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Preview: Brightsurf Science News :: Stem Cells News

Stem Cells Current Events and Stem Cells News from Brightsurf

Stem Cells Current Events and Stem Cells News Events, Discoveries and Articles from Brightsurf

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Scientists tackle the aberrant epigenetic programming underlying childhood cancers

Tue, 20 Feb 18 00:15:00 -0800

Researchers at UFRGS and the US NIH have targeted proteins that regulate chromatin in Ewing sarcoma cells, hindering malignant tumor growth. They induced chromatic relaxation by treating the cells with histone deacetylase inhibitors, reducing expression of the EWSR1-FLI-1 oncogene and other pluripotency/cell viability genes, while impairing sarcoma cell survival and growth. Decreased survival of stem-like cancer cells and re-expression of a neuronal differentiation marker were also observed.

Pillars of academic innovation

Tue, 20 Feb 18 00:14:30 -0800

Highlights from the Sixth Annual Conference of the National Academy of Inventors, including high-tech solutions to combat child pornography and radicalization materials; groundbreaking programs to promote STEM major retention; and new materials for wearable technology.

Scientists find new antimalarial drug targets

Tue, 20 Feb 18 00:00:50 -0800

Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies to use this knowledge to develop new antimalarial drugs - a critical step in the battle against drug-resistant malaria.

'Brain on a chip' reveals how the brain folds

Mon, 19 Feb 18 00:16:00 -0800

Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles - smooth brain syndrome - suffer from severe developmental deficiencies and their life expectancy is markedly reduced. The gene that causes this syndrome recently helped Weizmann Institute of Science researchers to probe the physical forces that cause the brain's wrinkles to form.

Highly mutated protein in skin cancer plays central role in skin cell renewal

Mon, 19 Feb 18 00:06:50 -0800

Researchers have shown for the first time that a key protein called KMT2D (and is often mutated in skin cancer) is involved in the epigenetic regulation of gene expression that guide skin cell turnover.

Reshaping drug tests

Mon, 19 Feb 18 00:06:00 -0800

Researchers have improved on the currently available methods for screening drugs for heart-related side effects.

Lab-grown human cerebellar cells yield clues to autism

Fri, 16 Feb 18 00:15:50 -0800

Increasing evidence has linked autism spectrum disorder (ASD) with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like features.

Scientists produce human intestinal lining that re-creates living tissue inside organ-chip

Fri, 16 Feb 18 00:01:00 -0800

Scientists created human intestinal lining outside an individual's body that mirrors living tissue inside microengineered Intestine-Chips, opening possibilities for personalized testing of medicines. The re-created intestinal lining, derived from an adult's cells that were converted into stem cells and grown into organoids, bore the adult's genetic fingerprint. The findings potentially could change how patients are treated for gastrointestinal diseases. The study was conducted by the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Emulate, Inc.

Rice U. reports progress in pursuit of sickle cell cure

Fri, 16 Feb 18 00:02:40 -0800

Rice University bioengineer Gang Bao and his colleagues use gene editing to correct the mutation responsible for sickle cell disease in up to 40 percent of patients' cells used for lab testing.

New stem-cell based stroke treatment repairs damaged brain tissue

Thu, 15 Feb 18 00:13:40 -0800

A team of researchers at the University of Georgia's Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies in animal models.

Countries with greater gender equality have lower percentage of female STEM graduates

Thu, 15 Feb 18 00:13:50 -0800

Although women currently are well represented in life sciences, they continue to be underrepresented in inorganic sciences, such as computer science and physics. Now, researchers from the University of Missouri and Leeds Beckett University in the United Kingdom have found that as societies become wealthier and more gender equal, women are less likely to obtain degrees in STEM. The researchers call this a 'gender-equality paradox.' Researchers also discovered a near-universal sex difference in academic strengths and weaknesses that contributes to the STEM gap.

Catching up to brain cancer

Thu, 15 Feb 18 00:14:40 -0800

University of Delaware researchers have produced a new and freely available computer program that predicts cancer cell motion and spread with high accuracy. This new system gives researchers a faster way of examining rapidly spreading glioblastoma tumors -- an aggressive and devastating form of brain cancer -- and a new way of predicting the likely impact different treatments might have.

Researchers find adult endothelial stem cells that can make fully functional blood vessels

Thu, 15 Feb 18 00:00:00 -0800

Stem cells are increasingly used to treat disorders caused by defective tissues. The repair of blood vessels by vascular endothelial stem cells (VESCs) is an attractive therapeutic option, but the existence of this type of stem cell has not been conclusively shown. Researchers identified a VESC that can regenerate blood vessels and treat a rare bleeding disorder. These VESCs have the potential to serve as a new cell-based therapy for blood vessel-related diseases.

Stem cell vaccine immunizes lab mice against multiple cancers

Thu, 15 Feb 18 00:05:20 -0800

Stanford University researchers report that injecting mice with inactivated induced pluripotent stem cells (iPSCs) launched a strong immune response against breast, lung, and skin cancers. The vaccine also prevented relapses in animals that had tumors removed. The work appears in the journal Cell Stem Cell on Feb. 15.

Induced pluripotent stem cells could serve as cancer vaccine, Stanford researchers say

Thu, 15 Feb 18 00:04:40 -0800

Induced pluripotent stem cells, or iPS cells, are a keystone of regenerative medicine. Outside the body, they can be coaxed to become many different types of cells and tissues that can help repair damage due to trauma or disease. Now, a study in mice from the Stanford University School of Medicine suggests another use for iPS cells: training the immune system to attack or even prevent tumors.

Building better tiny kidneys to test drugs and help people avoid dialysis

Thu, 15 Feb 18 00:11:20 -0800

A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies. The three-study series provides the first cellular and molecular characterization of how the human kidney develops in a mother's womb. The new, open-source data, available at, provides the first systematic, high-resolution atlas or databank for human kidney genesis.

Could sugar chains be the answer to bone growth in osteoporosis?

Wed, 14 Feb 18 00:01:20 -0800

Scientists at the University of York have shown that altering the structure of sugar chains on the surface of stem cells could help promote bone growth in the body.

Countries with greater gender equality have a lower percentage of female STEM graduates

Wed, 14 Feb 18 00:04:40 -0800

Countries with greater gender equality see a smaller proportion of women taking degrees in science, technology, engineering and mathematics (STEM), a new study has found. Policymakers could use the findings to reconsider initiatives to increase women's participation in STEM, say the researchers.

Cells 'walk' on liquids a bit like geckos

Wed, 14 Feb 18 00:04:00 -0800

Researchers at Queen Mary University of London have discovered that cells can 'walk' on liquids a bit like the way geckos stick to other surfaces.

Living human tracheas

Wed, 14 Feb 18 00:06:10 -0800

Biomedical engineers at Case Western Reserve University in Cleveland, Ohio, and Worcester Polytechnic Institute in Worcester, Mass. are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure-without relying on scaffolding strategies currently being investigated by other groups.

Understanding how the body builds immunity, to build better influenza vaccines

Wed, 14 Feb 18 00:08:20 -0800

Scientists are now equipped with a more detailed picture of the human immune system's response to influenza vaccination, thanks to the results of a new investigation.

Clues to aging found in stem cells' genomes

Tue, 13 Feb 18 00:13:30 -0800

In fruit flies, repeating genetic elements shrink with age, but then expand in future generations, a resurgence that may help explain how some cells stay immortal.

In effort to treat rare blinding disease, researchers turn stem cells into blood vessels

Tue, 13 Feb 18 00:07:50 -0800

People with a mutated ATF6 gene have a malformed or missing fovea, the eye region responsible for detailed vision. From birth, vision is severely limited, and there is no cure. UC San Diego School of Medicine researchers were the first to link ATF6 to this type of vision impairment. Now, in a study published Feb. 13 in Science Signaling, the team discovered that a chemical that activates ATF6 converts patient stem cells into blood vessels.

True to type: From human biopsy to complex gut physiology on a chip

Tue, 13 Feb 18 00:10:00 -0800

Published in Scientific Reports, Donald Ingber's team at the Wyss Institute leverages the organoid approach to isolate intestinal stem cells from human biopsies, but goes on to break up the organoids and culture the patient-specific cells within our Organ Chips where they spontaneously form intestinal villi oriented towards the channel lumen, and the epithelium in close apposition to human intestinal microvascular endothelium

Web-based teaching can improve science understanding for struggling pupils

Mon, 12 Feb 18 00:10:10 -0800

Web-based learning tools can help deepen science knowledge among all middle school students, and ease the science literacy gap for underachieving students, according to a three-year study published today in the International Journal of Science Education.

Cancer killing clue could lead to safer and more powerful immunotherapies

Mon, 12 Feb 18 00:07:50 -0800

The study, led by Dr Misty Jenkins from the Walter and Eliza Hall Institute of Medical Research, explains the crucial mechanisms by which CAR-T cell therapy is able to rapidly target and kill cancer cells, and why it may cause serious side effects.

Chinese researchers report first lung stem cell transplantation clinical trial
A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot clinical trial. The study can be found in the open-access journal Protein