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Adhesive skin patch

Tue, 03 May 2016 08:00:00 EDT

The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.



Electronic nasal aspirator

Tue, 29 Sep 2015 08:00:00 EDT




Double threaded guidance or stiffening wire for multiple use vertebral augmentation (VA) balloon

Tue, 11 Aug 2015 08:00:00 EDT

A catheter device that includes a double-threaded guidance wire that allows multiple use of a compliant cavity creation device (i.e., treatment of more than one level). The double-threaded guidance wire may be connected with the luer part of the device and a distal part of the balloon using a threaded engagement to avoid lengthening of the inner tube, avoid lengthening of the balloon, and to limit the plastic deformation of the system in axial direction. In other implementations, the double-threaded guidance wire may be reconnected to the distal part of the balloon with a distal thread of the double-threaded guidance wire in order to restore the nominal length.



Medical device with orientable tip for robotically directed laser cutting and biomaterial application

Tue, 26 May 2015 08:00:00 EDT

A medical device used in a medical robotic system has a conduit and an orientable tip. An optical fiber coupled to a laser source and/or a catheter coupled to one or more biomaterial sources extends through the conduit and tip so that the tip of the medical device may be robotically directed towards a target tissue for laser and/or biomaterial application as part of a medical procedure performed at a surgical site within a patient. A protective sheath covers the fiber as it extends through the conduit and tip. A first coupler adjustably secures at least the sheath to the medical device and a second coupler adjustably secures the fiber to at least the sheath. A similar dual coupler mechanism may be used to secure the sheathed catheter to the medical device.



Absorbent article

Tue, 26 May 2015 08:00:00 EDT

An absorbent article, such as a sanitary napkin and the like, constituted of an absorbing body between permeable (skin contact surface) and impermeable (skin non-contact surface) sheets, is provided with intermittent recess grooves formed in a longitudinal direction on the absorbent article on the skin non-contact surface side of the absorbing body, a plurality of laterally elongated peripheral embosses formed at intervals in the longitudinal direction of the absorbent article on absorbent body areas located peripherally to the recess grooves, and an absorbing body deficit portion formed at least between the recess grooves. Thus achieved are close contact with buttock cleavage and prevention of leakage to the rear.



Three-dimensional materials

Tue, 26 May 2015 08:00:00 EDT

A material having a first surface and a second surface is disclosed. The first or second surface comprises a texture. The texture is defined by peaks and valleys such that the textured surface may have an Average Peak to Peak Distance in the range of about 3 mm to about 16 mm, an Average Height Differential of at least 1 mm, and a Surface Topography Index from about 0.1 to about 5. The material may comprise a surfactant.



Her2 DNA vaccine as adjunct treatment for cancers in companion animals

Tue, 26 May 2015 08:00:00 EDT

The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.



Analyte monitoring devices and methods therefor

Tue, 26 May 2015 08:00:00 EDT

Method and apparatus for performing a discrete glucose testing and bolus dosage determination including a glucose meter with bolus calculation function are provided.



Antiseptic applicators and packaging techniques

Tue, 26 May 2015 08:00:00 EDT

This disclosure describes example antiseptic applicators that may be used in combination with one or more cleansing, antimicrobial and/or antiseptic agents to reduce or eliminate contaminates on a surface. According to some embodiments, the disclosure describes that the applicators may contain an impermeable layer and a permeable layer, where the impermeable layer prevents contaminates for transferring from a user's hand to the permeable layer and the surface.



IVC filter catheter with imaging modality

Tue, 26 May 2015 08:00:00 EDT

A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter.



IVC filter catheter with imaging modality

Tue, 26 May 2015 08:00:00 EDT

A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter.



