Subscribe: Untitled
http://www.freepatentsonline.com/rssfeed/rssapp604.xml
Added By: Feedage Forager Feedage Grade C rated
Language: English
Tags:
body  catheter  configured  device  distal end  distal  end portion  end  include  includes  injection  layer  member  portion 
Rate this Feed
Rate this feedRate this feedRate this feedRate this feedRate this feed
Rate this feed 1 starRate this feed 2 starRate this feed 3 starRate this feed 4 starRate this feed 5 star

Comments (0)

Feed Details and Statistics Feed Statistics
Preview: Untitled

Untitled





 



METHODS FOR STIMULATING A DORSAL ROOT GANGLION

Thu, 06 Apr 2017 08:00:00 EDT

Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.



Remineralisation of Calcified Tissue

Thu, 06 Apr 2017 08:00:00 EDT

A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralisation.



IONTOPHORESIS INJECTION DEVICE AND INJECTION METHOD

Thu, 06 Apr 2017 08:00:00 EDT

An iontophoretic drug delivery apparatus comprises an electrode unit comprising a plurality of iontophoresis electrodes and a plurality of tissue resistivity measurement electrodes; a programmable current unit configured to control a current that is supplied to the iontophoresis electrodes to thereby control the amount of drug delivered; an impedance detection unit comprising a detection mode that selectively measures a load resistance value between the iontophoresis electrodes or a tissue resistivity value between the tissue resistivity measurement electrodes so as to monitor the amount of drug delivered; and a control unit configured to control the programmable current unit by determining the amount of drug delivered or whether the drug is to be delivered, based on the load resistance or tissue resistivity value measured in the impedance detection unit.



SPINAL CATHETER HAVING MULTIPLE OBSTRUCTION-CLEARING FEATURES

Thu, 06 Apr 2017 08:00:00 EDT

A spinal catheter for insertion into the epidural space of a human or animal subject includes first and second lumens. A pressurized fluid can be discharged through the first lumen directly onto a tissue obstruction to form a partial/pilot or full/final opening in the tissue obstruction. If a full opening was not formed sufficient for passage of the stimulator lead, the distal-end portion of the stimulator lead can be inserted into the partial opening and then a pressurized fluid can be delivered through the second lumen and into a distensible balloon for expanding the balloon to clear the tissue obstruction sufficient for passage of the stimulator lead. In this way the catheter can be advanced past a tissue obstruction and into place for use within the epidural space, without having to remove and reinsert multiple surgical implements.



Sterile Caps For IV Line Care

Thu, 06 Apr 2017 08:00:00 EDT

This invention is directed to a sterile IV tube end cap comprising: a housing attached to a strip; an end cap received in the housing and removably attached to the strip; so that when the IV tube is attached to the end cap, the IV tube cannot be removed from the end cap without removing the end cap from the strip. The end cap can receive the male end of an IV tube wherein a portion of the IV tube is received in the housing and the IV tube is secured to the strip so that the IV tube cannot be removed from the end cap without removing the end cap from the strip.



Vascular Access Ports And Processes For Their Manufacture

Thu, 06 Apr 2017 08:00:00 EDT

A vascular access port includes a base with a floor. A cap is engaged with the base to form a reservoir above the floor as a septum seals the reservoir in a fluid-tight manner. An outlet is in fluid communication with the reservoir. At least one of the base and cap is formed by metal injection molding. The cap and base may be engaged with a snap fit connection or a rotatable connection. The fluid communication may be along a non-tangential non-radial flow path. The flow path may be asymmetrical and may also include textured walls.



UNIVERSAL MICROPORT

Thu, 06 Apr 2017 08:00:00 EDT

The present invention is directed to a device that provides an implantable port, particularly for use with animal models, such as small animal models like mouse models. A microport device according to an embodiment of the present invention includes a reservoir and a catheter for delivery of substances held within the reservoir. The catheter can be barbed and can decrease in diameter from its proximal end to its distal end. The reservoir can include diaphragms for the delivery of substances to be held within the reservoir. The device can also include a sleeve that covers the device and a tip protector that covers the distal tip of the catheter.



