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METHOD FOR THE TREATMENT OF ACNE

Thu, 03 Nov 2016 08:00:00 EDT

This application is directed to a method of treating a patient with acne by applying a photodynamic agent to skin having acne lesions, waiting at least 12 hours, and then exposing the skin to which the photodynamic agent has been applied to light that causes an activation reaction.



MEDICAL DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

A medical device which absorbs a difference in dimension between the members, can be applied to an existing device without generating a dead space in a flow path of a therapeutic substance when administrating the therapeutic substance, and is high in versatility. The medical device includes a feeding member, a connected member and a joint member, and the joint member includes an inner tapered portion and an outer tapered portion, the joint member is configured so that the tip end of the joint member is located on the inner tapered connecting portion when the joint member is connected to the hub.



MEDICAL CONNECTORS AND METHODS OF USE

Thu, 03 Nov 2016 08:00:00 EDT

A medical connector for use in a fluid pathway includes a substantially transparent housing having a proximal end with a proximal opening and a distal end with a distal opening, and a cavity extending therebetween. The connector provides a substantially visible fluid flow path extending through a substantial portion of the connector.



Implantable Access Port

Thu, 03 Nov 2016 08:00:00 EDT

An implantable access port for use in transferring a fluid transdermally between an external fluid storage or dispensing device and a site within a patient's body is disclosed. The access port includes a base, a bowl-shaped reservoir defined within the base by a smooth surfaced wall, and a septum secured to the base and enclosing the reservoir within the base. The access port also has an outlet passageway defined within the base and extending in communication with a reservoir outlet defined within the reservoir and an external opening defined in the exterior of the base.



TRIGGERABLE SHAPE MEMORY INDUCTION DEVICES

Thu, 03 Nov 2016 08:00:00 EDT

In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. In certain embodiments, the polymer network comprises a covalently crosslinked polymeric material and a non-crosslinked polymeric material associated with the crosslinked polymeric material. In some cases, the polymer network has a first configuration (e.g., as polymerized), and a second configuration (e.g., upon heating and deformation), such that the polymer network can be triggered to recover the first configuration upon heating the polymeric material above a softening temperature of the polymeric material. In certain embodiments, the polymer network comprises a plurality of particles capable of increasing the temperature of the polymer network (e.g., above the softening temperature) in the presence of an external stimulus such as induction, radio frequency, or magnetic resonance, such that the polymer network changes configuration. The polymeric material may be molded into any suitable shape.



SURGICAL ACCESS ASSEMBLY AND METHOD OF USING SAME

Thu, 03 Nov 2016 08:00:00 EDT

A surgical access assembly is described that includes an outer sheath and a selectively removable obturator. The outer sheath is defined by an open distal end and an open proximal end and includes a hollow body portion therebetween. The obturator is defined by a distal end and a proximal end, wherein the distal end further comprises a tapered distal tip member. The obturator is configured to be received within the outer sheath such that the tapered distal tip member protrudes from the open distal end of the outer sheath when the obturator is in an introducing configuration. The outer sheath further includes a gripping member, wherein the gripping member includes at least one retaining notch formed on an outer surface thereof



CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL

Thu, 03 Nov 2016 08:00:00 EDT

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.



SURGICAL CAVITY DRAINAGE AND CLOSURE SYSTEM

Thu, 03 Nov 2016 08:00:00 EDT

A surgical drain device includes a matrix of biodegradable polymer material and a plurality of drain tubes attached to the matrix. The device is implanted within a surgical wound to treat the presence of seromas, for example, and is used to promote drainage, tissue adhesion, and wound closure. The drain tubes converge into a common collection tube that leads wound fluid outside the body under gravity feed or negative pressure applied to the collection tube. The matrix contains an array of apertures that allow tissue contact across the device. A preferred embodiment comprises a tissue anchoring system including anchor elements such as hooks or barbs. The device can be used with a negative pressure system to further improve the drainage band can also be used with a wound dressing. The device and systems containing the device are particularly useful to promote the healing of surgical wounds from abdominal surgery.



BALLOON CATHETER

Thu, 03 Nov 2016 08:00:00 EDT

A balloon catheter includes an inner shaft with a distal variant portion and a proximal variant portion. A bulged portion is provided at the distal end of a reinforcement member, and the bulged portion is configured to move in an axial direction between the distal variant portion and the proximal variant portion. Thus, the balloon catheter may smoothly pass through a curved blood vessel with improved kink resistance of the reinforcement member.



TRANSRADIAL CELIAC ARTERY CATHETER

Thu, 03 Nov 2016 08:00:00 EDT

The present disclosure provides unique products and methods for accessing the vasculature of a patient. The catheter arrangements disclosed herein include a distal segment having a first substantially straight portion, a laterally extending portion, a tip-opposing portion, a tip-deflecting portion and a distal tip. The first substantially straight portion has a longitudinal axis that extends between the tip-opposing portion and the distal tip. The tip-deflecting portion extends transverse to and passes or crosses through the longitudinal axis and deflectably supports the distal tip such that the distal tip can deflect towards the tip-opposing portion upon an external force.



