Thu, 27 Oct 2016 08:00:00 EDTDisclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
Thu, 27 Oct 2016 08:00:00 EDTAn antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
Thu, 27 Oct 2016 08:00:00 EDTThe invention relates to a device for the cosmetic treatment of keratin materials with an electric current, comprising at least: —a power supply system (1), —a reservoir (3) containing a cosmetic composition (P), —an end piece (2) comprising an electrode (4) and at least one applicator member (6, 7), said applicator member (6, 7) delimiting an outer wall (61, 71) that is able to be filled with product contained in the reservoir (3), —a counter electrode (5), —a system for regulating the quantity of composition (P) exiting the reservoir (3) on the basis of the impedance measured between the electrode (4) and the keratin materials, the electrode (4) and the applicator member (6, 7) being designed such that the composition (P) is the only conductive substance in contact with the skin while the device is being used.
Thu, 27 Oct 2016 08:00:00 EDTThe invention relates to a device for the cosmetic treatment of keratin materials with an electric current, comprising: —an end piece (25) comprising at least two electrodes (101, 102) connected to the same polarities of at least one current generator, —at least one counter electrode (60), —a power supply system (13), the electrodes (101, 102) being managed independently of one another by the power supply system (13).
Thu, 27 Oct 2016 08:00:00 EDTEmbodiments of a tamper-proof adapter can be configured to provide interconnection of medical tubing or other devices with varying fitting or coupling types. In one embodiment, the adapter can permanently couple a first male Luer fitting to a second male ISO 80639-6 compliant fitting.
Thu, 27 Oct 2016 08:00:00 EDTAn assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. The tabs may be retained on the carrier by friction fit into the holes of the carrier. The carrier may also include a mounting hole to hang on a pole of an IV line.
Thu, 27 Oct 2016 08:00:00 EDTA medical valve assembly includes a tube extending between proximal and distal tube ends. A plunger plate extends radially from the distal tube end, and a valve housing surrounds the tube and extends between proximal and distal valve housing ends. The valve housing includes a flange extending radially inwardly from the distal valve housing end and disposed in spaced relationship with the plunger plate to define a distance dimension D extending therebetween. An elastomeric seal is compressed between the plunger plate and the flange to establish a closed condition of the medical valve assembly. The elastomeric seal axially moves one of the valve housing and the tube relative to the other when a medical device is inserted into the medical valve assembly to automatically increase the distance dimension and establish an open and sealed condition of the medical valve assembly with the inserted medical valve.
Thu, 27 Oct 2016 08:00:00 EDTThe invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.
Thu, 27 Oct 2016 08:00:00 EDTAn eyelid margin wipe comprising chemical means for adjusting the temperature of the wipe relative to the ambient temperature. The wipe is particularly useful for treatment of disorders of the eyelid or eyelid margin such as meibomian gland dysfunction.
Thu, 27 Oct 2016 08:00:00 EDTDrug delivery devices having a drug-permeable component and methods of making and using the same are provided. Drug delivery devices include a housing having a first and second wall structures that are adjacent one another and together form a tube defining a drug reservoir lumen. The second wall structure, or both the first wall structure and the second wall structure, are permeable to water, and the first wall structure is impermeable to the drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.
Thu, 27 Oct 2016 08:00:00 EDTAlzheimer's disease is a neurological disorder marked by progressive memory and cognitive impairments that eventually result in death. Currently, there are no effective therapies or cures that slow or halt the relentless progression of Alzheimer's disease. The invention teaches that the underlying mechanism responsible for the initiation of Alzheimer's disease is due to the insufficient flow of cerebrospinal fluid through apertures in the cribriform plate. The cribriform plate is a flat bony structure at the top of the nasal cavity directly below the olfactory bulbs. Naturally occurring apertures in the cribriform plate provide conduits for cranial nerve 1 fibers passing from the olfactory epithelium below, into the olfactory bulb above. Cerebrospinal fluid in the extracellular compartment above seeps through these apertures and into the nasal submucosa below, where it is removed by lymphatic vessels. This outflow allows cerebrospinal fluid to flow into the olfactory bulbs from continguous brain structures that include the basal forebrain and medial temporal lobe. Cerebrospinal fluid flow along this route removes metabolites and debris from those regions of the brain, including factors that accumulate in the early stages of Alzheimer's disease. Obstructions of cribriform plate apertures reduce or stop this outflow of cerebrospinal fluid, resulting in the accumulation of plaques and tangles and other Alzheimer's disease related pathologies. The invention teaches that patients with Alzheimer's disease and other forms of dementia can be treated by inserting shunts that facilitate the outflow of cerebrospinal fluid from an area above the cribriform plate to other parts of the body including but not limited to other regions of the brain, the nasal submucosa, the peritoneal cavity, and the pleural cavity. It provides a method of treating any patient in need thereof for neurological or psychiatric disease. The invention teaches how shunts can be configured and implanted with two independent claims and five dependent claims.
