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Last Build Date: Wed, 13 Dec 2017 10:29:00 +0000

 



Comment on Adaptive immune defenses: Antibodies by Snehal Shinde

Wed, 13 Dec 2017 10:29:00 +0000

I want to know approximate number of antibodies and Memory cells(B and T) that are created after the infection. can anyone suggest me on this?



Comment on TWiV 471: Songs of innocence and experience by TWiV 471: Songs of innocence and experience - VETMEDICS

Mon, 11 Dec 2017 01:16:06 +0000

[…] The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” […] Source link […]



Comment on TWiV 471: Songs of innocence and experience by TWiV 471: Songs of innocence and experience - Virology

Sun, 10 Dec 2017 16:37:47 +0000

[…] The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” […] Source link […]



Comment on Retroviral influence on human embryonic development by RayOne

Sun, 10 Dec 2017 13:48:00 +0000

This may be a aspect of STEM CELL treatment.



Comment on Viruses and the tree of life by John Millington

Sat, 09 Dec 2017 16:42:00 +0000

life... that which grows larger an heavier or smaller and lighter or both, e.g. pregnancy/birth. inanimacy... that which gets larger and lighter or smaller and heavier or both e.g. supernovae. Best, J.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Brian Hanley

Fri, 08 Dec 2017 20:25:00 +0000

You are in good company with the PNAS authors who published a paper taking down Mark Z Jacobson's malarkey claim that 100% renewables is attainable (and soon.) MZJ has filed suit over the publication of this paper that has 20 some authors. So apparently it is the latest "last refuge of the incompetent," to invoke the courts. http://www.legislation.gov.uk/ukpga/2013/26/section/17 - 2013 reform act. You are in better shape than you were before 2013 in the UK. England was a notorious venue shop for defamation'libel cases. That is somewhat improved, and those trials can no longer demand a jury. In English legal precedent truth is not a sufficient defense in defamation. So, there were cases where the plaintiff won when the "defamation" was true. But in those cases, typically the damage award was 1 shilling, or 1 pound. If the Bristol attorney is not keeping up on recent changes to the law (quite common for attorneys) then she may be thinking she can file against you based on the law prior to 2013's reforms. It used to be, she could have done that, and if you didn't mount a vigorous (and costly) defense, get a summary judgement and at the very least cause you trouble if you re-entered the UK. These days, you should be able to retain a solicitor to retain a barrister to file for dismissal with prejudice should that happen and not spend ungodly amounts of money. You could, conceivably, then file against that attorney at Bristol personally for barratry and it would perhaps fly far enough she would seriously regret it.



Comment on Trial By Error, Continued: The CMRC Affirms Full Support for Libelous Esther by Trial By Error: My One-Sided Correspondence with Professor Crawley

Fri, 08 Dec 2017 19:02:54 +0000

[…] Trial By Error, Continued: The CMRC Affirms Full Support for Libelous Esther […]



Comment on Trial By Error, Continued: An Open Letter to the Board of the CFS/ME Research Collaborative by Trial By Error: My One-Sided Correspondence with Professor Crawley

Fri, 08 Dec 2017 19:01:13 +0000

[…] Trial By Error, Continued: An Open Letter to the Board of the CFS/ME Research Collaborative […]



Comment on TWiV 469: Mycovirus stuffed potatoes by Tama Bell

Fri, 08 Dec 2017 13:56:00 +0000

Hello all-you guys are all so smart and so amazing, but you are also such nerds. Just sayin'. Love your programs; thank you for being you and bringing the awesome information, stories, articles, studies, about our beloved viruses (and just because I do love viruses, I am sure this classifies me as a nerd as well).



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Postscript to ‘Reasons for proposing a hedge school’. | Iain Biggs

Fri, 08 Dec 2017 11:06:46 +0000

[…] sent me a link to the academic and investigative journalist David Tuller’s most recent post: Trial by Error: My One-sided correspondence with Professor Crawley. This brilliantly summarises an exchange that, among other things, highlights Bristol […]



Comment on A problem with dengue virus vaccine by A problem with dengue virus vaccine - VETMEDICS

Fri, 08 Dec 2017 09:40:40 +0000

[…] A dengue virus vaccine was recently developed not only to prevent first infections, but to avoid severe disease that may occur upon second and third infections. This consequence, called antibody dependent enhancement (ADE), now appears to be caused by the vaccine itself. Primary dengue virus infection may lead to a disease that includes fever, headache, […] Source link […]