SYSTEMS AND METHODS FOR ANCHORING MEDICAL DEVICES

Thu, 03 Nov 2016 08:00:00 EDT

Some embodiments of a medical device anchor system include an anchor device, a tether, and an adapter for securing a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.



Two-Piece Catheter Securement System and Method for Using Same

Thu, 03 Nov 2016 08:00:00 EDT

A two-piece catheter securement system has a separable, stand-alone fixation pad with an adhesive undersurface and an antimicrobial flap. On an upper surface of the pad are cooperative first attachment members. A separable, stand-alone upper capture and retention shell has an outer shell wall. The first and second ends of the shell may have a plurality of slots for capturing and retaining administration and catheter tubing. The shell has an inner shell ceiling having a plurality of spaced apart second attachment members thereon. The first and second attachment members are aligned to cooperatively engage when the shell is urged into releasable engagement with the pad with the slots capturing and retaining the tubes. The shell is fully separable from the pad when the cooperating attachment members are disengaged. The shell may be reused and the pad disposed.



INTRAVENOUS SPLINT COVER AND ASSOCIATED METHODS

Thu, 03 Nov 2016 08:00:00 EDT

An intravenous splint cover may include a main body, a pair of opposing securing members, and a splinting member. The main body may be rectangular shaped and have a bottom portion and a top portion. The pair of opposing securing members may be rectangular shaped and be connected to and extend outwardly from the main body and have a bottom portion and a top portion. The splinting member may be rectangular shaped and be carried by the bottom portion of the main body and extend outwardly from the main body to create an elevated portion of the main body. The bottom portions of the pair of opposing securing members may have an adhesive material applied thereto. The bottom portion of the main body that does not carry the splinting member may have an adhesive material applied thereto.



Adjustable Bent Sheath Tube

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to a steerable sheath tube (100) including a tube body (110), a traction mechanism (120) and a fixing and connecting mechanism (130). The traction mechanism (120) includes an anchor ring (121) and a traction wire (122). The anchor ring (121) is coaxially embedded in a distal elastic segment (111) of the tube body (110). The traction wire (122) is arranged in a side wall of the tube body (110), and extends along the axial direction of the tube body (110). The traction wire (122) includes a first segment and a second segment connected to each other, wherein the first segment is connected to the fixing and connecting mechanism (130) near a proximal end of the tube body (110), and the second segment hooks the anchor ring (121).



MULTIPLE-USE INTRAVENOUS CATHETER ASSEMBLY SEPTUM AND SEPTUM ACTUATOR

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to a multiple-use intravenous (IV) catheter assembly septum and septum actuator. In particular, the present invention relates to an IV catheter assembly having a stationary septum actuator and a blood control septum, wherein the blood control septum is configured to slide within a catheter adapter of the IV catheter assembly between a compressed state and an uncompressed state. When in the compressed state, a slit of the blood control septum is opened and the septum comprises stored compressive potential energy. When the septum is released from the compressed state, the stored compressive potential energy is release and the blood control septum is restored to its original shape, thereby closing the septum's slit.



Catheter Shaft and Method of Its Manufacture

Thu, 03 Nov 2016 08:00:00 EDT

A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.



PRESSURE-MAINTAINING SMOKE EVACUATION IN AN INSUFFLATOR

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to an insufflator with a flue gas extraction, which is configured such that the abdominal pressure remains substantially constant during the extraction process.



ADAPTOR/TUBING WITH ALARM(S)

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to connectors for uses where an indicator/alarm must be activated if the axial force rises above a predetermined value. It can be used in applications where excessive forces on tubings/connectors are not acceptable, for example, in tubes/couplings in fluids, and in electronic/electric, optical and other systems where a strain-relief cannot be employed.



Measuring Valve Health by Pressure Monitoring

Thu, 03 Nov 2016 08:00:00 EDT

A medical fluid infusion system includes a pump system configured to deliver a fluid drug to a patient. The system includes a pump, such as a piston pump, for driving fluid to a patient. One or more pressure sensors are configured to measure and detect changes in fluid pressure in a fluid flow line of the infusion system. The changes in fluid pressure, when detected, can be an indication of proper or improper functioning of a valve system of the pump system of the fluid infusion system.



SYRINGE FOR INJECTING DRUG SOLUTION INTO UPPER LAYER OF SKIN

Thu, 03 Nov 2016 08:00:00 EDT

A syringe for injecting a drug solution into an upper layer of skin includes an injection needle having a needle hole communicating from a needle tip to a needle proximal end, the injection needle having a blade face at the needle tip; and a needle hub having a distal end portion and a proximal end portion, the needle hub holding the injection needle at the distal end portion. The needle hub has a needle tip side end face, and the needle tip protrudes from the needle tip side end face. A protruding needle length of the needle tip from the needle tip side end face is 1.15 mm±0.1 mm, and a blade face length of the blade face along an axis of the injection needle is 0.60 mm±0.15 mm.



