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Science Signaling

Science Signaling, the Signal Transduction Knowledge Environment

Published: 2016-09-26T11:09:35-05:00


[Research Article] Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells
Blocking tumor-derived cytokine signaling in dendritic cells enables engineered dendritic cells to function as an antitumor vaccine.

[Research Article] Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling
Two soluble binding proteins that differ in inhibitory ability and abundance finetune signaling by the cytokine interleukin-22.

[Research Article] The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100
The NF-κB subunit RelB determines whether inhibitory or transcriptionally active complexes are formed during noncanonical signaling.

[Editors' Choice] Immunosuppression even in death
Dying tumor cells release potassium ions that suppress the activity of tumor-infiltrating T cells.

[Editors' Choice] One way fumarate can promote metastasis
Accumulation of the metabolite fumarate induces epigenetic changes that promote the epithelial-to-mesenchymal transition.

[Editors' Choice] Inhibiting the inflammasome
The kinase PKA phosphorylates and inactivates the NLRP3 inflammasome to restrain inflammation.

[Editors' Choice] Lupus and leptin
The hormone and cytokine leptin promotes disease progression in mouse models of systemic lupus erythematosus.