Last Build Date: Tue, 28 Mar 2017 07:54:01 EDTCopyright: Copyright 2017 American Association for the Advancement of Science (AAAS); All rights reserved.
Tue, 28 Mar 2017 00:00:00 EDT(Baylor College of Medicine) Researchers from various institutions, including Baylor College of Medicine, have developed a new way to approach breast cancer treatment. First, they search for the proteins that drive tumor growth, and then test in the lab drugs that potentially neutralize these specific biological drivers.
Mon, 27 Mar 2017 00:00:00 EDT(Massachusetts Institute of Technology) MIT researchers have now developed a way to determine, by sequencing DNA of liver cells, whether cells have been exposed to aflatoxin. This profile of mutations could be used to predict whether someone has a high risk of developing liver cancer, potentially many years before tumors actually appear.
Mon, 27 Mar 2017 00:00:00 EDT(Kent State University) An online publication in Nature Nanotechnology this week by Kent State University researchers and their colleagues at Kyoto University in Japan, however, may offer new understanding about what turns good cells bad.
Mon, 27 Mar 2017 00:00:00 EDT(University of Miami Miller School of Medicine) Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML).
Mon, 27 Mar 2017 00:00:00 EDT(Columbia University Medical Center) A public-private research effort aims to develop more accurate ways of tracking a patient's response to cancer therapy.
Mon, 27 Mar 2017 00:00:00 EDT(University of Texas M. D. Anderson Cancer Center) A study of racial disparities in health-related quality of life of colorectal cancer patients revealed among several findings, that Hispanics and blacks had a higher burden of poor health-related quality-of-life (HR-QoL) than white patients and that poor HR-QoL resulted in shorter median survival. Yet Hispanics had an average survival time of 85.4 months as compared to blacks at 47.8 months and whites at 43.2 months.
Mon, 27 Mar 2017 00:00:00 EDT(American Institute of Physics) Proton therapy is a promising form of radiation treatment used to kill cancerous cells and effectively halt their rapid reproduction, and the fundamental understanding for it is contained in the radiation induced water chemistry that occurs immediately after the interaction. The ensuing processes are therefore a subject of considerable scientific interest. Researchers describe their work exploring this ionization with an experimental setup, with enhanced temporal resolution, in this week's Applied Physics Letters.
Mon, 27 Mar 2017 00:00:00 EDT(American Friends of Tel Aviv University) A new Tel Aviv University study discloses the role of three proteins in killing fast-duplicating cancer cells while they're dividing. The research finds that these proteins can be specifically modified to unleash an inherent 'death mechanism' that self-eradicates duplicating cancer cells.
Mon, 27 Mar 2017 00:00:00 EDT(Baylor College of Medicine) An international consortium of researchers led by Dr. Melissa Bondy, professor of medicine at Baylor College of Medicine, has conducted the largest study to date of malignant brain tumors looking for genetic markers of glioma, a highly aggressive form of brain cancer.
Mon, 27 Mar 2017 00:00:00 EDT(Future Science Group) A new perspective piece brings together the opinions of over 50 leading experts in the skin cancer field to assess controversies in current melanoma screening guidelines, as well as provide their own data-derived recommendations.
Mon, 27 Mar 2017 00:00:00 EDT(University of Bath) A simple color changing test to help scientists investigate potential cancer drugs has been developed by University of Bath scientists, allowing research to progress at a much greater speed than has been possible until now.
Mon, 27 Mar 2017 00:00:00 EDT(Florida Atlantic University) More than 35 million Americans are trying to quit smoking. Researchers reassure clinicians and their patients that varenicline, whose brand name is Chantix, is a safe and effective way to achieve smoking cessation and that failure to use this drug has caused preventable heart attacks and deaths from cardiovascular disease. Just a few months ago, the FDA removed the black box warning from varenicline.
Mon, 27 Mar 2017 00:00:00 EDT(Johns Hopkins Medicine) In a research effort that merged genetics, physics and information theory, a team at the Schools of Medicine and Engineering at Johns Hopkins University has added significantly to evidence that large regions of the human genome have built-in variability in reversible epigenetic modifications made to their DNA.