PERCUTANEOUS DELIVERY DEVICE AND METHOD FOR TENDON-LIGAMENT-MUSCLE REPAIR

Thu, 03 Nov 2016 08:00:00 EDT

Embodiments include systems, methods and devices for the percutaneous delivery of therapeutic agents to tendons, ligaments and muscle. Certain embodiments include a device comprising a needle-catheter based delivery system with adjustable characteristics to allow a clinician to control the angle and depth of needle and/or catheter deployment to a desired location. System embodiments may include a controller unit where a clinician can adjust the axial position depth and location of needles and/or catheters.



A Connecting Structure for a Syringe Needle Base and a Syringe Tube in a Safety Syringe

Thu, 03 Nov 2016 08:00:00 EDT

A connecting structure for the syringe needle base and the syringe tube in the safety syringe, wherein a syringe needle base is in the shape of a column, and the front end of the syringe needle base is used for being connected with the syringe needle; the connecting structure comprises elastic connecting pieces arranged at the rear end of the syringe needle base and first connecting parts arranged at the inner side of the connecting tube; the outer sides of the connecting pieces are provided with second connecting parts; the syringe needle base is sleeved with the connecting tube; the connecting pieces are provided with an expanding part; the expanding part is abutted against the inner side of the connecting pieces so that the outer sides of the connecting pieces are expanded to be in contact with the inner side of the connecting tube.



MEDICAL PUNCTURE NEEDLE AND METHOD OF MANUFACTURING PUNCTURE NEEDLE

Thu, 03 Nov 2016 08:00:00 EDT

A medical puncture needle includes an end portion including a needle tip; and a main body portion contiguous with the end portion, having a substantially circular cross-sectional outer shape. The end portion includes a first bevel formed by a curved surface, the bevel having an angle that gradually decreases toward the needle tip in an axial direction, in a cross-section orthogonal to the axial direction, relative to an imaginary plane that extends along an axis of the main body portion.



Frontal Attachment Device For Syringe With Rotationally Activated Retractable Needle

Thu, 03 Nov 2016 08:00:00 EDT

A medical device attachable to the front of a conventional syringe and having a hub assembly selectively attachable to the syringe, a nose projecting forwardly from the hub assembly, a rearwardly biased needle retraction mechanism seated inside the nose, a retractable needle projecting forwardly of the nose, and a fluid flow path from the fluid chamber through the hub assembly, nose, needle retraction assembly and needle, wherein the needle is retracted into the nose and a retraction tube external to the syringe by rotating the syringe relative to the nose.



SAFETY SYRINGE

Thu, 03 Nov 2016 08:00:00 EDT

A safety syringe includes a barrel including a hollow cylindrical tip; a needle assembly including a hollow needle hub on the tip; a hinge including a bifurcated base and a moveable bifurcation on the needle hub, the movable bifurcation having two relaxation length of hinge ends pivotably secured to the base, a wall member formed with the bifurcation, and a V-shaped resilient member having two ends hingedly secured to the bifurcation and the base respectively; and a needle protection housing including a grooved body and a latch releasably secured to the wall member. When the needle protection housing is pivoted about both the resilient member and the hinge ends, resilient energy is stored in the resilient member. When the resilient energy reaches a set value, the resilient member releases the resilient energy to pivot the needle protection housing toward a hypodermic needle until the hypodermic needle is lockingly concealed in the grooved body.



Safety Device for a Drug Delivery Device

Thu, 03 Nov 2016 08:00:00 EDT

The invention relates to a safety device (S) for a drug delivery device (1), comprising: —a support body (2) adapted to receive and hold the drug delivery device (1), —a needle shield (8) slidably arranged relative to the support body (2), —an inner locking mechanism (12) arranged inside the needle shield (8) between a front end of the needle shield (8) and a front end of the support body (2) and adapted to lock and unlock the needle shield (8).



ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

Assembly for a drug delivery device and drug delivery device An assembly for a drug delivery device (1) is described comprising an activation member (6A) adapted and arranged to be axially moved in a delivery direction for triggering a dose delivery operation of the assembly, a first interaction member (17) and a second interaction member (18) which are adapted and arranged to mechanically cooperate with one another during a dose delivery operation of the assembly and to be rotated with respect to one another during the dose delivery operation, wherein the assembly is configured such that movement of the activation member (6A) in the delivery direction brings the interaction members (17, 18) into mechanical contact for generating a friction between the interaction members (17, 18), wherein an amount of friction controls a relative rotational speed of the interaction members (17, 18) during a dose delivery operation. Furthermore, a drug delivery device comprising the assembly is described.



INJECTOR APPARATUS HAVING A CLUTCH TO INHIBIT FORWARD MOVEMENT OF THE PLUNGER

Thu, 03 Nov 2016 08:00:00 EDT

An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.



