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Preview: Brightsurf Science News :: Esophageal Cancer News

Esophageal Cancer Current Events and Esophageal Cancer News from Brightsurf

Esophageal Cancer Current Events and Esophageal Cancer News Events, Discoveries and Articles from Brightsurf

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Study tracks evolutionary transition to destructive cancer

Fri, 23 Feb 18 00:00:10 -0800

In a new study, researchers at ASU's Biodesign Institute led an international team to explore how evolutionary processes guide the pathways of cells. Their results, which appear in the advanced online edition of the journal Nature Communications, point to influences leading some cells to remain stable over time while driving others to become cancerous and expand without limit.

Finnish research group discovers a new immune system regulator

Thu, 22 Feb 18 00:16:30 -0800

Academy Professor Riitta Lahesmaa's research group from Turku Centre for Biotechnology of the University of Turku and Åbo Akademi University, Finland, has discovered a new regulator of the immune system, a key factor that controls development of regulatory T cells. The discovery provides basis for new strategies for the treatment of both cancer and immune-mediated diseases.

Cancer risk associated with key epigenetic changes occurring through normal aging process

Thu, 22 Feb 18 00:00:30 -0800

Some scientists have hypothesized that tumor-promoting changes in cells during cancer development--particularly an epigenetic change involving DNA methylation--arise from rogue cells escaping a natural cell deterioration process called senescence. Now, researchers at the Johns Hopkins Kimmel Cancer Center demonstrated that instead, tumor-associated epigenetic states evolve erratically during early stages of tumor development, eventually selecting for a subset of genes that undergo the most changes during normal aging and in early tumor development.

NEJM reports positive results for larotrectinib against TRK-fusion cancer

Thu, 22 Feb 18 00:04:20 -0800

55 patients representing 17 cancer types tested positive for TRK fusion and were treated with larotrectinib. Overall response rate was 75 percent.

UT Dallas scientists isolate cancer stem cells using novel method

Thu, 22 Feb 18 00:13:50 -0800

Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers -- a significant step toward developing new drugs that might target these cells.

An under-the-radar immune cell shows potential in fight against cancer

Thu, 22 Feb 18 00:01:20 -0800

One of the rarest of immune cells, Type-2 innate lympoid cells might be a potent weapon in slowing the spread of cancer to other parts of the body. Though known primarily for their role in causing asthma, University of British Columbia scientists found that implanted cancers metastasize much more easily in mice lacking ILC2 cells.

Five novel genetic changes linked to pancreatic cancer risk

Wed, 21 Feb 18 00:14:10 -0800

In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other institutions worldwide discovered changes to five new regions in the human genome that may increase the risk of pancreatic cancer.

Genes activated in metastasis also drive the first stages of tumour growth

Tue, 20 Feb 18 00:02:10 -0800

Researchers headed by Jordi Casanova at the Institute for Research in Biomedicine (IRB Barcelona) now demonstrate that genes activated during metastasis are also able to initiate primary tumour development, and they explain the molecular mechanism involved. Made using the fly model Drosophila melanogaster, this finding has been published in PloS Genetics this week.

Oncotarget: Cancer pioneer employs physics to approach cancer in last research article

Tue, 20 Feb 18 00:07:30 -0800

In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer. Co-author Dr. Coffey, ex-deputy director of the Johns Hopkins Kimmel Cancer Center and Professor of Urology, died before this paper was published at 85.

Researchers discover novel mechanism linking changes in mitochondria to cancer cell death

Mon, 19 Feb 18 00:04:30 -0800

Researchers at the University of Notre Dame discovered that the activation of a specific enzyme may help suppress the spread of tumors.

Nitrate in drinking water increases the risk of colorectal cancer

Sun, 18 Feb 18 00:16:10 -0800

Nitrate in groundwater and drinking water, which primarily comes from fertilisers used in the agricultural production, has not only been subject to decades of environmental awareness -- it has also been suspected of increasing the risk of cancer. The largest epidemiological study ever carried out in this area now shows that there is a correlation - also when the amount of nitrate in the drinking water is far below the current drinking water standard.

Breast reconstruction patients often less satisfied than expected post surgery

Fri, 16 Feb 18 00:14:50 -0800

Many breast cancer patients undergoing mastectomy with or without immediate reconstruction mispredict future satisfaction with aspects of physical and sexual health post-surgery, according to a new study published by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James).