Comment on A problem with dengue virus vaccine by A problem with dengue virus vaccine - Virology

Fri, 08 Dec 2017 05:50:29 +0000

[…] A dengue virus vaccine was recently developed not only to prevent first infections, but to avoid severe disease that may occur upon second and third infections. This consequence, called antibody dependent enhancement (ADE), now appears to be caused by the vaccine itself. Primary dengue virus infection may lead to a disease that includes fever, headache, […] Source link […]



Comment on Trial By Error, Continued: A Follow-Up Post on FITNET-NHS by Trial By Error: My One-Sided Correspondence with Professor Crawley

Fri, 08 Dec 2017 03:55:22 +0000

[…] Trial By Error, Continued: A Follow-Up Post on FITNET-NHS […]



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Polly

Thu, 07 Dec 2017 19:30:00 +0000

Encouraging any one who is unwell to think of themselves as 'muppets' is not OK. Yes, in this case it was a misguided acronym but even though the term can be used in a loving way, it can also be used as an insult. La Crawley should have been aware that a nurse was suspended for calling a patient 'a muppet'. That the professional attendees for that infamous 'day with the muppets' may get continuing education credits is wrong on every level imaginable. The good outcome is that the use of the acronym adds to the growing list of things she says and does that discredit her.



Comment on TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study by Interview with neuroscientist Michael VanElzakker: Vagus Nerve, ME/CFS, latent infection and more | Microbe Minded

Thu, 07 Dec 2017 19:18:33 +0000

[…] ME/CFS. The Trial’s results don’t fit with what most ME/CFS patients experience in real life. Please read journalist David Tuller’s detailed critique the […]



Comment on TWiV 430: The persistence of herpesvirus by scott

Wed, 06 Dec 2017 18:04:00 +0000

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Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Janneke

Wed, 06 Dec 2017 16:50:00 +0000

thank you so much for fighting for the MEpatients. just enough recovered to actually read on the internet I find this debate, the idiotic PACEstudy, I do not think that I would have come away with that for my masterthesis, it's just plain unbelievable. you're the hero of the MEcommunity, though I do not think that has ever be your aim. I'm from Holland, awaiting what our national health organization will say of it. Unsurprisingly, the committee is made up of people who feel CBT and GET are just a fine intervention for MEpatients. Thanks to the elderly familydoctor who treated me as a teenager, i've never done any graded activity, rest and healthy diet is my recipe. This is the third bout of it and I still handle it as he told me 40 years ago, recovered from severe to mild...but now I seem to be stuck



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Janneke

Wed, 06 Dec 2017 16:01:00 +0000

thanks for your unwavering fight for ME-patients. Since some weeks I'm able to somewhat follow the debate and I'm absolutely baffled about what is happening, I'm from Holland, the fitnet is still going on, I had a look at their website. Not even a small remark that there is some international debate.... Grateful for the old family doctor who advised rest and diet the first time I came to lay in bed with this disease, at 16. I'm now in my fifties and struggling with the fourth bout of it, still hope to recover eventually. At least I'm out of bed. But help from doctors instead of obstruction would make the going decidedly less hard.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Janneke

Wed, 06 Dec 2017 16:01:00 +0000

thanks for your unwavering fight for ME-patients. Since some weeks I'm able to somewhat follow the debate and I'm absolutely baffled about what is happening, I'm from Holland, the fitnet is still going on, I had a look at their website. Not even a small remark that there is some international debate.... Grateful for the old family doctor who advised rest and diet the first time I came to lay in bed with this disease, at 16. I'm now in my fifties and struggling with the fourth bout of it, still hope to recover eventually. At least I'm out of bed. But help from doctors instead of obstruction would make the going decidedly less hard.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by pinklil

Wed, 06 Dec 2017 13:33:00 +0000

It's very not ok.... for any of us. It's a scandal of immense proportions. It will break through the public consciousness eventually, but will we have to wait until the central proponents are dead or senile first? Thought tbh I'd be inclined to think 'senility' plays quite a large part in the design of the paradigm anyway....



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Polly

Wed, 06 Dec 2017 03:36:00 +0000

Thanks again, pinkill. 'A sane response to an insane situation' works for me too. Which is probably why I admire David's take on this so much. And could also be why, when my GP said 'I encounter neuro-normals as boring', life got a lot better for me. But my darling friend who has ME still has shoddy treatment, which is not OK.