Mechanical Dose Expelled Indicator

Thu, 03 Nov 2016 08:00:00 EDT

The present invention concerns a dosing unit for an injection device (100) and an injection device incorporating the dosing unit. The dosing unit comprises a housing (102) extending along a longitudinal axis from a proximal housing end to a distal housing end, the distal housing end being adapted for connection with a variable volume reservoir, an injection mechanism for expelling a dose of a substance held in a connected variable volume reservoir, the injection mechanism being arranged at least partially in the housing (102) and comprising an injection button (157), a dose defining structure (140) configured to move from a start position to an end-of-dose position in response to a dose expelling operation of the injection button (157), and a piston rod (160) configured to move in a dose delivery direction from a first position to a second position in response to a movement of the dose defining structure (140) from the start position to the end-of-dose position, and a dose delivered indicator (109) configured to move axially in a distal direction from a dose ready position to a dose delivered position in response to the movement of the dose defining structure (140) from the start position to the end-of-dose position, wherein during movement from the dose ready position to the dose de livered position a portion of the dose delivered indicator (109) emerges increasingly from the distal housing end.



ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

An assembly for a drug delivery device (1) is described comprising at least one drive member (19, 26) adapted and arranged to be moved in a delivery direction during a dose delivery operation of the assembly and in a direction opposite to the delivery direction during a dose setting operation of the assembly, an energy storing member (16) adapted and arranged to store energy and to cause movement of the drive member (19, 26) in the delivery direction, and an interaction system adapted and arranged to generate a friction onto the drive member (19, 26), wherein an amount of friction regulates a speed of movement of the drive member (19, 26) when drive member (19, 26) is moved in the delivery direction. Furthermore, a drug delivery device comprising the assembly is described.



ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

An assembly for a drug delivery device (1) is described comprising a piston rod (12) adapted and arranged to be displaceable in a delivery direction for dispensing a dose of a drug (10) from the device (1), an energy storing member (16) which is adapted and arranged to store energy and to move the piston rod (12) in the delivery direction, and an interaction member (7) adapted and arranged to mechanically cooperate with the piston rod (12), wherein the interaction member (7) is displaceable between a first position and a second position with respect to the piston rod (12), wherein the interaction member (7) is configured to be moved from the first position towards the second position to increase a friction onto the piston rod (12) and, wherein the interaction member (7) is configured to be moved from the second position back into the first position to decrease the friction onto the piston rod (12). Furthermore, a drug delivery device (1) comprising the assembly is described.



MONITOR FOR PARTICLE INJECTOR

Thu, 03 Nov 2016 08:00:00 EDT

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.



PREFILLED SYRINGE JET INJECTOR

Thu, 03 Nov 2016 08:00:00 EDT

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.



Auto-Injection Device with Button Activation

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to an auto-injection device (100) repeatedly activateable for automatically expelling multiple set doses of a liquid drug. An activation button (190) protrudes from a proximal end of a housing (101) and is axially moveable between an activateable position and an activated position. The auto-injection device includes dose setting means comprising a dose setting device (170) that performs a helical movement away from a zero dose position during setting of a dose and returns by a helical movement to the zero dose position as the set dose is expelled. The dose setting device (170) is coupled to the activation button (190) to retain the activation button in the activated position when the dose setting device (170) assumes its zero dose position.



FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL

Thu, 03 Nov 2016 08:00:00 EDT

Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.



Operating an Infusion Pump System

Thu, 03 Nov 2016 08:00:00 EDT

Some embodiments an infusion pump system can be configured to control dispensation of medicine according to a closed-loop delivery mode that is responsive to feedback information provided from a monitoring device, and the infusion pump system permits a user to interrupt the closed-loop delivery mode for purposes of dispensing a user-selected manual bolus dosage.



AMBULATORY INFUSION SYSTEM INCLUDING A STEP SWITCHING MECHANISM FOR VALVE CONTROL

Thu, 03 Nov 2016 08:00:00 EDT

A dosing unit for an ambulatory infusion system, including a metering pump unit including a dosing cylinder and a piston, the piston in sealing sliding engagement inside the dosing cylinder; a valve unit having a filling port and a draining port, the filling port being couplable with a liquid drug reservoir, the draining port being couplable with an infusion site interface, and a shut-off body movable between a filling position where it couples the filling port with the dosing cylinder and a draining position where it couples the dosing cylinder with the draining port; and a valve driver coupler coupled to or integral with the shut-off body and being the output element of a step switching mechanism. Also disclosed is a drive unit that may be used in combination with a dosing unit, an ambulatory infusion system and a method for coupling a dosing unit and a drive unit.



Method and System for Leakage Detection in Portable Medical Devices

Thu, 03 Nov 2016 08:00:00 EDT

A medical therapy system including liquid detection is disclosed. A medical therapy includes a case with an interior and an exterior. Within the interior of the case is the liquid detection system that includes a first electrode set with a first positive electrode and a first negative electrode. The liquid detection system further includes an impedance measurement circuit coupled to the first electrode set to determine impedance values between the first positive electrode and the first negative electrode. A threshold detector compares impedance values between the first electrode set to a first threshold impedance. A microprocessor is programmed to initiate an alarm when measured impedance from the first electrode set is below the first threshold impedance.



