueous extract (AE) were evaluated as adjuvants in a bovine viral diarrhea virus (BVDV) vaccine in mice. Animals were immunized on days 0 and 14 with antigen plus either QB-90 or AE or an oil-adjuvanted vaccine. Two-weeks after boosting, antibodies were measured by ELISA; cellular immunity was evaluated by DTH, lymphoproliferation, cytokine release and single cell IFN-γ production. Serum anti-BVDV IgG, IgG1 and IgG2b were significantly increased in QB-90- and AE-adjuvanted vaccines. A robust DTH response, increased splenocyte proliferation, Th1-ty...



Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 1 July 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 143 Author(s): Jeong-Jun Lee, Aeri Shim, Jae Young Jeong, Song Yi Lee, Hyun-Jeong Ko, Hyun-Jong Cho Itraconazole (ITZ)-loaded microemulsion (ME) systems for intranasal (IN) delivery were developed for the treatment of human rhinovirus serotype 1B (HRV1B) infection. ITZ was incorporated into the oil-in-water (o/w) ME formulation composed of benzyl alcohol (oil), Cremophor EL (surfactant), Solutol HS15 (cosurfactant), and water. The optimized composition of ME was determined by constructing pseudo-ternary phase diagram. ITZ ME formulation with about 150nm mean diameter and spherical shape was prepared and the solubility of ITZ in blank ME was markedly improved (up to 13.9mg/mL). The initial value of d...



Evaluation of protective efficacy of a novel inactivated Salmonella Pullorum ghost vaccine against virulent challenge in chickens

Sat, 26 Mar 2016 23:00:00 +0100

In conclusion, our results suggest that Salmonella Pullorum ghosts may be used as a safe and effective novel inactivated vaccine candidate to protect against virulent Salmonella Pullorum infection. (Source: Veterinary Immunology and Immunopathology)



Keratinocytes express functional CARD18, a negative regulator of inflammasome activation, and its altered expression in psoriasis may contribute to disease pathogenesis

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Molecular Immunology, Volume 73 Author(s): Anikó Göblös, Judit Danis, Krisztina Vas, Zsuzsanna Bata-Csörgő, Lajos Kemény, Márta Széll Caspase recruitment domain family member 18 (CARD18, Iceberg) is known as a negative regulatory molecule that inhibits inflammatory events by terminating inflammasome activation due to a direct interaction with pro-caspase-1. During the investigation of molecular mechanisms in keratinocytes that contribute to the pathogenesis of psoriasis, we found that CARD18 expression differs in healthy and psoriatic skin; moreover, CARD18 demonstrated altered response under inflammatory conditions in healthy and psoriatic skin. In healthy skin, low basal CARD18 expression was detected, which showed significant elevation i...



Individualized Household Allergen Intervention Lowers Allergen Level But Not Asthma Medication use: A Randomized Controlled Trial

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions Targeted allergen avoidance measures do not allow for reduction in asthma pharmacologic therapy compared with usual care in patients already receiving optimal controller therapy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Oral amoxicillin-associated anaphylaxis, 1 year after negative penicillin testing and oral amoxicillin challenge

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Nicolas Urriola, Lee Paganini, Sean Riminton, Sandhya Limaye (Source: The Journal of Allergy and Clinical Immunology: In Practice)



Acute generalized exanthematous pustulosis due to diltiazem: Investigation of cross-reactivity with other calcium channel blockers

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Mercedes Sáenz de Santa María García, Blanca Noguerado-Mellado, Patricia Rojas Pérez-Ezquerra, Ignacio Hernandez-Aragües, Manuel De Barrio Fernández (Source: The Journal of Allergy and Clinical Immunology: In Practice)



Oral viscous budesonide can be successfully delivered through a variety of vehicles to treat eosinophilic esophagitis in children

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Juhee Lee, Michelle Shuker, Terri Brown-Whitehorn, Antonella Cianferoni, Laura Gober, Amanda Muir, Ritu Verma, Chris Liacouras, Jonathan M. Spergel (Source: The Journal of Allergy and Clinical Immunology: In Practice)



Component‐resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness

Sat, 26 Mar 2016 22:34:16 +0100

ConclusionsIncreased IgG4‐EW, IgA‐EW and IgA2‐EW during eOIT are associated with clinical response to eOIT. Lower pre‐treatment IgE‐EW and IgE‐OVM are also associated with SU. Future studies are needed to evaluate and validate these potential biomarkers.This article is protected by copyright. All rights reserved. (Source: Allergy)



Advances in cancer immunology and cancer immunotherapy.