Comment on Reovirus infection of farmed salmon by Impacts of Salmon Farming – Grassroots Rendering

Tue, 05 Dec 2017 21:47:12 +0000

[…] waters, has now been proven to exist in west coast salmon farms. There is growing evidence that this virus is linked to the deadly Heart and Skeletal Muscle Inflammation disease, which is evident in recent footage of […]



Comment on Ten cool facts about viruses by Kaya Nieto

Tue, 05 Dec 2017 21:07:00 +0000

It helped me with science homework to.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by pinklil

Tue, 05 Dec 2017 20:08:00 +0000

I 'feel' your rant. A perfectly rational response to the irrational.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Jeremy bearman

Tue, 05 Dec 2017 16:40:00 +0000

dave,youre the best. we are so lucky to have you fighting for the advancement of the wellbeing of ME patients. will donate when possible. jeremy bearman



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Sue

Tue, 05 Dec 2017 15:35:00 +0000

Brilliant. Just brilliant. As a former research chemist and an ex nurse. I love good critique and adequately examined research. Don’t have the old words to use properly these days. Yesterday I struggled in a game to remember three things that are in tins. I applaud your work. Keep it up!



Comment on Are Viruses Living? by lil sammy

Tue, 05 Dec 2017 14:20:00 +0000

yall best be listening to lil sammy on soundcloud



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Polly

Tue, 05 Dec 2017 13:40:00 +0000

Thank you, pinkill. Escaping the clutches of the psychobabble merchants was relatively easy, for me. Although at the time it felt like one of the biggest fights in my life to get re-diagnosed with MdDS, compared to others, I got off lightly. One woman I met at a 'rare' conference was told that if she didn't accept a 'somatoform disorder' dx she would be removed from her primary care practice. Fortunately she ignored the threat and got a rational diagnosis shortly afterwards. [For the full horror show, google 'management of somatoform disorders at the NBT' - it is both hilarious and terrifying, as all good horror should be.] Via a medical student who entered and won the Findacure essay competition last year I heard about another woman who had a rational diagnosis of a rare intestinal condition which got overruled to 'an eating disorder'. This completely disrupted her successful treatment and caused her physical harm. I could go on ... The meme 'what you learn from the study of rare conditions brings added knowledge to common conditions' makes me conscious that the rare patient diagnostic odyssey, which often involves at least one quack dx, is probably not rare at all. Meanwhile 'MUS'/'functional' are alive and kicking as a diagnoses, at least if the draft NICE guidelines for suspected neurological conditions (charmingly referred to as neuro-problems) is anything to go by. If they come out in anything close to the current version, diagnosis, patient care and - crucially - research could be set back by 10 - 15 years. Not OK. Rant over - for now. And back to the saga of La Crawley and her outstanding abilities to shoot herself in both feet [whilst putting them in her mouth] with stuff like the Muppets malarkey. That one's never going to get old.



Comment on Trial By Error, Continued: The Dutch Studies (Again!), and an Esther Crawley Bonus by Trial By Error: My One-Sided Correspondence with Professor Crawley

Tue, 05 Dec 2017 11:21:56 +0000

[…] Trial By Error, Continued: The Dutch Studies (Again!), and an Esther Crawley Bonus […]



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by pinklil

Tue, 05 Dec 2017 10:26:00 +0000

Very interesting perspective..thank you. I'm not surprised by Bristol's behaviour, although I'm sure it's countrywide, because they do seem to have chased themselves down the rabbit hole when it comes to trying to appropriate anything 'unknown' to the MUS wastebasket. I applaud *your* tenacity in dealing with them so effectively and for recognising the pattern of behaviour in other diseases in similar settings.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Elizabeth Sanchez

Tue, 05 Dec 2017 01:23:00 +0000

Thank you David for your persistence and your clear, unambiguous and transparent defense of ethical and evidence based science.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Polly

Mon, 04 Dec 2017 22:26:00 +0000

Gripping stuff - well worth the hazards of scrolling. In the interests of transparency I don't have ME or CSF but do have a rare neurological condition (Mal de Debarquement Syndrome) that is sometimes considered in the dated way ME has been. In the rare conditions world I have witnessed many shocking attempts to land-grab poorly understood conditions as being 'medically unexplained'/'functional' or whatever expression is in vogue at the time, so have followed the ME story when I can since it parallels our experiences. Also I live in Bristol and it was here that a neuro-psych attempted to land-grab MdDS as 'functional', via me. Epic fail. And one that resulted in the North Bristol Trust telling me that they would consider taking legal action against me if I wrote anything they considered 'defamatory' about them. My response was to say they were welcome to read anything I intended to make public before I did, since a) I didn't want to be defamatory about them (since I now receive great care there) and b) I didn't want them to waste tax payers' money on a legal process. Their response was along the lines of 'it doesn't work that way' - tell me about it ;) So, it's a different saga but I applaud you and thank you, David.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Steve Hawkins

Mon, 04 Dec 2017 21:50:00 +0000

I think that you ought to be getting in touch with Nature about SAS using the 'Maddox Prize' to promote quackery. Although they have awarded this year's main prize to a vaccination campaigner as a way of bashing the antivaxxers in a way that Maddox might have done, I doubt that he would have agreed to their continued commending and promotion of Crawley's discredited work, or her refusal to engage in scientific debate: "Professor Crawley works to promote a better understanding of CFS/ME in the face of complaints to her employer and professional bodies and accusations of fraud and misconduct." If Nature is to be taken seriously in its name being put to this assertion, it must surely be able to come up with evidence as to why complaints about Prof Crawley's research, conduct, and vilification of M.E patients are not justified. A respected science journal should not be letting its name be used for political purposes by a libertarian group with an axe to grind against any upstart members of the public, or patients, who dare to question the vested interests in control of much of UK medicine. http://senseaboutscience.org/activities/2017-john-maddox-prize/



Comment on Did hepatitis C virus originate in horses? by Cyn Ellis

Mon, 04 Dec 2017 19:50:00 +0000

As in Tetnus vaccines???



Comment on Trial By Error: The Crawley Chronicles, Continued by johnnydme

Mon, 04 Dec 2017 19:33:00 +0000

Sorry to hear it happened to him too. I just had remembered that someone from PACE wrote a letter that he was a patient, and supposedly this, somehow, disqualified him from publishing scienctific articles on the topic?! This is an ongoing pattern when the biospychosocial "research" on Myalgic Encephalomyelitis is scrutinized. Hopefully the pattern be documented somewhere (in a website or a thread?) so there is an easy historical record to refer when the journalists in the U.K. will finally cover it. Of course the irony has been pointed out many times before but harassment and intimidation is precisely what they accuse desperately ill ME patients of doing! Often from large platforms such as the Guardian, Daily Mail, BBC... Even if the reader is not inclined to read the background on these stigmatizing campaigns by them, hopefully many will sense something is "not right" about doctors maligning the very group they profess to care for...



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Wendy Boutilier

Mon, 04 Dec 2017 18:03:00 +0000

You have conducted yourself with full transparency. I suspect that EC has no experience with transparency and therefore can’t recognize it. The UK & European Psychiatric Collaboration has caused irreparable harm to those who have no hope of ever leading a normal full life again. Maybe this is all they have to offer. All their cruelty, manipulation, no compassion, no understanding, and certainly no empathy. As hard as Myalgic Encephalomyelitis is to live with, given the choice I would never exchange it for their emptiness.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Sleepyblondie

Mon, 04 Dec 2017 17:48:00 +0000

Freedom of information request???



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Lois Addy

Mon, 04 Dec 2017 17:22:00 +0000

often someone is called muppet in a loving way in a family, or say my carer, if I drop something, will say you muppet, let me take it etc. but it can turn and be something nasty also - it depends on context. as such acronyms should be very carefully framed so they AREN'T able to be twisted to make people feel 'lesser'. I hope Prof Crawley has a rethink about the acronym.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Lois Addy

Mon, 04 Dec 2017 17:20:00 +0000

I'm also quite shocked by the use of 'muppets;. on the one hand yes, they're cute puppets by Jim Hensen. but yes very much so, a muppet is someone who has no critical thinking and just plunges through life from one crisis to another. so if someone makes a silly mistake (like putting the milk in the dishwasher instead of the fridge) they're a muppet. I am shocked they didn't consider the derogatory nature of the acronym. it doesn't even work, it should be mupps as an acronym. considering there's equality and awareness training, and we aren't allowed to say things like blue sky thinking because it has bad connotation for some (epileptics maybe? I can't remember) then I am startled that muppets made it as far as it did. then again maybe is a generational thing, I think the reach of social media, and hte internet comes as something as a shock to some in their 40s+ it's not something we grew up with and if one doesn't engage with it, one doesn't realise how far and how fast it goes.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Lois Addy

