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Science Signaling



Science Signaling, the Signal Transduction Knowledge Environment



Published: 2017-02-10T15:40:26-05:00

 



[Research Article] The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection
Targeting a microRNA that inhibits type I interferon production may be a strategy to treat Japanese encephalitis virus infection.



[Research Article] Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Acetylation ofMDM2 promotes its oncogenic function by blocking its self-ubiquitination while enhancing its ubiquitination of the tumor suppressor p53.



[Research Resource] A high-throughput, image-based screen to identify kinases involved in brown adipocyte development
Multiple kinases are potential targets to enhance the development and function of brown fat.



[Editors' Choice] Tamoxifen as an immunotherapy
Antiestrogen drugs may treat some estrogen receptor-negative tumors by limiting the proliferation and activity of suppressive immune cells.



[Editors' Choice] When silencing mRNA, position matters
The mechanism of posttranscriptional silencing by an RNA-binding protein depends on the position of the protein-binding sequence in the mRNA.



[Editors' Choice] Pseudophosphatase as E3 ubiquitin ligase inhibitor
The pseudophosphatase STYX prevents the substrate recognition subunit FBXW7 from binding the catalytic E3 ubiquitin ligase complex.