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Preview: Breast cancer blog from medicineworld.org

Breast cancer blog from medicineworld.org



Breast cancer blog from medicineworld.org adds a personal touch to the stories related to breast cancer. This breast cancer blog brings you stories of hope, stories of survivors and latest news and research related to breast cancer.



Last Build Date: Mon, 12 Jan 2009 12:24:09 GMT

 



Insulin levels may have a say in breast cancer risk

Mon, 12 Jan 2009 12:24:09 GMT

(image) Higher-than-normal levels of insulin place postmenopausal women at increased risk of breast cancer, scientists at Albert Einstein College of Medicine of Yeshiva University report. Their findings, reported in the January 7 issue of the Journal of the National Cancer Institute, suggest that interventions that target insulin and its signaling pathways may decrease breast cancer risk in these women........



Structure of key breast cancer target enzyme

Mon, 12 Jan 2009 12:24:09 GMT

(image) The molecular details of Aromatase, the key enzyme mandatory for the body to make estrogen, are no longer a mystery thanks to the structural biology work done by the Ghosh lab at the Hauptman-Woodward Medical Research Institute (HWI) in Buffalo, New York. Dr. Debashis Ghosh's solution of the three-dimensional structure of aromatase is the first time that researchers have been able to visualize the mechanism of synthesizing estrogen........



Breast Cancer Gene Linked To Disease Spread

Mon, 12 Jan 2009 12:24:09 GMT

(image) A team of scientists at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all patients with breast cancer, spreading the disease, resisting traditional chemotherapies and eventually leading to death. The gene, called "Metadherin" or MTDH, is located in a small region of human chromosome 8 and may be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to blood vessels in distant organs. The gene also makes tumors more resistant to the powerful chemotherapeutic agents normally used to wipe out the deadly cells........



Preventing breast cancer with broccoli

Mon, 12 Jan 2009 12:24:09 GMT

(image) Women should go for the broccoli when the relish tray comes around during holiday celebrations this season. While it has been known for some time that eating cruciferous vegetables, such as broccoli, cauliflower, and cabbage, can help prevent breast cancer, the mechanism by which the active substances in these vegetables inhibit cell proliferation was unknown until now........



Obesity and Lymphedema Risk in Breast Cancer

Mon, 12 Jan 2009 12:24:09 GMT

(image) Throughout the world, 10 million breast cancer survivors have a lifetime risk for developing lymphedema, a chronic condition that involves swelling of the limbs and impacts physical and psychosocial health. Second only to the recurrence of cancer, it is the most dreaded effect of breast cancer therapy. In a new study, University of Missouri scientists observed that the risk of developing lymphedema is 40 percent to 60 percent higher in women with body mass index (BMI) classified as overweight or obese in comparison to normal weight women. The scientists recommend increased health education for breast cancer survivors........



Breast cancer genome shows evolution

Mon, 12 Jan 2009 12:24:09 GMT

(image) A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said scientists at Baylor College of Medicine in a report that appears online in the journal Genome Research "It's like a computer program that has become buggy and transcends into something dangerous," said Dr. Aleksandar Milosavljevic, associate professor in the BCM Human Genome Sequencing Center. "It makes the cell escape normal controls on cell proliferation. Experimentally, some of the rearrangements in the genome that we found produce fusion genes that confer uncontrolled cell growth and prevent tumor cells from dying, allowing them to grow outside their normal tissue environment. These are all essential attributes of cancer"........



Meta-analyses finds in favor of aromatase inhibitors

Mon, 12 Jan 2009 12:24:09 GMT

(image) Two separate meta-analyses of clinical trials from around the world that tested tamoxifen against aromatase inhibitor drugs in postmenopausal women with early breast cancer have each reached the same conclusion: aromatase inhibitors are more effective in preventing breast cancer from coming back. Patients using aromatase inhibitors had more than a 3 percent lower cancer recurrence 6-8 years after diagnosis, in comparison to women using tamoxifen alone........