Filamentary devices for treatment of vascular defects

Tue, 26 May 2015 08:00:00 EDT

Braid-balls suitable for aneurysm occlusion and/or parent vessel occlusion/sacrifice (e.g., in treating neurovascular defects) are disclosed. Especially for aneurysm treatment, but also for either one of the aforementioned treatments, the form of the ball is very important. In particular, the density of the device is paramount in applications where braid itself is intended to moderate or stop blood flow—allowing thrombosis within a volume formed by the ball.



Systems and methods for treating pulmonary hypertension

Tue, 26 May 2015 08:00:00 EDT

A system for treating heart disease, such as pulmonary hypertension or right heart failure, including an implantable component and external components for monitoring the implantable component is provided. The implantable component may include a compliant member, e.g., balloon, coupled to a reservoir via a conduit. Preferably, the compliant member is adapted to be implanted in a pulmonary artery and the reservoir is adapted to be implanted subcutaneously. The external components may include a clinical controller component, monitoring software configured to run a clinician's computer, a patient monitoring device, and a mobile application configured to run on a patient's mobile device.



Shape modification system for a cooling chamber of a medical device

Tue, 26 May 2015 08:00:00 EDT

The present invention provides a medical device having an catheter body defining proximal and distal portions, and a guidewire lumen at least partially disposed within and movable within the catheter body. The medical device may include an expandable element defining a proximal end and a distal end, wherein the proximal end is coupled to the distal portion of the catheter body and the distal end is coupled to the guidewire lumen. In addition, an actuator element may be coupled to the guidewire lumen for longitudinal movement thereof, and a tensioning element may further be coupled to the guidewire lumen to bias the guidewire lumen and/or the expandable element towards a particular geometric configuration.



Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders

Tue, 26 May 2015 08:00:00 EDT

Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.



Systems and methods for sustained medical infusion and devices related thereto

Tue, 26 May 2015 08:00:00 EDT

Embodiments of the invention are directed to systems, methods and devices for sustained medical infusion with controlled rate injection of a fluid into a body. Such a system may include a first separate reusable unit, a second separate depletable unit a third separate disposable unit having a cannula, and may include a fourth separate remote control unit. Emission of appropriate instructions from the fourth unit, when the first unit, the second unit, and the third unit are coupled together in associative operation and disposed on the skin, power is supplied to an engine for generating motion to a fluid transfer system, and when the cannula is inserted in the body, fluid is transferred from the reservoir to the body, via the tube and the cannula.



Micromechanical force devices for wound healing acceleration

Tue, 26 May 2015 08:00:00 EDT

An apparatus provides micromechanical forces on a wound bed to accelerate healing of a wound. The apparatus includes a pressure chamber having a substantially airtight plunger and an inlet fluidly connected to a first end of a conduit. A constant force spring is operatively connected to apply a constant force to the plunger. A suction cup is in fluid communication with a second end of the conduit.



Apparatus for treating obesity by extracting food

Tue, 26 May 2015 08:00:00 EDT

The present invention is directed to an apparatus and method for treating obesity. A tube is positioned that passes through a patient's abdominal wall into the upper digestive system of the patient. The patient is allowed to carry out his/her everyday affairs including ingesting food. After the patient has ingested food, the food is extracted by pumping it out of the upper digestive system through the tube. The present invention is less invasive than current surgical procedures for reducing weight and allows patients to live a normal and active lifestyle without experiencing adverse side effects.



Apparatus and methods for catheter steerability

Tue, 26 May 2015 08:00:00 EDT

A catheter assembly having first and second shaft members that provide stearability for the catheter assembly. The first shaft member has a plurality of longitudinally spaced apart first ring members that are interconnected with a longitudinally extended first spine member. The second shaft member is positioned within the first shaft member and is connected to a distal end portion of the first shaft member. The second shaft member has a plurality of longitudinally spaced apart second ring members that are interconnected with a longitudinally extending second spine member. Alternatively, the second shaft member includes a plurality of protrusions extending radially outward from the longitudinally extending second spine member. The second shaft member is operable to move at least portions of the first ring members longitudinally relative to each other to bend the first shaft member.