Sat, 26 Mar 2016 21:34:04 +0100

The objective clinical response observed in patients treated with antibodies that block the immune checkpoints, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell-death protein 1 (PD-1)/programmed cell-death 1 ligand 1 (PD-L1) pathways, has led to their FDA approval for the treatment of melanoma in 2011 and in 2014, respectively. The anti-PD-1 antibody nivolumab has received the FDA-approval in March 2015 for squamous lung cancer treatment. In addition, antibodies targeting PD-1 or PD-L1 have demonstrated their efficacy and safety in additional tumors, including non-small cell lung carcinoma (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's lymphoma. Almost at the same time, the field of adoptive cell transfer has exploded. The chimeric antigen recept...

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Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations.

Sat, 26 Mar 2016 19:03:01 +0100

Authors: Barbosa JS, Almeida Paz FA, Braga SS Abstract Montelukast sodium is a leukotriene antagonist of growing interest as an alternative therapy for asthma across different age groups due to its bronchoprotective, anti-inflammatory and anti-allergic properties. Currently, montelukast is commercialized only in oral solid dosage forms, which are the favourite of adult patients but may pose challenges in administration to children of young age or patients suffering from dysphagia. This review presents a comprehensive revision of scientific reports and patents on emerging strategies for the delivery of montelukast. A common ground to these reports is the pursue of an enhanced montelukast performance, by increasing its bioavailability and physico-chemical stability. A wide variety of...



Vitamin D in Atopic Dermatitis, Chronic Urticaria and Allergic Contact Dermatitis.

Sat, 26 Mar 2016 18:31:02 +0100

Authors: Quirk SK, Rainwater E, Shure AK, Agrawal DK Abstract Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. A...



Symptomatic Treatment of Subepithelial Infiltrates after Viral Conjunctivitis: Loteprednol or Dexamethasone?

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: The study has found that in the treatment of SEI, which developed after EKC, statistically similar results can be obtained with loteprednol, which is known to have fewer adverse effects. PMID: 27015587 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Comparison of Subtenon Triamcinolone Acetonide Injection with Topical Nepafenac for the Treatment of Pseudophakic Cystoid Macular Edema.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: Our visual and OCT results suggest that both treatment modalities are effective with few side-effects. However, nepafenac is more efficacious than subtenon TA in terms of visual gain and its correlation with the reduction in CRT. PMID: 27015572 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Regarding Comments by Kaya et al. on "Evaluation of the Choroid, Fovea and Retinal Nerve Fiber Layer in Patients with Rheumatoid Arthritis".

Sat, 26 Mar 2016 18:29:01 +0100

Regarding Comments by Kaya et al. on "Evaluation of the Choroid, Fovea and Retinal Nerve Fiber Layer in Patients with Rheumatoid Arthritis". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Tetikoglu M, Temizturk F, Sagdik HM, Aktas S, Ozcura F, Ozkan Y, Temizturk S PMID: 27015389 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Response to Letter from Dr. Salih Uzun et al. Regarding "Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness in Children with Familial Mediterranean Fever".

Sat, 26 Mar 2016 18:29:01 +0100

Response to Letter from Dr. Salih Uzun et al. Regarding "Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness in Children with Familial Mediterranean Fever". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Alim S, Özer S, Demir S, Ortak H, Sönmezgöz E, Er E, Demir O PMID: 27015371 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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In Response to: "Khochtali S, Abroug N, Kahloun R, et al. Pattern of Acute Retinal Necrosis in a Referral Center in Tunisia, North Africa".