Thu, 27 Oct 2016 08:00:00 EDTAn apparatus comprises an absorbent body, a non-permeable feature, and a port feature. The absorbent body comprises a wicking feature. The non-permeable feature is coupled with the absorbent body. The non-permeable feature and at least a portion of the absorbent body are configured to fit in an opening in a paranasal sinus wall. The port feature extends through the absorbent body. The port feature defines a lumen. The wicking feature extends outwardly relative to the port lumen. During installation of the apparatus, the non-permeable feature is positioned in an opening in the paranasal sinus wall. The absorbent body is oriented such that the wicking feature is in contact with mucosal tissue in a sinus cavity defined by the paranasal sinus wall. A proximal portion of the absorbent body is positioned outside the paranasal sinus wall.
Thu, 27 Oct 2016 08:00:00 EDTA device for draining bodily fluids is described herein which generally may comprise an elongate body defining one or more lumens configured to receive a bodily fluid from a cavity, e.g., bladder, of a patient body. The one or more lumens are in fluid communication with a reservoir which may receive the bodily fluid. A pumping mechanism may be used to urge the bodily fluid through the one or more lumens, where the pumping mechanism is configured to maintain an open space within the one or more lumens such that outflow of the bodily fluid through the one or more lumens remains unobstructed such that a negative pressure buildup in the cavity is inhibited. The device may also include a vent or valve mechanism in communication with the elongate body to allow air to enter or exit the one or more lumens.
Thu, 27 Oct 2016 08:00:00 EDTA method and an article of manufacture are presented for stimulation of cervical canal, induction of labor, monitoring and control of reproductive system conditions. This specification provides an inflatable system, with one or more balloons that are configured to keep the system in an exact position within woman's reproductive system, monitor pressures inside uterus, control pressures inside uterus, exert controllable pressure on the cervical canal walls, stimulate cervical canal, monitor pressures inside cervical canal, and, if desired, rupture amniotic sac, and the like. In an embodiment a uterine balloon is positioned inside the uterus adjacent to the cervical internal OS; a vaginal balloon is positioned in the vagina for applying pressure on the external cervical OS; and a cervical balloon is positioned in the cervical canal. One or more balloons may be inflated by nontoxic fluids to accurately sense and/or control the intracorporeal pressures by extracorporeal sensors and devices.
Thu, 27 Oct 2016 08:00:00 EDTA guide wire having a non-metallic, non-woven core wire is disclosed. Monofilar, polymeric fibers of multifilar helically-wound non-metallic fibers are preferred core wire materials. The guide wire optionally includes further coatings and other materials on the core wire. In one embodiment, a non-metallic distal coil wire is disclosed. The guide wire of this invention is particularly useable for magnetic resonance imaging applications.
Thu, 27 Oct 2016 08:00:00 EDTA needle retraction apparatus comprising a body having a forwardly projecting needle, a needle retraction mechanism seated inside the body and biasing the needle rearwardly relative to the body, a slide member attachable to the body and having an opening communicating with a needle retraction cavity projecting away from the body, and an actuator rotatable relative to the slide member to reposition the slide member from a first position preventing needle retraction to a second position permitting needle retraction. An IV catheter introducer comprising the subject needle retraction apparatus is also disclosed.
Thu, 27 Oct 2016 08:00:00 EDTNeedle devices are disclosed in which a needle having a wall defining a needle lumen has a notch (120) formed through the wall. A transparent or semi-opaque window cover (130) made from a biocompatible material is provided over the notch. Blood flow through the needle lumen can be viewed through the notch with the window cover. The needle with the notch and window cover may be used with a variety of needle applications, including as catheter assemblies, indwelling assemblies, and most if not all over-the-needle type devices.
Thu, 27 Oct 2016 08:00:00 EDTA steering tool (200) includes an internal tube (12) disposed inside an external tube (14). The internal and external tubes are arranged for longitudinal axial movement relative to one another. A distal end of the internal tube is fixedly joined to a distal end of the external tube. At least one of the internal and external tubes is slotted near the distal end thereof, and the longitudinal axial movement causes bending of the distal ends of the tubes.
Thu, 27 Oct 2016 08:00:00 EDTA catheter assembly includes a pull wire and a control member subassembly, wherein the pull wire is secured to a post of the subassembly that may extend through a slot of a handle, and an engagement feature of the subassembly, being supported by an elastically deformable support of the subassembly resting on a railway of the handle, confronts a mating feature of the handle to interlock therewith, responsive to the support being un-deformed. The post, engagement feature, and support may be integrally formed together in a single-piece component, wherein the engagement feature may be one or two rows of teeth formed in a surface of an upper portion of the component, and the support may be a pair of flexible cantilever beam members of a lower portion of the component. Furthermore, the mating surface and railway may be integrally formed in an inner surface of a shell of the handle.
Thu, 27 Oct 2016 08:00:00 EDTA pharmaceutical injection device may comprise a main body case in the interior of which a pharmaceutical syringe can be mounted; a drive means that is provided inside the main body case and pushes out the pharmaceutical inside the pharmaceutical syringe through a syringe needle; a cover that opens and closes an opening on the side of the main body case where the syringe needle is mounted; an outside air temperature sensor that measures a first temperature, which is the temperature outside the main body case; a display component; and a controller that controls the drive means and the display component and acquires the first temperature at predetermined intervals. When the cover is closed, the controller causes the display component to display information about the storage state of the pharmaceutical in the mounted pharmaceutical syringe on the basis of the first temperature.
Thu, 27 Oct 2016 08:00:00 EDTA bandage has a first section having a first section adhesive backing formed on a rear surface of the first section. An opening is formed through a central area of the first section. An indicator is formed on a front surface of the first section showing when an area around and in the opening has been sterilized. A cover member is attached to the first section closing the opening
Thu, 27 Oct 2016 08:00:00 EDTA method for manufacturing a needle tapered along the longitudinal direction by electroforming comprises: a step of immersing a core material (122) having an outer peripheral surface that is tapered along the longitudinal direction in an electrolyte and forming a first electroformed body (126) on an outer peripheral surface (124) of the core material (122); a step of immersing the first electroformed body (126) in an electrolyte to which particles having a prescribed particle size are added and forming a second electroformed body (134) having multiple protrusions (30) on an outer peripheral surface (128) of the first electroformed body (126); a step of cutting the first electroformed body (126) and second electroformed body (134) into a prescribed length and forming a needle (10) having a sharp needle tip (16); and a step of pulling out the core material (122) from the cut first electroformed body (126).
Thu, 27 Oct 2016 08:00:00 EDTA retractable needle device attachable to the front of a fluid collection or infusion device such as a syringe, the retractable needle device comprising a housing having an engagement member, a slide support surface, a retraction cavity and a first pinch surface; a needle; a needle alignment member comprising a needle tube and a second pinch surface; and a needle retraction mechanism positioned within the needle tube and configured to bias the needle rearwardly; wherein the first and second pinch surfaces are configured so that a pinching force applied to them will cause relative lateral movement between the housing and needle alignment member. This translational movement from an injection position, wherein the needle is aligned with the syringe connector, to a retraction position, wherein the needle is aligned with the retraction cavity, allows the needle retraction mechanism to force the needle into the retraction cavity.
Thu, 27 Oct 2016 08:00:00 EDTDescribed is a cap (60) for covering a needle shield (29) on a needle (26) of a medicament container (20), the cap (60) comprising a cylindrical portion (61) having a first outer diameter, a disc portion (62) disposed on a distal end of the cylindical portion (61), the disc portion (62) having a second outer diameter larger than the first outer diameter; and a gripping surface (63) disposed on an inner surface of the cylindiral portion (61) and adapted to frictionally engage a needle shield (29) on a needle (26).
