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Dose-escalated radn does not up survival in localized prostate CA

Fri, 16 Mar 2018 18:00:01 EDT

(HealthDay)—Dose escalation from 70.2 to 79.2 Gy is not associated with improved overall survival (OS) in intermediate-risk prostate cancer, according to a study published online March 15 in JAMA Oncology.

Smart software can diagnose prostate cancer as well as a pathologist

Fri, 16 Mar 2018 10:29:04 EDT

Chinese scientists and clinicians have developed a learning artificial intelligence system which can diagnose and identify cancerous prostate samples as accurately as any pathologist. This holds out the possibility of streamlining and eliminating variation in the process of cancer diagnosis. It may also help overcome any local shortage of trained pathologists. In the longer term it may lead to automated or partially-automated prostate cancer diagnosis.

Potential of 3-D nanoenvironments for experimental cancer research

Fri, 16 Mar 2018 09:50:02 EDT

Researchers at Okayama University employed a 3-D nano-matrix to gain insights into how different cells types mimic the properties of cancer stem cells in this environment. Their results published in the journal PLOS One show that a nano-environment promotes distinct patterns of cell aggregation and biological properties that are reminiscent of tumors.

New findings on type 2 diabetes and colorectal cancer survival rates

Fri, 16 Mar 2018 09:48:03 EDT

Researchers from the University of Hawaiʻi Cancer Center and Office of Public Health Studies found that patients who have type 2 diabetes in addition to other chronic diseases have a lower survival rate for colorectal cancer.

Researchers create a drug to extend the lives of men with prostate cancer

Fri, 16 Mar 2018 09:14:47 EDT

Fifteen years ago, Michael Jung was already an eminent scientist when his wife asked him a question that would change his career, and extend the lives of many men with a particularly lethal form of prostate cancer.

Study extends potential for personalized immunotherapy to large variety of cancers

Fri, 16 Mar 2018 09:08:04 EDT

A Ludwig Cancer Research study shows that ovarian cancer, which has proved resistant to currently available immunotherapies, could be susceptible to personalized immunotherapy. Led by Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells, which kill infected and cancerous cells. The study demonstrates how they can be identified and selectively grown for use in personalized, cell-based immunotherapies.

Barriers to colorectal cancer screening among poor identified

Fri, 16 Mar 2018 04:50:01 EDT

(HealthDay)—Improving colorectal cancer screening rates among lower-income populations requires addressing structural, personal, and health care system barriers, according to research published in the April issue of Diseases of the Colon & Rectum.

One quarter of penis cancer sufferers don't get recommended treatment—halving the survival rate

Fri, 16 Mar 2018 03:26:25 EDT

A major international survey has found that around a quarter of patients are not receiving the recommended treatment for cancer of the penis. It also found that these patients had half the survival rate of those who were treated according to guidelines. The study, presented at the EAU conference in Copenhagen, finds that non-adherence is partly due to patients refusing treatment, or doctors being reluctant to treat appropriately or being unfamiliar with the best procedures.

Major study shows x5 greater suicide rate in patients with urological cancers

Fri, 16 Mar 2018 03:23:10 EDT

A major UK survey has shown that patients with urological cancer such as prostate, bladder or kidney cancer are five times more likely to commit suicide than people without cancer. The analysis also shows that cancer patients generally are around three times more likely to commit suicide than the general population, and that the proportion of attempted suicides which result in a completed or successful suicide was higher in cancer patients, with a higher proportion still in patients with urological cancers.

Study suggests that cancer survivors are more easily fatigued

Thu, 15 Mar 2018 12:04:21 EDT

Adults who have undergone successful cancer treatment years or decades previously become fatigued more quickly than their peers who don't have cancer histories, according to a new study in the journal Cancer from scientists at Johns Hopkins Bloomberg School of Public Health.

Joint supplement speeds melanoma cell growth

Thu, 15 Mar 2018 12:00:05 EDT

Chondroitin sulfate, a dietary supplement taken to strengthen joints, can speed the growth of a type of melanoma, according to experiments conducted in cell culture and mouse models.

Higher doses of radiation don't improve survival in prostate cancer

Thu, 15 Mar 2018 11:00:02 EDT

A new study shows that higher doses of radiation do not improve survival for many patients with prostate cancer, compared with the standard radiation treatment. The analysis, which included 104 radiation therapy oncology groups across North America, was led by researchers at Washington University School of Medicine in St. Louis.

Synthetic macromolecules kill multidrug-resistant cancer cells

Thu, 15 Mar 2018 09:39:49 EDT

Cancer continues to be a deadly threat to more than 14 million people who are diagnosed each year around the world. At the same time, five-year survival rates have been steadily improving over the last three decades to nearly 70 percent, according to the American Cancer Society. However, current cancer treatment regimens, such as traditional radiation therapies, often kill healthy cells along with diseased ones. Chemotherapy, or the use of anti-cancer drugs, can fail as drug resistance in the treatment of cancer has become commonplace, both with existing drug-resistant cancer cells as well as induced resistance. So devastating is the issue of drug resistance, that it is a critical aim of the Cancer Moonshot, a program established by the U.S. government, to vastly accelerate cancer research.

Machine-learning algorithm used to identify specific types of brain tumors

Thu, 15 Mar 2018 09:24:54 EDT

An international team of researchers has used methylation fingerprinting data as input to a machine-learning algorithm to identify different types of brain tumors. In their paper published in the journal Nature, the team describes studying DNA methylation fingerprinting to create a system that is able to identify central nervous system (CNS) tumors and report on its accuracy.

