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Science Signaling

Science Signaling, the Signal Transduction Knowledge Environment

Published: 2017-01-13T10:57:23-05:00


[Focus] Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer
Targeting TNF receptor 2 may be a new avenue for treating ovarian cancer (Torrey et al., in 17 January 2017 issue).

[Research Article] Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs
An antibody against TNFR2 may treat ovarian cancer by killing tumor cells while limiting the activity of suppressive immune cells.

[Research Article] The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer
NRP2b connects oncogenic TGFβ to enhanced responsiveness to the promigratory growth factor HGF in non-small cell lung cancer cells.

[Research Article] De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
The tyrosine kinase Lck must undergo both conformational opening and phosphorylation to transduce signals from the T cell receptor.

[Editors' Choice] B cells prevent preterm labor
Premature labor and consequent neonatal mortality may be prevented by stimulating the expression of PIBF1 in uterine B cells.

[Editors' Choice] Translational complex for differentiation
NAT1 interacts with a subset of eukaryotic translation initiation factors to enable expression of transcripts required for stem cell differentiation signals.