Sat, 26 Mar 2016 18:29:01 +0100

In Response to: "Khochtali S, Abroug N, Kahloun R, et al. Pattern of Acute Retinal Necrosis in a Referral Center in Tunisia, North Africa". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Ilhan A, Yolcu U PMID: 27015232 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Evaluation of Macular Ganglion Cell-inner Plexiform Layer and Choroid in Psoriasis Patients Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: These findings suggest that choroidal alterations are seen without macular changes in patients with psoriasis. Severe psoriasis appears to be related to increases in SFCT as a consequence of possible inflammatory cascades that are part of the disease's pathogenesis. PMID: 27015161 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Authors reply to Letter to the Editor-In Response to: "Baddar D, Goldstein DA. HLA-A29-positive Birdshot Chorioretinopathy in a Hispanic Patient".

Sat, 26 Mar 2016 18:29:01 +0100

Authors reply to Letter to the Editor-In Response to: "Baddar D, Goldstein DA. HLA-A29-positive Birdshot Chorioretinopathy in a Hispanic Patient". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Goldstein D, Baddar D PMID: 27015040 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro. PMID: 27015032 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



In Response to: "Baddar D, Goldstein DA. HLA-A29-positive Birdshot Chorioretinopathy in a Hispanic Patient".

Sat, 26 Mar 2016 18:29:01 +0100

In Response to: "Baddar D, Goldstein DA. HLA-A29-positive Birdshot Chorioretinopathy in a Hispanic Patient". Ocul Immunol Inflamm. 2016 Mar 25;:1 Authors: Rodríguez-García A, Almanza-Santos M PMID: 27014945 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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In Response to: "Deuter CM, Zierhut M, Igney-Oertel A, et al. Tocilizumab in Uveitic Macular Edema Refractory to Previous Immunomodulatory Treatment".

Sat, 26 Mar 2016 18:29:01 +0100

In Response to: "Deuter CM, Zierhut M, Igney-Oertel A, et al. Tocilizumab in Uveitic Macular Edema Refractory to Previous Immunomodulatory Treatment". Ocul Immunol Inflamm. 2016 Mar 25;:1-2 Authors: Mesquida M, Llorenç V, Adán A PMID: 27014943 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Effect of Allergic Diseases on Keratoconus Severity.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: Patients with VKC or AC were at increased risk of KC. They had more severe KC and should be closely followed up and intensively treated. PMID: 27014800 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Comparative plasma and milk dispositions, faecal excretion and efficacy of per os ivermectin and pour‐on eprinomectin in horses

Sat, 26 Mar 2016 17:07:37 +0100

In conclusion, due to the relatively low excretion in milk, EPM and IVM may be used safely in lactating mares if their milk is used for human consumption. Nevertheless, much lower plasma and faecal availabilities of EPM could result in subtherapeutic concentrations, which may increase the risk of drug resistance in nematodes after pour‐on EPM administration compared with per os IVM. (Source: Journal of Veterinary Pharmacology and Therapeutics)



Biomonitoring of Prenatal Analgesic Intake and Correlation to Infantile Anti Aeroallergens IgE

Sat, 26 Mar 2016 03:25:22 +0100

This article is protected by copyright. All rights reserved. (Source: Allergy)



The 5 Best Remedies For Sinus Problems

Sat, 26 Mar 2016 01:42:43 +0100

SPECIAL FROM Here’s an appetizing tidbit: Your sinus produces one to two liters of mucus every day—that’s the size of two large soda bottles. Under normal conditions, most of the mucus dribbles undetected down your throat. Yes, it’s gross but also very important: Mucus filters out bacteria, viruses, and fungi in the air that we breathe, and moistens the nasal passages and sinuses, allowing us to breathe easier and lessen risk of infections.  Sometimes, due to allergens, environmental pollution, nasal obstruction or inflammation, the system goes haywire, filling you with congestion. According to American Family Physician, “sinusitis is one of the most common conditions treated by primary care physicians. Each year in the United States, sinusitis affe...



