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Preview: EurekAlert! - Cancer

EurekAlert! - Cancer Research News



The premier online source for science news since 1996. A service of the American Association for the Advancement of Science.



Last Build Date: Thu, 19 Oct 2017 10:54:02 EDT

Copyright: Copyright 2017 American Association for the Advancement of Science (AAAS); All rights reserved.
 



Moonshot grant will help researchers see two of cancer's key food sources at once

Thu, 19 Oct 2017 00:00:00 EDT

(University of Pennsylvania School of Medicine) Imagine trying to take a picture of a runner, but only being able to see her feet. If you could see her whole body, you'd get the full picture of how she uses both legs to put one foot in front of the other to reach top speed. That's the idea behind a cancer imaging project that just received $1.4 million in funding from the National Institutes of Health.



Early data shows nearly 2x prolonged median survival for inoperable pancreatic cancer

Thu, 19 Oct 2017 00:00:00 EDT

(ViewRay) A retrospective review of 42 inoperable, locally-advanced pancreatic cancer patients treated at four institutions found that higher delivered radiation doses enabled via ViewRay's MRIdian adaptive MR-guided radiation therapy showed a near doubling of median overall survival (27.8 months compared to 14.8 months) and resulted in favorably lower toxicities (0 percent compared to 15.8 percent grade 3 or higher toxicity).



Researchers 'drug the undruggable' through unique collaboration

Thu, 19 Oct 2017 00:00:00 EDT

(University of Liverpool) A new study published in Nature, conducted by an alliance between industry and academia involving the University of Liverpool, highlights a new approach to targeting key cancer-linked proteins, thought to be 'undruggable'.



An international consortium identifies the breast cancer patients who would benefit from a treatment

Thu, 19 Oct 2017 00:00:00 EDT

(Institute for Research in Biomedicine (IRB Barcelona)) This new knowledge may be key to the early detection of patients who would benefit from zoledronic acid and those who should be spared, and it may accelerate the administration of the first preventive treatment of metastasis.



Mutant gene found to fuel cancer-promoting effects of inflammation

Thu, 19 Oct 2017 00:00:00 EDT

(University of California - San Diego) A study by UC San Diego biologists uncovered a new mechanism linking a human gene's function to chronic inflammation. Through large-scale genomic analyses, the researchers discovered that 'mutant p53' amplifies the impact of inflammation, leading to increases in the invasive behavior of cancer. Thus, rather than fighting tumor growth, mutant forms of p53 appear to be tapping into the body's immune response system to fuel pro-inflammatory responses that increase cancer growth.



Walking below minimum recommended levels linked to lower mortality risk

Thu, 19 Oct 2017 00:00:00 EDT

(American Cancer Society) A new study finds regular walking, even if not meeting the minimum recommended levels, is associated with lower mortality compared to inactivity.



Indoor tanning dependency common in young women, especially in those with depression

Thu, 19 Oct 2017 00:00:00 EDT

(Georgetown University Medical Center) A survey of young, white women who have used indoor tanning at least once in the past year showed that more than one in five of them have signs of being addicted to the high dose of ultraviolet (UV) radiation from tanning beds. In addition, women with symptoms of depression were three times more likely to meet the criteria for having a tanning dependence.



One in five young non-Hispanic white women who tan indoors are dependent on indoor tanning

Thu, 19 Oct 2017 00:00:00 EDT

(American Association for Cancer Research) More than 20 percent of non-Hispanic white women ages 18 to 30 who reported using an indoor tanning device one or more times in the past 12 months were dependent on indoor tanning. Dependence was strongly associated with beliefs about physical appearance and depressive symptoms.



UChicago Medicine first site in Illinois offering pioneering CAR T-cell therapy for cancer

Wed, 18 Oct 2017 00:00:00 EDT

(University of Chicago Medical Center) The FDA today approved the use of a breakthrough cancer treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma, a form of non-Hodgkin lymphoma. The treatment is a form of CAR T-cell therapy now labelled Yescarta (axicabtagene ciloleucel). The University of Chicago Medicine is the first site in Illinois certified by both Kite Pharma Inc. and Novartis.



Scientists reveal herbal remedies containing aristolochic acid may cause liver cancer

Wed, 18 Oct 2017 00:00:00 EDT

(Duke-NUS Medical School) Mutational signatures reveal high burdens of AA-related mutations in Asian liver cancers, with Taiwan most intensely affected.



New study reveals breast cancer cells recycle their own ammonia waste as fuel

Wed, 18 Oct 2017 00:00:00 EDT

(Harvard Medical School) Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth, report scientists from Harvard Medical School. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strategies to slow tumor growth.



Researchers watch in real time as fat-encased drug nanoparticles invade skin cells

Wed, 18 Oct 2017 00:00:00 EDT

(University of Colorado Anschutz Medical Campus) A University of Colorado Cancer Center study published today in the journal ACS Nano describes the use of cutting-edge microscopy technology to visualize how liposomes escape from blood vessels into surrounding cells in a living mouse, offering clues that may help researchers design better drug delivery systems.