URETERAL STENT DRUG DELIVERY DEVICE, KIT, AND METHOD

Thu, 06 Apr 2017 08:00:00 EDT

Ureteral stent devices having improved drug delivery capabilities are provided. The ureteral stent device includes a ureteral stent comprising two opposed ends, and a drug delivery component associated with at least one end of the ureteral stent. The drug delivery component includes a drug housing defining a drug reservoir containing a drug, wherein the drug housing is configured to release the drug in-vivo.



METHOD AND TOOLS FOR IMPLANTED DEVICE

Thu, 06 Apr 2017 08:00:00 EDT

A method and toolset capable of remotely moving a rotor of an implanted device in a first arcuate direction and detecting a first limit of travel, moving the rotor in a second, opposite direction and detecting a second limit of travel without altering the current performance setting of the implanted device, comparing the first and second limits of travel with known values for a plurality of selectable performance settings, and indicating the current performance setting of the implanted device.



DEVICES AND METHODS FOR PROVIDING FOCAL COOLING TO THE BRAIN AND SPINAL CORD

Thu, 06 Apr 2017 08:00:00 EDT

Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF). Certain embodiments may include circulating heat transfer fluid within a CSF-containing space near the brain or spinal cord using a catheter. Particular methods may be used to determine the length and amount of cooling.



SUPPORT DEVICE FOR A DRAIN SYSTEM USED IN POST-SURGICAL PROCEDURES

Thu, 06 Apr 2017 08:00:00 EDT

A support device configured to support post-surgical drain bulbs at locations adjacent to a body of a wearer. The support device including a band of flexible material having a first end and a second end defining a band length there between, the band further including a pair of D-rings positioned proximate to the first end of the band and sized to accommodate a portion of the band proximate to the second end of the band, one or more snap fastener parts positioned proximate to the second end of the band and configured to selectively couple to one or more snap fastener counterparts positioned along the band length between the first end and the second end, and a band of hook and loop fastener material fixedly coupled to an outer surface of the band along the length of the band from a point proximate to the first end to a point proximate to the second end and configured to selectively couple to one or more securement members comprised of a counterpart to the hook and loop fastener material.



Catheter Structure with Improved Support and Related Systems, Methods, and Devices

Thu, 06 Apr 2017 08:00:00 EDT

Certain embodiments herein relate to an extension catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the extension catheter having a distal tubular member and a proximal elongated shaft coupled to the distal tubular member, wherein the proximal shaft has a length or section containing at least one discontinuous or segmented structure, and further wherein such structures that can be modified or varied to modify the torsional compliance characteristics of the device. Further embodiments relate to a multi-layer catheter having a protective wrap at or near the distal end of the catheter.



Smart Torquer and Methods of Using the Same

Thu, 06 Apr 2017 08:00:00 EDT

Smart torquers are provided. Aspects of the smart torquers include: an engager for releasably engaging an elongated intravascular device; a communications module; a contact associated with the engager and configured to communicatively contact an elongated intravascular device engaged by the engager with the communications module; and a manipulator configured to allow a user to torque an elongated intravascular device engaged by the engager. Aspects of the invention further include methods of using the smart torquers, as well as systems and kits employed in such methods.



CATHETER PORT

Thu, 06 Apr 2017 08:00:00 EDT

A catheter port adapted to be selectively secured topically to a patient's body about a site at which a catheter is to be inserted into the patient's body. The catheter port includes a cushion adapted to be secured to the patient's epidermis at its bottom surface about the site and at its top surface to a member, an inner tube having one portion mounted on the member and having another portion that is adapted to extend into the patient's body about the site for guiding movement of a catheter relative to the site and for preventing any portion of the catheter from ever contacting the patient's epidermis, an outer tube having a proximal end mounted on one of the member and inner tube, an intermediate portion extending away from the one of the member and the inner tube in a distal end and a septum mounted on the outer tube.



SYSTEMS, DEVICES, KITS, AND METHODS FOR DELIVERING THERAPEUTIC AGENTS

Thu, 06 Apr 2017 08:00:00 EDT

An injection catheter includes a drive mechanism, an elongate, flexible tubular body, and a first inner member. The tubular body has a distal end portion, a proximal end portion, and defines a first lumen extending therebetween. The first inner member includes a proximal end coupled to the drive mechanism and is rotatably disposed within the first lumen. The first inner member and the first lumen define an annular gap therebetween configured to deliver a therapeutic agent contained therein from the proximal end portion to the distal end portion of the tubular body when the first inner member is rotated within the lumen such that shear stresses exerted on the therapeutic agent are less than 500 pascals.



DETACHABLE POLYMER BOND

Thu, 06 Apr 2017 08:00:00 EDT

This disclosure concerns polymer catheter designs incorporating joints that break under tension. The joints are generally formed from two tubular elements comprising two different polymers with dissimilar thermal and/or mechanical characteristics, which are overlapped and exposed to heat and pressure. The disclosure also concerns methods of making and using such catheters, for instance to deliver medical implants.



CATHETER WITH CURVILINEAR POLYGON CROSS-SECTIONAL SHAPE

Thu, 06 Apr 2017 08:00:00 EDT

In some examples, a catheter may include a catheter body configured such that at least one of a proximal portion or a medial portion of the catheter body has a cross-sectional shape including at least three apexes, adjacent apexes being connected by curvilinear sidewalls, the cross-section being taken substantially orthogonal to a longitudinal axis of the catheter body. In some examples, the entire catheter body has the cross-sectional shape including at least three apexes, adjacent apexes being connected by curvilinear sidewalls. In other examples, only a portion of the catheter body has the cross-sectional shape.



LARGE LUMEN GUIDE CATHETER

Thu, 06 Apr 2017 08:00:00 EDT

A large lumen guide catheter (10) has an elongate tubular body (22), which has an outer surface (24), an inner surface (44), and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.



A REGIONAL ANAESTHESIA INJECTION APPARATUS

Thu, 06 Apr 2017 08:00:00 EDT

A regional anaesthesia injection apparatus comprising an injection volume determiner. The apparatus configured to determine a volume of a regional anaesthetic injection into a target tissue; an injection pressure determiner configured to determine a pressure of the injection; and a controller coupled to the injection volume determiner and to the injection pressure determiner and configured to provide an injection signal to control injection of fluid into the target tissue based on the determined pressure and the determined volume.



Means and Method to Invade Skin, Mucosa, and Underlying Tissues with Little or No Pain

Thu, 06 Apr 2017 08:00:00 EDT

A means and a method is disclosed to diminish or eliminate the pain associated with a sharp object penetrating the skin, during such procedures as an injection, biopsy, or deriving a blood sample. To this end, repeated tapping, pressing, or rubbing or vibrating is performed over the skin at or near the site of penetration of the sharp object in conjunction with applying electricity on the skin. The invention discloses a method of using a skin-puncturing means, with enhanced features, to provide local anesthesia at the site of penetration of a sharp object.



NEEDLE SYSTEM

Thu, 06 Apr 2017 08:00:00 EDT

A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles move relative to the die using one or more actuators. The actuators are controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used among other treatments for drug delivery, blood extraction, blood analysis, glucose measurements, blood measurements, nerve system stimulus treatment, hair removal, skin lesions coloring or removal or tattoo painting or removal.



CONSTANT FORCE HOLD TIP PROTECTOR FOR A SAFETY CATHETER

Thu, 06 Apr 2017 08:00:00 EDT

A tip protector for a safety catheter includes an outer member releasably engaged with the interior cavity of the catheter hub. The outer member includes a generally fixed radially outwardly projecting portion to provide a holding force, and an inner member axially shiftably received within the outer member. A needle cannula received in the inner and outer members is operable to axially shift the inner member between a distal position wherein the distal tip extends distally of the tip protector, and a proximal position wherein the distal tip is within the outer member. The holding force of the outer member to the interior wall of the catheter hub remains substantially constant irrespective of the position of the inner member between the distal and proximal positions.



MICROCARTRIDGE

Thu, 06 Apr 2017 08:00:00 EDT

A container for delivering a medicament to a target location includes a housing having a proximal end and a distal end, the housing including a cap locking tab at the distal end, and a vial containing medicament. The container includes a plunger slidable within the vial from the proximal end to the distal end of the vial to dispel the medicament, an injection member associated with the distal end, such that medicament dispelled from the vial passes through the injection member to the target location, and a slidable interaction member associated with the distal end of the vial configured to slide with the vial. An interaction between the slidable interaction member and cap locking tab causes the cap locking tabs to bias outward, and placement of a safety cap on the container after use locks the safety cap onto the container via the interaction with the cap locking tabs.



Dual Chamber Syringe With Retractable Needle

Thu, 06 Apr 2017 08:00:00 EDT

Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.



TIP PROTECTOR FOR A SAFETY CATHETER

Thu, 06 Apr 2017 08:00:00 EDT

A safety catheter includes a catheter hub, a needle cannula having a tip, and a tip protector. The tip protector includes an outer member and an inner member therein. The outer member has a projection releasably engaging the catheter hub. The inner member has a pair of arms extending to free ends from a base. The inner member is axially shiftable relative to the outer member between a first position wherein the needle tip is distal of the tip protector and the free ends of the arms are spread apart such that the distal tip is not shielded, and a second position wherein the tip is within the inner and outer members and the free ends of the arms are brought into close proximity such that the distal tip is shielded. The inner member is entirely received within the outer member in both the fort and the second positions thereof.



MEDICAL INJECTOR WITH RATCHETING PLUNGER

Thu, 06 Apr 2017 08:00:00 EDT

A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector. The displacement from the ready state causes distal displacement of the engagement portion with the engagement portion engaging one or more of the ratchet teeth and causing distal displacement of the plunger with the engagement portion.



WEIGHT-BASED DOSING SYRINGE

Thu, 06 Apr 2017 08:00:00 EDT

A system includes a syringe barrel, a syringe plunger, and an annular collar. The syringe barrel has a longitudinal axis aligned axially between a discharge end and a cylinder end. The syringe plunger has a cap disposed on a first end, a piston disposed on a second end and configured for disposition in a bore of the barrel, and has a body disposed between the first end and the second end. The body has an external thread on a first surface and the body has a visible calibration indication aligned axially. The annular collar has at least one interrupted internal thread segment on an interior surface. The collar has elasticity such that in a first state, the internal thread is configured to engage the external thread and in a second state, in which a compressive force is exerted on opposing sides of the collar, the internal thread is disengaged from the external thread.



SELF-INJECTION DEVICE

Thu, 06 Apr 2017 08:00:00 EDT

A device for delivering a medicament into a patient's body by injection into or through the patient's skin includes a body having a reservoir disposed therein for containing the medicament, an injection needle for penetrating the skin of the patient, the needle having a lumen and communicating with the reservoir, and a pressurizing system for pressurizing the reservoir. The device also includes indicator means visible outside the device for indicating that delivery of the medicament is substantially complete.



ROTATABLE END OF DOSE FEEDBACK MECHANISM

Thu, 06 Apr 2017 08:00:00 EDT

An injection device for injecting a medicament includes a housing, a dose setting member (20) movable to set a dose to be injected, and a signal part (7). The signal part rotates from a first rotational position to a second rotational position to increase loading on a spring or spring arm when a dose is set due to rotation of the dose setting member. An internal pressure builds up in the injection device during injection which results in the signal part being captured in the second rotational position between first and second internal parts of the injection device. After the internal pressure dissipates by a sufficient amount during injection, the signal part rotates under the urging of the loaded spring from the second rotational position back to the first rotational position. A portion of the signal part moves into contact with a surface when the signal part reaches the first rotational position to produce tactile or audible feedback indicating that an end of dose condition has been reached.



BLOOD GLUCOSE CONTROL SYSTEM

Thu, 06 Apr 2017 08:00:00 EDT

Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient's needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).



PERSONAL INJECTION DEVICE

Thu, 06 Apr 2017 08:00:00 EDT

A personal injection device wearable by a user to deliver fluid from a reservoir to the user, the personal injection device including: a quartz oscillator operable to generate a constant frequency signal; a control circuit operably connected to the quartz oscillator, the control circuit being operable to generate a drive signal in response to the constant frequency signal; a stator operably connected to the control circuit and defining a rotor gap, the stator being operable to generate an oscillatory field in the rotor gap in response to the drive signal; a magnetic rotor disposed in the rotor gap, the magnetic rotor being operable to rotate in response to the oscillatory field; and a pump operably connected to the magnetic rotor, the pump being operable to move the fluid from the reservoir to the user in response to the rotation of the magnetic rotor.