Mon, 04 Dec 2017 17:15:00 +0000

oh what a good saying. and it's totally true.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Lois Addy

Mon, 04 Dec 2017 17:15:00 +0000

don't be. you use sentances. and paragraphs and proper grammar. so I can read some. then pick up again after a rest. and so on. repeatedly. take the space you need to make the argument and conclusions. also, you don't pad your writing with unecessary fluff and it's flowing well so not hard to read and take in.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Jen

Mon, 04 Dec 2017 17:06:00 +0000

You have been libelled and your good name bismirched by Crawley at public events (as have patients been unjustly maligned). Bristol should be quite concerned. I hope they look into it more thoroughly and don't just take Crawleys version of events as this could leave them with considerable egg on their face.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Abbie RavenMoon Wayne

Mon, 04 Dec 2017 16:47:00 +0000

We can't thank you enough for bringing this huge issue out into the open, why on earth would I put my daughter's welfare into this woman's hands when she can't substantiate her evidence ? She does not speak for my daughter, she does not have my consent to gather any information on my daughter nor myself, not without absolute proof that her 'treatments' work, if M.E is at a cellular level, mitochondrial, then how on this Earth is grading up exercise going to help ? After trying to get my daughter into school, a place she once loved, to now wheelchair bound due to exhaustion on all levels, this woman is dangerous to all of our children.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Jen

Mon, 04 Dec 2017 16:45:00 +0000

It was a good read. I can only manage a heartfelt thank you and how much I appreciate the efforts you have made to challenge poor studies and unsound representation of the data. I hope this helps the science to become more rigorous and robust so we have an honest analysis to what therapies help patients, which have no effect and which may hinder recovery. I was harmed by the GET CBT combo, after trusting the PACE trial as being honest about its findings. I do not think it's too much to ask that treatments are safe for patients and set up is not lax and results aren't fudged for a political agenda. How can we as patients trust science, when studies of such poor quality are not challenged thoroughly. Thank you for not being fobbed off, or scared off by unfounded accusations. Keep up the good work.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Leela D

Mon, 04 Dec 2017 16:44:00 +0000

It's a total gift to have such a powerful and persistent advocate. You are so articulate and thorough, and your passion for this long-overdue discussion and clarification is beyond heartwarming. Thank you so much, davetuller, for amplifying the patient voice that others are desperately trying to silence and co-opt. Oh, the irony--on so many levels--in "Dare to Disrupt"!



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Trial By Error: My One-Sided Correspondence with Professor Crawley - VETMEDICS

Mon, 04 Dec 2017 16:18:45 +0000

[…] By David Tuller, DrPH Well, last week was certainly exciting! As I wrote on Wednesday, I was planning to post about Professor Esther Crawley’s SMILE trial. However, that plan changed when Sue Paterson, the University of Bristol’s director of legal services, e-mailed me what I guess was supposed to be a scary letter. The letter […] Source link […]



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Alison Orr

Mon, 04 Dec 2017 16:14:00 +0000

I braced myself for your snacking and sarcasm, but saw very little of it. I thought your tone was professionally informal and absolutely acceptable. Thank you for being our terrier and not letting it go!



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by Seven

Mon, 04 Dec 2017 15:53:00 +0000

Can we find out who does the nominations? Follow the trail?



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by davetuller

Mon, 04 Dec 2017 15:14:00 +0000

I wouldn't necessarily know. I might only find out something like that if there were a formal complaint and then Berkeley completed an investigation. I had never heard about their institutional relationship, but Berkeley has relationships with umpteen universities here and there. I think to file such a complaint would not be a good idea for Bristol in the end. They would lose, and it would likely get significant press coverage that would make Bristol look very bad. So the idea is ridiculous. Esther has accused me of libel, and never communicated with me about it despite all my invitations and offers. I have a right to be informed about mistakes and then to correct them if I want. They have no cause to complain unless they document what is libelous, and I refuse to correct legitimate mistakes. My tone is not a cause for complaint.



Comment on Trial By Error: My One-Sided Correspondence with Professor Crawley by cluecat

Mon, 04 Dec 2017 14:56:00 +0000

Have UC Berkeley and Bristol actually had that private conversation at the senior level about your behavior, or is that smoke and mirrors like the non-existent cease and desist? (Do they actually have an institutional relationship?)