Can our genes help predict how women respond to ovarian cancer treatment?

Thu, 15 Feb 18 00:14:00 -0800

New research, led by Professor Anna deFazio from the Westmead Institute and Westmead Hospital, has shown that the genes we inherit can have a significant impact on how the body processes chemotherapy drugs, which may lead to different clinical outcomes for ovarian cancer patients.

Self-sampling identifies twice as many women at risk of cervical cancer

Thu, 15 Feb 18 00:15:10 -0800

Using self-sampling followed by HPV testing, more than twice as many women at risk of developing cervical cancer could be identified and offered preventive treatment. This is shown by researchers at Uppsala University in the first randomised study in the world comparing two ways of identifying cervical cancer, published today in the British Journal of Cancer.

First comparison of common breast cancer tests finds varied accuracy of predictions

Thu, 15 Feb 18 00:01:50 -0800

Commercially available prognostic breast cancer tests show significant variation in their abilities to predict disease recurrence, according to a study led by Queen Mary University of London of nearly 800 postmenopausal women.

New research highlights how cancer cells repair themselves following proton beam therapy

Thu, 15 Feb 18 00:02:40 -0800

Collaborative research conducted in Liverpool and Oxford, published in The Red Journal, identifies the specific cellular process that helps cancer cells damaged as a result of proton beam therapy, repair themselves.

New report: Labs differ widely in BRCA testing protocols

Thu, 15 Feb 18 00:11:00 -0800

A new article published in npj Genomic Medicine showcases the wide differences in BRCA testing protocols at labs around the world. The article surveyed 86 laboratories around the world about their BRCA testing practices and found that all the labs differed widely in their approach.

A gene that increases the risk of pancreatic cancer controls inflammation in normal tissue

Wed, 14 Feb 18 00:06:50 -0800

A group of researchers at the Spanish National Cancer Research Centre has now discovered an unexpected link between the two processes: in the pancreas, one of the genes that increases the risk of developing pancreatic cancer also controls inflammation. This finding offers 'a major conceptual change,' explains Paco Real, from the CNIO, which, as well as helping to understand the origin of tumors, suggests new strategies to improve the prevention of pancreatic cancer.

Possible new principle for cancer therapy

Wed, 14 Feb 18 00:07:50 -0800

A study published in Science Translational Medicine shows that small molecules that specifically inhibit an important selenium-containing enzyme may be useful in combating cancer. When researchers at Karolinska Institutet in Sweden treated cancer in mice using these molecules, they observed rapid tumoricidal effects. Researchers now hope that this new principle for cancer treatment will eventually be developed for use in humans.

Cutting off cervical cancer's fuel supply stymies tumors

Wed, 14 Feb 18 00:07:40 -0800

Researchers at Washington University School of Medicine in St. Louis have shown that cervical tumors that don't respond to radiation may be vulnerable to therapies that also attack the cancer's fuel supply.

Study suggests possible link between highly processed foods and cancer

Wed, 14 Feb 18 00:11:40 -0800

A study published by The BMJ today reports a possible association between intake of highly processed ('ultra-processed') food in the diet and cancer.

Screening for ovarian cancer not recommended

Tue, 13 Feb 18 00:01:50 -0800

The US Preventive Services Task Force (USPSTF) recommends against screening for ovarian cancer in women without symptoms and who are not known to be at high risk (such as those who have certain hereditary cancer syndromes that increase the risk for ovarian cancer).

Huntington's disease provides new cancer weapon

Mon, 12 Feb 18 00:10:50 -0800

Patients with Huntington's disease, a fatal genetic illness that causes the breakdown of nerve cells in the brain, have up to 80 percent less cancer than the general population. Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer, a new study reports.

Study sheds new light on mechanism of breast cancer treatment resistance

Mon, 12 Feb 18 00:01:00 -0800

A study by researchers at Dana-Farber Cancer Institute has illuminated a specific mechanism by which estrogen receptor-positive (ER+) breast cancers can become resistant to standard therapies and metastasize.

Novel classification can lead to new ways to diagnose and treat cancer

Mon, 12 Feb 18 00:05:20 -0800

A novel approach to studying cancer has enabled researchers to group about 10,000 human cancers of 32 different types into 10 classes based on the molecular pathways that drive tumor growth. A better understanding of these pathways can potentially lead to novel ways to diagnose and treat cancer.

