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PHOTODYNAMIC THERAPY USING IN SITU NONLINEAR PHOTON UPCONVERSION OF NIR LIGHT BY BIOLOGICAL MEDIUM

Thu, 23 Feb 2017 08:00:00 EST

Photodynamic therapy methods using near infrared light and visible-light-absorbing photosensitizers and methods of generating visible light in an individual. The methods use upconverted incident near infrared light, for example, to excite the photosensitizer or facilitate drug delivery. The methods can be carried out on humans and non-human animals.



Integumentary System Therapy

Thu, 23 Feb 2017 08:00:00 EST

Described are methods, kits, apparatus, and compositions for integumentary system therapy. For example, a method for therapy may include providing a subject in need of therapy for a condition. The condition may be associated with a substrate located in the subject's integumentary system. The method may include contacting a therapeutic agent and the substrate in the subject's integumentary system. The method may include modulating a depth of at least one ionic species in the subject's integumentary system. The at least one ionic species may include one or more of: the therapeutic agent; a bound therapeutic agent:substrate complex; and a reaction product of one or both of the therapeutic agent and the substrate. The method may be effective to at least partly ameliorate the condition in the subject.



PLASMA HYDROGEL THERAPY

Thu, 23 Feb 2017 08:00:00 EST

Disclosed herein is a plasma treatment method comprising: providing a plasma source and a screen comprising a hydrogel and positioning the screen between the plasma source and a surface of a target to be treated with the plasma such that substantially all of the plasma from the plasma source passes through the screen prior to contacting the surface of the target and the screen reduces the concentration of one or more species from the plasma; and/or contacting a surface of a target to be treated with the gel composition comprising a gel forming material and a liquid phase comprising plasma activated liquid.



WEARABLE SOAKING PHYSIOTHERAPEUTIC DEVICE WITH INFLATABLE SEAL

Thu, 23 Feb 2017 08:00:00 EST

A physiotherapeutic device comprises a skin soaker for soaking a portion of the user's skin with a liquid when the device is attached to the user. The soaker comprises a tub for receiving the liquid and a resilient seal at a brim of the tub for sealing engagement with the skin to prevent leak of the liquid. The device also has an electrical stimulator comprising a first electrode and a second electrode for contacting the skin to stimulate tissues under the soaked portion of the skin. The soaked portion of the skin extends between the electrodes and the electrodes are isolated from the liquid.



Apparatus for electrically mediated delivery of therapeutic agents

Thu, 23 Feb 2017 08:00:00 EST

Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to in a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.



DISINFECTING CAP

Thu, 23 Feb 2017 08:00:00 EST

A device for cleaning medical implements is disclosed, in particular a device for cleaning vascular or other fluid access sites. The device includes a cap having an opening to receive an access site. The cap may be used in the following manner: A healthcare worker may, with gloved hands, open the cap packaging and place the cap over the port of a medical implement to be cleaned. The healthcare worker may wipe the site by either applying a turning motion or by simply pushing the cap onto the port. The cap could then remain secured in place by threads other mechanisms. A cap in place on a medical implement may be a positive indication that a desired site of the medical implement is clean. The cap may include a disinfecting substance.



NEEDLELESS VALVE INFECTION PREVENTION AND PRE-OPENING DEVICE

Thu, 23 Feb 2017 08:00:00 EST

A disinfecting and pre-opening device is disclosed for use with a female needleless connector. The disinfecting and pre-opening device includes a housing comprising a chamber having a distal opening and configured to fit over the female needleless connector, and an elongated finger attached to the housing and disposed within the chamber such that the elongated finger opens the fluid path through the female needleless connector when the distal opening of the disinfecting and pre-opening device is placed proximally adjacent to the septum and the disinfecting and pre-opening device is advanced in the distal direction.