INFUSION PUMP DRIVE WITH COMPRESSION SPRING

Thu, 03 Nov 2016 08:00:00 EDT

An infusion pump drive and its methods of use are disclosed. In one embodiment, the infusion pump drive may include a transmission component and a spring in line with the transmission component. Displacing the transmission component may compress the spring to apply a force causing fluid to dispense from an associated reservoir. Depending on the particular embodiment, the transmission component may either be displaced continuously or displaced multiple times to dispense fluid from the reservoir.



DRUG DELIVERY DEVICE WITH DISPOSABLE CARTRIDGE AND DISPOSABLE INJECTOR

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to a drug delivery device for dispensing a liquid medicament, comprising: a housing (12) having at least one feeder member (100), a disposable injector (60) comprising an injection needle(65), a flexible tube (64) and an injector fluid coupling (68), wherein the injection needle (65) is in fluid communication with the fluid coupling (68) via the flexible tube (64), a disposable cartridge (70) comprising a reservoir (80) at least partially filled with the liquid medicament and comprising a cartridge fluid coupling (90) in fluid communication with the reservoir (80), wherein the injector (60) and the cartridge (70) are releasably attachable to the housing (12) and arrestable to the housing (12) in an undeployed configuration (4), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are disconnected, and wherein one of injector (60) and cartridge (70) is displaceable relative to the other one of injector (60) and cartridge (70) from the undeployed configuration (4) into the deployed configuration (6) while attached to the housing (12), wherein when in deployed configuration the injector fluid coupling (68) and the cartridge fluid coupling (90) are in fluid communication.



DISPOSABLE DELIVERY ASSEMBLY FOR A DRUG DELIVERY DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to a disposable delivery assembly for a drug delivery device to dispense a liquid medicament, the delivery assembly comprising: a disposable injector (60) comprising an injection needle (65), a flexible tube (64) and an injector fluid coupling (68), wherein the injection needle (65) is in fluid communication with the fluid coupling (68) via the flexible tube (64), a disposable cartridge (70) comprising a reservoir (80) at least partially filled with the liquid medicament and comprising a cartridge fluid coupling (90) in fluid communication with the reservoir (80), wherein the injector (60) and the cartridge (70) are mechanically interconnected in an undeployed configuration (4), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are disconnected, and—wherein the cartridge (70) is displaceable relative to the injector (60) into a deployed configuration (6), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are in fluid communication.



PLASMAPHERESIS DEVICE

Thu, 03 Nov 2016 08:00:00 EDT

A plasmapheresis device includes a column or other flow mechanism in which plasma flows following separation of the plasma from cellular components like blood cells, platelets and the like. The column includes a moiety, such as an antibody, which selectively binds to galectin-3. By removing galectin-3 from the blood stream of a mammal by at least 10%, improvements in the treatment of inflammation, suppression of the formation of fibroses, and a variety of cancer treatments can be effected or improved. The device provides for multiple columns to remove a variety of elements but includes one which selectively removes galectin-3 from the blood flow. Other agents may be added to the plasma before recombination with the cellular components of the blood, and before returning the recombined flow to the patient.



MILK STORAGE BAG ADAPTER AND HOLDER

Thu, 03 Nov 2016 08:00:00 EDT

The present disclosure provides an adapter for use with a breast pump assembly for use for securely attaching a milk storage bag thereto. Specifically, the present disclosure provides an adapter having clips thereon for securely engaging multiple different kinds of breast milk storage bags securely thereto for the receiving of expressed breast milk therein.



Blood Bag System and Tube Holder

Thu, 03 Nov 2016 08:00:00 EDT

In order to prevent or suppress a blood component from being unnecessarily mixed to other bags by returning blood moved to a tube from a bag before centrifuge to the bag during the centrifuge. A blood bag system (10) has a cassette (50) (tube holder) for holding at least a part of the first transfer tube (21). The cassette (50) holds the first transfer tube (21) such that a distance between a rotation center (O) in application of a centrifugal force and the first transfer tube (21) increases toward the blood collection bag (11) side across a length between a flow path close position caused by the first clamp (71) in the first transfer tube (21) and the blood collection bag (11).



SYSTEM FOR DYNAMIC CONTROL OF MEDICAL VACUUM

Thu, 03 Nov 2016 08:00:00 EDT

A method and system of controlling medical suction is disclosed. The system comprises a vacuum regulator comprising a valve, wherein the first end of the regulator may be fluidly connected to a vacuum source and the second end of the regulator may be fluidly connected to a patient interface. The valve may comprise a small orifice or pathway, allowing fluid to pass from the second end of the regulator to the first end of the regulator while the valve is closed. The system may also comprise a flow detector, wherein the flow detector is capable of sensing when the patient interface is in contact with a liquid and cause the valve to open, thereby allowing full flow of fluids from the second regulator end to the first regulator end.