Cancer killing clue could lead to safer and more powerful immunotherapies

Mon, 12 Feb 18 00:07:50 -0800

The study, led by Dr Misty Jenkins from the Walter and Eliza Hall Institute of Medical Research, explains the crucial mechanisms by which CAR-T cell therapy is able to rapidly target and kill cancer cells, and why it may cause serious side effects.

How do children's cancer diagnoses affect parents' income?

Mon, 12 Feb 18 00:09:10 -0800

A new study from Sweden found that social benefits often ease the financial burdens experienced by the parents of children recently diagnosed with cancer, but mothers experienced persistently lower income after benefits diminished. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings indicate that additional efforts may be needed to address the financial hardships experienced by the mothers of children with cancer.

Science self-corrects: Cancer gene does not pass reproducibility test

Mon, 12 Feb 18 00:10:20 -0800

About 10 years ago, several labs discovered that a gene called MELK is overexpressed, or turned on to a high degree, in many cancer cell types. This evidence has prompted multiple ongoing clinical trials to test whether drugs that inhibit MELK can treat cancer in patients. Now, CSHL researchers report that MELK is not actually involved in cancer. It's a story about how science self-corrects.

Blood test plus ultrasound boosts liver cancer detection by 40 percent

Fri, 09 Feb 18 00:08:10 -0800

Combining ultrasound imaging with a blood test for high alpha fetoprotein (AFP) levels improves detection of early-stage liver cancer by as much as 40 percent, researchers at UT Southwestern's Simmons Cancer Center found.

Study shows liver cells with whole genome duplications protect against cancer

Fri, 09 Feb 18 00:08:30 -0800

Researchers at the Children's Medical Center Research Institute (CRI) at UT Southwestern have discovered that cells in the liver with whole genome duplications, known as polyploid cells, can protect the liver against cancer.

Researchers develop breakthrough technique to combat cancer drug resistance

Thu, 08 Feb 18 00:05:10 -0800

The ability for cancer cells to develop resistance to chemotherapy drugs -- known as multi-drug resistance -- remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to 'turn off' their resistance capabilities.

Molecular 'magnets' could improve cancer immunotherapy

Thu, 08 Feb 18 00:10:20 -0800

Chemicals that attract specialised immune cells toward tumours could be used to develop better immunotherapies for cancer patients, according to new research published in Cell. Scientists at the Francis Crick Institute have discovered that immune cells called Natural Killer cells accumulate in tumours and release chemicals that attract specialised dendritic cells (cDC1) - white blood cells known for triggering anti-cancer immune responses - to the tumour.

Versatile sensor against tumor initiating cells

Wed, 07 Feb 18 00:13:30 -0800

The IBS researchers developed the first fluorescent sensor to visualize TICs. Functional in lung, central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer cell cultures, this could become a useful tool for biopsy-free post-treatment assessment and anti-TIC drug development.

Scientists halt breast cancer spread

Wed, 07 Feb 18 00:01:00 -0800

Scientists have discovered that an amino acid called asparagine is essential for breast cancer spread, and by restricting it, cancer cells stopped invading other parts of the body in mice, according to research part-funded by Cancer Research UK and published in the journal Nature today.

Insight into chromatin therapies for breast cancer could aid personalized medicine

Wed, 07 Feb 18 00:03:30 -0800

Most traditional chemotherapy for cancer has dangerous side effects, but new research is finding ways to develop 'targeted agents' that reduce the side effects and are better tailored to individual patient needs. While these innovations are exciting, a new study shows how certain cancer inhibitors need to be examined more carefully to better understand fine-grained effects and counter-effects, which could yield more effective and safer therapies.

UPMC researchers solving treatment resistance in most common breast cancer

Wed, 07 Feb 18 00:10:00 -0800

For the first time researchers have identified recurrent ESR1 fusion proteins in human breast cancer, to understand how they function and help lead to improved treatments for the disease.

Recreating liver tumors as organoids for faster, more accurate drug screening

Wed, 07 Feb 18 00:15:20 -0800

A major challenge in developing liver cancer drugs is that preclinical testing occurs in tumor models that do not accurately reflect human tumor features, causing drug candidates to later fail in clinical testing. Now, Singaporean researchers have grown organoids from liver tumors on specially engineered 3-D scaffolds. These organoids replicate important features of the original tumor, including genetic changes and intra-tumor heterogeneity, and could serve as tumor avatars for high-throughput drug screening.

Starving liver cancer

Tue, 06 Feb 18 00:08:00 -0800

Scientists at the University of Delaware and the University of Illinois at Chicago have found a new way to kill liver cancer cells and inhibit tumor growth. This research could accelerate the development of new treatments for liver cancer, which is currently difficult to cure.

Scientists target glioma cancer stem cells, which could improve patient survival

Mon, 05 Feb 18 00:09:50 -0800

Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers at Dartmouth's Norris Cotton Cancer Center have devised a strategy to treat these tumors by identifying a secretion-mediated pathway that's essential for maintaining glioma cancer stem cells.

Loved one's death could spur aggressive measures against breast cancer

Mon, 05 Feb 18 00:15:00 -0800

A woman's memories of a loved one's experience with cancer could play a significant role in how she approaches breast cancer prevention in her own life, a new study has found.

Health indicators for newborns of breast cancer survivors may vary by cancer type

Mon, 05 Feb 18 00:01:40 -0800

In a study published in the International Journal of Cancer, researchers from the UNC Lineberger Comprehensive Cancer Center analyzed health indicators for children born to young breast cancer survivors in North Carolina.

UA Cancer Center team targets tumor suppressor to treat 'triple-negative' breast cancer

Mon, 05 Feb 18 00:02:50 -0800

A team led by UA Cancer Center researchers Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, screened for drugs that could target triple-negative breast cancer tumors, producing several new therapeutic candidates for this difficult-to-treat cancer.

Aging immune system may explain age-related cancer risk increase

Mon, 05 Feb 18 00:04:10 -0800

Study published in Proceedings of the National Academy of Sciences suggests aging immune system plays a larger role in cancer incidence than previously thought. Findings may explain higher likelihood of men developing cancer than women. This epidemiological research could have major implications for global fight against cancer if borne out by further studies.

New focus on where heart disease and breast cancer treatment meet

Thu, 01 Feb 18 00:09:00 -0800

The American Heart Association has released the first scientific statement about heart disease and breast cancer, calling for more research and collaboration between the fields of oncology and cardiology to treat and prevent both diseases.

Simmons Cancer Center researchers part of historic CAR-T breakthrough

Thu, 01 Feb 18 00:06:50 -0800

A historic study involving researchers from UT Southwestern's Harold C. Simmons Comprehensive Cancer Center demonstrates the effectiveness of CAR-T therapy, which uses genetically modified immune cells to treat acute lymphoblastic leukemia in children and young adults.

Regular exercise halves complication rate after lung cancer surgery

Thu, 01 Feb 18 00:08:40 -0800

Exercising regularly before surgery for lung cancer halves the complication rate afterwards, finds a synthesis of the available published evidence in the British Journal of Sports Medicine.

Cancer patients: Web-based help improves quality of life

Wed, 31 Jan 18 00:08:30 -0800

A diagnosis of cancer causes huge psychological stress, but many patients do not receive any psychological support. An online stress management program can significantly improve their quality of life, as shown by a study conducted by researchers from the University of Basel and University Hospital Basel, and published in the Journal of Clinical Oncology.

MD Anderson study evaluates need for biopsies during follow-up care in women with early breast cancer

Wed, 31 Jan 18 00:14:20 -0800

In an analysis of more than 120,000 women diagnosed with and treated for early-stage breast cancer, researchers from The University of Texas MD Anderson Cancer Center determined the rate of additional breast biopsies needed for these patients during their follow-up care. The findings, reported in JAMA Surgery, are the first comprehensive nationwide population-based study regarding the need for breast biopsies performed during follow up after treatment for invasive breast cancer.

HPV may lurk in your throat

Wed, 31 Jan 18 00:01:00 -0800

URMC researchers found human papilloma virus (HPV), the culprit behind cervical and head and neck cancers, hiding in small pockets on the surface of tonsils. They believe HPV may evade the immune system in this hiding place, allowing the virus to lay in wait for an opportunity to reinstate an infection or invade the tonsil tissue to develop cancer.

Study reveals substantial impact of chronic diseases on cancer risk

Wed, 31 Jan 18 00:06:40 -0800

Several common chronic diseases together account for more than a fifth of new cancer cases and more than a third of cancer deaths, finds a study published by The BMJ today.