COUPLING DEVICES FOR TUBE SETS USED WITH SURGICAL GAS DELIVERY SYSTEMS

Thu, 23 Feb 2017 08:00:00 EST

A coupling system is disclosed for connecting a tube set to a trocar that includes a multi-lumen trocar having a housing that has a connector extending outwardly from the housing, the connector having a plurality of coaxial flow passages defined therein by a plurality of concentric annular walls, a multi-lumen tube set including a plurality of tubes arranged in a parallel relationship, a coupling including a generally cylindrical body having a first end portion adapted and configured to selectively mate with the coaxial flow passages of the connector of the trocar and a second end portion adapted and configured for attachment to the parallel tubes of the tube set, and a latch assembly operatively associated with the cylindrical body of the coupling for selectively engaging the connector of the trocar housing when the coupling mates with the connector.



Microneedles and Methods of Manufacture Thereof

Thu, 23 Feb 2017 08:00:00 EST

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.



SPACE-EFFICIENT CONTAINMENT DEVICES AND METHOD OF MAKING SAME

Thu, 23 Feb 2017 08:00:00 EST

Containment devices and methods of manufacture and assembly are provided. In an embodiment, the device includes at least one microchip element, which includes a containment reservoir that can be electrically activated to open, and a first electronic printed circuit board (PCB) which comprises a biocompatible substrate. The first PCB may have a first side on which one or more electronic components are fixed and an opposed second side on which the microchip element is fixed in electrical connection to the one or more electronic components. The device may further include a second PCB and a housing ring securing the first PCB together with the second PCB. The microchip element may include a plurality of containment reservoirs, which may be microreservoirs, and/or which may contain a drug formulation or a sensor element.



METHODS FOR IMPROVING DRUG EFFICACY

Thu, 23 Feb 2017 08:00:00 EST

The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.



MEDICAMENT APPLICATOR

Thu, 23 Feb 2017 08:00:00 EST

Apparatus and methods for inserting a medicament into a body cavity are described. The apparatus comprises an elongate tube with a plunger rod therein. The plunger rod has at least one projection which cooperatively interacts or engages with at least one discontinuity on the inside of the elongate tube so that proximal movement of the plunger rod with respect to the elongate tube expels the medicament into the body cavity.



SYSTEM FOR MARKING A LOCATION FOR TREATMENT WITHIN THE GASTROINTESTINAL TRACT

Thu, 23 Feb 2017 08:00:00 EST

A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract.



SWALLOWABLE DRUG DELIVERY DEVICE AND METHODS OF DRUG DELIVERY

Thu, 23 Feb 2017 08:00:00 EST

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.



PERFUSION CATHETERS AND RELATED METHODS

Thu, 23 Feb 2017 08:00:00 EST

This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other.



DUAL BALLOON DUAL SYRINGE DELIVERY DEVICE AND METHOD OF USE

Thu, 23 Feb 2017 08:00:00 EST

The present invention relates to a dual balloon catheter with controlled expansion and solution flow, a multi-port manifold and a dual syringe delivery device and method with intended use in sclerotherapy.



BALLOON DILATION CATHETER FOR USE IN SINUS PASSAGEWAYS

Thu, 23 Feb 2017 08:00:00 EST

A balloon dilation catheter includes a substantially rigid inner guide member and a movable shaft coupled to a balloon that is slidably mounted on the substantially rigid inner guide member. To treat a sinus cavity of a subject using the balloon dilation the substantially rigid inner guide member is advanced into a drainage pathway of the sinus (e.g., frontal recess) of the subject via a nasal passageway. The shaft and balloon are advanced in a distal direction over the substantially rigid inner guide member to place the balloon in the drainage pathway. The balloon is inflated to expand or otherwise remodel the drainage pathway.



ANCHORED GUIDEWIRE WITH MARKINGS TO FACILITATE ALIGNMENT

Thu, 23 Feb 2017 08:00:00 EST

An apparatus for treating a treatment area in the vasculature using a catheter, such as one designed to deliver a payload (such as a therapeutic agent (e.g., a drug, such as paclitaxel, rapamycin, heparin and the like), a stent, a stent graft, or a combination thereof) or a working element (such as a cutter, focused force wire, or the like) to a specified location within the vasculature. The catheter may include at least one first radiopaque marking. A guidewire (26) for guiding the catheter to the treatment area includes an anchor (26a) for selectively anchoring the guidewire to the vasculature, and at least one second radiopaque marking (26b) for corresponding to the at least one first radiopaque marking of the catheter when positioned at the treatment area.