I.V. infusion or blood collection apparatus

Tue, 26 May 2015 08:00:00 EDT

An I.V. infusion or blood collection apparatus comprises an I.V. infusion set (100) and a safety shield (200). The I.V. infusion set has a wing body (105) from which a pair of wings (140) extend outward there from and a grip (145) extending upward there from. One end of the wing body mounts a needle (120) or catheter and medical tubing (130) is connected to the opposite end. The wing body includes a bore so that fluid flows between the needle and the medical tubing. A safety shield has a top, a bottom and opposing side walls and defines a cavity (227) that is adapted to receive the I.V. infusion set. The safety shield has slots (250) in each of the side walls and a slot (255) in the top. The respective wings and grip are adapted to be positioned in the slots and to slidably move therein. The slot in the top includes a lock that is adapted to receive the grip so that when the needle is retracted into the cavity; the grip is permanently captured therein, thus locking the needle in the fully retracted safety position.



Treating bacteria with electric fields

Tue, 26 May 2015 08:00:00 EDT

Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time at particular frequencies with particular filed strengths. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.



Unitary withdrawal spike unit suitable for factory fitting

Tue, 26 May 2015 08:00:00 EDT

A withdrawal spike unit (200) comprises a withdrawal spike component (30′) and an integrally formed adapter component (60′) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component parts (30′, 60′) makes fully automated manufacture and assembly of assemblies comprising such a withdrawal spike unit (200) coupled to a vial (10) possible. As such, human errors associated with the assembly at the point of use are mitigated.



Coupling component for transmitting medical substances

Tue, 26 May 2015 08:00:00 EDT

A coupling component is disclosed for transmitting medical substances, comprising two channels for conveyance of medical substances in two substantially opposite directions and a means for releasable connection to a second coupling component having a further channel for creating a coupling. The connecting means is a thread. A method for conveying medical substances to and from a container is also disclosed.



Absorbent pad and absorbent article

Tue, 26 May 2015 08:00:00 EDT

An absorbent pad and an absorbent article configured that engagement members are arranged at both corners of a ventral-side portion and a back-side portion on an outer sheet of the absorbent pad; a waist band including a belt-shaped body with hook materials and engagement portions attached to both end portions thereof, first and second ventral-side engagement portions across which the engagement members at the ventral-side portion of the absorbent pad are engaged, and first and second back-side engagement portions across which the engagement members at the back-side portion of the absorbent pad are engaged; and hook materials capable of engaging with the engagement members of the absorbent pad are attached to internal surfaces of the first and second ventral-side engagement portions and the first and second back-side engagement portions.



Refastenable training pant with offset and thin seam

Tue, 26 May 2015 08:00:00 EDT

An absorbent article including a chassis having a front waist portion and a back waist portion, front side panels having an inside surface and an outside surface, back side panels having an inside surface and an outside surface, and seams adapted to attach the front side panels to the back side panels in an overlapped configuration offset toward the front waist portion, the seams made up of one or more fastening components attached to the outside surface of each of the back side panels.



Disposable pull-on garment

Tue, 26 May 2015 08:00:00 EDT

An absorbent article having a longitudinal centerline, a front region, a crotch region, and a back region. The absorbent article has a main portion, a side portion, and a waist portion. The waist portion has a belt portion that has a front belt portion having elastomeric material and a back belt portion having elastomeric material. The front belt portion has a first elastic section and a second elastic section, each section having force zones. The back belt portion has a third elastic section and a fourth elastic section, each section having force zones. The force zones in the portions alternate between a high force zone and a low force zone in at least one belt portion.



Body attachment wafer for an ostomy device

Tue, 26 May 2015 08:00:00 EDT

Provided is a body attachment wafer for attaching an ostomy device to a wearer. The body attachment wafer includes a plastic film having an opening therein, a layer of adhesive coated onto one side of the plastic film, and a stiffening layer releasably attached to the plastic film on the side thereof opposite to the side coated with adhesive. The layer of adhesive comprises a region surrounding the opening in the plastic film in which the thickness of the layer of adhesive is decreasing in a direction towards the circumference of the plastic film, the layer of adhesive having its largest thickness adjacent to the opening in the plastic film. The adhesive consists of a silicone gel adhesive having a softness exceeding 8 mm.



Hemostatic device and method

Tue, 26 May 2015 08:00:00 EDT

A method of arresting blood flow from a bleeding wound including the steps of (1) providing a solid hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery onto a bleeding wound, the tablet defining a proximal portion and a distal portion, (2) applying the proximal portion against the bleeding wound to improve the rate of adhesion to a bleeding wound surface, and then (3) applying pressure against the tablet over the wound site. After the seal is formed from the interaction of blood or exudates with the proximal portion of the tablet, the distal portion of the tablet delaminates from the proximal portion to form a reservoir to stop further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.



Method and apparatus for liquid dispensing

Tue, 26 May 2015 08:00:00 EDT

This invention provides for a method and a device for dispensing precise quantities of a predetermined volume of medicaments or other liquids onto the eye, via one or more discrete drop(s) generated by the device in a practical and innoxious way to users.



Filament-based catheter

Tue, 26 May 2015 08:00:00 EDT

A membrane-free perfusion catheter comprising an exchange surface having a filament structure, a delivery unit for delivery of perfusion fluid to a lumen of the filament structure in a manner to allow for an exchange of substances between a medium surrounding the lumen and the perfusion fluid via the filament structure, and a drain unit for draining the medium surrounding the exchange surface and/or for draining the perfusion fluid delivered to the lumen of the filament structure after the exchange of substances between the medium surrounding the lumen and the perfusion fluid via the filament structure.



Elastic seal member for prefilled syringe

Tue, 26 May 2015 08:00:00 EDT

In a prefilled syringe including an elastic seal member to be pierced with a needle for use to eject a protein pharmaceutical preparation therefrom, the elastic seal member ensures smooth and reliable piercing thereof with the needle while reliably preventing an active substance of the protein pharmaceutical preparation from being adsorbed thereon. When a protective film (3) is laminated to a top surface of a seal body (2) of an elastic material, the protective film (3) is stretched to a greater extent by a recess (4) provided in the top surface. Further, the piercing portion to be pierced with the needle is provided in a bottom of the recess (4). Thus, the protective film (3) is formed as locally having a smaller thickness in the piercing portion.



Intravenous therapy

Tue, 26 May 2015 08:00:00 EDT

A medical device is disclosed that can be used to provide a space at an IV catheter site so that kinking of the IV is substantially prevented. The disclosed medical device includes a spacer and an attachment material. The attachment material maybe an elongated strap. The spacer may comprise an elongated member. The elongated strap may be elastomeric and self-adhesive.



Anchor deployment apparatus

Tue, 26 May 2015 08:00:00 EDT

An anchor deployment apparatus for deploying an anchor about a therapy delivery element includes an anchor receiving element having an elongate member having a lumen. The lumen is configured to slidably receive at least a portion of a therapy delivery element. The anchor deployment tool further includes an anchor engagement element having (i) a body forming a channel in which the elongate member of the anchor receiving element is axially movable, and (ii) an engagement feature forming at least a part of the channel. The engagement feature is configured to engage the anchor when the anchor is disposed about the elongate member and the elongate member is moved relative to the engagement element, and to cause the anchor to move distally along the elongate member when the feature is engaged with the anchor and the elongate member is moved relative to the engagement element.



Tube for the enteral feeding of a patient

Tue, 26 May 2015 08:00:00 EDT

A tube unit for the enteral feeding of a patient, with a tube segment that extends along at least a segment of the axial direction (S), and a retention device on the distal end of the tube segment, which extends in at least one direction radially to axial direction (S) beyond the distal end of the tube segment in an extended position and which has a smaller diameter in an elongated position, in which the retention device is elongated along axial direction (S). The retention device moves from an extended position into the elongated position is supported by a control device.