Procedures to Assist Health Care Providers to Determine When Home Assessments for Potential Mold Exposure Are Warranted

Fri, 25 Mar 2016 23:00:00 +0100

We present the procedures in the form of a guided 2-part interview. The first part has 5 questions that triage the patient toward a more detailed questionnaire that reflects features of housing conditions known to be reliably associated with exposures to mold and dampness contaminants. We chose the questions based on the conditions associated with moisture problems in homes across the United States and Canada. The goal is to facilitate the clinician's effort to help patients reduce exposure to environmental triggers that elicit symptoms to better manage their disease. (Source: The Journal of Allergy and Clinical Immunology: In Practice)



Lung Sound Analysis and Airway Inflammation in Bronchial Asthma

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Among the 4 LSA parameters investigated, E/I MF demonstrated the highest correlation with airway inflammation, and also with bronchial hyperresponsiveness. (Source: The Journal of Allergy and Clinical Immunology: In Practice)



Sensitivity of IgG ELISA for diagnosing cysticercosis in high risk group in and around Aligarh District of Uttar Pradesh, India

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Cysticercosis is a health problem in and around Aligarh with higher risk in males. Seroprevalence of cysticercosis in high risk community of Aligarh is 7.4%. (Source: Asian Pacific Journal of Tropical Disease)

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Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma

Fri, 25 Mar 2016 23:00:00 +0100

MicroRNAs (miRNAs) are emerging as important regulatory molecules that might be involved in the pathogenesis of various diseases. Circulating miRNAs might be noninvasive biomarkers to diagnose and characterize asthma and allergic rhinitis (AR). (Source: Journal of Allergy and Clinical Immunology)



Childhood atopic dermatitis and risk of attention deficit/hyperactivity disorder: A cohort study

Fri, 25 Mar 2016 23:00:00 +0100

Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease and it is the most common chronic disease of childhood.1 Inflammatory processes are known to play an important role in the development of psychiatric diseases.2 Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders.3 However, only 1 questionnaire-based follow-up study exists on the association between AD and ADHD and it does not report results related to sex. (Source: Journal of Allergy and Clinical Immunology)



Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma

Fri, 25 Mar 2016 23:00:00 +0100

Children with asthma have low vitamin D levels; however, we do not know whether low vitamin D is associated with impaired T-regulatory (Treg) cell population or high IgE receptors (CD23 and CD21) on B cells. (Source: Annals of Allergy, Asthma and Immunology)

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A case of acquired angioedema possibly associated with adenocarcinoma of the colon

Fri, 25 Mar 2016 23:00:00 +0100

Acquired angioedema (AAE) is an uncommon condition characterized by angioedema without wheals associated with low C1 inhibitor, C4, and C1q levels secondary to disproportionate activation or depletion of C1 esterase inhibitor (C1INH). First described by Caldwell et al1 in 1972, AAE is clinically indistinguishable from hereditary angioedema (HAE) and leads to unpredictable angioedema episodes that last 2 to 5 days. AAE is most commonly due to lymphoproliferative disorders.2 Less common causes include solid organ tumors, infection, and systemic lupus erythematosus. (Source: Annals of Allergy, Asthma and Immunology)



Plant‐based active photoprotectants for sunscreens

Fri, 25 Mar 2016 23:00:00 +0100

Abstract Excessive exposure to the sun's radiation is the major exogenous mediator of skin damage, which accelerates skin ageing and increases the risk of developing skin cancer. Compounds with photoprotectant activity are extremely useful for decreasing the effect of ultraviolet (UV) radiation on the skin; however, numerous sun filters, especially organic sunscreens, are allergenic. Therefore, the development of formulations containing plant extracts, which may be potentially safer, is extensively being explored. Plant‐based cosmetics are commonly used to avoid skin ageing because they contain antioxidant agents that minimize free radical activity, and numerous studies have investigated the skin‐protectant effects of related plant species. In addition to their antioxidant properties, ...