Oldest old 'hanging in the balance?'

Mon, 12 Jan 2009 12:24:09 GMT

(image) A lack of clear-cut, scientific evidence illustrating the benefits of mammography screening in women over 80 has created a trail of controversy leading to a disturbing conclusion about cancer care in America. "We are ill-prepared from a scientific knowledge perspective to provide cancer health care rationally, ethically, equitably and humanely to the 'booming' older population," say two leading cancer researchers........



First international conference on inflammatory breast cancer

Mon, 12 Jan 2009 12:24:09 GMT

(image) The University of Texas M. D. Anderson Cancer Center will hold the first international inflammatory breast cancer (IBC) conference on December 6-7, to bring together internationally recognized breast cancer clinicians and scientists. Participants will present new clinical discoveries and participate in educational workshops, with the goal of improving diagnosis and management of this rare but deadly disease........



Calcium and vitamin D may not be the only protection

Mon, 12 Jan 2009 12:24:09 GMT

(image) Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones, as per a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM). The study observed that increasing the alkali content of the diet, with a pill or through a diet rich in fruits and vegetables has the opposite effect and strengthens skeletal health........



Novel basis identified for tamoxifen failure

Mon, 12 Jan 2009 12:24:09 GMT

(image) Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal Breast Cancer Research suggests that in patients who show reduced or absent expression of the protein E-cadherin, usually used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour........



New breast imaging technology targets hard-to-detect cancers

Mon, 12 Jan 2009 12:24:09 GMT

(image) Breast-specific gamma imaging (BSGI) is effective in the detection of cancers not found on mammograms or by clinical exam, as per a research studypresented today at the annual meeting of the Radiological Society of North America (RSNA). "BSGI can identify the most difficult to detect breast cancerinvasive lobular carcinoma," said lead author Rachel F. Brem, M.D., professor of radiology and director of the Breast Imaging and Interventional Center at The George Washington University Medical Center in Washington, D.C. "It also can help us detect additional lesions of all types of breast cancer in women whose mammograms show only one suspicious lesion.".......



Eating eggs when pregnant affects breast cancer in offspring

Mon, 12 Jan 2009 12:24:09 GMT

(image) A stunning discovery based on epigenetics (the inheritance of propensities acquired in the womb) reveals that consuming choline-a nutrient found in eggs and other foods-during pregnancy may significantly affect breast cancer outcomes for a mother's offspring. This finding by a team of biologists at Boston University is the first to link choline consumption during pregnancy to breast cancer. It also is the first to identify possible choline-related genetic changes that affect breast cancer survival rates........



Mammograms may detect some cancers that would have otherwise regressed

Mon, 12 Jan 2009 12:24:09 GMT

(image) Breast cancer rates increased significantly in four Norwegian counties after women there began undergoing mammography every two years, as per a report in the November 24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Rates among regularly screened women remained higher than rates among women of the same age who were screened only once after six years, suggesting that some of the cancers detected by mammography may have spontaneously regressed had they not been discovered and treated........



Causes of bone loss in breast cancer survivors

Mon, 12 Jan 2009 12:24:09 GMT

(image) Osteoporosis is a growing concern among breast cancer survivors and their doctors, because certain cancer drugs can cause bone loss. But a new study has observed that cancer drugs aren't the only culprits. Among 64 patients with breast cancer referred to a bone health clinic, 78 percent had at least one other cause of bone loss, including vitamin D deficiency, excessive calcium excretion in urine and an overactive parathyroid gland........



Psychological interventions associated with breast cancer survival

Mon, 12 Jan 2009 12:24:09 GMT

(image) A new study finds that patients with breast cancer who participate in intervention sessions focusing on improving mood, coping effectively, and altering health behaviors live longer than patients who do not receive such psychological support. Reported in the December 15, 2008 issue of CANCER, a peer-evaluated journal of the American Cancer Society, the study indicates that reducing the stress that can accompany cancer diagnosis and therapy can have a significant impact on patients' survival........