Fluid delivery devices, systems and methods

Tue, 26 May 2015 08:00:00 EDT

Fluid delivery devices, systems and methods. The fluid delivery devices may be used to delivery fluid (e.g., insulin) to a user. The devices may have one or more inlets, and may be configured for use with an injection device, such as a syringe, and/or with a pump.



Connection and alignment systems and methods

Tue, 26 May 2015 08:00:00 EDT

A delivery system for delivering fluidic media to a user having a second housing portion configured to be selectively operatively engaged with and disengaged from a first housing portion, the first housing portion and the second housing portion configured to be slidable relative to each other to operatively engage each other; and a fluid connector supported by one the housing portions in a position to engage a reservoir supported by an other of the housing portions in a case where the first housing portion and the second housing portion are slid relative to each other to operatively engage each other.



Medical catheter assembly including a balloon bolster

Tue, 26 May 2015 08:00:00 EDT

A medical catheter assembly including either a reinforced balloon bolster or the combination of a balloon bolster and a wire-basket bolster. According to one embodiment, the medical catheter assembly is a low-profile replacement PEG device comprising a feeding tube, an external bolster, an end cap and an internal bolster. The internal bolster comprises a first expandable structure and a second expandable structure. In one embodiment, the first expandable structure is a balloon and the second expandable structure comprises reinforcing members. In another embodiment, the first expandable structure is a balloon and the second expandable structure is a wire basket bolster. The feeding tube has a feeding lumen and an inflation lumen, extending parallel longitudinally. The external bolster is fixed to the external end of the feeding tube and has a feeding lumen aligned with that of the tube and an inflation lumen aligned with that of the tube.



Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders

Tue, 26 May 2015 08:00:00 EDT

Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.



Medication safety enhancement for secondary infusion

Tue, 26 May 2015 08:00:00 EDT

A system and method determine when fluid is not flowing properly from a secondary infusion source during a secondary infusion. The system includes an upstream pressure sensor and a processor programmed to receive signals from the sensor and analyze the signals to determine if secondary fluid flow is proper. The processor samples the output signals from the upstream pressure sensor and analyzes the sampled signals to determine if a pressure rise in the infusion line has occurred when the secondary infusion is initiated. If a pressure rise, indicating that fluid from the secondary container has begun flowing into the infusion line, has not been detected, the processor is programmed to provide a signal indicating that attention should be given to the infusion set up.



Medication injection site and data collection system

Tue, 26 May 2015 08:00:00 EDT

A medication delivery apparatus for use with a medication container includes a housing, a fluid conduit at least partially extending within the housing and configured to deliver medication within the medication container to a patient, a medication port extending from the housing and configured to be coupled to a fluid outlet of the medication container, the medication port being fluidically coupled to the fluid conduit, and at least one sensor disposed within the housing to generate information characterizing administration of the medication for processing by a remote data collection system. The housing can have a size and shape that enables it to be supported by a first hand of a user while the user administers the medication from the medication container via the medication port using a second hand of the user. Related apparatus, systems, and techniques are also described.



Medicine delivery device having detachable pressure sensing unit

Tue, 26 May 2015 08:00:00 EDT

A fluid medicament delivery device includes a patient attachment unit and a separate indicator unit. The patient attachment unit includes a housing and a fluid channel located therein, wherein at least a portion of the fluid channel includes a flexible member substantially coterminous with the housing. The separate indicator unit is adapted to be detachably coupled to the housing of the patient attachment unit and includes a first sensing element for contacting the flexible member when the indicator unit is coupled to the housing to sense a flexure of the flexible member.



Retention systems and methods

Tue, 26 May 2015 08:00:00 EDT

A system for retaining a fluid delivery device, the fluid delivery device may include a reservoir and a plunger arm operatively connected to a plunger head arranged for movement within the reservoir, the plunger arm having an arm portion operatively engageable with a drive member configured to move the plunger arm and the plunger head when the plunger arm and the plunger head are connected to the drive member. The system may include a rigid member arranged for movement and a bias member configured to urge the rigid member toward the plunger arm to force the plunger arm against the drive member to operatively engage the plunger arm to the drive member.



Apparatus and methods for treating intracorporeal fluid accumulation

Tue, 26 May 2015 08:00:00 EDT

A fluid management system for the treatment of ascites, pleural effusion or pericardial effusion is provided including an implantable device including a pump, control circuitry, battery and transceiver; a charging and communication system configured to periodically charge the battery and communicate with the implantable device to retrieve performance data; and monitoring and control software, suitable for use with conventional personal computers, for configuring and controlling operation of the implantable device and charging and communication system. The implantable device includes a number of features that provide automated movement of fluid to the bladder with reduced risk of clogging, with no patient involvement other than occasional recharging of the battery of the implantable device. The monitoring and control software is available only to the treating physician, such that the physician interacts with the implantable device via the charging and communication system.



Fibrous sheet that disintegrates in water, process for manufacturing said fibrous sheet, core consisting of strips of said fibrous sheet

Tue, 26 May 2015 08:00:00 EDT

A fibrous sheet having a basis weight of between 20 and 1000 g/m2 that disintegrates in water, has 10% to 70% starch on the basis of the total weight of the dry fibrous sheet. The disintegration time in water, measured in accordance with standard NF Q34-020 applied to a specimen of the sheet of 9×8 cm2, is less than 50 seconds. A loss of strength of the sheet measured in accordance with a defined table test corresponds to a loss of strength of a specimen of said sheet forming an angle of at least 85° after having being wetted with water for a duration of 6 seconds, and/or a residual wet strength of the sheet relative to its dry strength, as measured according to a defined ring crush test, is less than 1%. The fibrous sheet may be used for the manufacture of a water disintegrable core in a roll of tissue paper.



Ocular implants with asymmetric flexibility

Tue, 26 May 2015 08:00:00 EDT

An ocular implant having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.



Devices and methods for gastrointestinal bypass

Tue, 26 May 2015 08:00:00 EDT

Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.



Dialysis system with enhanced features

Tue, 26 May 2015 08:00:00 EDT

A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.



Regional citrate anticoagulation

Tue, 26 May 2015 08:00:00 EDT

A system or method automates and optimizes citrate anticoagulant supplementation in a blood filtration circuit during CRRT. A processor-based control system interfaces with a blood filtration circuit to detect patient blood flow into the circuit, detect fluid loss through a hemofilter, and sense vital electrolyte concentrations in the blood flow, and in response, control the addition of citrate, substitution fluid, and electrolyte supplements to ensure stability of plasma concentrations in post-dilution flow returned to the patient. The controller executes the method embodied as process control algorithms for calculating an optimal citrate flow rate as a function of selected, detected, and calculated system parameters. Citrate may be added to the circuit separately, or as part of a substitution solution or a dialysate.



Chronic access system for extracorporeal treatment of blood including a continuously wearable hemodialyzer

Tue, 26 May 2015 08:00:00 EDT

A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from CHF patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia.



Shaft element for an endoscopic instrument

Tue, 26 May 2015 08:00:00 EDT

A shaft element for an endoscopic instrument includes a first, proximal shaft segment and a second, distal shaft segment, such that the second shaft segment is connected with the first shaft segment by three connecting elements, such that the connecting elements each include a first two-axis joint, such that the first joints form a triangle and such that the first connecting element is connected with the first shaft segment in such a way that it cannot slide with respect to the latter in a longitudinal direction, and a second and third connecting elements can each be slid with respect to the first shaft segment in a longitudinal direction independently of one another. The invention also relates to an endoscopic instrument, in particular an endoscope with such a shaft segment.