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Science Signaling

Science Signaling, the Signal Transduction Knowledge Environment

Published: 2016-10-21T15:25:17-05:00


[Research Article] A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo
Fat tissue produces the secreted protease ADAMTS1, which activates a pathway that inhibits diet- or glucocorticoid-stimulated expansion of adipose tissue.

[Research Resource] Combinatorial interaction network of transcriptomic and phenotypic responses to nitrogen and hormones in the Arabidopsis thaliana root
Multivariate analysis reveals a hormone- and nutrient-regulated network that shapes root architecture.

[Podcast] Science Signaling Podcast for 25 October 2016: How glucorticoids stimulate fat
A secreted protease inhibits diet- and glucocorticoid-induced differentiation of adipocytes (Wong et al., in 25 October 2016 issue).

[Editors' Choice] Improving the health of newborns of obese mothers
AMPK activators may rescue brown adipose tissue development in neonates of obese mothers.

[Editors' Choice] Pathogen exploits Wnt receptors
Clostridium difficile toxin B blocks Wnt signaling and damages colonic epithelial cells by binding to Frizzled.

[Editors' Choice] Kinase inhibitors that block bromodomain interactions
Interference with protein interactions may be the mechanism of the anti-inflammatory and antiproliferative activity of dual function ERK5 inhibitors.

[Editors' Choice] A tauopathy kinase
Inhibiting the kinase NUAK1 could slow the accumulation of tau in Alzheimer's disease and progressive supranuclear palsy.