Improved capture of cancer cells in blood could help track disease

Thu, 15 Mar 2018 09:00:01 EDT

Tumor cells circulating throughout the body in blood vessels have long been feared as harbingers of metastasizing cancer - even though most free-floating cancer cells will not go on to establish a new tumor.

New research could lead to more effective chemotherapy

Thu, 15 Mar 2018 07:01:33 EDT

An international team of researchers led by Hassan Beyzavi of the University of Arkansas, is studying the use of platinum and gold to enable more effective forms of chemotherapy.

Little evidence for any direct impact of national cancer policies on short-term survival in England

Wed, 14 Mar 2018 19:30:02 EDT

A study published by The BMJ today finds little evidence for any direct impact of national cancer policy initiatives implemented since 2000 on short term cancer survival in England.

Obesity may promote resistance to antiangiogenic therapy for breast cancer

Wed, 14 Mar 2018 14:05:53 EDT

Obesity—which is already known to reduce survival in several types of cancer—may explain the ineffectiveness of angiogenesis inhibitors in the treatment of breast cancer. A research team led by Massachusetts General Hospital (MGH) investigators describes finding, for the first time, that obesity and obesity-related molecular factors appear to induce resistance to antiangiogenic therapy in breast cancer patients and in two mouse models of the disease. Their report in Science Translational Medicine also details specific obesity-related factors underlying that resistance and outlines potential therapeutic strategies that may overcome it.

Using implementation science to improve cervical cancer prevention in sub-Saharan Africa

Wed, 14 Mar 2018 13:17:47 EDT

While cervical cancer - one of the most common cancers in women - has significantly decreased in the United States, it is still the second most common cancer in women who live in less developed countries, according to the World Health Organization. Women in sub-Saharan Africa (SSA) have the largest age-standardized incidence and mortality rates of this potentially preventable and non-communicable disease due to the difficulty in implementing prevention, screening, and treatment programs.

Area surrounding a tumor impacts how breast cancer cells grow

Wed, 14 Mar 2018 13:10:51 EDT

Cancer is typically thought of as a tumor that needs to be removed or an area that needs to be treated with radiation or chemotherapy. As a physicist and cancer researcher, Joe Gray, Ph.D., thinks differently.

Vit D concentration associated with reduced risk of cancer

Wed, 14 Mar 2018 11:20:01 EDT

(HealthDay)—Higher plasma concentration of 25-hydroxyvitamin D is associated with reduced risk of total cancer in a Japanese population, according to a study published online March 7 in The BMJ.

Scientists caution that a rare childhood liver cancer can spread to the brain

Wed, 14 Mar 2018 10:05:02 EDT

Early detection is key for managing metastatic brain cancer. Above, a secondary brain tumor originating from melanoma skin cancer.

New insights into prostate cancer treatment and screening

Wed, 14 Mar 2018 09:17:13 EDT

In four recent publications in the Journal of Clinical Oncology (JCO), Maha Hussain, MD, deputy director of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, detailed new findings related to therapies for advanced prostate cancer, and called for a balanced approach to early detection of the disease.

Cancer incidence and survival statistics for Northern Ireland 2012-2016

Wed, 14 Mar 2018 08:00:12 EDT

The Queen's University N. Ireland Cancer Registry (NICR) today released the number of new cancer cases diagnosed (incidence) in Northern Ireland in 2016. Legislation designating the Northern Ireland Cancer Registry (NICR) as an official producer of statistics came into place 1 April 2012. Website available at: .

Machines see the future for patients diagnosed with brain tumors

Tue, 13 Mar 2018 17:56:22 EDT

For patients diagnosed with glioma, a deadly form of brain tumor, the future can be very uncertain. While gliomas are often fatal within two years of diagnosis, some patients can survive for 10 years or more. Predicting the course of a patient's disease at diagnosis is critical in selecting the right therapy and in helping patients and their families to plan their lives.

Surprising discovery provides insights into aggressive endometrial cancers

Tue, 13 Mar 2018 12:00:04 EDT

New research from Huntsman Cancer Institute (HCI) at the University of Utah (U of U) indicates steroid and hormone receptors are simultaneously active in many endometrial cancer tissues. The findings, published today in the journal Cell Reports, yield insights about factors that contribute to more aggressive endometrial tumors.

Screening mammography for women 40-49 detects more cancers compared with older age groups

Tue, 13 Mar 2018 11:58:16 EDT

When compared to the screening population ages 50 and over, screening mammography in women ages 40-49 detects 19.3% additional cancers at the expense of an overall 1.5% increase in callbacks and 0.1% in increased biopsies, according to a study to be presented at the ARRS 2018 Annual Meeting, set for April 22-27 in Washington, DC.

Presidential panel says high-priced cancer drugs harm patient care

Tue, 13 Mar 2018 10:10:39 EDT

(HealthDay)—"Financial toxicity" caused by high cancer drug prices is harming people's ability to fight the dreaded disease, a new report from the President's Cancer Panel warns.

80% cut in liver metastasis by restricting the blood vessels supplying it

Tue, 13 Mar 2018 09:53:31 EDT

The International Journal of Cancer has just published the results of an experimental therapy tested on mice. The research achieved an 80 percent reduction in liver metastasis brought about by colon cancer. Nanoparticles were used to slow down the growth of the blood vessels that reach the tumour cells, and thus cut the supply of oxygen and nutrients to these cells so that their growth is also curtailed.

New biomarkers for neuroblastoma, a type of cancer in children

Tue, 13 Mar 2018 09:10:38 EDT

Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment.