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BIO TECHNOLOGY INFORMATION





Updated: 2016-09-07T21:35:59.858-07:00

 



Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

2011-05-01T08:42:00.326-07:00

textOriginal ArticleActa Pharmacologica Sinica (2010) 31: 821–830; doi: 10.1038/aps.2010.67; published online 28 June 2010Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivoChen Zhang1, Kun-zheng Wang1, Hui Qiang1, Yi-lun Tang1, Qian Li2, Miao Li2 and Xiao-qian Dang11. 1Department of Orthopedic Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China2. 2Department of Ultrasound, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, ChinaCorrespondence: Xiao-qian Dang, E-mail dang_xiaoqian@sohu.comReceived 22 February 2010; Accepted 6 May 2010; Published online 28 June 2010.Top of pageAbstractAim:To investigate the therapeutic potential of adeno-associated virus (AAV)-mediated expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP).Methods:Four experimental groups were administered the following AAV vector constructs: rAAV-hVEGF165-internal ribosome entry site (IRES)-hBMP-7 (AAV-VEGF/BMP), rAAV-hVEGF165-GFP (AAV-VEGF), rAAV-hBMP-7-GFP (AAV-BMP), and rAAV-IRES-GFP (AAV-GFP). VEGF165 and BMP-7 gene expression was detected using RT-PCR. The VEGF165 and BMP-7 protein expression was determined by Western blotting and ELISA. The rabbit ischemic hind limb model was adopted and rAAV was administered intramuscularly into the ischemic limb.Results:Rabbit bone marrow-derived mesenchymal stem cells (BMSCs) were cultured and infected with the four viral vectors. The expression of GFP increased from the 7th day of infection and could be detected on the 28th day post-infection. In the AAV-VEGF/BMP group, the levels of VEGF165 and BMP-7 increased with prolonged infection time. The VEGF165 and BMP-7 secreted from BMSCs in the AAV-VEGF/BMP group enhanced HUVEC tube formation and resulted in a stronger osteogenic ability, respectively. In rabbit ischemic hind limb model, GFP expression increased from the 4th week and could be detected at 8 weeks post-injection. The rAAV vector had superior gene expressing activity. Eight weeks after gene transfer, the mean blood flow was significantly higher in the AAV-VEGF/BMP group. Orthotopic ossification was radiographically evident, and capillary growth and calcium deposits were obvious in this group.Conclusion:AAV-mediated VEGF and BMP gene transfer stimulates angiogenesis and bone regeneration and may be a new therapeutic technique for the treatment of avascular necrosis of the femoral head (ANFH).Keywords:adeno-associated virus; vascular endothelial growth factor; bone morphogenetic protein (BMP); avascular necrosis of the femoral head (ANFH); gene therapyTop of pageIntroductionRecent insight into the pathogenesis of avascular necrosis of the femoral head (ANFH) has not identified satisfactory methods to increase blood circulation in necrotic areas of the femoral head, to promote bone regeneration, or to prevent osteonecrosis. The rapid development of gene therapy technology is increasingly recognized as a new therapeutic option for the treatment of ANFH, especially through therapeutic neovascularization and bone formation. Among growth factors, vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP) play important roles and have been extensively studied.The VEGF family of growth factors is one of the most important cytokine families involved in angiogenesis. These factors promote the division of vascular endothelial cells and induce angiopoiesis. VEGF growth factors are essential for bone formation and repair during the bone regeneration process, which directly attracts endothelial cells and osteoclasts and enhances the differentiation of osteoblasts1, 2. BMP growth factors are the only signaling molecules that are individually sufficient for the induction of bone formation at orthotopic and heterotopic sites. They have defined roles in stimulating the proliferation and differentiation of mesenchymal and osteoprogenitor cells and have efficient bone induction activity3, 4. Because bone formation is[...]



The Biotechnology Industry By Richard Graydon, M.D.

2011-04-28T01:18:10.969-07:00

The primary goal of the biotechnology industry is to invent new biologically-active substances, for the treatment of disease, the pharmaceutical industry, and the management of agriculture.The U.S. is the world leader in biotechnology, currently providing employment for more than 300,000 people in over 6,000 U.S. biotech companies, with an estimated market capitalization of approximately USD 281 billion in 2008. The biotechnology industry has more than tripled in size since 2000, with revenues increasing from USD 25 billion in 2000 to more than USD 80 billion in 2008. In 2007, Amgen, Inc., the world's largest biotechnology company, achieved total sales of USD 14.7 billion. Expectations are that the biotechnology market will increase to more than USD 130 billion by 2011.Geographically, the U.S. accounts for 65% of the biotechnology market, Europe 23%, Canada 7%, Australia 3%, and the rest of the world, 2%.Today, genomics and bioinformatics development both are being pursued within major pharmaceutical companies. There have been key collaborations with traditional IT technology companies such as IBM, Hitachi, Ltd., Samsung, SK Telecomm and Motorola. The U.S. biotechnology research and pharmaceutical industry spent a record USD 8.5 billion in 2007 on the R&D of new medicines and vaccines. As of 2006, the biotechnology industry compared favorably with the pharmaceutical industry in terms of R&D expenditures per employee. Venture capital investments in bioscience companies reached USD 11.6 billion in 2007.Ernst & Young reported that in 2006, 82 publicly-traded Canadian biotech firms claimed S3.2 billion in revenue, accounting for 4.4% of global biotech revenues. Human health accounts for the largest segment of the Canadian biotech industry, representing more than half the interest of all biotech companies, approximately 70% of all biotech revenues and nearly 90% of all biotech R&D. Bioinforrnatics provides an important capability for the Canadian biotech industry, encompassing genomics and other "omics", tissue engineering and drug discovery technology.Canadian bioinformatics companies include Bioinformatics Solutions, Inc., DNA LandMarks, Inc., and Kinexus Bioinformatics Corporation. Montreal, Quebec, has Canada's leading biotech cluster, followed by Toronto, Ontario; Vancouver, British Columbia; and Winnipeg, Manitoba.Five European Union (E.U.) member states-Denmark, Finland, Germany, Sweden and the U.K.-continue to be world leaders in biotech innovation along with the U.S. and Japan. In the second half' of 2007, European biotech companies reached USD 765.3 million in venture capital investment. In January and February of 2008, venture capital funds invested a total of USD 145.6 million into new European biotech companies; however, with the economic stresses of the latter part of the year, many European biotech firms may find it harder to raise money in early 2009.The Biotechnology Industry Organization of Germany (BlO Deutschland), located in Berlin, has more than 180 members, including companies, BioRegions, and sector service providers. The goal of the organization is to support and promote a stable economy through innovation in bioscience. Among the German biotech companies are the Biotechnology Research and Information Network (BRAIN AG), 4SC. AG, Bionas, UmbEl and Direvo, which recently (September 2008) was purchased by the German pharmaceutical and chemicals giant Bayer HealthCare. In view of' the burgeoning German biotech sector, traditional German scientific companies like Eppendorf, AG, Sartorius, AG and Qiagen also have gotten into the act.Dr. Richard Graydon, http://www.medauthor.com, trained as an Oncologist, holding both M.D. and PhD degrees, specializing in molecular genetics and cancer research. His education and experience have provided him analytical and clinical skills for keen insight into diagnosis, treatment, and care of cancer patients. See http://www.medauthor.com for further informationArticle Source: http://EzineArticles.com/?expert=Richard_Graydon,_M.D.A[...]



Motivated research

2011-04-27T16:59:02.079-07:00

Motivated research

Antoine Danchin
Three years ago, a senior politician attended his country's Annual Congress for the Advancement of Science to give the introductory lecture. He asked the attending scientists to make science and research more attractive to young students and the general public, and asked his countrymen to support scientists to address the urgent challenges of global climate change, energy needs and dwindling water resources.

if you student or college in university  you must have

Motivated research for case ctuy, discustion and sharing

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Press release Polaris Software Lab Limited (POLARIS.NS)(532254.BO)

2011-04-27T16:47:07.379-07:00

ts release from http://www.businesswireindia.com if you share release gaian or new release you can email in hereSource: Polaris Software Lab Limited (POLARIS.NS)(532254.BO)Wednesday, April 27, 2011 11:49 AM IST (06:19 AM GMT)Editors: General: Economy; Business: Business services, Defence & security, Financial Analyst, Information technology, Stock exchanges; TechnologyPolaris Enters Cloud Computing Space through Strategic Investment in IdenTrustTMInvestment in US-based Global Leader in Trusted Identity Solutions uniquely positions Polaris to drive the most robust digital security infrastructure in the US & European marketsChennai, Tamil Nadu, India and New York, United States, Wednesday, April 27, 2011 -- (Business Wire India)Polaris Software Lab Limited (POLS.BO), a leading global Financial Technology Company today announced a strategic investment in IdenTrustTM, a global leader in trusted identity solutions recognized by global financial institutions and one of the premier providers of digital identity authentication services to several key banks, United States federal identity programs as well as supply chain markets. This strategic investment will mark Polaris’ entry into the cloud computing space for Financial Technology solutions.IdenTrust™ Inc. was founded in 1999 by a group of financial institutions that included Citigroup, Bank of America, Chase, Barclays, HSBC, and Deutsche. As the only bank-developed identity authentication system, IdenTrustTM provides a unique legally and technologically interoperable environment for authenticating and using identities worldwide. IdenTrustTM provides applications that use electronic identities that establish contracts, grant authority, support secure encrypted data and information storage and secure online interactions/transactions.IdenTrustTM shareholders include 20 banks, and the company brings with it an existing customer base of ten of the world’s largest banks; a portfolio of patents, and the associated intellectual property and expertise around identity, authentication, encryption, and electronic signatures on a global basis; and strong operational and hosting capabilities, led by a solid management team. Digital security is key for next generation banking, and IdenTrust’s existing products such as Trust SignTM in the certificate space and Trust PrimeTM in the eBAM space are supported by a globally interoperable legal and technology framework to deliver the highest levels of security on a cloud.For IdenTrustTM, Polaris’ global customer base is a logical channel and network accelerator, and for its existing customers, the investment by Polaris reinforces their belief in the company as the leading global identity platform, while giving them a direct access to a comprehensive suite of next generation financial technology solutions.On choosing Polaris as its lead investor, Mr. John Sculley, Chairman of the Board of Directors, IdenTrustTM said, “IdenTrust and Polaris are both innovative and powerful players in the banking space, and I am confident that, together, they will be able to drive even more compelling new products and services on a global basis.”IdenTrustTM is also an active player in several US Government programs, including the External Certificate Authority (ECA) policy under the auspices of the Defense Information Systems Agency (DISA), and the Access Certificates for Electronic Services (ACES) under the auspices of the General Services Administration (GSA). IdenTrustTM is authorized to operate in both spaces, and issues digital certificates to non-government employees or entities that are required to comply with either the ACES or ECA policies.Zions Bancorporation, one of US' premier financial services companies, will be a significant equity holder in IdenTrustTM. Polaris has a significant majority in the shareholding pattern, while Zions will maintain a substantial minority position. Speaking on the occasion, Mr. Doyle Arnold, Vice Chairman and CFO, Zions Ba[...]



Beberapa tips memilih emas

2011-04-25T01:34:09.981-07:00

Beberapa tips pemilihan emas:
  1. Update Kurs Emas Update kurs emas bisa anda dapatkan setiap hari, pada pukul 09.30 atau anda bisa menghubungi langsung ke PT Antam, Tbk.
  2. Perhatikan Dua Faktor Penentu yaitu faktor harga emas dunia dan faktor kurs rupiah terhadap dolar. Oleh karena itu disarankan untuk selalu meng-update setiap saat, informasi dua faktor tersebut.
  3. Perhatikan Keaslian Emas Keaslian emas dapat mengacu pada sertifikat yang diperoleh pada saat transaksi emas batangan (lempengan). Dimana sertifikat itu harus dikeluarkan oleh PT Antam, Tbk. (khusus Indonesia) yang berstandar internasional dan telah diakui oleh London Bullion Market Association (LBMA). Sertifikat asli memiliki nomor seri yang juga terdapat pada lempengan emas, dan ukuran 5 x 6 cm. Sedangkan untuk memastikan keaslian emas lempengan, anda dapat melihat logo LM berbentuk segi lima yang tertera, serta terdapat tulisan Fine Gold .9999, dan apabila nilai emas lebih dari 5 gram disertai nomor seri pada lempengan (yang biasanya diawali dengan dua karakter huruf dan tiga digit angka).
  4. Pastikan Kadar Kemurnian Emas, sesuai dengan Standar Internasional Emas 24 Karat (emas murni) berkomposisi 99.99% emas, Emas 22 Karat berkomposisi 91.7% emas dan 8.3% campuran bahan lain (perak), Emas 20 Karat berkomposisi 83.3% emas, Emas 18 Karat berkomposisi 75.0% emas, Emas 16 Karat berkomposisi 66.6% emas, Emas 14 Karat berkomposisi 58.5% emas, dan Emas 9 Karat berkomposisi 37.5% emas.
  5. Biaya Produksi Biaya produksi yang dikenakan berkisar antara Rp 33.500,- sampai dengan Rp 102.000,-/keping emas.
  6. Simpan Bukti Pembelian dan Bukti Keaslian Emas Hal ini adalah sebagai bukti keaslian bilamana anda menjual emas kembali ke tempat Anda membelinya, karena tentu akan lebih mudah dan tidak ada banya pertanyaan seputar emasnya.




    Posted in: Emas Batangan, Investasi Emas, logam mulia.
    Tagged: Cek Keaslian Emas · emas 14 karat · emas 18 karat · Emas 22karat · emas 9 karat · Investasi Emas · investasi logam mulia · Kadar Kemurnian Emas · keping emas · Kurs Emas · logam mulia · London Bullion Market Association · PT Antam · tips investasi

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Switching Careers - 7 Key Steps By Alotta Candor Article Source: EzineArticles.e

2011-04-20T15:39:38.476-07:00

Are you thinking about switching careers? If you are, you're not alone. Most Americans switch careers three times in their lifetime. Nevertheless, switching careers is scary. And it's especially paralyzing the older you get. But making a career switch is very possible and much more common than you might think. Before you're ready to leap, realize that it's a heavyweight decision that deserves some time and solid thought. Here are seven steps to help you on your way.1. Gain insight from your current situation.When considering a career switch, the first thing you should do is learn from your current situation. To do this, take a step back and study what you do for a living today and why you do it. Examine the reasons that you are in your current job or career. Was it what you went to school for? Was it what your parents wanted you to do? Was it the "hot career" at one time? Did you just "fall into it"? Did you love it at one time? Did you do it for the money you could make? Was it just to pay the bills? The answers to these questions can provide valuable insight into the core reasons that you want or need to change.Now examine why you want to leave your current career field. Remove any company or management related politics that are specific to your current employer from the picture. See your situation for what it is and ask yourself why you are looking to switch. Are you being forced out because of market shifts of business trends? Are you burnt out? Do you want to make more money? Are you miserable doing what you do? Have you tried your best but found that your career is "just not a good fit"? Have you decided its time to pursue a long lost career love?Inspecting your current situation and reasons for your desire to change careers will provide a foundation for your next step.2. Look insideWhether you already have a career in mind or you are searching for a new career, you must look inward. In order to gain the most from your reflection, it is essential to start with a clean slate. Set aside any notions (real or imagined) about what type of money certain careers offer. Discard any stereotypes or judgments of occupations. Distance yourself from any pre-conceived ideas about what you are right or destined for.Now seriously examine what you truly love. First start with the obvious. Look at your hobbies and interests. List out the things you are passionate about or in which you have talent. Give yourself credit for things you are good at and don't be afraid to write things down that you love, but are not yet good at. Write them all down, even if you think they may not be a possible career path. You're just brainstorming at this point and you should not eliminate anything right out of the gate. And it's important to bear in mind that what you may think are your interests are not necessarily all of your interests. To help you get a good look at your interests, observe the simple things. What kinds of news stories perk your interest? What kinds of TV shows do you enjoy? What kinds of books magazines do you find yourself drawn to? What kind of people do you like to associate with or find interesting? What parts of your current career have brought you the most satisfaction?Next, remind yourself of what you wanted to be when you grew up. Is it something you still want to be? Do you still get stars in your eyes when you think about it? This may give you some real clues. And of course, depending on what you wanted to be, that young dream may be out of reach. Or...is it? Think about it. If your ideal career aspiration at the age of 10 was to be an astronaut and you are now over the age limit or are not physically able to, you can rule it out. But what about other careers associated with astronauts or astronomy? There is a wide array of careers that touch upon astronomy from teaching, to marketing telescopes, to writing for a science magazine, to building models or sets for movies to working at a muse[...]



Biology Terms: Countershading By Gwen Nicodemus Diamond Quality Author Article Source:

2011-04-20T15:08:49.071-07:00



Many marine creatures are countershaded, which is a type of camouflage for them. What exactly is countershading?

Imagine that you are in a boat on the ocean and looking down. The ocean water looks dark blue. If you were an animal in the ocean, what color should you be to hide from animals in the sky, or higher up in the ocean, than you are?

Now, imagine you are SCUBA diving on the bottom of the ocean floor and look up, toward the sky. During the daytime, the sunlight filters into the water. What color should an animal be so it can blend into the water and hide from the animals below it in the water?

Animals selected for countershading

Animals that are darkly colored on their top part and lightly colored on their underside are said to be countershaded.

Animals that are darkly colored on their top part, where their dorsal fins are located, are less likely to be found and eaten by sky creatures or ocean animals higher up in the ocean than they are. Their dark colored skin blends into the color of the ocean around them and they have higher survival rates than animals that are lightly colored on the top.



Animals that are lightly colored on their underside blend into the ocean better when looking from the ground upward. They are found and eaten less often by the fish and animals underneath them in the water, so they have better survival rates than animals with darker colored under sides.

So, animals with both of these features have an even better chance of living to an age that they can reproduce.

What kind of animals are countershaded?

Countershading of the type, where the animal blends into its background, is most prevalent with marine animals. Sharks, dolphins, porpoises, fish, and penguins all present this kind of countershading.

Another type of countershading has the same type of principles, but the animals don't blend completely into their background. Instead, their coloring makes it difficult for predators to see where their bodies start and end. Some lizards and caterpillars present this type of countershading.

What have we learned from the animals?

An artist and naturalist named Abbott Thayer studied countershading. He described and published his nature studies regarding countershading in 1892. In fact, sometimes countershading is called Thayer's law. Thayer made his contribution in World War I by suggesting that the military paint their ships using countershading techniques.

Countershading and camouflage techniques are used frequently by the military. Clothing fashions are also influenced by these types of color schemes.

I'm an engineer who quit full-time work and now freelance so I can homeschool my two children. I also teach science classes at a local homeschooling cooperative. As a temporarily retired engineer, I try to keep my brain active by reading, writing, and teaching. Check out the free resources, including unit studies, videos, tutorials, and little books at Unit Studies By Gwen or her blog at GwenOnline.
©2011, Gwen Nicodemus

Article Source: http://EzineArticles.com/?expert=Gwen_Nicodemus

Gwen Nicodemus - EzineArticles Expert Author

Article Source: http://EzineArticles.com/6195944

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Fun Science Experiment For Kids - How To Make Giant Bubbles! By Kalpana Nair

2011-04-20T15:03:46.855-07:00


Fun Science Experiment For Kids - How To Make Giant Bubbles!
By Kalpana Nair



Fun Science experiments are not only liked by children but adults as well. Personally, I have tried many Science experiments when I was a kid and later on with my own family members. Making giant bubbles is an absolute favorite of mine and you can do this experiment too in a matter of minutes.

Things You Will Need

In order to make giant bubbles, you need to get your hands on the following items -

1. Washing liquid.
2. Glycerine or corn syrup.
3. Jug
4. Water.
5. A large bucket.
6. A spoon.
7. A wire coat hanger.
8. A ball of string.
9. An electrical tape.

How To Make Your Own Giant Bubbles



1. Fill the large bucket with water.
2. Mix the washing liquid and glycerine/corn syrup in the jug. In order to make the best bubbles, try using one part of washing liquid and a quarter part of glycerine/corn syrup to every 15 parts of water. This solution can be really sticky!
3. Pour this mixture into the large bucket.
4. Shape the wire coat hanger in the form of a tennis racquet i.e, an arm handle with a large circle on top.
5. The arm of the wand and the circle should be tightly wound with the string.
6. You can fasten the string onto its place by using the electrical tape.
7. Insert your wand into the large bucket filled with pre-made mixture of solutions.
8. Swirl your wand in the air and see what happens!

Due to surface tension the water molecules are held together. The presence of washing liquid tends to weaken the surface tension and this is why giant bubbles are formed.

Science projects can be a lot of fun to do especially when you are idle. Not only are some of the experiments absolutely entertaining, but each of them have something to teach you. It is always recommended that an adult be always present for guidance whenever a tough Science experiment is being performed. Like for example, making an electric motor requires the usage of wires and bulbs. Additionally the experiment also involves cutting off pieces of wire in order to create the equipment. This is to be done under the strict surveillance of an adult!

By encouraging your child to do Science experiments, you are only helping them to understand Science concepts in a more clear and precise manner. You can find numerous experiments on the Web which you can perform in the comfort of your own home without the need of purchasing any expensive materials. You will be surprised to see how many high quality education materials are available online -- all for free! Take your time out in noting all these experiments down and then encourage your child to try them out at home.

Kalpana Nair is into Science big time! She has written many Science articles and has published various pages on Science experiments online which have benefitted many students worldwide. One of her best Science pages include - Making Fun Science Models.
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The Biotechnology Industry By Richard Graydon, M.D.

2011-04-20T15:01:55.248-07:00

The primary goal of the biotechnology industry is to invent new biologically-active substances, for the treatment of disease, the pharmaceutical industry, and the management of agriculture.The U.S. is the world leader in biotechnology, currently providing employment for more than 300,000 people in over 6,000 U.S. biotech companies, with an estimated market capitalization of approximately USD 281 billion in 2008. The biotechnology industry has more than tripled in size since 2000, with revenues increasing from USD 25 billion in 2000 to more than USD 80 billion in 2008. In 2007, Amgen, Inc., the world's largest biotechnology company, achieved total sales of USD 14.7 billion. Expectations are that the biotechnology market will increase to more than USD 130 billion by 2011.Geographically, the U.S. accounts for 65% of the biotechnology market, Europe 23%, Canada 7%, Australia 3%, and the rest of the world, 2%.Today, genomics and bioinformatics development both are being pursued within major pharmaceutical companies. There have been key collaborations with traditional IT technology companies such as IBM, Hitachi, Ltd., Samsung, SK Telecomm and Motorola. The U.S. biotechnology research and pharmaceutical industry spent a record USD 8.5 billion in 2007 on the R&D of new medicines and vaccines. As of 2006, the biotechnology industry compared favorably with the pharmaceutical industry in terms of R&D expenditures per employee. Venture capital investments in bioscience companies reached USD 11.6 billion in 2007.Ernst & Young reported that in 2006, 82 publicly-traded Canadian biotech firms claimed S3.2 billion in revenue, accounting for 4.4% of global biotech revenues. Human health accounts for the largest segment of the Canadian biotech industry, representing more than half the interest of all biotech companies, approximately 70% of all biotech revenues and nearly 90% of all biotech R&D. Bioinforrnatics provides an important capability for the Canadian biotech industry, encompassing genomics and other "omics", tissue engineering and drug discovery technology.Canadian bioinformatics companies include Bioinformatics Solutions, Inc., DNA LandMarks, Inc., and Kinexus Bioinformatics Corporation. Montreal, Quebec, has Canada's leading biotech cluster, followed by Toronto, Ontario; Vancouver, British Columbia; and Winnipeg, Manitoba.Five European Union (E.U.) member states-Denmark, Finland, Germany, Sweden and the U.K.-continue to be world leaders in biotech innovation along with the U.S. and Japan. In the second half' of 2007, European biotech companies reached USD 765.3 million in venture capital investment. In January and February of 2008, venture capital funds invested a total of USD 145.6 million into new European biotech companies; however, with the economic stresses of the latter part of the year, many European biotech firms may find it harder to raise money in early 2009.The Biotechnology Industry Organization of Germany (BlO Deutschland), located in Berlin, has more than 180 members, including companies, BioRegions, and sector service providers. The goal of the organization is to support and promote a stable economy through innovation in bioscience. Among the German biotech companies are the Biotechnology Research and Information Network (BRAIN AG), 4SC. AG, Bionas, UmbEl and Direvo, which recently (September 2008) was purchased by the German pharmaceutical and chemicals giant Bayer HealthCare. In view of' the burgeoning German biotech sector, traditional German scientific companies like Eppendorf, AG, Sartorius, AG and Qiagen also have gotten into the act.Dr. Richard Graydon, http://www.medauthor.com, trained as an Oncologist, holding both M.D. and PhD degrees, specializing in molecular genetics and cancer research. His education and experience have provided him analytical and clinical skills for k[...]



The 10th Annual Multi-Unit Franchising Conference.

2011-04-20T15:00:53.113-07:00

The 10th Annual Multi-Unit Franchising Conference.

For ten years, the Multi-Unit Franchising Conference has been the premier conference for multi-unit franchisees. This annual event continues to be the nexus point of learning, networking, and deal-making for multi-unit franchising.
THIS YEAR'S CONFERENCE - WHAT'S NEXT

We all know how to improve our performance by learning from the past. But today's complex business decisions require the ability to see what's on the horizon and anticipate what's next. At this year's conference we'll explore the changes and trends affecting the future of multi-unit franchising and the strategies you need to set in motion today to maintain your competitive advantage.
KEYNOTE SPEAKERS


WHO SHOULD ATTEND

Expected attendance to this event will be over 700 multi-unit franchisees, franchisors, and franchise business solution providers.

Who should attend:

* Multi-Unit Franchisees
* Multi-Concept Franchisees
* Area Developers



* Area Representatives
* Chain Store Operators
* Franchisors


The 10th Annual Multi-Unit Franchising Conference.

* Franchise Investors
* Real Estate Professionals
* Finance Professionals
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Special Seminar: Agricultural Biotechnology in Indonesia

2011-04-16T19:32:40.415-07:00

Thu, January 13, 2011. 12:00-13.30
Prof. Hadi Susilo Arifin attended a Special Seminar of Agricultural Biotechnology in Indonesia
By Dr. M. Herman, Senior Scientist, ICABIOGRAD Biotechnology Center, Bogor, Indonesia.
Agenda
Day/Date: Thursday, January 13, 2011
Time: 12:00 noon – 1:30 p.m.
Venue: 271 Plant and Soil Sciences Building, Michigan State University
Seminar is organized by: WorldTAP/College of Agriculture and Natural Resources and ISP/Asian Studies Center
Pizza Lunch will be served.
Prof. Hadi Susilo Arifin and Dr. Muhammad Herman are colleagues in the team member of POKJA Ahli – Dewan Ketahanan Pangan Nasional RI (Taskforce Expertist - National Board of Food Security, the Republic of Indonesia) – 2010/2013.  In the end of the seminar, they have talked together regarding collaboration program in education and capacity building among MSU – IPB – UNPAD. Through an informal discussion, Prof. Karim (Biotechnology – MSU), Prof. Siddharth Chandra (Director of Asian Studies Center), and Prof. Hadi Susilo Arifin (IPB) have expected that for the future collaboration in education and capacity building between MSU and IPB should be expanded not only in biotechnology, but included climate change, environmental management and other actual issues. Some modules and curricula could be established together and delivering them for short courses, workshops, or summer school. These programs should be involved more universities in Indonesia.
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How to Choose Speaker

2011-04-01T19:48:03.891-07:00

This article can be used for reference in selecting speakers. Choosing speakers is tricky. Easy in the sense that the speaker now has a quality that is reliable. difficult, too many outstanding speakers, So making our  confused to choice. Therefore here I will share some experience about choosing the speakers.
Here are some points to  selecting the speakers:

How to Choose Speaker

  1. Set option for what the speaker to used, whether used indoors or outdoors, because of different types. For speakers who used outside the room, select the type of full range of means all tone is created by the speakers. By using this type of full range, a tone that is created will not be lost, either low or high-pitched tone. But the shortcomings, the speakers full-range tone that created less tender. Meanwhile, if you want to buy speakers for use in the room chose the type woofer (not a sub woofer, because different species), with the woofer low tone will be heard by more soft and smooth. If speakers are used outside the room then the low tone will be lost.
  2. The larger diameter of the speaker, the lower the tone that can be produced, but certainly require a large power amplifiers. 80-10 inches is suitable for home, but the size of 14 inches is not big enough to use a small stage. At least 18 inches, if you want to use in the room, then 10 inches is more than enough.
  3. The speakers that have a large magnet usually have good quality, but the price usually also follow, that meaning is more expensive.
  4. Look for speakers with great power. Do not be fooled by the big power contained labeled (sticker). Look more closely. There are speakers that include the ability to direct the magnetic power, but many were written on a paper sticker. Find a written directly in the magnet, because it is the original power of the speaker. You better choose the power of 150 watts is written directly in the magnet from the power of 300 watts but written on a paper sticker.
  5. The speakers will not produce good sound if it stands alone, so even if you buy any expensive speakers, if you will not be accompanied by Midle range and tweeter will be useless.
  6. large spool having a better quality and will produce a louder sound.
  7. Note the flexibility of the leaves of the speakers, the more flexible will usually produce a low tone more soft and smooth.
  8. Notice the brand, Look for brands that are trusted for speaker manufacturers.
So what can I share with you all, may be useful for visitors, thank you.

How to Choose Speaker

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UNITED THERAPEUTICS IS AMONG THE COMPANIES IN THE BIOTECHNOLOGY INDUSTRY WITH THE HIGHEST EPS GROWTH (UTHR, GENZ, ALXN, CELG, CEPH)

2011-03-30T06:19:34.613-07:00

Mar 30, 2011 (SmarTrend(R) News Watch via COMTEX) -- Below are the top 5 companies in the Biotechnology industry ranked by the year-over-year expected EPS growth rate. The long-term growth rate is the expected annual increase in operating EPS over the next three to five years.
United Therapeutics (NASDAQ:UTHR) EPS is expected to grow 283.1% year-over-year, better than the company's long-term growth rate of 60%. Based on the forward P/E of 12.7x its PEG ratio is 0.21, which signifies a discount in value relative to growth.
Genzyme (NASDAQ:GENZ) EPS is expected to grow 234.8% year-over-year, better than the company's long-term growth rate of 19.3%. Based on the forward P/E of 18.6x its PEG ratio is 0.96, which signifies a discount in value relative to growth.
Alexion Pharmaceuticals (NASDAQ:ALXN) EPS is expected to grow 118.3% year-over-year, better than the company's long-term growth rate of 38.8%. Based on the forward P/E of 43.9x its PEG ratio is 1.13, which signifies a premium valuation given for growth.
Celgene (NASDAQ:CELG) EPS is expected to grow 60% year-over-year, better than the company's long-term growth rate of 25.7%. Based on the forward P/E of 16.4x its PEG ratio is 0.64, which signifies a discount in value relative to growth.
Cephalon (NASDAQ:CEPH) EPS is expected to grow 49.3% year-over-year, better than the company's long-term growth rate of 10.2%. Based on the forward P/E of 7x its PEG ratio is 0.68, which signifies a discount in value relative to growth.
SmarTrend currently has shares of Genzyme in an Uptrend and issued the Uptrend alert on July 23, 2010 at $60.20. The stock has risen 26.3% since the Uptrend alert was issued.
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Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

2011-03-30T06:18:35.086-07:00

Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivoChen Zhang1, Kun-zheng Wang1, Hui Qiang1, Yi-lun Tang1, Qian Li2, Miao Li2 and Xiao-qian Dang11Department of Orthopedic Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China2Department of Ultrasound, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, ChinaCorrespondence: Xiao-qian Dang, E-mail dang_xiaoqian@sohu.comReceived 22 February 2010; Accepted 6 May 2010; Published online 28 June 2010. Top of pageAbstractAim: To investigate the therapeutic potential of adeno-associated virus (AAV)-mediated expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP).Methods: Four experimental groups were administered the following AAV vector constructs: rAAV-hVEGF165-internal ribosome entry site (IRES)-hBMP-7 (AAV-VEGF/BMP), rAAV-hVEGF165-GFP (AAV-VEGF), rAAV-hBMP-7-GFP (AAV-BMP), and rAAV-IRES-GFP (AAV-GFP). VEGF165 and BMP-7 gene expression was detected using RT-PCR. The VEGF165 and BMP-7 protein expression was determined by Western blotting and ELISA. The rabbit ischemic hind limb model was adopted and rAAV was administered intramuscularly into the ischemic limb.Results: Rabbit bone marrow-derived mesenchymal stem cells (BMSCs) were cultured and infected with the four viral vectors. The expression of GFP increased from the 7th day of infection and could be detected on the 28th day post-infection. In the AAV-VEGF/BMP group, the levels of VEGF165 and BMP-7 increased with prolonged infection time. The VEGF165 and BMP-7 secreted from BMSCs in the AAV-VEGF/BMP group enhanced HUVEC tube formation and resulted in a stronger osteogenic ability, respectively. In rabbit ischemic hind limb model, GFP expression increased from the 4th week and could be detected at 8 weeks post-injection. The rAAV vector had superior gene expressing activity. Eight weeks after gene transfer, the mean blood flow was significantly higher in the AAV-VEGF/BMP group. Orthotopic ossification was radiographically evident, and capillary growth and calcium deposits were obvious in this group.Conclusion: AAV-mediated VEGF and BMP gene transfer stimulates angiogenesis and bone regeneration and may be a new therapeutic technique for the treatment of avascular necrosis of the femoral head (ANFH).Keywords: adeno-associated virus; vascular endothelial growth factor; bone morphogenetic protein (BMP); avascular necrosis of the femoral head (ANFH); gene therapyTop of pageIntroductionRecent insight into the pathogenesis of avascular necrosis of the femoral head (ANFH) has not identified satisfactory methods to increase blood circulation in necrotic areas of the femoral head, to promote bone regeneration, or to prevent osteonecrosis. The rapid development of gene therapy technology is increasingly recognized as a new therapeutic option for the treatment of ANFH, especially through therapeutic neovascularization and bone formation. Among growth factors, vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP) play important roles and have been extensively studied.The VEGF family of growth factors is one of the most important cytokine families involved in angiogenesis. These factors promote the division of vascular endothelial cells and induce angiopoiesis. VEGF growth factors are essential for bone formation and repair during the bone regeneration process, which directly attracts endothelial cells and osteoclasts and enhances the differentiation of osteoblasts1, 2. BMP growth factors are the onl[...]



Insanity Workout - Pushing Workout To The Extreme

2011-03-27T08:07:06.550-07:00

Are you sick and tired of the standard workout and diet that does not cause you to lose weight whatsoever? Then how about using a different sort of exercise method that will definitely make you shed the unwanted fats you long to take away for years. Shaun T’s insanity workout could be the answer to your desired body figure. It’s a 60-day workout program that will absolutely help you get the body weight and figure you’ve been wishing for in years. Compared to the other intense routines out in the market, this program only takes shorter time however still enable you to do the extensive movements that will ensure to make you sweat off the extra fat away. This program will be suitable for those who rarely have the time and chance to visit the gym.
insanity workout In case you are unhappy with shorter time frame of workout, you might try out something with similar intense and complex exercise moves which you could find in px90. It’s a 90-day intense workout program created by Tony Horton. The said program includes intense workout, complex actions that needs the use of resistance bands and yoga mat to further attain your weight goal. Both this programs will surely help you obtain the body figure and weight you always wished to have. insanity workout,

Insanity Workout - Pushing Workout To The Extreme

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Cell therapy strategies and improvements for muscular dystrophy

2011-03-19T02:58:52.684-07:00

Edited by R De MariaM Quattrocelli1, M Cassano1, S Crippa1, I Perini1 and M Sampaolesi1,21. 1Translational Cardiomyology, SCIL Katholieke Universiteit Leuven, Herestraat 49 bus 814, Leuven 3000, Belgium2. 2Human Anatomy, University of Pavia, Via Forlanini 8, Pavia 27100, ItalyCorrespondence: M Sampaolesi, Translational Cardiomyology, Stem Cell Research Institute, University Hospital Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium. Tel: +32 0163 30295; Fax: +32 0163 30294; E-mail: maurilio.sampaolesi@med.kuleuven.beReceived 9 July 2009; Revised 8 September 2009; Accepted 21 September 2009; Published online 30 October 2009.Top of pageAbstractUnderstanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.Keywords:muscular dystrophy; animal models; cell therapy; stem cellsAbbreviations:ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2; ALP, alkaline phosphatase; αsg, α-sarcoglycan; bg, natural killer (NK) cell-deficient mice (beige); BM, bone marrow; BMD, Becker muscular dystrophy; BMSCs, bone marrow-derived stem cells; BMT, bone marrow transplantation; βsg, β-sarcoglycan; c-MYC, cellular myelocytomatosis oncogene; cDNA, complementary DNA; Cxcr4, chemokine (C-X-C motif) receptor 4; DMD, Duchenne muscular dystrophy; ESCs, embryonic stem cells; FACS, fluorescence-activated cell sorting; Flk1, fetal liver kinase 1; GFP, green fluorescent protein; GLP–GMP, good laboratory practice–good manufacturing practice; GRMD, Golden Retriever muscular dystrophy; Gy, Gray (unit); HCT, haemopoietic cell transplantation; hMADS, human multi-potent adipose-derived stem cells; HLA, human leukocyte antigen; Hmgb1, high mobility group box 1; IGF1, Insulin-like growth factor 1; iPS, induced pluripotent stem cells; KLF4, Kruppel-like factor 4; KO, knockout; KSN, mice strain with high natural killer activity; LGMD, limb-girdle muscular dystrophy; MABs, mesoangioblasts; Mac1, integrin alpha M; MagicF1, cMet-activating genetically improved factor1; MAPCs, multipotent adult progenitor cells; mdx, muscular dystrophy X-linked (?); μDYS, micro-dystrophin; MGF, mechano growth factor; MMP9, matrix metallopeptidase 9; mRNA, messenger ribonucleic acid; MyoD, myoblast determination protein; Myf5, myogenic factor 5; NCAM, neural cell adhesion molecule; NG2, chondroitin sulfate proteoglycan 4; NICD, Notch1 intracellular domain; NOD, non-obese diabetic; OCT4, octamer-binding transcription factor 4; Pax3, paired box gene 3; PDGFRα, platelet derived growth factor receptor alpha; PIGF, phosphatidylinositol glycan anchor biosynthesis, class F; PTC124, 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid (C15H9FN2O3); RT-PCR, retrotranscription-based polymerase chain reaction; Sca1, stem cell antigen 1; scid, severe combined immuno-deficiency; SDF1, stromal-derived factor 1; SMPs, skeletal muscle precursors; SOX2, SRY (sex determining region Y)-box 2; SP, side population; TNF-α, tumor necrosis factor-α; VEGFR2, vascular endothelial growth factor receptor 2; Wnt3a, wingless-type MMTV integration site family, me[...]



In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin

2011-03-19T02:58:03.727-07:00


N Gyémánt, H Engi, Z Schelz, I Szatmári, D Tóth, F Fülöp, J Molnár and P A M de Witte
Background:
The multidrug resistance (MDR) proteins are present in a majority of human tumours. Their activity is important to understand the chemotherapeutic failure. A search for MDR-reversing compounds was conducted among various Betti-base derivatives of tylosin.
Methods:
Here, we evaluate the in vitro and in vivo P-glycoprotein (P-gp)-modulating activity of the most promising compound N-tylosil-1-α-amino-(3-bromophenyl)-methyl-2-naphthol (TBN) using human MDR1 gene-transfected and parental L5178 mouse lymphoma cell lines.
Results:
In vitro experiments showed that TBN dramatically increased the P-gp-mediated cellular uptake of the fluorescent substrate rhodamine 123. Similarly, TBN was found to act as a very potent enhancer of the cytotoxicity of doxorubicin on the resistant cell line. We also provide in vivo evidence using DBA/2 mice in support for an increased tumoural accumulation of doxorubicin, without affecting its tissue distribution, resulting in an enhanced antitumoural effect.
Conclusion:
Our results suggest that TBN is a potent modulator of the P-gp membrane pump and that the compound could be of clinical relevance to improve the efficacy of chemotherapy in MDR cancers.

British Journal of Cancer 103, 178-185
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Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

2011-03-19T02:57:10.180-07:00

Original ArticleActa Pharmacologica Sinica (2010) 31: 821–830; doi: 10.1038/aps.2010.67; published online 28 June 2010Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivoChen Zhang1, Kun-zheng Wang1, Hui Qiang1, Yi-lun Tang1, Qian Li2, Miao Li2 and Xiao-qian Dang11Department of Orthopedic Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China2Department of Ultrasound, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, ChinaCorrespondence: Xiao-qian Dang, E-mail dang_xiaoqian@sohu.comReceived 22 February 2010; Accepted 6 May 2010; Published online 28 June 2010. Top of pageAbstractAim: To investigate the therapeutic potential of adeno-associated virus (AAV)-mediated expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP).Methods: Four experimental groups were administered the following AAV vector constructs: rAAV-hVEGF165-internal ribosome entry site (IRES)-hBMP-7 (AAV-VEGF/BMP), rAAV-hVEGF165-GFP (AAV-VEGF), rAAV-hBMP-7-GFP (AAV-BMP), and rAAV-IRES-GFP (AAV-GFP). VEGF165 and BMP-7 gene expression was detected using RT-PCR. The VEGF165 and BMP-7 protein expression was determined by Western blotting and ELISA. The rabbit ischemic hind limb model was adopted and rAAV was administered intramuscularly into the ischemic limb.Results: Rabbit bone marrow-derived mesenchymal stem cells (BMSCs) were cultured and infected with the four viral vectors. The expression of GFP increased from the 7th day of infection and could be detected on the 28th day post-infection. In the AAV-VEGF/BMP group, the levels of VEGF165 and BMP-7 increased with prolonged infection time. The VEGF165 and BMP-7 secreted from BMSCs in the AAV-VEGF/BMP group enhanced HUVEC tube formation and resulted in a stronger osteogenic ability, respectively. In rabbit ischemic hind limb model, GFP expression increased from the 4th week and could be detected at 8 weeks post-injection. The rAAV vector had superior gene expressing activity. Eight weeks after gene transfer, the mean blood flow was significantly higher in the AAV-VEGF/BMP group. Orthotopic ossification was radiographically evident, and capillary growth and calcium deposits were obvious in this group.Conclusion: AAV-mediated VEGF and BMP gene transfer stimulates angiogenesis and bone regeneration and may be a new therapeutic technique for the treatment of avascular necrosis of the femoral head (ANFH).Keywords: adeno-associated virus; vascular endothelial growth factor; bone morphogenetic protein (BMP); avascular necrosis of the femoral head (ANFH); gene therapyTop of pageIntroductionRecent insight into the pathogenesis of avascular necrosis of the femoral head (ANFH) has not identified satisfactory methods to increase blood circulation in necrotic areas of the femoral head, to promote bone regeneration, or to prevent osteonecrosis. The rapid development of gene therapy technology is increasingly recognized as a new therapeutic option for the treatment of ANFH, especially through therapeutic neovascularization and bone formation. Among growth factors, vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP) play important roles and have been extensively studied.The VEGF family of growth factors is one of the most important cytokine families involved in angiogenesis. These factors promote the division of vascular endothelial cells a[...]



Insurance Income Protection Insurance - Comparison With Critical Illness Insurance Income Protection Insurance - Comparison With Critical Illness Insurance

2011-03-01T02:21:13.804-08:00

There are several companies out there, which provide insurance policies. A person can approach these companies directly or via internet. It is far better to consult these companies on the websites, since many of the companies possess online customer care services. An individual can read the portfolio of a company on the web, and can decide which one would be better for him.

If you are interested to gain the quotes, you are required to find out a company, which can provide you more benefits. A suitable company would be one, which does not charge high fee for providing insurance cover.

The good thing is that, the insurance is provided on monthly basis. Hence those who have lost the job, or could not find feasible to join the office due to sickness may acquire the compensated amount every month.

Insurance provides reassurance to an individual, he feels secured and safe. He come to the realization that the world will not go to an end, if he would not maintain his position in the company or developed any illness.

Quotes are much better as compared to the critical illness insurance. The can be provided in any type of illness, no matter if it is a minor or a critical one. On the contrary, the critical illness insurance is provided to an individual only at the time of critical illness.

Insurance furnishes the ease in the life of person. He does develop stress if in case; he acquires any type of illness. He does not care, whether the company will provide him wages or not, and he remain able to spend money on the treatment of his disease.

If you want to get income protection insurance, you should try to find out those companies which are the best in their dealing, and which can provide a lot of benefits to the individuals. Income Protection Quotes should be protected at any cost, and it is the right of every individual.


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Stem cell From Wikipedia, the free encyclopedia

2011-02-26T19:07:35.253-08:00

Stem cells are biological cells found in all multicellular organisms, that can divide through mitosis and differentiate into diverse specialized cell types. In mammals, there are two broad types of stem cells: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenished in adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.Stem cells can now be artificially grown and transformed into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Highly plastic adult stem cells are routinely used in medical therapies. Stem cells can be taken from a variety of sources, including umbilical cord blood and bone marrow. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.[1] Research of stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s.[2][3]PropertiesThe classical definition of a stem cell requires that it possess two properties: * Self-renewal - the ability to go through numerous cycles of cell division while maintaining the undifferentiated state. * Potency - the capacity to differentiate into specialized cell types. In the strictest sense, this requires stem cells to be either totipotent or pluripotent - to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells.[edit] Self-renewalTwo mechanisms exist to ensure that the stem cell population is maintained: 1. Obligatory asymmetric replication - a stem cell divides into one father cell that is identical to the original stem cell, and another daughter cell that is differentiated 2. Stochastic differentiation - when one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two stem cells identical to the original.[edit] Potency definitionsPluripotent, embryonic stem cells originate as inner mass cells within a blastocyst. The stem cells can become any tissue in the body, excluding a placenta. Only the morula's cells are totipotent, able to become all tissues and a placenta.Human embryonic stem cellsA: Cell colonies that are not yet differentiated.B: Nerve cellMain article: Cell potencyPotency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell.[4] * Totipotent (a.k.a omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types. Such cells can construct a complete, viable, organism.[4] These cells are produced from the fusion of an egg and sperm cell. Cells produced by the first few divisions of the fertilized egg are also totipotent.[5] * Pluripotent stem cells are the descendants of totipotent cells and can differentiate into nearly all cells,[4] i.e. cells derived from any of the three germ layers.[6] * Multipotent stem cells can differentiate into a number of cells, but only those of a closely related family of cells.[4] * Oligopotent stem cells can differentiate into only a few cells, such as lymphoid or myeloid stem cells.[4] * Unipotent cells can prod[...]



biotechnology from wikipedia

2011-01-30T22:38:45.682-08:00

iotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Modern use of similar terms includes genetic engineering as well as cell- and tissue culture technologies. The concept encompasses a wide range of procedures (and history) for modifying living organisms according to human purposes - going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. By comparison to biotechnology, bioengineering is generally thought of as a related field with its emphasis more on higher systems approaches (not necessarily altering or using biological materials directly) for interfacing with and utilizing living things. The United Nations Convention on Biological Diversity defines biotechnology as:[1]

"Any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use."

Biotechnology draws on the pure biological sciences (genetics, microbiology, animal cell culture, molecular biology, biochemistry, embryology, cell biology) and in many instances is also dependent on knowledge and methods from outside the sphere of biology (chemical engineering, bioprocess engineering, information technology, biorobotics). Conversely, modern biological sciences (including even concepts such as molecular ecology) are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry.(image)



biotechnology information media,news

2011-01-30T22:35:39.471-08:00

biotechnology information media,newsISAAA RILIS KAMPANYE “SEJUTA TANGAN PENYEMBUHAN UNTUK MEMBANTU SEMILIAR ORANG KELAPARAN”Tanggal : 15 October 2010Pada peringatan Hari Pangan Sedunia, International Service for the Acquisition of Agri-biotech Applications (ISAAA) merilis suatu Kampanye Pengetahuan mengenai bioteknologi yang bertajuk “A million healing hands to help a billion hungry”. Disertai satu dekade berbagi pengetahuan, ISAAA merilis profil tinggi Kampanye Pengetahuan guna memenuhi rasa haus akan pengetahuan dalam bidang teknologi tanaman, pangan dan pertanian baik di negara berkembang maupun industri demi memerangi kemiskinan dan kelaparan – suatu tujuan moral yang mulia. Kampanye tersebut bertujuan untuk mengedukasi, menginformasikan dan memobilisasi masyarakat untuk berpartisipasi dan menjadi ujung tombak pengetahuan, mengeliminasi celah pengetahuan serta membangun sebuah jembatan berkesinambungan antara sains dan masyarakat. Pusat Kampanye Pengetahuan ISAAA adalah “orang-orang” – mobilisasi massa dengan sejuta pasang tangan penyembuhan, menawarkan pengetahuan mengenai bioteknologi tanaman, guna membantu 1 miliar orang yang sedang mendertia kemiskinan dan kelaparan. Dalam konteks ini, tema kampanye Pengetahuan ISAAA adalah “A million healing hands to help a billion hungry".Sesuai dengan semangat Sasaran Pembangunan Milenium PBB untuk memangkas setengah angka kemiskinan dan kelaparan antara tahun 1990 sampai 2015, ISAAA menegaskan kembali komitmennya bagi bioteknologi tanaman dan pengembangan pertanian sebagai kunci dalam mencapai sasaran ini. Diperkirakan bahwa para petani dan buruh di Asia, Afrika dan Amerika Latin mewakili 70% dari miliaran orang miskin di dunia. Dengan demikian, ISAAA menegaskan kembali keyakinan kuatnya atas peran penting pengetahuan berbasis sains tentang bioteknologi tanaman, sebagai kontribusi penting guna menekan kemiskinan dan kelaparan, yang secara moral tidak dapat diterima dalam suatu masyarakat yang adil.Kampanye Pengetahuan ISAAA mengenai bioteknologi tanaman tersebut dipersembahkan kepada Dr. Norman Borlaug – peraih Nobel perdamaian di tahun 1970 yang merupakan patron pertama ISAAA. Dengan dukungan dan inisiatif penuhnya, ISAAA mendirikan Global Knowledge Center on Crop Biotechnology di tahun 2000 di Filipina dengan node aktif yang disebut Biotechnology Information Centers (BIC) di 24 negara di dunia. Pada tahun 2010, ISAAA dan keluarga global BICnya merayakan satu dekade keberhasilan dalam memimpin berbagi pengetahuan dan pengembangan kemampuan mengenai bioteknologi tanaman guna membantu mengurangi kemiskinan di negara-negara berkembang.ISAAA telah melembagakan berbagi pengetahuan mengenai bioteknologi tanaman dengan menciptakan dan mendistribusikan newsletter email mingguan - Crop Biotech Update (CBU) – yang membagi pengetahuan mengenai bioteknologi tanaman secara gratis, penting, menghormati hak-hak orang lain untuk membuat keputusan berbasis sains dan pengetahuan. CBU meringkas perkembangan-perkembangan terkini dunia dalam bidang pertanian, pangan dan bioteknologi tanaman yang relevan bagi negara-negara berkembang. CBU kini disebarkan secara mingguan ke lebih dari 850,000 pelanggan di 200 negara - tujuan Kampanye Pengetahuan ISAAA tentang tanaman bioteknologi adalah untuk meningkatkan jumlah pelanggan menjadi 1 juta pada 31 Desember 2010.Dengan menegaskan kembali misinya bagi pengetahuan, teknologi dan pengentasan kemiskinan, Kampanye Pengetahuan ISAAA tentang bioteknologi tanaman menghara[...]



bio technology today

2011-01-23T18:04:44.253-08:00

bio technology today,bio technology today news
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HARGA KAKAO TURUN TERUS, PETANI PUSING

2011-01-21T09:12:51.195-08:00

MAMUJU, KOMPAS.com - Sebagian besar petani tanaman Kakao di Kabupaten Mamuju, Sulawesi Barat (Sulbar) mengeluh, menyusul harga komoditi unggulan bagi petani di daerah ini sejak beberapa pekan terakhir mulai turun.

Suparman, (42) petani kakao di Mamuju, Minggu (4/7/2010) mengatakan, para petani Kakao di sejumlah kecamatan di Kabupaten Mamuju mulai tidak bersemangat karena terus anjloknya harga coklat di sejumlah pasar di daerah ini.

"Sudah beberapa pekan terakhir ini, harga komoditi Kakao anjlok dari harga normal," katanya.

Harga kakao saat ini hanya sekitar Rp 21.000/kilogram, padahal sebelumnya, harga kakao cukup menguntungkan para petani di daerah ini dengan kisaran sebesar Rp 28.000/kilogram hingga Rp 29.000/kilogram.

"Turunnya harga kakao di pasar tradisional di Mamuju membuat petani Kakao sedikit pusing karena biaya yang dikeluarkan untuk pembelian pupuk cukup tinggi," katanya.

Dia mengatakan, selain harga komoditi itu jatuh di pasaran, tingkat produksi hasil panen juga cenderung berkurang, karena buah saat memasuki musim panen banyak yang rusak akibat terserang hama.

"Jika berjalan normal maka tingkat produksi hasil panen raya untuk komoditi kakao dapat mencapai ratusan ton, namun, kali ini produksinya turun dua kali lipat akibat terserang penyakit atau hama," katanya.

Ia berharap, pemerintah daerah yang mencanangkan program gerakan nasional peningkatan mutu dan produksi kakao (Gernas-pro Kakao) tidak hanya dijadikan simbol, namun, diharapkan program ini dapat diimplementasikan ke petani yang ada di Sulbar.

"Selama ini banyak membantu petani melalui program gernas, namun, program ini belum menyentuh secara merata terhadap petani," katanya.

Mestinya, pihak Dinas Perkebunan (Disbun) yang mewadahi petani dapat melakukan pendataan petani kakao, sehingga bantuan itu tersalurkan secara merata kesemua petani yang ada.

"Jangan ada pengecualian, karena petani sangat mengharapkan bantuan itu untuk memenuhi program peningkatan mutu dan produksi kakao," katanya.

Ia juga berharap pemerintah daerah segera menurunkan petugas penyuluh pertanian untuk mendampingi petani kakao yang mayoritas penduduknya bertumpu di bidang pertanian.

"Sekitar 60 persen dari penduduk Sulbar bertumpu pada sektor pertanian tanaman Kakao, sehingga peran pemerintah itu sangat diharapkan dapat membantu secara optimal kepada petani di Sulbar," katanya.
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Konferensi Internasional ke-14 mengenai Riset Komputasional Biologi Molekular

2011-01-21T09:11:46.376-08:00

Konferensi Internasional ke-14 mengenai Riset Komputasional Biologi Molekular akan diadakan di Lisbon, Portugal dari 12 sampai 15 Agustus 2010. Acara tersebut merupakan seri keempat belas dalam menjembatani bidang komputasi, ilmu matematika dan biologi.  Konferensi itu  akan menampilkan pembicara utama oleh para ilmuwan yang unggul dalam ilmu kehidupan, bersama-sama dengan presentasi makalah-makalah penelitian di bidang komputasi biologi.

Untuk informasi lebih lanjut, silahkan kunjungi: http://kdbio.inesc-id.pt/recomb2010/home.html.
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