Mon, 27 Mar 2017 00:00:00 EDT(University of Texas M. D. Anderson Cancer Center) Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system, researchers at The University of Texas MD Anderson Cancer Center report in Nature Medicine.
Mon, 27 Mar 2017 00:00:00 EDT(Wellcome Trust Sanger Institute) Wellcome Trust Sanger Institute scientists and their collaborators have developed a new analysis tool that showed, for the first time, which genes were expressed by individual cells in different genetic versions of a benign blood cancer. Reported in Nature Methods today, the new computer tool -- Single Cell Consensus Clustering -- was shown to be more accurate and robust than existing methods of analyzing single-cell RNA sequence data, and is freely available for researchers to use.
Mon, 27 Mar 2017 00:00:00 EDT(Institute of Cancer Research) Scientists have uncovered a treasure trove of information about the genetic causes of brain cancer in the largest ever study of the disease.
Mon, 27 Mar 2017 00:00:00 EDT(University of Cambridge) A genetic trawl through the DNA of almost 100,000 people, including 17,000 patients with the most common type of ovarian cancer, has identified 12 new genetic variants that increase risk of developing the disease and confirmed the association of 18 of the previously published variants.
Mon, 27 Mar 2017 00:00:00 EDT(Cincinnati Children's Hospital Medical Center) Scientists partially re-insulated ravaged nerves in mouse models of multiple sclerosis (MS) and restored limb mobility by treating the animals with a small non-coding RNA called a microRNA. In a study published online March 27 in Developmental Cell, researchers report that treatment with a microRNA called miR-219 restarted production of a substance called myelin that is critical to normal function of the central nervous system.
Fri, 24 Mar 2017 00:00:00 EDT(Fred Hutchinson Cancer Research Center) The US Food and Drug Administration yesterday granted accelerated approval to the checkpoint inhibitor Bavencio (avelumab) for the treatment of patients with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy. Avelumab is the first FDA-approved treatment for metastatic MCC and the first disease that the drug has ever been approved to treat.
Fri, 24 Mar 2017 00:00:00 EDT(University of Texas Medical Branch at Galveston) More women are requesting BRCA gene testing associated with certain types of cancer thanks to increased interest in the procedure. Traditionally women tested for mutations in the cancer-susceptibility genes BRCA1 and BRCA2 have been those diagnosed with early onset breast or ovarian cancer in order to guide treatment options.
Fri, 24 Mar 2017 00:00:00 EDT(Bentham Science Publishers) The products obtained via bismuth salts-mediated reactions are medicinally active or starting materials for the synthesis of biologically active molecules including sex hormones, anticancer agents, antibacterial agents and agents for chagas diseases.
Fri, 24 Mar 2017 00:00:00 EDT(University of Colorado Anschutz Medical Campus) A University of Colorado Cancer Center study published in the journal Oncogene pinpoints a protein that may be essential to Ewing's sarcoma metastasis -- when researchers knocked down the protein KDM3A in Ewing's sarcoma tumor cells, one of a family known as Jumonji proteins, they also inhibited the cancer's metastatic ability.
Fri, 24 Mar 2017 00:00:00 EDT(McMaster University) These findings suggest that one of the most important risk factors for heart disease and type 2 diabetes, which is excess total and central fat in the body, is present relatively early in survivors of childhood brain tumors. This may program their future risk of these diseases and impact their outcomes.
Fri, 24 Mar 2017 00:00:00 EDT(InSilico Medicine, Inc.) Insilico Medicine, a Big Data analytics company applying deep learning techniques to drug discovery, biomarker development and human longevity research will present new research applying generative adversarial networks to developing new molecular structures for leads in oncology and other diseases at the BioDataWorld West, San Francisco, April 26-27.
Fri, 24 Mar 2017 00:00:00 EDT(Oxford University Press USA) A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program -- it can emphasize or silence genes. The new research shows that if epigenetics is disrupted, it might switch on oncogenes (genes that in certain circumstances transform cells into tumor cells) or shut down tumor suppressors. Both events will transform cells into tumor cells and cause cancer.