STORAGE CONTAINER

Thu, 03 Nov 2016 08:00:00 EDT

A storage container includes a storing section including a storage space and an inflow port, and a water sealing section. The storing section includes an inflow section connectable to a tube and a volume changing section capable of changing the volume of the storage space. The volume changing section is deformed to increase the volume of the storage space when pressure in the storage space is about to rise to be equal to or higher than a reference pressure set in advance and is deformed to reduce the volume of the storage space when the pressure in the storage space is about to drop to be lower than the reference pressure.



POST-SURGICAL SUPPORT MEMBER FOR SURGICAL SITE

Thu, 03 Nov 2016 08:00:00 EDT

A post-surgical support member is configured to be placed a post-surgically between a supine patient and a support surface so as to isolate an anatomical load from a post-surgical wound against the support surface, the anatomical load produced by the weight of the supine patient.



METHODS AND DEVICES FOR MANIPULATING SUBDERMAL FAT

Thu, 03 Nov 2016 08:00:00 EDT

The present invention features methods of manipulating subdermal fat in a treatment area. Such methods include inserting a needle (e.g., a micro-coring needle) through the dermis to the subdermal fat layer in order to excise a portion of tissue from the treatment area. These insertions result in a portion of the dermis and a portion of subdermal fat to enter into the needle. Removal of the needle results in excision of the portion of dermis and subdermal fat that entered into the needle.



INFLATABLE IMBIBED POLYMER DEVICES

Thu, 03 Nov 2016 08:00:00 EDT

The present invention provides a stretchable material suitable for use in an inflatable medical device. The stretchable material has at least one reinforcing polymer layer with a top and bottom side forming a porous matrix which is imbibed with a sealing material to infiltrate and substantially seal spaces of the porous matrix and extend beyond the reinforcing polymer layer to form a surface coating.



FLUSHABLE CATHETERS

Thu, 03 Nov 2016 08:00:00 EDT

A flushable catheter assembly that includes at least one shrinkable portion that shrinks from a first configuration to a second compact configuration to reduce the size of the catheter assembly for passage through the sewer system. The flushable catheter may also be made from a water disintegratable polymer that dissolves, degrades or hydrolyzes while within the sewer system.



A Process for Making a Hydrophilic Nonwoven Structure, a Nonwoven Structure Produced Thereby and an Article Containing the Nonwoven Structure

Thu, 03 Nov 2016 08:00:00 EDT

A process for making a hydrophilic nonwoven structure comprising: forming a nonwoven structure comprising fibers; and exposing the nonwoven structure to an atmospheric plasma comprising an inert gas and a substance having a polar group and which can be vaporized or made into an aerosol and which forms a free radical upon exposure to a dielectric barrier discharge is provided. Also provided are nonwoven structures produced thereby and articles containing the nonwoven structures.



BELT WITH TREATED INNER SURFACE

Thu, 03 Nov 2016 08:00:00 EDT

An absorbent article having a belt structure, wherein the inner surface of the belt comprises a treatment and wherein the inner surface of the belt is different than the outer surface of the belt.



PHARMACEUTICAL KIT AND METHODS FOR CANCER TREATMENT VIA INTRACAVITY DELIVERY AND FOR PREPARING METAL NANOPARTICLE-ANTIBODY FRAGMENT CONJUGATE

Thu, 03 Nov 2016 08:00:00 EDT

The present invention provides a pharmaceutical kit, methods for cancer treatment and for preparing a metal nanoparticle-antibody fragment conjugate, which can reduce the recurrence rate of cancer and provide a safer and less invasive therapeutic method for cancer treatment.



UPCONVERSION OF LIGHT FOR USE IN OPTOGENETIC METHODS

Thu, 03 Nov 2016 08:00:00 EDT

Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths into the visible light spectrum. Also provided herein are methods activating light-responsive opsin proteins expressed on plasma membranes of neurons and selectively altering the membrane polarization state of the neurons using the light delivered by the lanthanide-doped nanoparticles.



METHOD FOR TREATING OTIC INFECTIONS AFTER TYMPANOSTOMY TUBE PLACEMENT

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to methods for treating a microbial infection comprising administering a composition comprising one or more antibiotic compounds to the site of the infection by instilling the composition into the tympanostomy tube. A delivery cannula can be used to instill the composition into the tympanostomy tube.



PHARMACOKINETICS OF IONTOPHORETIC SUMATRIPTAN ADMINISTRATION

Thu, 03 Nov 2016 08:00:00 EDT

Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.



COVER MATERIAL-EQUIPPED PATCH AND COVER MATERIAL-EQUIPPED PATCH KIT

Thu, 03 Nov 2016 08:00:00 EDT

A cover material-equipped patch comprising: a patch; anda cover material, whereinthe patch comprises a support layer and a drug reservoir layer which is stacked on one surface of the support layer and which contains a drug and a drug reservoir base agent,the cover material comprises a cover layer and an adhesive layer which is stacked on one surface of the cover layer and which contains an adhesive base agent,the patch and the cover material are arranged in such a manner that the adhesive layer is stacked on another surface of the support layer, anda solubility parameter (SPa) of the drug, a solubility parameter (SPb) of the drug reservoir base agent, and a solubility parameter (SPc) of the adhesive base agent simultaneously satisfy conditions represented by the following formulae (1) to (3): 0≦|SPa−SPb|≦1.5 (1), 2.0≦(SPa−SPc)≦2.8 (2), and 1.0≦(SPb−SPc)≦2.8 (3).



TRANSDERMAL METHODS AND SYSTEMS FOR THE DELIVERY OF ANTI-MIGRAINE COMPOUNDS

Thu, 03 Nov 2016 08:00:00 EDT

Iontophoretic patches for the delivery of anti-migraine compounds and methods of using the patches are described.



ELECTROSTATIC PRINTING OF CYCLODEXTRIN COMPOSITIONS

Thu, 03 Nov 2016 08:00:00 EDT

Disclosed herein are methods of electrostatically printing a cyclodextrin composition on a substrate, the method including forming an electrostatically printable composition comprising a polymer and one or more cyclodextrins, one or more cyclodextrin inclusion complexes, or a combination thereof, and electrostatically printing the composition on a substrate. Also described are electrostatically printable compositions, methods of making the compositions, printing systems employing the compositions, substrates having the composition electrostatically printed thereon, laminates thereof, and uses of the printed substrates and laminates.



DOSING CONTROL COUPLING FOR ENTERAL FLUID TRANSFER

Thu, 03 Nov 2016 08:00:00 EDT

An enteral dosing control coupling comprising a cylindrical collar defining a hollow internal chamber and a lumen extension tip projecting axially into the internal chamber, the lumen extension tip defining an internal lumen extending therethrough. In example forms, the lumen extension tip is integrally formed with the cylindrical collar. In other example forms, the lumen extension tip is a separate piece and is removably engageable within the cylindrical collar.



SYRINGE FILL SYSTEM AND METHOD

Thu, 03 Nov 2016 08:00:00 EDT

A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe Tillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.



Seal System for Cannula

Thu, 03 Nov 2016 08:00:00 EDT

A system includes a needle hub having a proximal end and a distal end. The proximal end of the needle hub has a connection portion configured to receive a first container. The system further includes a cannula received by the needle hub with the cannula having a proximal end and a distal end and a cannula seal having a resilient sleeve enclosing at least a portion of the cannula. The system also includes a vial adapter configured to be attached to a second container with the vial adapter having a vial seal that is configured to engage the cannula seal. The cannula seal has a first position where the cannula seal encloses the distal end of the cannula and a second position where the cannula seal is retracted to expose the distal end of the cannula.



DUAL-CHAMBER PACK FOR EXTENDED RELEASE SUSPENSION COMPOSITIONS

Thu, 03 Nov 2016 08:00:00 EDT

The present invention relates to a dual-chamber pack comprising a first chamber prefilled with a suspension base and a second chamber prefilled with a powder for suspension comprising an active ingredient, wherein upon activation of the dual-chamber pack, the contents of both the chambers are mixed to form an extended release suspension composition which is characterized by having no substantial change in the in-vitro dissolution release profile of the active ingredient upon storage for at least seven days.



SOFT NON-WOVEN CLOTH FOR USE AS AN OUTER LAYER OF DISPOSABLE ABSORBENT ITEMS

Thu, 03 Nov 2016 08:00:00 EDT

Summary of the invention: The present invention covers a non-woven fabric for laminate on a polyethylene layer, such thata. it is comprised by a mixture of polypropylene hydrophobic and hydrophilic fibers;b. it is manufactured by means of a carding process followed by thermal bondingc. during the thermal bonding is engraved in at least 15% of its aread. has a minimum base weight of 13 gr/m2



BREATHABLE AND LIQUID IMPERMEABLE WEB AND METHOD OF MAKING THE WEB

Thu, 03 Nov 2016 08:00:00 EDT

A method is disclosed for modifying the physical characteristics of a web which involves passing the web between at least one pair of interengaged rolls to incrementally stretch the web, and then withdrawing the incrementally stretched web from between the rolls under tension. A web modified according to the disclosed method has desirable breathability and liquid impermeability, as well as extensibility and a soft, cloth-like textured surface.



ABSORBENT ARTICLE

Thu, 03 Nov 2016 08:00:00 EDT

An absorbent article includes an absorbent body provided between a liquid permeable topsheet and a backsheet; and embosses formed at both sides of the liquid permeable topsheet, wherein each of the embosses includes a body fluid expelling part emboss formed at an area corresponding to a body fluid expelling part along a longitudinal direction of the absorbent article, and is constituted of a shaped line protruding outward in a width direction of the absorbent article, longitudinal direction embosses formed at front and rear of the body fluid expelling part emboss along the longitudinal direction of the absorbent article, respectively, and inclined embosses extending from outer end portions of the longitudinal direction embosses, respectively, and being inclined toward a center side in the width direction of the absorbent article, and wherein end portions of the right and left inclined embosses are spaced apart from each other in the width direction.



