Last Build Date: Tue, 25 Oct 2016 04:54:01 EDTCopyright: Copyright 2016 American Association for the Advancement of Science (AAAS); All rights reserved.
Mon, 24 Oct 2016 00:00:00 EDT(University of Georgia) The University of Georgia's Ping Ma will use a new grant to crunch big data numbers, not uncommon for a statistics professor. What is unusual is that his work may help save lives.
Mon, 24 Oct 2016 00:00:00 EDT(Oregon State University) Researchers have found that a specific detoxification compound, glutathione, helps resist the toxic stresses of everyday life -- but its levels decline with age and this sets the stage for a wide range of health problems. It may be possible to restore glutathione levels and help prevent some of the metabolic declines associated with aging.
Mon, 24 Oct 2016 00:00:00 EDT(Baylor College of Medicine) Analysis of vast amounts of molecular data from a set of more than 1,000 non-small cell lung cancers identifies distinct subtypes, each with its own molecular profile and potentially different response to therapy.
Mon, 24 Oct 2016 00:00:00 EDT(Massachusetts Institute of Technology) Researchers at MIT's Koch Institute for Integrative Cancer Research have developed a new strategy for using immunotherapy to treat cancer. The researchers used a combination of four different therapies to activate both branches of the immune system, producing a coordinated attack that led to the disappearance of large, aggressive tumors in mice.
Mon, 24 Oct 2016 00:00:00 EDT(St. Jude Children's Research Hospital) An international team of researchers from the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (PCGP) and the Children's Oncology Group (COG) has identified the genetic changes that underpin a subtype of the most common cancer found in children. This form of B-precursor acute lymphoblastic leukemia (B-ALL) features genetic changes to two transcription factors known as DUX4 and ERG, proteins that closely control the activities of other crucial genes in human blood cells.
Mon, 24 Oct 2016 00:00:00 EDT(University of Chicago Medical Center) Tumor cells collected during the removal of a cancerous bladder and transplanted into mice with weakened immune systems could help physicians rapidly identify high-risk cancers, determine prognosis and refine the use of biomarkers to personalize care for patients with this common cancer.
Mon, 24 Oct 2016 00:00:00 EDT(Boston University Medical Center) Researchers have determined that two Phase 1 drugs (CX-4945 and JQ1) can work together to efficiently kill T-cell acute lymphoblastic leukemia cells while having minimal impact on normal blood cells.
Mon, 24 Oct 2016 00:00:00 EDT(McGill University Health Centre) The study suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments. The researchers found that prolactin hormone was able to reduce the aggressive behavior of cancerous cells. It does so by decreasing their ability to divide and form new tumors.
Mon, 24 Oct 2016 00:00:00 EDT(JCI Journals) This week in the JCI, research led by Jayanta Debnath at UCSF has shown that inhibiting autophagy does not impair the immune response to tumors during chemotherapy, providing support for the idea that combining autophagy inhibitors with certain chemotherapies may aid cancer treatment.
Mon, 24 Oct 2016 00:00:00 EDT(The JAMA Network Journals) The proportion of cancer deaths attributable to cigarette smoking varied across the United States but was highest in the South, where nearly 40 percent of cancer deaths in men were estimated to be connected to smoking in some states, according to a new article published online by JAMA Internal Medicine.
Mon, 24 Oct 2016 00:00:00 EDT(Wiley) A new study examines how one early example of precision medicine -- tumor genome testing -- is being used in women with breast cancer to reduce overtreatment and maximize the benefits of chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that physician recommendations and final treatment decisions correlated highly with test results, suggesting genome testing helped physicians identify which patients could most benefit from chemotherapy, and those for whom chemotherapy could be safely omitted.
Mon, 24 Oct 2016 00:00:00 EDT(University of Michigan Health System) One of the earliest widespread applications of precision medicine in cancer care is helping patients and physicians decide whether chemotherapy is needed, a new study finds.
Mon, 24 Oct 2016 00:00:00 EDT(American College of Physicians) A new evidence-based clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology says that calcium with or without vitamin D intake from food or supplements that does not exceed the tolerable upper level of intake should be considered safe from a cardiovascular standpoint.
Fri, 21 Oct 2016 00:00:00 EDT(Cleveland Clinic) Vice President Joe Biden has been added to the agenda of Cleveland Clinic's 2016 Medical Innovation Summit to discuss how the United States plans to end cancer as we know it, Monday, Oct. 24, 10 a.m. at the Huntington Convention Center of Cleveland.
Fri, 21 Oct 2016 00:00:00 EDT(Baylor College of Medicine) The new oncogene MNX1 is more active in African American than in European American prostate cancer.
Fri, 21 Oct 2016 00:00:00 EDT(Medical University of South Carolina) Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia. Targeting this pathway with a novel lipid-based therapeutic showed efficacy in a preclinical model of AML. These findings were reported in an article published in the Oct. 13, 2016 issue of Blood.
Fri, 21 Oct 2016 00:00:00 EDT(University of Wisconsin-Madison) A study in the current journal Oncotarget provides the first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer.
Fri, 21 Oct 2016 00:00:00 EDT(Sanford Health/Sanford Research) Sanford Health has opened another clinical trial exploring the power of the body's immune system to fight cancer. The immunotherapy trial is focusing on colorectal cancer and involves an investigational drug Sanford is already studying as a potential therapy for other types of cancer.
Fri, 21 Oct 2016 00:00:00 EDT(Wiley) Cisplatin is one of the most widely used agents in cancer chemotherapy. It cross-links DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team have now set up a universal, genome-wide assay to detect the specific cisplatin action sites. In the journal Angewandte Chemie they report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.
Fri, 21 Oct 2016 00:00:00 EDT(Aarhus University) A Danish research team has developed a new method for studying how a tracer is distributed in a cancer tumor via its extensive vascular network.The method can be used for studying closely the effect of medical treatment using cancer inhibitors.
Fri, 21 Oct 2016 00:00:00 EDT(Charité - Universitätsmedizin Berlin) Pathogen epitopes are fragments of bacterial or viral proteins. Nearly a third of all existing human epitopes consist of two different fragments. Known as 'spliced epitopes', these types of epitopes have long been regarded as rare. The fact that they are so highly prevalent might, among other things, explain why the immune system is so highly flexible. Results from this study have been published in the current issue of the journal Science.*
Fri, 21 Oct 2016 00:00:00 EDT(Queensland University of Technology) A QUT professor has become the first Australian since Professor Ian Frazer to receive the prestigious West Lake Friendship award.
Fri, 21 Oct 2016 00:00:00 EDT(Kumamoto University) Pancreatic cancer is one of the most lethal forms of cancer. Early detection is essential to improve prognoses. Working toward that goal, a collaboration of researchers in Japan has discovered proteins in the blood which improve the detection of pancreatic cancer. When used in combination with conventional pancreatic cancer biomarkers, it enables the diagnosis of early stage pancreatic cancer, which was previously thought to be difficult.
Fri, 21 Oct 2016 00:00:00 EDT(Okinawa Institute of Science and Technology (OIST) Graduate University) When treated with an anti-cancer drug, ICRF-193, fission yeast produce an 'arched and snapped' phenotype that may be used to screen for other cancer drugs.
Fri, 21 Oct 2016 00:00:00 EDT(American Association for Cancer Research) Among Japanese patients with esophageal cancer, those whose cancer tested positive for DNA from the bacterium Fusobacterium nucleatum had shorter cancer-specific survival compared with those whose cancer had no DNA from the bacterium.