MULTI-LANGUAGE / MULTI-PROCESSOR INFUSION PUMP ASSEMBLY

Thu, 06 Apr 2017 08:00:00 EDT

An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. The processing logic includes a primary microprocessor configured to execute one or more primary applications written in a first computer language; and a safety microprocessor configured to execute one or more safety applications written in a second computer language.



Integrated Double Cannula for ECMO

Thu, 06 Apr 2017 08:00:00 EDT

The present invention relates to an integrated double cannula for ECMO. The integrated double cannula is configured to be inserted into a blood vessel through skin for ECMO. The integrated double cannula includes a cannula body in which a blood introduction part and a blood supply part are integrally formed inside a single pipe with a partition wall being therebetween, wherein an end of the cannula body is opened through an end hole, another end of the cannula body is opened through an outlet and an inlet arranged side by side and connected respectively to the blood introduction part and the blood supply part, and one or more side holes and one or more discharge holes connected respectively to the blood introduction part and the blood supply part are formed in a lateral portion of the cannula body.



DIALYSIS SYSTEM HAVING INVENTORY MANAGEMENT INCLUDING ONLINE DEXTROSE MIXING

Thu, 06 Apr 2017 08:00:00 EDT

An automated peritoneal dialysis system and machine configured to perform dextrose mixing are disclosed. An example dialysis machine includes at least one pump, a first dialysate having a first dextrose level placed in fluid communication with the at least one pump, and a second dialysate having a second dextrose level placed in fluid communication with the at least one pump. The example dialysis machine also includes first and second valves placed between the first and second dialysates and the at least one pump. The example dialysis machine further includes a logic implementer programmed to operate the at least one pump and the first and second valves to mix the first and second dialysates so as to form a third dextrose level.



INHALATION DEVICE

Thu, 06 Apr 2017 08:00:00 EDT

An inhalation device includes a nozzle, a separator, a housing, a battery portion, a circuit board, and a piezoelectric blower. The piezoelectric blower has a suction hole that opens near the center of an upper surface of the piezoelectric blower and a discharge hole that opens at the center of a bottom surface of the piezoelectric blower. The piezoelectric blower is mounted on a first main surface of the circuit board on the side of an upper housing. The circuit board applies a drive voltage to the piezoelectric blower to drive the piezoelectric blower. The circuit board has a through-hole facing the discharge hole. The through-hole overlaps the discharge hole, out of the suction hole and the discharge hole, when the first main surface of the circuit board is viewed from a front side.



DEVICE AND METHOD FOR WOUND THERAPY

Thu, 06 Apr 2017 08:00:00 EDT

A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.



PEELABLE HEAT-SHRINK TUBING

Thu, 06 Apr 2017 08:00:00 EDT

A heat shrink tubing, which can be readily peeled in the longitudinal direction after use (e.g., to remove the heat shrink tubing from an underlying material) is provided herein. The heat shrink tubing can be of various compositions, and generally is produced from at least one fluorinated, copolymeric resin. The tubing can exhibit desirable physical properties such as good optical clarity (e.g., translucency or transparency) and/or peelability, exhibiting one or more of complete, straight, and even peeling along a given length of tubing.



ADIPOSE-DERIVED STEM CELL PRODUCT

Thu, 06 Apr 2017 08:00:00 EDT

The present invention discloses adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF), their compositions and kits containing the ADSC's and their enriched fractions, and enzyme blends useful for their isolation, as well as methods of their isolation and use.



ARTICLE WITH TACKIFIER-FREE ADHESIVE

Thu, 06 Apr 2017 08:00:00 EDT

Disposable absorbent articles assembled from a collection of components using an adhesive comprising an amorphous polyolefin composition and a heterophase polyolefin composition comprising amorphous character and crystalline blocks.



HOT MELT ADHESIVE

Thu, 06 Apr 2017 08:00:00 EDT

A hot melt adhesive material and articles made using the hot melt adhesive to assemble structures in an article. The adhesive material typically is manufactured by blending amorphous polymer with a heterophase polymer having crystallinity into an adhesive composition.



COMPOSITION FOR INTRAVASCULAR DELIVERY OF THERAPEUTIC COMPOSITION

Thu, 06 Apr 2017 08:00:00 EDT

The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.



PREPARATIONS OF POLY(LACTIC-CO-GLYCOLIC ACID)/POLYDOPAMINE CORE/SHELL HYBRID NANOPARITCLE FOR PHOTOTHERMAL APPLICATIONS

Thu, 06 Apr 2017 08:00:00 EDT

Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.



DVDMS SENSITIZER FOR CANCER SONODYNAMIC THERAPY

Thu, 06 Apr 2017 08:00:00 EDT

A method for treatment of hyperproliferative tissue by injection of and subsequently exposing the hyperproliferative tissue to a frequency of ultrasound. The invention further includes purified bis [1-[6,7-bis [2-(sodium carbonate ethyl]-1,3,5,8,-tetramethyl-2-vinyl-porphin-4-yl]ethyl]ether (DVDMS) for use in sonodynamic treatment of hyperproliferative tissue including cancer and further includes a kit including a dosage controllable injection device charged with a biologically compatible fluid containing DVDMS.



VACCINATION WITH IMMUNO-ISOLATED CELLS PRODUCING AN IMMUNOMODULATOR

Thu, 06 Apr 2017 08:00:00 EDT

Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as GM-CSF (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or preventative vaccination against tumors or infectious agents.



ARTICLES WITH ACTIVE AGENT CONCENTRATED AT THE SUBSTRATE CONTACTING SURFACE AND RELATED METHODS

Thu, 06 Apr 2017 08:00:00 EDT

Compositions and methods to produce adhesive articles with active agents concentrated at the substrate contacting surface. The active agents are applied in powder form, or in combination with a liquid or gel vehicle, to the substrate contacting surface of an adhesive layer of an adhesive article. The active agent compositions are directly applied to the adhesive layer, or are first applied to a release liner, which is then brought into contact with the adhesive layer to dispose the active agent compositions to the substrate contacting surface of the adhesive layer. Upon application of the adhesive article to a substrate, the active agent is delivered to a region of interest on the substrate.



TRANSDERMAL ABSORPTION SHEET AND METHOD OF MANUFACTURING TRANSDERMAL ABSORPTION SHEET

Thu, 06 Apr 2017 08:00:00 EDT

Provided are a transdermal absorption sheet capable of suppressing a sheet portion from being curled and of improving impact resistance of the sheet portion, and a method of manufacturing the transdermal absorption sheet, capable of suppressing a sheet portion from being curled in drying and of shortening a time required for drying a base material liquid. A transdermal absorption sheet includes: a sheet portion; a plurality of needle-like protruding portions that are arranged on one surface of the sheet portion; and a sheet-like mesh structure body that is included in the sheet portion and that has an area, in a plan view, including at least a part of a region in which the plurality of needle-like protruding portions are arranged.



NANO-DEVICES HAVING IMPELLERS FOR CAPTURE AND RELEASE OF MOLECULES

Thu, 06 Apr 2017 08:00:00 EDT

A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide transfer of molecules to or from the storage chamber, and a plurality of impellers attached to the containment vessel. The plurality of impellers are of a structure and are arranged to substantially block molecules from entering and exiting the storage chamber of the containment vessel when the impellers are static and are operable to impart motion to the molecules to cause the molecules to at least one of enter into or exit from the storage chamber of the containment vessel.



PRESSURE-REGULATING VIAL ADAPTORS

Thu, 06 Apr 2017 08:00:00 EDT

According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.



PORTABLE DEFECATION ASSISTIVE EQUIPMENT

Thu, 06 Apr 2017 08:00:00 EDT

The portable defecation assistive equipment comprises a collecting receptacle, a guiding cover, and a pump motor. The collecting receptacle has an opening and a handle. The guiding cover is connected to the collecting receptacle and has a guiding hole. The guiding hole communicates with the opening of the collecting receptacle. The pump motor is connected to the collecting receptacle. The portable defecation assistive equipment has a wing radially formed around the guiding cover, such that the wing and guiding cover can seal the buttock of the user to maintain the negative pressure condition and avoid the reduction of attraction force. The portable defecation assistive equipment adopts a pump motor having smaller attraction. So the portable defecation assistive equipment has no need to adopt an additional pressure regulator valve, the structure is simplified, and the risk of the breakdown of the pressure regulator valve is avoided.



ABSORBENT ARTICLES WITH IMPROVED CORE

Thu, 06 Apr 2017 08:00:00 EDT

An absorbent article including a wearer-facing topsheet, a backsheet and an absorbent core disposed between the topsheet and the backsheet, characterized in that the absorbent core includes: a first absorbent layer comprising a first substrate, a layer of first superabsorbent polymer particles deposited on the first substrate, and a fibrous layer of thermoplastic adhesive material covering the layer of first superabsorbent polymer particles; a second absorbent layer, the second absorbent layer comprising a second substrate and a mixed layer deposited on the second substrate, the mixed layer comprising a mixture of second superabsorbent particles and cellulosic fibers, the first absorbent layer and the second absorbent layer being combined together such that at least a portion of the fibrous layer of thermoplastic adhesive material of the first absorbent layer contacts at least a portion of the mixed layer of the second absorbent layer, and wherein the first absorbent layer is placed closer to the topsheet than the second layer.



DISPOSABLE DIAPER WITH CONVENIENT LAY-OPEN FEATURES

Thu, 06 Apr 2017 08:00:00 EDT

A disposable diaper having features that improve its ability to lay open in a flat configuration is disclosed. The diaper may include fastening members having a minimum basis weight, and a minimum width and a minimum surface area relative the chassis dimensions, along with other features that tend to cause the diaper to lay open in a flat configuration, for the convenience of the caregiver during application of the diaper to a baby.



SANITARY ABSORBING CONSTRUCTION

Thu, 06 Apr 2017 08:00:00 EDT

A sanitary absorbing construction to be used by children and infants to hold and restrain liquid and solid dejections, which article is conventionally called napkin, of a single-use or disposable kind, made by combining different raw synthetic or natural materials, comprising apple waste materials, being industrially transformed into composite sub-layers which are assembled together to form articles having different shapes depending on technical or aesthetical requirements, and being biodegradable either before or after their use, when released into the environment, and being compostable or able to be transformed to into organic amending materials, when properly collected and separated or mixed with other organic domestic waste materials and then let into the compost cycle, per se or together with organic waste materials either from foodstuff or not.



ONE PIECE FLAT DEVICE OF FOR THE DRAINAGE OF AQUEOUS HUMOR FROM THE EYE

Thu, 06 Apr 2017 08:00:00 EDT

The invention relates to a stainless steel device for permanent insertion into the sclerocorneal limbus, with different drainage and anchorage systems, enabling the aqueous humour to discharge through one or more virtual spaces from the anterior chamber to an intrascleral space in cases of simple glaucoma or to the equatorial episclera in cases of complex glaucoma, such as neovascular glaucoma. The space is virtual, not real, as in the case of the tubular device. It enables the aqueous humour to discharge slowly and continuously, minimizing the possibility of the chamber being flat or of germs penetrating through the device. Furthermore, the anchorage system is less aggressive, thus reducing the possibility of bleeding.



VARIABLE DIAMETER CANNULA AND METHODS FOR CONTROLLING INSERTION DEPTH FOR MEDICAMENT DELIVERY

Thu, 06 Apr 2017 08:00:00 EDT

An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.



STERILE SURGICAL TRAY

Thu, 06 Apr 2017 08:00:00 EDT

A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray.



SYSTEMS AND METHODS SYSTEMS RELATED TO ELECTROSURGICAL WANDS WITH SCREEN ELECTRODES

Thu, 06 Apr 2017 08:00:00 EDT

An electrosurgical wand for treating tissue at a target site within or on a patient's body is described, having an elongate shaft with a handle and a distal end portion. The distal end portion has an active electrode, an insulative spacer body and a return electrode; the active electrode supported by the insulative spacer body and spaced away from the return electrode. The active electrode has both lateral and medial edge surfaces. The insulative spacer body has an aspiration cavity fluidly connected with an aspiration lumen, and at least one tapered aperture extending beyond at least one of the electrode medial edge surfaces and directed to the aspiration cavity.



DRUG DELIVERY CUSTOMIZED EAR CANAL APPARATUS

Thu, 06 Apr 2017 08:00:00 EDT

The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on or in the ear canal of a person. In embodiments of the invention, elements of the system, including drug delivery devices, are positioned on or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.