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Science Signaling

Science Signaling, the Signal Transduction Knowledge Environment

Published: 2016-11-23T13:39:25-05:00


[Research Article] Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus
Oxidative stress oligomerizes an outer mitochondrial membrane protein to trigger an antiviral response in the absence of infection.

[Research Article] Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia
Homotypic interactions between pre-B cell receptors generate survival signals in human acute lymphoblastic leukemia cells.

[Research Article] Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Biased agonists of the kappa opioid receptor may relieve intractable itch without causing unwanted side effects.

[Podcast] Science Signaling Podcast for 29 November 2016: Pre-B cell receptor signaling in leukemia
Transient homotypic interactions between pre-B cell receptors promote survival of acute lymphoblastic leukemia cells (Erasmus et al., in 29 November 2016 issue).

[Editors' Choice] A taste for the light
A photoreceptor with homology to taste receptors enables worms to avoid excessive UV exposure.

[Editors' Choice] ERK blocks pre-miRNA export
Blocking the ERK-dependent suppression of miRNA biogenesis may alleviate chemotherapeutic resistance in patients with liver cancer.

[Editors' Choice] Battling over mTORC1 in Treg cells
Metabolism in T regulatory cells depends on the balance between inflammatory signals and the transcriptional regulator Foxp3.

[Editors' Choice] Harmonizing ribosomal proteins and rRNA
An rRNA processing protein has an additional role in regulating the transcription of ribosomal proteins.