SAFE CATHETER

Thu, 23 Feb 2017 08:00:00 EST

Provided is a catheter, which can protect a medical personnel and a patient from a needle stick injury when it is disposed of after use. In an example embodiment, the catheter includes a needle, a plug having a front end coupled to the needle, a first case formed to enclose the needle, a socket coupled to a front end of the first case, a gear vertically coupling the first case and the socket to each other and having a tooth formed on an outer periphery of one side and a needle groove formed therein to allow the needle to pass therethrough, a catheter hub fastened by the tooth of the gear, and a tube coupled to the front end of the catheter hub.



SAFETY DEVICE FOR A HOLLOW MEDICAL NEEDLE

Thu, 23 Feb 2017 08:00:00 EST

Method, system and device involving a needle device with a needle safety element with improved stable structure. A frame can surround the needle safety element to provide added stiffening of the needle safety element. The frame can include stays extending laterally of the needle safety element. The needle safety element with the frame can be slidably located on a needle and in a catheter hub in a ready to use position and be removable from the catheter hub in a protective position.



ANTI-BEND CATHETER BRACE

Thu, 23 Feb 2017 08:00:00 EST

An anti-bend catheter brace includes a disk-like pad having a peripheral edge therearound, a topside and a substantially planar underside, and strapping configured to hold the pad over tissue surrounding the subcutaneous catheter while maintaining substantial planarity of the underside and a region of tissue thereunder.



HEMOSTASIS VALVE FOR GUIDE CATHETER CONTROL

Thu, 23 Feb 2017 08:00:00 EST

An extension member is has a body with a proximal end and an opposing distal end. It includes a hollow lumen extending therethrough from the proximal end to the distal end. It has a female luer lock connector proximate its proximal end and a male luer lock connector proximate its distal end. Its body has an outer surface with a driven member.



ECHOGENIC PROBE

Thu, 23 Feb 2017 08:00:00 EST

Echogenic markers can be applied to probes such as medical needles, including radiofrequency cannulae, injection needles, biopsy needles, microwave antennae, and spinal needles, among others. For example, in certain embodiments, the probes may have a distal end, a proximal end, a shaft, and an echogenic feature in the form of one or more indentations on the shaft. In certain embodiments, the probes may have a first echogenic feature in the form of an indentation in a surface of the probe and a second echogenic feature in the form of a roughening of the surface of the probe.



DEVICES FOR DELIVERING SUBSTANCES THROUGH AN EXTRA-ANATOMIC OPENING CREATED IN AN AIRWAY

Thu, 23 Feb 2017 08:00:00 EST

Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.



DEVICES AND METHODS FOR ENDOVASCULAR ACCESS AND THERAPY

Thu, 23 Feb 2017 08:00:00 EST

The present invention provides for devices and methods for providing endovascular therapy, including facilitating establishment of vascular access, placement of endovascular sheaths, catheter tip localization, and administration of vascular occlusion. The inventions includes a vessel cannulation device, an expandable sheath, an occlusion catheter, and a localizer each of which may be provided separately or used as part of a system.



METHODS AND KITS FOR TREATING DYSMOTILITY

Thu, 23 Feb 2017 08:00:00 EST

Described herein are methods and kits for treating dysmotility. Certain methods for treating dysmotility involve delivering a local anesthetic to at least one of the greater, lesser or least splanchnic nerves of a patient having dysmotility, or to the celiac plexus of the patient having dysmotility, to thereby reduce symptoms of dysmotility. Other method for treating dysmotility involve ablating a portion of at least one of the greater, lesser or least splanchnic nerves of a patient having dysmotility, to thereby reduce symptoms of dysmotility. Certain kits are for use in performing splanchnic nerve block or celiac plexus block to treat dysmotility. Other kits are for use in performing splanchnic nerve ablation to treat dysmotility.