CONTAINMENT PANT WITH ATTACHMENT MECHANISMS

Thu, 03 Nov 2016 08:00:00 EDT

A permanently closed containment pant including a chassis and a sling that is positioned within the chassis and is joined to the front waist region and the back waist region is disclosed. The sling is attached to the chassis with an attachment mechanism to secure the sling to the chassis. The attachment mechanism may comprise a bonded attachment and an attachment elastic material at a middle portion of the sling to the chassis at the crotch region; a bond attachment adjacent the pouch in a transition material; or elastics extending from the leg openings and attaching to the sling in the crotch region.



DISPOSABLE DIAPER

Thu, 03 Nov 2016 08:00:00 EDT

The present invention aims at providing a disposable diaper having excellent maintainability of a surface space and capable of being easily produced. It is characterized in that a lower layer absorbent body has, at least at center of a crotch portion in a width direction, an elongated lower layer through section piercing in a thickness direction and extending in a front-back direction; an upper layer absorbent body has an upper layer through section piercing in the thickness direction at least within a range corresponding to the lower layer through section in the front-back direction, the upper layer through section has an elongated middle section extending in the front-back direction so as to be located above the lower layer through section, and extending sections which extend, in the width direction, from both sides of a back side position of the middle section, and a side edge of the extending section has a shape in which at least a part of the front side thereof is located further outside in the width direction toward the back side.



Urinary Incontinence Pad

Thu, 03 Nov 2016 08:00:00 EDT

A urinary incontinence pad for females. The urinary incontinence pad includes an absorbent, tubular pad having a hollow interior. The pad includes a rounded first end and an open second end, wherein the rounded end serves as a barrier against the clitoris of a female user so as to prevent the pad from sliding when worn. The urinary incontinence pad further includes a channel that extends from the second end of the pad towards the first end thereof. The sides of the channel are flexible and biased towards one another so as to removably secure the pad to the labia of a user. In operation, the pad is removably secured between the labia majora and labia minora, wherein the channel is positioned facing the urethral meatus so as to absorb urine within the interior of the pad.



REUSABLE SHIELD AND LINER FOR USE DURING MENSTRUATION

Thu, 03 Nov 2016 08:00:00 EDT

A reusable shield and liner for use by a woman during menstruation is disclosed. The liner has a predetermined shape and comprises two or more layers. The predetermined shape can be an octagon, a circle, or an oral. The shield contains one water-resistant layer.



SHEAR RESISTANT WOUND DRESSING FOR USE IN VACUUM WOUND THERAPY

Thu, 03 Nov 2016 08:00:00 EDT

A cover layer for a vacuum wound therapy dressing includes a backing layer formed from a flexible polymeric membrane and an adhesive layer for affixing the backing layer over a wound bed to provide a substantially fluid-tight seal around a perimeter of the wound bed. The cover layer is reinforced with a reinforcement layer extending to a peripheral region of the backing layer to distribute forces associated with evacuating a reservoir, as defined by or within the cover, to stimulate healing of the wound bed.



NEGATIVE PRESSURE WOUND THERAPY DRESSING

Thu, 03 Nov 2016 08:00:00 EDT

A wound dressing suitable for use in negative pressure wound therapy system includes a cover layer adapted to establish a reservoir over a wound in which a negative pressure may be maintained. The cover layer includes an opening therein through which atmospheric gasses and wound exudates may pass through the cover layer. A vacuum port is affixed to the cover layer, and establishes a substantially fluid tight seal about the opening in the cover layer. The vacuum port includes a hollow interior in fluid communication with the opening in the cover layer and a connector to facilitate connection to a vacuum source. A packing member is affixed to the cover layer, to provide a wound dressing that may be applied in a single step process. The packing member is adapted to fill the wound and support the cover layer when a negative pressure is applied to the reservoir.



INJECTION NEEDLE

Thu, 03 Nov 2016 08:00:00 EDT

An injection needle includes a needle tube having a discharging port at a needle point for discharging a treatment liquid, the needle tube including a stabbing tube having a blade surface with the discharging port formed thereon, and a main needle tube which is thicker than the stabbing tube, with the stabbing tube provided on a tip portion of the main needle tube, wherein the stabbing tube satisfies a dimension condition such that an outer diameter is 70 μm or less (not including zero), and an inner diameter is 40 μm or less (not including zero), and a tilt angle θ of the blade surface with respect to a central axis of the stabbing tube satisfies a condition of 30°



NAVIGATING INTRODUCER FOR TISSUE ACCESS SYSTEM

Thu, 03 Nov 2016 08:00:00 EDT

A surgical access system is disclosed that includes an outer sheath, an introducer, and a navigational stylet. The outer sheath is defined by an open distal end and an open proximal end and includes a hollow body portion therebetween. The obturator is defined by a distal end and a proximal end. The distal end further comprises a tapered distal tip member that terminates in a distal tip. The navigational stylet is configured to be selectively fixed to the obturator and is configured to indicate the location of the obturator within a patient during use. The obturator is configured to be received within the outer sheath such that the tapered distal tip member protrudes from the open distal end of the outer sheath when the obturator is in an introducing configuration.