Expression of 11beta-hydroxysteroid-dehydrogenase type 2 in human thymus

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Steroids Author(s): Giovanni Almanzar, Christina Mayerl, Jan-Christoph Seitz, Kerstin Höfner, Andrea Brunner, Vanessa Wild, Daniel Jahn, Andreas Geier, Martin Fassnacht-Capeller, Martina Prelog 11beta-hydroxysteroid-dehydrogenase type 2 (11β-HSD2) is a high affinity dehydrogenase which rapidly inactivates physiologically-active glucocorticoids to protect key tissues. 11β-HSD2 expression has been described in peripheral cells of the innate and the adapative immune as well as in murine thymus. In absence of knowledge of 11β-HSD2 expression in human thymus, the study aimed to localize 11β-HSD2 in human thymic tissue. Thymic tissue was taken of six healthy, non-immunologically impaired male infants below 12 months of age ...

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Continuous intraarticular and periarticular levobupivacaine for management of pain relief after total knee arthroplasty: A prospective randomized, double-blind pilot study

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion The use of a mix of levobupivacaina, ketoral-trometamina, and adrenalin provides a safe and effective means in post-operative pain relief in patients undergoing TKA. Level of evidence Level II therapeutic study. (Source: Journal of Orthopaedics)



This Woman Fit 3 Years Of Her Trash In A Freaking Mason Jar

Fri, 25 Mar 2016 22:16:34 +0100

Sustainability never looked so stylish -- or straightforward. Lauren Singer runs Trash Is for Tossers, a no-waste lifestyle blog that is brimming with smart, simple and sleek-looking tips, tricks and DIY projects for adopting a more sustainable life. "I would like people to take away that we can all, regardless of our background, our beliefs, where we live or our socioeconomic status, take simple steps to reduce our environmental impact. It is simple to say no to a plastic straw or carry a reusable bag," Singer told The Huffington Post. Singer’s environmental epiphany struck her three years ago when she was a senior at NYU, where she was earning a degree in environment studies. “One day after class I went home to make dinner and opened my refrigerator and saw that everything i...



Trader Joe's Issues Voluntary Allergy Alert on Undeclared Milk in Chocolate Orange Sticks and Chocolate Raspberry Sticks

Fri, 25 Mar 2016 20:16:00 +0100

Trader Joe's of Monrovia, California is voluntarily recalling all codes of Trader Joe's Chocolate Orange Sticks (UPC 00847162) and Trader Joe's Chocolate Raspberry Sticks (UPC 00847122) because the products may contain more than the stated traces of milk on the label. All affected product has been removed from store shelves. (Source: Food and Drug Administration)



HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample.

Fri, 25 Mar 2016 18:53:03 +0100

Conclusions. The prevalence of HIV-OMH in the study population was 18.5%, the gingiva being the most commonly affected site. It appears that the CD4+ T cell count does not play any role in the biopathology of HIV-OMH. PMID: 27006825 [PubMed] (Source: AIDS Research and Treatment)

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Immune response profiling of malignant pleural mesothelioma for diagnostic and prognostic biomarkers.

Fri, 25 Mar 2016 18:52:01 +0100

Authors: Creaney J, Dick IM, Musk AW, Olsen NJ, Robinson BW Abstract The asbestos induced cancer malignant mesothelioma (MM) is difficult to diagnose and has a poor prognosis. MM is an immunological cancer, therefore autoantibodies may be suitable biomarkers and associated with prognosis. We used Protoarray(®) microarrays to determine immune responses to 8798 antigens in 10 MM and 10 asbestos exposed controls and developed diagnostic panels using 17 antigens from this. The AUC of these panels were independently tested in these 10 MM patients and controls and in a validation group of 36 controls and 35 MM patients using luminex assays; none of the antigens identified were validated. Immune responses to RAB38 were associated with a better prognosis. PMID: 27009350 [PubMed ...



FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Chung S, Lee TJ, Reader BF, Kim JY, Lee YG, Park GY, Karpurapu M, Ballinger MN, Qian F, Rusu L, Chung HY, Unterman TG, Croce CM, Christman JW Abstract Inflammatory monocyte and tissue macrophages influence the initiation, progression, and resolution of type 2 immune responses, and alveolar macrophages are the most prevalent immune-effector cells in the lung. While we were characterizing the M1- or M2-like macrophages in type 2 allergic inflammation, we discovered that FoxO1 is highly expressed in alternatively activated macrophages. Although several studies have been focused on the fundamental role of FoxOs in hematopoietic and immune cells, the exact role that FoxO1 plays in allergic asthmatic inflammation in activated macrophages has not been investigated. Growing eviden...



Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents.

Fri, 25 Mar 2016 16:53:02 +0100

Authors: Harris RA, Shah R, Hollister EB, Tronstad RR, Hovdenak N, Szigeti R, Versalovic J, Kellermayer R Abstract Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC...



TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages.

Fri, 25 Mar 2016 16:53:02 +0100

Authors: Philip M, Chiu EY, Hajjar AM, Abkowitz JL Abstract Pathogenic bacteria have evolved multiple mechanisms to capture iron or iron-containing heme from host tissues or blood. In response, organisms have developed defense mechanisms to keep iron from pathogens. Very little of the body's iron store is available as free heme; rather nearly all body iron is complexed with heme or other proteins. The feline leukemia virus, subgroup C (FeLV-C) receptor, FLVCR, exports heme from cells. It was unknown whether FLVCR regulates heme-iron availability after infection, but given that other heme regulatory proteins are upregulated in macrophages in response to bacterial infection, we hypothesized that macrophages dynamically regulate FLVCR. We stimulated murine primary macrophages or macro...

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Neutrophils: Their Role in Innate and Adaptive Immunity.

Fri, 25 Mar 2016 16:53:02 +0100

Authors: Rosales C, Demaurex N, Lowell CA, Uribe-Querol E PMID: 27006954 [PubMed - in process] (Source: Journal of Immunology Research)



Renal abnormalities in a cohort of HIV-infected children and adolescents

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART. (Source: Pediatric Nephrology)



Stinging insect identification: are the allergy specialists any better than their patients? - Baker TW, Forester JP, Johnson ML, Sikora JM, Stolfi A, Stahl MC.

Fri, 25 Mar 2016 16:13:53 +0100

BACKGROUND: It has been reported that the general population is not skillful at identifying stinging insects with the exception of the honeybee. No information is available to evaluate allergy physicians' accuracy with stinging insect identification. ... (Source: SafetyLit)

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MicroRNAs in the key events of systemic lupus erythematosus pathogenesis.

Fri, 25 Mar 2016 15:35:02 +0100

CONCLUSION: Distinct miRs are differentially expressed in both SLE mice models and human patients and promote autoimmune features of immune processes. MiRs are important molecules modulating susceptibility to SLE as well as its onset, clinical diversity and progression. PMID: 27003314 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)



Postepy Hig Med Dosw 2016; 70:251-257 "Immunological markers of rheumatoid arthritis"

Fri, 25 Mar 2016 15:08:52 +0100

Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and death mainly due to premature cardiovascular disease. Early diagnosis and appropriate treatment are essential for prognosis and quality of life improvement. In 2010 the American College of Rheumatology (ACR) and The European League Against Rheumatism (EULAR) established new RA classification criteria. Besides clinical symptoms it includes two immunologic criteria: rheumatoid factor (RF) and anti-citrullinated protein antibodies (anti-CCP antibodies). RF is the first well-known RA immunologic marker. It is observe...



Strategies to Block Bacterial Pathogenesis by Interference with Motility and Chemotaxis.

Fri, 25 Mar 2016 14:18:01 +0100

Authors: Erhardt M Abstract Infections by motile, pathogenic bacteria, such as Campylobacter species, Clostridium species, Escherichia coli, Helicobacter pylori, Listeria monocytogenes, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Salmonella species, Vibrio cholerae, and Yersinia species, represent a severe economic and health problem worldwide. Of special importance in this context is the increasing emergence and spread of multidrug-resistant bacteria. Due to the shortage of effective antibiotics for the treatment of infections caused by multidrug-resistant, pathogenic bacteria, the targeting of novel, virulence-relevant factors constitutes a promising, alternative approach. Bacteria have evolved distinct motility structures for movement across surfaces and in aqueous environmen...