Hydration System

Thu, 23 Feb 2017 08:00:00 EST

A medical gas condition system for supplying a liquid hydration fluid to a hydrator before or during an ongoing medical procedure by coupling the flow of liquid hydration fluid into the hydrator to either the absence of flow of medical insufflation gas into the hydrator or to a condition where the liquid hydration fluid can be absorbed by a hydrator without being forced through the hydrator in liquid form.



SMART CONNECTION INTERFACE

Thu, 23 Feb 2017 08:00:00 EST

A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.



INTEGRATED NEEDLE AND CANNULA FOR PLASTIC SURGERY

Thu, 23 Feb 2017 08:00:00 EST

An integrated needle and cannula assembly for plastic surgery including a syringe connected to a blunt-tipped cannula where the blunt-tipped cannula is inserted into the hollow annular space of a hypodermic needle. In operation, the medical practitioner penetrates into the patient's skin using the hypodermic needle and then slides the blunt-tipped cannula through the annular space of the needle. A transporter assembly can be interposed between the syringe and the overlapping needle/cannula. The transporter assembly may include a retractable inner needle tube attached to the hypodermic needle and an external transporter housing which connects the syringe to the cannula through a cannula connector. Once the blunt tipped cannula is under the patient's skin, the needle is preferably withdrawn from the patient's skin to allow sub-dermal substances to be injected using only the blunt-tipped cannula. Withdrawal of the needle can be assisted with either a pull spring or push spring. In an alternative embodiment, a sharp-tipped trocar inside a cannula is used to penetrate the patient's skin. In a further alternative embodiment, a barbed surgical thread may be attached to said cannula to perform thread-lift procedures.



Device for percutaneous delivery of therapeutic agents, and a method for its use

Thu, 23 Feb 2017 08:00:00 EST

A device for percutaneous delivery of therapeutic agents includes a first wheel having an axis of rotation, a first axial surface rotably mounted on the head, a second axial surface, an outer surface, and a plurality of needles disposed upon the outer surface, each needle having a tip projecting away from the axis of rotation of the wheel. The device includes a second wheel having an axis of rotation, a first axial surface affixed to the second axial surface of the first wheel, a second axial surface, an outer surface, and a plurality of needles disposed upon the outer surface, each needle having a tip projecting away from the axis of rotation.



NEEDLE SAFETY SHIELD

Thu, 23 Feb 2017 08:00:00 EST

A needle safety shield assembly for an injector comprises: a needle shield (231) for shielding a needle of the injector; and a shield locking means comprising a track (233, 236) adapted to engage with a runner (224), the track comprising at least one unidirectional barrier (232, 237) through which the runner can pass; in which movement of the needle shield to expose the needle for use and to subsequently re-shield the needle causes movement of the runner (224) along the track (233, 236) through the at least one unidirectional barrier (232, 237) and into a locked position in which further movement of the runner and needle shield is prevented.



INDICATOR

Thu, 23 Feb 2017 08:00:00 EST

An auto-injector for delivering a liquid medicament comprises: a collapsible container for containing the liquid medicament (26); an openable closure; and an elongate indication member (21) located at least partially within the rigid outer container (22) and arranged to move longitudinally towards the distal end of the collapsible container when the openable closure is opened, in which longitudinal movement of the elongate indication member (21) produces visual, and/or audio and/or tactile feedback relating to injection progress to a user of the auto-injector.



LENGTH-REDUCING SYRINGE DRIVING DEVICE

Thu, 23 Feb 2017 08:00:00 EST

Disclosed herein is a length-reducing syringe driving device, the length-reducing syringe driving device wherein a drive for syringe device is installed at a syringe device (10), and pushes and drives a piston (12) equipped at an injection cartridge (11) which has a discharging outlet (13) at one dead end thereof. The length-reducing syringe driving device (100) comprises: a rotation driving part (110) installed at one or more places at an outer sidewall surface at the other dead end of the injection cartridge (11); and a one-way bending member (120) provided to be contacted to the piston (12) at one dead end thereof, configured to be bended exclusively to one direction, and having a sidewall surface of a bending direction driven by the rotation driving part (110) and pushing the piston (12).In the present invention, main elements of the invention are disposed at an outer sidewall surface of an injection cartridge and the entire length (L) of a driving device is remarkably reduced when having the same stroke. Therefore, it is to provide a syringe device which is convenient to be carried and to make syringe devices having many different embodiments possible.