Genetic testing recommended for children considered at risk for most common eye cancer

Wed, 18 Oct 2017 00:00:00 EDT

(American Academy of Ophthalmology) Children who are considered to be at risk of developing eye cancer should receive genetic counseling and testing as soon as possible to clarify risk for the disease. This is the consensus of leading ophthalmologists, pathologists and geneticists, who worked for two years to develop the first U.S. guidelines on how to screen for the most common eye tumor affecting children.



Oncotarget: Researchers identify novel therapeutic strategy for drug-resistant thyroid cancers

Wed, 18 Oct 2017 00:00:00 EDT

(CG Life) New findings by a Harvard Medical School team suggest that palbociclib, a drug that is FDA-approved to treat advanced breast cancer, may be able to overcome vemurafenib resistance in PTC.



New findings explain how UV rays trigger skin cancer

Wed, 18 Oct 2017 00:00:00 EDT

(Cornell University) Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the US in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the majority of them come from sources unknown -- until now.



German research advances in cancer and blood disorders reported in human gene therapy

Wed, 18 Oct 2017 00:00:00 EDT

(Mary Ann Liebert, Inc./Genetic Engineering News) Virotherapy capable of destroying tumor cells and activating anti-tumor immune reactions, and the use of engineered hematopoietic stem cells (HSCs) to deliver replacement genes that have the potential to cure blood diseases are among the key areas of gene therapy being advanced by German researchers.



Drug yields high response rates for lung cancer patients with harsh mutation

Wed, 18 Oct 2017 00:00:00 EDT

(University of Texas M. D. Anderson Cancer Center) A targeted therapy resurrected by the Moon Shots Program™ at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatment-resistant mutation.



Terry Fox research team's model for detecting lung cancer saves lives, is a world leader

Wed, 18 Oct 2017 00:00:00 EDT

(Terry Fox Research Institute) A pan-Canadian team of cancer researchers has developed a predictive model for detecting early-stage lung cancer in high-risk individuals with significantly greater accuracy than other leading models. This Terry Fox Research Institute study suggests the team's innovative approach could be considered for use in lung cancer screening programs both in Canada and around the world.



From Dr. Jekyll to Mr. Hyde of cancer immunotherapy

Wed, 18 Oct 2017 00:00:00 EDT

(University of Bonn) Novel immunotherapies can strengthen the body's own defenses against cancer cells. Treatment of patients with advanced disease can promote partial and complete tumor regressions. However, such strategies also frequently fail. The underlying mechanisms are incompletely understood. An international research team led by the University Hospitals of Magdeburg and Bonn has now discovered a previously unrecognized braking mechanism that limits the efficacy of cancer immunotherapies. The results provide a scientific basis to further develop cancer immunotherapy.



Rare cancer linked with textured breast implants may be underreported, misunderstood

Wed, 18 Oct 2017 00:00:00 EDT

(Penn State) A rare cancer in patients with breast implants may be on the rise, but not all patients and physicians may be aware of the risks associated with the procedure, according to a group of Penn State College of Medicine researchers.



First ESMO award for immuno-oncology goes to Laurence Zitvogel

Wed, 18 Oct 2017 00:00:00 EDT

(European Society for Medical Oncology) The European Society for Medical Oncology (ESMO) has granted the newly established ESMO Award for Immuno-Oncology to Prof Laurence Zitvogel for her innovating and internationally recognised achievements in the field.



Battling flames increases firefighters' exposure to carcinogens

Wed, 18 Oct 2017 00:00:00 EDT

(American Chemical Society) The threat of getting burned by roaring flames is an obvious danger of firefighting, but other health risks are more subtle. For example, firefighters have been found to develop cancer at higher rates than the general population. Now researchers have measured how much firefighters' exposure to carcinogens and other harmful compounds increases when fighting fires. Their study, appearing in ACS' Environmental Science & Technology, also points to one possible way to reduce that exposure.



Community engagement interventions may reduce disparities in lung cancer outcomes among minorities

Tue, 17 Oct 2017 00:00:00 EDT

(International Association for the Study of Lung Cancer) Community-based interventions implemented in minority community sites resulted in changes in participants' knowledge, attitudes and beliefs about cancer, as well as perceived benefits and self-efficacy measures regarding lung cancer screening. Dr. Lovoria Williams of Augusta University in the United States presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan.



Exercise interventions in advanced lung cancer patients led to increased functionality

Tue, 17 Oct 2017 00:00:00 EDT

(International Association for the Study of Lung Cancer) Physical exercise and psycho-social interventions in patients with advanced stage lung cancer improved functional capacity, which may be linked to quality of life benefits. Dr. Quist of the University of Copenhagen in Denmark presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan.



TGen develops processing procedures for 'single-cell' sequencing

Tue, 17 Oct 2017 00:00:00 EDT

(The Translational Genomics Research Institute) The Translational Genomics Research Institute (TGen) today announced grant support from the Chan Zuckerberg Initiative (CZI) donor advised fund, an advised fund of the Silicon Valley Community Foundation, that will help revolutionize how researchers identify the genetic source of diseases and how best to treat each patient.