Kent woman 'allergic' to being pregnant used sandpaper and a FORK to ease itch

Fri, 25 Mar 2016 13:17:16 +0100

Josie Barker, 26, from Kent, developed hives so itchy she would scratch her body until it bled while she was pregnant with her children Freddie and Elsie. She was diagnosed with a condition called ICP. (Source: the Mail online | Health)



Current prevalence rate of latex allergy: Why it remains a problem?

Fri, 25 Mar 2016 12:49:02 +0100

CONCLUSIONS: Latex-derived products are ubiquitous, and latex allergy remains a highly prevalent health risk in many occupations and to the general population. Developing alternative materials and increasing the ability to identify and label latex-derived products will be practicable approaches to effectively control the health risks associated with latex. PMID: 27010091 [PubMed - as supplied by publisher] (Source: Journal of Occupational Health)

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CD21‐/low B cells in human blood are memory cells

Fri, 25 Mar 2016 08:25:35 +0100

This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)



Effect of omalizumab on angioedema in H1‐antihistamine resistant chronic spontaneous urticaria patients: results from X‐ACT, a randomised controlled trial

Fri, 25 Mar 2016 08:25:16 +0100

ConclusionOmalizumab was an effective treatment option for patients with moderate‐to‐severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment.This article is protected by copyright. All rights reserved. (Source: Allergy)



Steroid Transnasal Nebulization for Chronic RhinosinusitisSteroid Transnasal Nebulization for Chronic Rhinosinusitis

Fri, 25 Mar 2016 08:16:40 +0100

Steroid transnasal nebulization provides clinicians with another therapeutic option for this difficult to treat condition. Current Opinion in Allergy and Clinical Immunology (Source: Medscape Allergy Headlines)

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Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: OHT and SG were common in patients with JIA-associated uveitis. Use of immunosuppressive drugs may decrease the risk of developing OHT. PMID: 27003850 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes. PMID: 27003735 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Clinical Characteristics of Primary Vitreoretinal Lymphoma in an Indian Population.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: PVRL in India was likely to be mistaken for an infectious variety of uveitis. A high index of suspicion and thorough clinical examination is necessary to make the diagnosis. PMID: 27003620 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Chronic recurrent presentation and development of complications and 'sunset glow fundus' are associated with a worse sensitivity outcome. PMID: 27003480 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Adalimumab for Ocular Inflammation.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Adalimumab was moderately effective in controlling inflammation in a group of highly pre-treated cases of ocular inflammatory disease. PMID: 27003323 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Treatment of Non-infectious Uveitic Macular Edema with the Intravitreal Dexamethasone Implant.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: The dexamethasone intravitreal implant can be safely used to treat ME due to non-infectious uveitis, but with a limited and short effect on BCVA. PMID: 27003221 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Visual Functioning and Health-related Quality-of-Life are Compromised in Patients with Uveitis.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Patients with uveitis have significantly poorer VR- and HR-QoL than healthy control subjects. Uveitis has a more debilitating impact on VR-QoL than DR. PMID: 27002552 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Does the Microbiome Cause B27-related Acute Anterior Uveitis?

Fri, 25 Mar 2016 06:34:02 +0100

Authors: Rosenbaum JT, Lin P, Asquith M Abstract The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets. PMID: 27002532 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: T-cell IOL has variable clinical manifestations and prognosis. Systemic involvement, SRD, and vitreoretinal involvement were frequently observed. PMID: 27002464 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Serum Vitamin D Levels in Patients with Acute Anterior Uveitis.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: We found significantly low serum levels of vitamin D in patients with AAU, which suggest that vitamin D deficiency may play a role in the pathogenesis of anterior uveitis. Further studies are necessary to demonstrate the efficacy of vitamin D supplementation in the management of patients with anterior uveitis. PMID: 27002415 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Reason of Choroidal Thickening in Rheumatoid Arthritis May be Temperature Rise of the Body.

Fri, 25 Mar 2016 06:34:02 +0100

Authors: Kaya A, Sağdiç SK, Topal T PMID: 27002345 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)