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Science Signaling

Science Signaling, the Signal Transduction Knowledge Environment

Published: 2017-03-20T10:35:08-05:00


[Research Article] Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation
Structural analysis of the interactions between a receptor and monomeric or dimeric forms of its ligand may aid in drug design.

[Research Article] Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking
An inflammation-associated kinase also stimulates glucose uptake through plasma membrane translocation of GLUT4 in response to insulin.

[Research Resource] Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
Common changes in signaling pathway-associated gene expression may explain why chronic pain or stress can lead to depression.

[Editors' Choice] Autophagy and vitamin D
Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression.

[Editors' Choice] New connections: Getting the good without the bad, opiate edition
Researchers identify strategies to limit the adverse effects and liabilities of opioid receptor-targeting drugs.