Thu, 27 Oct 2016 08:00:00 EDTInjection device comprising a tubular elongated main body, a needle shield slidably arranged in said main body, a needle shield link slidably connected to said needle shield, a enclosure containing medicament arranged in said main body, a needle connected to said enclosure, a plunger operatively arranged to said enclosure for ejecting said medicament through said needle and arranged on its upper part with a number of outwardly extending stop members, spring means arranged to said plunger for operating said plunger, a dose activating means, a needle shield spring surrounding the needle shield link. The invention is characterised in that said injection device further comprises a first tubular member rotationally and slidably arranged inside said needle shield link, said tubular member comprises a number or ridges and protrusions on both its outer and inner surfaces, said ridges and protrusions on the outer surface of the tubular member co-operate with guide members arranged on the inner surface of said needle shield link, said ridges and protrusions on the inner surface of the tubular member co-operate with the outwardly extending stop members of the plunger that said injection device further comprises a second tubular member arranged inside said housing, arranged and designed with a number of ridges and protrusions on its inner and outer surfaces capable of setting and delivering a certain preset dose.
Thu, 27 Oct 2016 08:00:00 EDTAn injection device for delivering a liquid composition, including a generally elongated housing, arranged to hold an exchangeable cartridge containing the liquid composition. The housing includes a drive device, and a plunger rod connected with the drive device and connected to a plunger within the cartridge, when the cartridge is held at the housing, for driving the plunger within the cartridge. The plunger includes a rod connector connected with a front end portion of the plunger rod. The rod connector comprises a rod stop portion, wherein there is a longitudinal play between the plunger rod on one hand and the entrance opening and the rod stop portion on the other hand, thereby enabling the front end portion to move back and forth between the entrance opening and the rod stop portion without moving the plunger.
Thu, 27 Oct 2016 08:00:00 EDTA substance delivery device for delivering a substance from a container includes a body, and a plunger movable with respect to the body so as to expel at least a portion of a substance from the container, a trigger mechanism, a latch member latched in a stationary position at least along the longitudinal axis of the device before use, and a lockout shroud movable along the longitudinal axis relative to the latch mechanism. User manipulation of the trigger mechanism causes the latch mechanism to become unlatched and move along the longitudinal axis and to cause movement of a plunger relative to the body, and in a first position of the lockout shroud along the longitudinal axis relative to the latch member, the lockout shroud prevents the trigger mechanism from unlatching the latch member, whereas in a second position the lockout shroud allows the trigger mechanism to unlatch the latch member.
Thu, 27 Oct 2016 08:00:00 EDTAn injection device for holding and actuating a pre-filled syringe including a barrel holder having an axial passageway adapted to hold the barrel of the pre-filled syringe, a grip movable relative to the barrel holder to move a plunger of the pre-filled syringe, the grip configured to be locked to the barrel holder to prevent axial movement therebetween and unlocked from the barrel holder to permit axial movement therebetween, and a needle guard arranged to retract into the barrel holder in response to force against an injection site to unlock the grip from the barrel holder.
Thu, 27 Oct 2016 08:00:00 EDTA tip cap is provided comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface. A syringe assembly is provided comprising a syringe comprising a barrel, and a syringe tip, extending through the barrel and a connector provided on the syringe tip. The syringe assembly further comprises a tip cap for sealingly covering the syringe tip and comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface having connection means for attaching to the syringe tip.
Thu, 27 Oct 2016 08:00:00 EDTIn one aspect of this invention, control systems are provided for controlling the inflation of a tissue tensioner or balloon for a fluid delivery system, such as for a needleless fluid injection device. In another aspect of the invention, a system for reducing the response time for jet injection of fluid is provided. In yet another aspect of the invention, systems and devices are provided for controlling the volume of fluid that is ejected from a fluid injection system, which systems include at least one stop that is selectively rotated to limit the movement of a shaft in a linear direction, thereby controlling the amount of fluid that is ejected from the system.
Thu, 27 Oct 2016 08:00:00 EDTThe present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.
Thu, 27 Oct 2016 08:00:00 EDTA blood glucose maintenance system for use by hyperglycemic individuals measures their blood glucose level and calculates an appropriate glucose or insulin dosage based on the measurement. Recheck intervals responsive to dosage history are determined. Warning or alert messages or signals are produced if certain measurements or calculations fall outside established normal ranges. It is particularly useful for patients in a hospital or in-patient environment.
