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Preview: Clinical Trials / Drug Trials News From Medical News Today

Clinical Trials / Drug Trials News From Medical News Today

Clinical trials are a type of research study to explore whether a medical treatment, drug, strategy or device is safe and effective for human use. The purpose of clinical trials is research, so the studies follow strict scientific standards. These standar

Copyright: Copyright 2016 Medical News Today

Investigational immunotherapy was safe, tolerable, and showed some activity against melanoma

Fri, 21 Oct 2016 00:00:00 PDT

The investigational immunotherapeutic IMC-20D7S was safe, well tolerated, and showed signs of modest clinical activity for patients with advanced melanoma, according to results from a...

Positive pivotal Phase 3 data announced demonstrating investigational Elagolix reduced endometriosis-associated pain

Thu, 20 Oct 2016 05:00:00 PDT

AbbVie, a global biopharmaceutical company in cooperation with Neurocrine Biosciences, Inc.

Depression could be treated with anti-inflammatory drugs

Tue, 18 Oct 2016 08:00:00 PDT

A new meta-analysis finds a new class of drugs used to treat inflammation in autoimmune diseases may also be an effective treatment for depression.

The placebo effect: Knowingly taking sham pills may reduce chronic pain

Mon, 17 Oct 2016 09:00:00 PDT

New study suggests it is not the expectation that a 'dummy pill' is real that elicits the placebo effect, but rather the ritual associated with taking it.

Caffeine did not induce arrhythmia in trial with heart failure patients

Mon, 17 Oct 2016 08:00:00 PDT

A trial where heart failure patients ingested 500 mg caffeine over 5 hours found no raised risk of arrhythmic episodes, even during treadmill stress test.

Breast cancer drug shows potential in patients with skin metastases

Fri, 14 Oct 2016 00:00:00 PDT

A study presented at the ESMO Congress reveals how the drug tucatinib led to a reduction in skin metastases for patients with breast cancer.

Cabozantinib improves progression-free survival in metastatic renal cell carcinoma

Wed, 12 Oct 2016 05:00:00 PDT

Cabozantinib significantly improves progression-free survival and response rate in patients with metastatic renal cell carcinoma compared to sunitinib, according to research presented at the ESMO...

Custirsen shows no survival benefits in metastatic prostate cancer

Wed, 12 Oct 2016 00:00:00 PDT

A phase III randomized controlled trial of custirsen in combination with cabazitaxel/prednisone in patients with previously-treated metastatic, castration-resistant prostate cancer has shown no...

MEK inhibition in KRAS-mutant non-small-cell lung cancer (NSCLC) did not improve survival

Wed, 12 Oct 2016 00:00:00 PDT

MEK inhibitor selumetinib in combination with docetaxel does not improve progression free or overall survival in individuals with KRAS-mutant non-small-cell lung cancer (NSCLC), according to data...

Greater patient selection may be needed for first line nivolumab to improve progression-free survival in advanced lung cancer

Tue, 11 Oct 2016 05:00:00 PDT

Greater patient selection may be needed for first line nivolumab to improve progression-free survival over chemotherapy in advanced lung cancer as the CheckMate 026 trial gave negative results in a...

Pembrolizumab new option for first line treatment of patients with advanced lung cancer and high PD-L1 expression

Tue, 11 Oct 2016 05:00:00 PDT

Pembrolizumab is set to become a new option for first line treatment of patients with advanced lung cancer and high PD-L1 expression, according to the results of the phase III KEYNOTE-024 trial...

Head and neck cancer: Immunotherapy drug a 'game-changer' for survival

Mon, 10 Oct 2016 07:00:00 PDT

A phase III trial of patients with head and neck cancer reveals the immunotherapy drug nivolumab greatly extended survival, compared with chemotherapy.

Reporting of adverse events in targeted therapy and immunotherapy trials is "suboptimal"

Mon, 10 Oct 2016 00:00:00 PDT

A significant number of trials of targeted therapies and immunotherapies in recent years show suboptimal reporting of adverse events, particularly the reporting of recurrent or late toxicities and...

Phase 3 results for Sun Pharma's investigational psoriasis medicine, tildrakizumab

Tue, 04 Oct 2016 00:00:00 PDT

Sun Pharma has announced late-breaking data from two pivotal Phase-3 clinical trials (reSURFACE 1 and 2) achieving the primary endpoint with tildrakizumab, an investigational IL-23p19 inhibitor, in...

Plaque psoriasis: CIMZIA (certolizumab pegol) Phase 3 trial results

Tue, 04 Oct 2016 00:00:00 PDT

UCB and Dermira, Inc. have announced topline results from CIMPASI-2, a Phase 3, multi-center, placebo-controlled clinical trial evaluating the efficacy and safety of CIMZIA® (certolizumab...

Psoriasis: Phase 3 guselkumab VOYAGE 1 data presented at EADV Congress

Mon, 03 Oct 2016 05:00:00 PDT

Janssen Research & Development, LLC (Janssen) has announced findings from the first of three pivotal Phase 3 studies evaluating guselkumab, a subcutaneously administered anti-interleukin (IL)-23...

Expectations may not match reality among cancer patients in some early phase clinical trials

Mon, 26 Sep 2016 00:00:00 PDT

In a study of cancer patients considering whether they should participate in phase I clinical trials, a high percentage were willing to participate after discussions with clinical staff, but nearly...

Sugar and heart disease: The sour side of industry-funded research

Wed, 21 Sep 2016 08:00:00 PDT

We investigate the discovery of an influential 1960s study that was funded by the sugar industry to play down the link between sugar and heart disease.

Under-reporting of side effects in clinical research

Tue, 20 Sep 2016 11:00:00 PDT

Side effects are incompletely reported in peer-reviewed journal articles describing research findings on the clinical benefits of drugs and other medical treatments, according to a systematic...

Positive data presented demonstrating erenumab significantly reduces monthly migraine days in patients with chronic migraine

Tue, 20 Sep 2016 00:00:00 PDT

Amgen has announced detailed global Phase 2 results showing erenumab demonstrated a statistically significant reduction in monthly migraine days compared with placebo in patients with chronic...

Statins: 'Harms have been overestimated,' says review

Fri, 09 Sep 2016 07:00:00 PDT

An in-depth review into the health outcomes of statin therapy suggests the benefits of the cholesterol-lowering drugs outweigh the risks.

New research method questions traditional efficacy trial model

Tue, 06 Sep 2016 00:00:00 PDT

Traditional efficacy trials have limited relevance to everyday clinical practice and should be changed, according the authors of a new study into chronic obstructive pulmonary disease (COPD)...

Asthma flare-ups reduced by antibody injection

Tue, 06 Sep 2016 00:00:00 PDT

Two trials have found that giving benralizumab injections over the course of a year may reduce the frequency of asthma exacerbations in severe asthma.

Pioneering Alzheimer's prevention study starts enrolling high-risk older adults

Fri, 26 Aug 2016 05:00:00 PDT

Researchers study whether two new drugs can reduce or eliminate protein linked to Alzheimer's.

Marijuana a better pain reliever for men than women

Fri, 19 Aug 2016 07:00:00 PDT

Compared with men who smoked marijuana, women did not experience a significant reduction in pain sensitivity, a new study reveals.