COAXIAL PISTON INJECTOR

Thu, 23 Feb 2017 08:00:00 EST

An apparatus for delivering an injectate to a patient includes a piston mechanism including an outer piston. The outer piston is slideably disposed in a chamber of the apparatus and has a channel extending therethrough. The piston mechanism also includes an inner piston including a stop and a plunger element, the plunger element being slideably disposed in the channel of the outer piston. The piston mechanism is configurable into a number of configurations including a first configuration in which the stop of the inner piston is not in contact with the outer piston such that the inner piston is movable in the channel without causing movement of the outer piston and a second configuration in which the stop of the inner piston is in contact with the outer piston such that the inner piston and the outer piston move together in the chamber.



WET INJECTION DETECTION AND PREVENTION SYSTEM AND METHOD

Thu, 23 Feb 2017 08:00:00 EST

In an embodiment, a medicament delivery system is provided. The medicament delivery system includes a container for storing a medicament prior to use, the container having a first end and a second end, an injection member in fluid communication with the container, an actuation mechanism associated with the container and configured to deliver the medicament from the container through the injection member when the actuation mechanism is activated. The medicament delivery system further includes at least one detection element associated with the system, wherein in a first mode of operation of the system, medicament is delivered through the injection member and in a second mode of operation of the system, medicament is not delivered through the injection member, and the mode of operation is dependent on an output from the at least one detection element.



PERSONALIZED PARAMETER MODELING METHODS AND RELATED DEVICES AND SYSTEMS

Thu, 23 Feb 2017 08:00:00 EST

Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method involves obtaining, by a computing device, historical measurements of a condition in a body of the patient previously provided by a sensing device, obtaining, by the computing device, historical operational context information associated with preceding operation of one or more of an infusion device and the sensing device, obtaining, by the computing device, historical values for a parameter from one or more of the infusion device and the sensing device, determining, by the computing device a patient-specific model of the parameter based on relationships between the historical measurements, the historical operational context information and the historical values, and providing, by the computing device via a network, the patient-specific model to one of the infusion device, the sensing device or a client device.



PERSONALIZED PARAMETER MODELING METHODS AND RELATED DEVICES AND SYSTEMS

Thu, 23 Feb 2017 08:00:00 EST

Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.



METHODS FOR PROVIDING SENSOR SITE ROTATION FEEDBACK AND RELATED INFUSION DEVICES AND SYSTEMS

Thu, 23 Feb 2017 08:00:00 EST

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves identifying a current site location on the body of the user associated with a sensing arrangement providing sensed measurements of a physiological condition in the body of the user at the current site location, determining one or more performance metrics associated with the current site location corresponding to operation of the infusion device to deliver the fluid in response to the sensed measurements, and providing sensor site feedback in a manner that is influenced by the one or more performance metrics. In one or more embodiments, the sensor site feedback includes recommended sensor site locations for rotation or replacement of the sensing arrangement determined based on historical data associated with the user for different sensor site locations.



INFUSION DEVICES AND RELATED PATIENT RATIO ADJUSTMENT METHODS

Thu, 23 Feb 2017 08:00:00 EST

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.



Infusion Pump with Program Key

Thu, 23 Feb 2017 08:00:00 EST

A wearable infusion pump allows a user to insert a program key into the device housing to select a continuous dosage rate. The program keys are shaped to close contacts on a printed circuit board within the housing to communicate the selected dosage to a microprocessor. In this way, a single disposable pump, sold with one SKU, can be used to deliver a plurality of dosage rates. The disposable pump is provided with on-board display and one-button on-board user operable control. In preferred embodiments, the infusion pump according to the invention may be used for the continuous delivery of insulin in the management of Type II diabetes.



Automatic Catheter Recognition and Associated Methods, Systems and Circuits

Thu, 23 Feb 2017 08:00:00 EST

Disclosed is a medical device for pumping fluid through a conduit, the pump including: one or more sensors to detect a parameter associated with the fluid; a circuit to (a) receive from the sensor a first signal indicative of one or more characteristics associated with the fluid; and (b) to determine if an occlusion is indicated based on a signal analysis of the first signal.