Thu, 27 Oct 2016 08:00:00 EDTThe invention relates to a device for treating an individual suffering from cardiac or circulatory arrest or from a stroke, comprising a blood withdrawal device (BE) that is applied to the individual (P), an analysis unit (BA) which is directly or indirectly connected to the blood withdrawal device for detecting a blood analysis result (BAE) providing at least one characteristic of the blood, directly or indirectly connected to a blood return device (BR) that is applied to the individual (P) and is designed to deliver a substance to the individual via the return device (BR).
Thu, 27 Oct 2016 08:00:00 EDTA surgical fluid management system includes a source of surgical media, a surgical instrument, a first pump, one or more filters, a second pump, and a controller. The first pump is operatively coupled between the source of surgical media and the surgical instrument. The one or more filters are configured to filter bodily discharge from a surgical site. The second pump is operatively coupled between the one or more filters and the first pump. The controller is in electrical communication with the first pump and the second pump to control the first and second pumps.
Thu, 27 Oct 2016 08:00:00 EDTImprovements in an adhesive patch for an infusion set include the addition of an antiperspirant, wound healing and/or antimicrobial agent to the adhesive surface, and the layering of different backing materials to improve performance characteristics of the patch. Patches may be offered as part of a product line, in which differently shaped patches are provided for attachment to different parts of the body, and different pressure sensitive adhesives provide different peel strength according to different use patterns of the end user.
Thu, 27 Oct 2016 08:00:00 EDTThe application discloses a drug infusion system comprising a base and a drug dispenser. The base is configured to receive a cannula that delivers a drug to beneath a wearer's skin. The base is attachable to the skin of the wearer. The reusable drug dispenser is removably attachable to the base and has a pump unit configured to establish fluid communication between a removably attachable drug reservoir and the cannula. The pump unit pumps the drug to the wearer upon activation by the wearer. The pump unit may have an inlet to contact the drug within the reservoir, which may be a needle. The pump unit may also have a receiving unit to receive the reservoir. Such a receiving unit may be a tubular for a cylindrical reservoir, or may have a cavity or an encasing unit to hold the reservoir.
Thu, 27 Oct 2016 08:00:00 EDTDescribed herein are subcutaneous medication delivery applicators and adhesive patches with one or more openings in the patches that designate one or more desired injection sites for subcutaneous injection of a medication. The medication delivery applicator and the adhesive patch may both include circuitry and wireless short-range communications interfaces that allow for the two devices to communicate with one another in order to determine if they are pre-associated in some manner, such as would be the case if both devices were packaged in the same injection kit. The medication delivery applicator may have some form of safety interlock that is only disengaged by the circuitry upon verifying that the two devices are pre-associated in some manner. Various other implementations are described as well.
Thu, 27 Oct 2016 08:00:00 EDTThe present invention relates to a disposable cartridge for a drug delivery device, the cartridge comprising: —a flexible bag (81; 181) to accommodate a liquid medicament and having an opening (81a, 181a) adjacent to a sidewall (81b, 181b), a socket (76, 176) having a fluid channel (86; 186) in fluid communication with a cartridge fluid coupling (90; 190), wherein the socket (76, 176) extends into the opening (81a, 181 a) of the flexible bag (81; 181), a housing (71; 171) covering at least a portion of the flexible bag (81; 181) and having a receptacle (71a, 171a) to receive the socket (76; 176) with the flexible bag (81; 181), wherein the flexible bag's (81; 181) sidewall (81b; 181b) is fixed between the socket (76; 176) and the receptacle (71a, 171a).
Thu, 27 Oct 2016 08:00:00 EDTThe invention is generally directed toward a novel fluid cartridge for medical infusion devices. The disclosed invention describes various protection sleeves and other structures for protecting the luer connection of a lineset that connects to the cartridge, to reduce the stresses placed on the luer connection when the lineset is worn on the body of patient, and to reduce the chances for unintentional disconnection, breakage, or leakage.
Thu, 27 Oct 2016 08:00:00 EDTDevices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.
Thu, 27 Oct 2016 08:00:00 EDTA contrast agent removing device configured to remove a contrast agent from blood vessels includes: an elongated outer tube 40; an inner tube 20 arranged in an interior of the outer tube 40; an expandable portion 30 interlocked with a distal portion of the inner tube 20 and configured to be capable of being stored within the outer tube 40 and to expand radially outward in a funnel shape opening in a distal direction by projecting from the outer tube in the distal direction; and a fixing portion 80 provided at the rim of the expandable portion 30 and configured to be capable of being fixed to a contact object.
Thu, 27 Oct 2016 08:00:00 EDTIn general, a dialysis device includes a first processing device for monitoring dialysis functions of the dialysis device, a second processing device, a display device, and memory. The memory is configured to store instructions that, when executed, cause the dialysis device to provide, on the display device, a first display region and a second display region, where the first display region is associated with the first processing device and the second display region is associated with the second processing device. At least a portion of the first display region cannot be obscured by the second display region.
Thu, 27 Oct 2016 08:00:00 EDTSystems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.
Thu, 27 Oct 2016 08:00:00 EDTSystems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.
Thu, 27 Oct 2016 08:00:00 EDTThe subject of the present invention is a composite wound packing material comprising a casing enclosing a material, or an assembly of materials, forming fluid flow channels, said casing being composed of a self-supporting interface material formed from a thin layer of a composition comprising a hydrophobic matrix and comprising through-holes, said hydrophobic matrix comprising, per 100 parts by weight of a styrene/saturated olefin/styrene triblock copolymer having a viscosity of between 0.2 and 2 Pa·s, as measured in a 10% (weight/weight) solution in toluene, from 400 to 1220 parts by weight of a plasticizer, preferably a plasticizing oil, and from 0 to 720 parts by weight of petroleum jelly, it being specified, moreover, that the total amount of plasticizer and petroleum jelly is greater than or equal to 750 parts by weight and the amount of petroleum jelly is between 400 and 720 parts by weight when the amount of plasticizer is between 1000 and 1220 parts by weight.
Thu, 27 Oct 2016 08:00:00 EDTAn apparatus comprises a body and a conduit. The body comprises an absorbent material. The conduit is in fluid communication with the body. The conduit has a suction opening positioned within the absorbent material. The conduit is operable to draw fluid away from the absorbent material. The apparatus may be positioned within the posterior choana or the nasopharynx of a patient using a deployment instrument. The apparatus may prevent fluids from draining from the nasal cavity into the patient's throat. In some instances, the apparatus is used as a plug during a sinus irrigation procedure to prevent irrigation fluid from traveling down the patient's throat.
Thu, 27 Oct 2016 08:00:00 EDTA sensitizing composition for thermal cancer therapy using electromagnetic waves. The sensitizing composition increases sensitivity upon treatment of cancer using electromagnetic waves, and includes a metal ion, a metal ion-bound material, “metal ion-noncovalently bound apotransferrin” (transferrin), or a metal ion-noncovalently bound apotransferrin derivative. The sensitizing composition that targets cancer enables selective delivery of the metal ion to tumorous tissue when administered in vivo, and thus the generation of heat in tumorous tissue in which the metal ion accumulates is increased upon thermal cancer therapy using electromagnetic waves, thereby maximizing the efficacy of the thermal cancer therapy using electromagnetic waves in treating cancer. A thermal therapy using the sensitizing composition is effective for treating cancer without pain or side effects and can also be used in combination with chemotherapy, radiation therapy, etc., ultimately increasing the potential to cure cancer.
Thu, 27 Oct 2016 08:00:00 EDTProvided is a method for controlled release of a chemical substance in vivo with femtosecond laser pulses. The method comprises a step of injecting into the body of a subject a liposome which is filled with the chemical substance and attached to metal nanoparticles. Then, a laser pulse train is applied to the liposome from outside the body with a constant or variable laser intensity, exposure time and time between exposures, thereby releasing a controlled amount of the chemical substance in the body from the liposome on a timescale fast enough to reproduce neural signaling.
Thu, 27 Oct 2016 08:00:00 EDTCompositions and methods are provided for photosynthetic correction of metabolic imbalances that occur in ischemic consitions. In the methods of the invention, an ischemic or potentially ischemic tissue is contacted with an effective dose of a photosynthetic system in the presence of a light source, where the dose or concentration is sufficient to increase oxygenation and simple sugar supply of the targeted tissue or organ.
Thu, 27 Oct 2016 08:00:00 EDTProvided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.