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HDAC & HDL Updates



Recent HD News and updates from HDLighthouse.org



Last Build Date: Sun, 6 Feb 2011 20:39:39 -0600

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University of Massachusetts Medical School and Lundbeck collaborate to develop RNAi [HDlighthouse.org]

Sun, 6 Feb 2011 12:01:02 -0600

A preclinical study of allele specific RNAi could prepare the way for clinical trials.



The Effects of Huntington's [HDAC.org]

Tue, 1 Feb 2011 12:01:02 -0600

Having HD can and does make my life extremely complicated. Everyday things that can come easily to other people can become a huge struggle.



Metalloproteinases [HDlighthouse.org]

Thu, 20 Jan 2011 12:01:02 -0600

Buck Institute researchers identify promising new targets.



The American ACR16 trial results [HDlighthouse.org]

Thu, 20 Jan 2011 12:01:02 -0600

The results of the HART trial are encouraging but not conclusive.



Everolimus Not Neuroprotective in the R6/2 mice [HDlighthouse.org]

Thu, 20 Jan 2011 12:01:02 -0600

A rapamycine derivative improves muscles but does not protect the brain.



2010 HDSA Covention Research Forum [HDlighthouse.org]

Wed, 19 Jan 2011 12:01:02 -0600

More from the convention!



Autophagy and Antioxidants [HDlighthouse.org]

Wed, 19 Jan 2011 12:01:02 -0600

Some antioxidants interfere with autophagy, an alternate way to clear away unwanted proteins.



Reduced Creatine Kinase [HDlighthouse.org]

Wed, 4 Aug 2010 12:01:02 -0500

Reduced creatine kinase is a promising biomarker.



Sirtuin Inhibition Achieves Neuroprotection by Decreasing Sterol Biosynthesis [HDlighthouse.org]

Sun, 25 Jul 2010 12:01:02 -0500

SIRT2 inhibition emerges as a promising therapeutic strategy.



Cargo Recognition is Impaired in HD [HDlighthouse.org]

Mon, 24 May 2010 12:01:02 -0500

Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol.



Neurosearch Amends the ACR-16 Results [HDlighthouse.org]

Mon, 24 May 2010 12:01:02 -0500

Statistical significance not achieved on primary endpoint.



Early Pre-Huntington's Symptoms? [HDAC.org]

Wed, 5 May 2010 12:01:02 -0500

The question of when “onset” occurs has always been a hard one to answer. People in HD families have known for many years that their loved ones' deterioration with HD occurred years before the doctors would or could diagnose it. Our HD does not become real to the medical world until the day we are diagnosed as symptomatic.



CoQ10 and Minocycline not helpful in Mouse Model [HDlighthouse.org]

Wed, 14 Apr 2010 12:01:02 -0500

Neither CoQ10 nor minocycline were helpful in the R6/2 mouse and high doses of minocycline resulted in decreased survival time.



The European trial of ACR16 yields good results [HDlighthouse.org]

Wed, 3 Feb 2010 12:01:02 -0600

ACR16 improves voluntary and involuntary movement. This is wonderful news!



A Sirtuin Inhibitor Enters Phase1a Clinical Trials in Europe [HDlighthouse.org]

Sun, 31 Jan 2010 12:01:02 -0600

Siena Biotech announces a safety and tolerability study with healthy volunteers, preparatory to trials in HD patients.