Drug Delivery Device

Thu, 23 Feb 2017 08:00:00 EST

The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and, an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.



DRIVE MECHANISM FOR INFUSION PUMP

Thu, 23 Feb 2017 08:00:00 EST

A patch pump utilizes piezoelectricity to dispense medicament from a cartridge syringe to a patient. Pump can include a plurality of piezoelectric elements that when energized cause linear motion of a pushrod that interfaces with the syringe in the cartridge to advance the syringe and dispense the medicament. The high torque generated by the piezoelectric elements is directly converted into the same amount of torque on the lead screw, so no torque increasing gear reduction system is needed and the pushrod utilized to drive the syringe can be contained within and connected directly to the motor assembly. Such a piezoelectric-based system can therefore be made smaller and with fewer moving parts than an electromagnetic motor of the same capability such that the pump has a smaller size than has heretofore been possible with prior art electromagnetic-based syringe pumps and other pumps that utilize gear reduction systems.



APPARATUS AND METHODS FOR SELF-ADMINISTRATION OF VACCINES AND OTHER MEDICAMENTS

Thu, 23 Feb 2017 08:00:00 EST

A medicament delivery device includes a housing, a medicament container disposed within the housing, an activation mechanism, a cover and an electronic circuit system. The activation mechanism includes an energy storage member configured to produce a force to deliver the dose of a medicament and/or vaccine. The cover is configured to receive at least a portion of the housing. The electronic circuit system is coupled to the housing such that a protrusion of the cover electrically isolates a battery from a portion of the electronic circuit system when the portion of the housing is received by the cover. The electronic circuit system is configured to be electrically coupled to the battery and to produce a recorded speech output when the portion of the housing is at least partially removed from the cover. The electronic circuit system configured to produce a signal when the activation mechanism is actuated.



ENEMA DISPENSER

Thu, 23 Feb 2017 08:00:00 EST

An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.



Apparatuses and Methods for Improving Post-Operative Recovery From Surgery

Thu, 23 Feb 2017 08:00:00 EST

This disclosure relates to apparatuses and methods for preventing the onset and progression of POI. In one example, a fan-like polyurethane heat-sealed bilayer that surrounds a plurality of wedge-shaped foam strips that join at a collecting foam portion, is subjected to negative pressure provided through silicone tubing which is sealed to the perforated collecting foam portion. Such negative pressure applied for approximately 48 to 72 hours after closure of the abdomen, helps prevent POI which in turn enhances patient recovery, and reduces the length of their hospital stay.



LIPOSUCTION DEVICE AND SYSTEM AND USE THEREOF

Thu, 23 Feb 2017 08:00:00 EST

Embodiments of the present invention disclose a device for removing adipose tissue with a needle(s), comprising a needle hub that comprises at least one needle that contains between 1-1000 holes around the diameter of the needle barrel which allows passage of adipose tissue and other lipoaspirate, and an adipose tissue collection and purification device comprising a plurality of self contained syringes wherein each of the syringes comprises an inner syringe included within an outer syringe and wherein a filter is attached inside the outer syringe barrel, the filter having a mesh pore size between 30 micro meters and 1000 micro meters, the device being attached to a needle hub. The present invention furhter provides a system for closed adipose tissue harvesting, purficiation, and grafting, comrpising an adipose tissue removal component, a collection and purification component, and a grafting component. Methods of using the devices or system are also disclosed.



Cell Membrane Translocation of Regulated Snare Inhibitors, Compositions Therefor, and Methods for Treatment of Disease

Thu, 23 Feb 2017 08:00:00 EST

Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, and transduction domains.



METHODS AND COMPOSITIONS FOR TREATING ROSACEA

Thu, 23 Feb 2017 08:00:00 EST

There is provided a method for treating rosacea comprising a composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.



TRANSDERMAL DELIVERY SYSTEM COMPRISING BUPRENORPHINE

Thu, 23 Feb 2017 08:00:00 EST

The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer.